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  • Albena Dinkova-Kostova
2020

Activation of transcription factor Nrf2 to counteract mitochondrial dysfunction in Parkinson’s disease

Bento-Pereira, C. & Dinkova-Kostova, A., 18 Jul 2020, In : Medicinal Research Reviews. 18 p.

Research output: Contribution to journalReview article

Open Access
File
7 Downloads (Pure)

Biomarker Exploration in Human Peripheral Blood Mononuclear Cells for Monitoring Sulforaphane Treatment Responses in Autism Spectrum Disorder

Liu, H., Zimmerman, A. W., Singh, K., Connors, S. L., Diggins, E., Stephenson, K. K., Dinkova-Kostova, A. & Fahey, J. W., 2 Apr 2020, In : Scientific Reports. 10, 1, p. 1-11 11 p., 5822.

Research output: Contribution to journalArticle

Open Access
File
24 Downloads (Pure)

Can activation of NRF2 be a strategy against COVID-19?

Cuadrado, A., Pajares, M., Benito, C., Jiménez-Villegas, J., Escoll, M., Fernández-Ginés, R., Garcia Yagüe, A. J., Lastra, D., Manda, G., Rojo, A. I. & Dinkova-Kostova, A. T., 14 Jul 2020, In : Trends in Pharmacological Sciences. 13 p.

Research output: Contribution to journalReview article

Open Access

KEAP1, a cysteine-based sensor and a drug target for the prevention and treatment of chronic disease

Dayalan Naidu, S. & Dinkova-Kostova, A., Jun 2020, In : Open Biology. 10, 6, p. 1-13 13 p., 200105.

Research output: Contribution to journalArticle

Open Access
File
8 Downloads (Pure)

Obesity and NRF2-mediated cytoprotection: Where is the missing link?

Vasileva, L. V., Savova, M. S., Amirova, K. M., Dinkova-Kostova, A. & Georgiev, M. I., Jun 2020, In : Pharmacological Research. 156, p. 1-9 9 p., 104760.

Research output: Contribution to journalReview article

Open Access
File
5 Citations (Scopus)
58 Downloads (Pure)

Oxidative Stress in Cancer

Hayes, J., Dinkova-Kostova, A. & Tew, K. D., 9 Jul 2020, In : Cancer Cell. 38, 31 p.

Research output: Contribution to journalReview article

Radiomodulatory effect of a non-electrophilic NQO1 inducer identified in a screen of new 6, 8-diiodoquinazolin-4(3H)-ones carrying a sulfonamide moiety

Soliman, A. M., Karam, H. M., Mekkawy, M. H., Higgins, M., Dinkova-Kostova, A. & Ghorab, M. M., 18 May 2020, In : European Journal of Medicinal Chemistry. 200, 12 p., 112467.

Research output: Contribution to journalArticle

Open Access
File
3 Downloads (Pure)

The chemopreventive power of isothiocyanates

Naidu, S. D., Brodziak-Jarosz, L., Gerhäuser, C. & Dinkova-Kostova, A. T., 2020, Natural Products for Cancer Chemoprevention: Single Compounds and Combinations. Pezzuto, J. M. & Vang, O. (eds.). Switzerland: Springer , p. 271-318 48 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2019

Broccoli or Sulforaphane: Is It the Source or Dose That Matters?

Yagishita, Y., Fahey, J. W., Dinkova-Kostova, A. T. & Kensler, T. W., Oct 2019, In : Molecules and Cells. 24, 19, p. 1-38 38 p., 3593.

Research output: Contribution to journalReview article

Open Access
File
14 Citations (Scopus)
203 Downloads (Pure)

Investigation into the use of histone deacetylase inhibitor MS-275 as a topical agent for the prevention and treatment of cutaneous squamous cell carcinoma in an SKH-1 hairless mouse model

Kalin, J. H., Eroglu, A., Liu, H., Holtzclaw, W. D., Leigh, I., Proby, C. M., Fahey, J. W., Cole, P. A. & Dinkova-Kostova, A. T., 13 Mar 2019, In : PLoS ONE. 14, 3, p. 1-13 13 p., e0213095.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
115 Downloads (Pure)
Open Access
File
1 Citation (Scopus)
136 Downloads (Pure)

The isothiocyanate sulforaphane inhibits mTOR in an NRF2-independent manner

Zhang, Y., Gilmour, A., Ahn, Y-H., de la Vega, L. & Dinkova-Kostova, A., 5 Aug 2019, In : Phytomedicine. 153062.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
97 Downloads (Pure)

Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases

Cuadrado, A., Rojo, A. I., Wells, G., Hayes, J., Cousin, S. P., Rumsey, W. L., Attucks, O. C., Franklin, S., Levonen, A-L., Kensler, T. W. & Dinkova-Kostova, A., Apr 2019, In : Nature Reviews Drug Discovery. 18, 4, p. 295-317 23 p.

Research output: Contribution to journalReview article

Open Access
File
134 Citations (Scopus)
204 Downloads (Pure)
2018

A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia

Baardman, J., Verberk, S. G. S., Prange, K. H. M., van Weeghel, M., van der Velden, S., Ryan, D. G., Wüst, R. C. I., Neele, A. E., Speijer, D., Denis, S. W., Witte, M. E., Houtkooper, R. H., O'neill, L. A., Knatko, E. V., Dinkova-Kostova, A. T., Lutgens, E., de Winther, M. P. J. & Van den Bossche, J., 20 Nov 2018, In : Cell Reports. 25, 8, p. 2044-2052.e5 15 p.

Research output: Contribution to journalArticle

Open Access
File
28 Citations (Scopus)
162 Downloads (Pure)

Author Correction: Pathogenic p62/SQSTM1 mutations impair energy metabolism through limitation of mitochondrial substrates (Scientific Reports DOI: 10.1038/s41598-017-01678-4)

Bartolome, F., Esteras, N., Martin-Requero, A., Boutoleau-Bretonniere, C., Vercelletto, M., Gabelle, A., Ber, I. L., Honda, T., Dinkova-Kostova, A. T., Hardy, J., Carro, E. & Abramov, A. Y., 1 Dec 2018, In : Scientific Reports. 8, p. 1-2 2 p., 4064.

Research output: Contribution to journalComment/debate

Open Access
File
147 Downloads (Pure)

C151 in KEAP1 is the main cysteine sensor for the cyanoenone class of NRF2 activators, irrespective of molecular size or shape

Dayalan Naidu, S., Muramatsu, A., Saito, R., Asami, S., Honda, T., Hosoya, T., Itoh, K., Yamamoto, M., Suzuki, T. & Dinkova-Kostova, A., 23 May 2018, In : Scientific Reports. 8, 1, p. 1-12 12 p., 8037.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
127 Downloads (Pure)
Open Access
File
42 Citations (Scopus)
145 Downloads (Pure)

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

Mills, E. L., Ryan, D. G., Prag, H. A., Dikovskaya, D., Menon, D., Zaslona, Z., Jedrychowski, M. P., Costa, A. S. H., Higgins, M., Hams, E., Szpyt, J., Runtsch, M. C., King, M. S., McGouran, J. F., Fischer, R., Kessler, B. M., McGettrick, A. F., Hughes, M. M., Carroll, R. G., Booty, L. M. & 15 others, Knatko, E. V., Meakin, P. J., Ashford, M. L. J., Modis, L. K., Brunori, G., Sévin, D. C., Fallon, P. G., Caldwell, S. T., Kunji, E. R. S., Chouchani, E. T., Frezza, C., Dinkova-Kostova, A. T., Hartley, R. C., Murphy, M. P. & O'Neill, L. A., 5 Apr 2018, In : Nature. 556, 7699, p. 113-117 5 p.

Research output: Contribution to journalArticle

Open Access
File
244 Citations (Scopus)
645 Downloads (Pure)

KEAP1 inhibition is neuroprotective and suppresses the development of epilepsy

Shekh-Ahmad, T., Eckel, R., Dayalan Naidu, S., Higgins, M., Yamamoto, M., Dinkova-Kostova, A., Kovac, S., Abramov, A. Y. & Walker, M. C., May 2018, In : Brain. 141, 5, p. 1390-1403 14 p.

Research output: Contribution to journalArticle

Open Access
File
32 Citations (Scopus)
171 Downloads (Pure)

Phenethyl isothiocyanate, a dual activator of transcription factors NRF2 and HSF1

Dayalan Naidu, S., Suzuki, T., Yamamoto, M., Fahey, J. W. & Dinkova-Kostova, A., 1 Sep 2018, In : Molecular Nutrition & Food Research. 62, 18, p. e1700908 9 p., 1700908.

Research output: Contribution to journalReview article

Open Access
File
9 Citations (Scopus)
153 Downloads (Pure)

Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors

Kalin, J. H., Wu, M., Gomez, A. V., Song, Y., Das, J., Hayward, D., Adejola, N., Wu, M., Panova, I., Chung, H. J., Kim, E., Roberts, H. J., Roberts, J. M., Prusevich, P., Jeliazkov, J. R., Burman, S. S. R., Fairall, L., Milano, C., Eroglu, A., Proby, C. & 14 others, Dinkova-Kostova, A., Hancock, W. W., Gray, J. J., Bradner, J. E., Valente, S., Mai, A., Anders, N. M., Rudek, M. A., Hu, Y., Ryu, B., Schwabe, J. W. R., Mattevi, A., Alani, R. M. & Cole, P. A., 4 Jan 2018, In : Nature Communications. 9, 1, p. 1-13 13 p., 53.

Research output: Contribution to journalArticle

Open Access
File
61 Citations (Scopus)
167 Downloads (Pure)

The role of Nrf2 signaling in counteracting neurodegenerative diseases

Dinkova-Kostova, A. T., Kostov, R. V. & Kazantsev, A. G., 1 Oct 2018, In : FEBS Journal. 285, 19, p. 3576-3590 15 p.

Research output: Contribution to journalReview article

Open Access
File
54 Citations (Scopus)
235 Downloads (Pure)
2017

Activation of Nrf2 signaling as a common treatment of neurodegenerative diseases

Dinkova-Kostova, A. T. & Kazantsev, A. G., Apr 2017, In : Neurodegenerative Disease Management. 7, 2, p. 97-100 4 p.

Research output: Contribution to journalEditorial

Open Access
File
9 Citations (Scopus)
178 Downloads (Pure)

Activation of Nrf2 signaling augments Vesicular Stomatitis Virus Oncolysis via Autophagy-Driven Suppression of Antiviral Immunity

Olagnier, D., Lababidi, R. R., Bel Hadj, S., Sze, A., Liu, Y., Dayalan Naidu, S., Ferrari, M., Jiang, Y., Chiang, C., Beljanski, V., Goulet, M-L., Knatko, E. V., Dinkova-Kostova, A. T., Hiscott, J. & Lin, R., 2 Aug 2017, In : Molecular Therapy. 25, 8, p. 1900-1916 17 p.

Research output: Contribution to journalArticle

Open Access
File
29 Citations (Scopus)
169 Downloads (Pure)

Crosstalk between NRF2 and HIPK2 shapes cytoprotective responses

Torrente, L., Sanchez, C., Moreno Dorta, R., Chowdhry, S., Cabello, P., Isono, K., Koseki, H., Honda, T., Hayes, J., Dinkova-Kostova, A. & de la Vega, L., 2 Nov 2017, In : Oncogene. 36, 44, p. 6204-6212 9 p.

Research output: Contribution to journalArticle

Open Access
File
25 Citations (Scopus)
215 Downloads (Pure)
Open Access
File
6 Citations (Scopus)
276 Downloads (Pure)

Flavonolignan 2,3-dehydrosilydianin activates Nrf2 and upregulates NAD(P)H: quinone oxidoreductase 1 in Hepa1c1c7 cells

Roubalová, L., Dinkova-Kostova, A. T., Biedermann, D., Křen, V., Ulrichová, J. & Vrba, J., Jun 2017, In : Fitoterapia. 119, p. 115-120 6 p.

Research output: Contribution to journalArticle

Open Access
File
13 Citations (Scopus)
172 Downloads (Pure)

Keap1, the cysteine-based mammalian intracellular sensor for electrophiles and oxidants

Dinkova-Kostova, A. T., Kostov, R. V. & Canning, P., 1 Mar 2017, In : Archives of Biochemistry and Biophysics. 617, p. 84-93 10 p.

Research output: Contribution to journalArticle

Open Access
File
81 Citations (Scopus)
163 Downloads (Pure)

KEAP1 and done? Targeting the NRF2 pathway with sulforaphane: Targeting the NRF2 Pathway with Sulforaphane

Dinkova-Kostova, A. T., Fahey, J. W., Kostov, R. V. & Kensler, T. W., Nov 2017, In : Trends in Food Science and Technology. 69, B, p. 257-269 13 p.

Research output: Contribution to journalReview article

Open Access
File
70 Citations (Scopus)
375 Downloads (Pure)

KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients

Quinti, L., Dayalan Naidu, S., Träge, U., Chen, X., Kegel-Gleason, K., Lleres, D., Connolly, C., Chopra, V., Low, C., Moniot, S., Sapp, E., Tousley, A. R., Vodicka, P., Van Kanegan, M. J., Kaltenbach, L. S., Crawford, L. A., Fuszard, M., Higgins, M., Miller, J. R. C., Farmer, R. E. & 19 others, Potluri, V., Samajdar, S., Meisel, L., Zhang, N., Snyder, A., Stein, R., Hersch, S. M., Ellerby, L. M., Weerapana, E., Schwarzschild, M. A., Steegborn, C., Leavitt, B. R., Degterev, A., Tabrizi, S. J., Lo, D. C., DiFiglia, M., Thompson, L. M., Dinkova-Kostova, A. & Kazantsev, A. G., 6 Jun 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 23, p. e4676-e4685 10 p.

Research output: Contribution to journalArticle

Open Access
File
28 Citations (Scopus)
162 Downloads (Pure)

Metabolic and Homeostatic Changes in Seizures and Acquired Epilepsy-Mitochondria, Calcium Dynamics and Reactive Oxygen Species

Kovac, S., Dinkova Kostova, A. T., Herrmann, A. M., Melzer, N., Meuth, S. G. & Gorji, A., 8 Sep 2017, In : International Journal of Molecular Sciences. 18, 9, p. 1-19 19 p., 1935.

Research output: Contribution to journalReview article

Open Access
File
21 Citations (Scopus)
165 Downloads (Pure)

NRF2 as an emerging therapeutic target

Copple, I. M., Dinkova-Kostova, A. T., Kensler, T. W., Liby, K. T. & Wigley, W. C., 31 Jan 2017, In : Oxidative Medicine and Cellular Longevity. 2017, p. 1-2 2 p., 8165458.

Research output: Contribution to journalEditorial

Open Access
File
19 Citations (Scopus)
178 Downloads (Pure)
Open Access
File
8 Citations (Scopus)
200 Downloads (Pure)

Oxidative stress and chronic inflammation in osteoarthritis: can Nrf2 counteract these partners in crime?

Marchev, A. S., Dimitrova, P. A., Burns, A. J., Kostov, R., Dinkova-Kostova, A. & Georgiev, M. I., 11 Sep 2017, In : Annals of the New York Academy of Sciences. 1401, p. 114-135 22 p.

Research output: Contribution to journalReview article

Open Access
File
49 Citations (Scopus)
398 Downloads (Pure)

Oxidative stress management in the hair follicle: Could targeting NRF2 counter age-related hair disorders and beyond?

Jadkauskaite, L., Coulombe, P. A., Schäfer, M., Dinkova-Kostova, A. T., Paus, R. & Haslam, I. S., 27 Jul 2017, In : BioEssays. 39, 8, p. 1-9 9 p., 1700029.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Pathogenic p62/SQSTM1 mutations impair energy metabolism through limitation of mitochondrial substrates

Bartolome, F., Esteras, N., Martin-Requero, A., Boutoleau-Bretonniere, C., Vercelletto, M., Gabelle, A., Le Ber, I., Honda, T., Dinkova-Kostova, A. T., Hardy, J., Carro, E. & Abramov, A. Y., 10 May 2017, In : Scientific Reports. 7, p. 1-14 14 p., 1666.

Research output: Contribution to journalArticle

Open Access
File
25 Citations (Scopus)
284 Downloads (Pure)

Regulation of the mammalian heat shock factor 1

Dayalan Naidu, S. & Dinkova-Kostova, A. T., Jun 2017, In : FEBS Journal. 284, 11, p. 1606-1627 22 p.

Research output: Contribution to journalReview article

Open Access
File
50 Citations (Scopus)
236 Downloads (Pure)

Transcription factors NRF2 and HSF1 have opposing functions in autophagy

Dayalan Naidu, S., Dikovskaya, D., Gaurilcikaite, E., Knatko, E., Healy, Z. R., Mohan, H., Koh, G., Laurell, A., Ball, G., Olagnier, D., de la Vega, L., Ganley, I., Talalay, P. & Dinkova-Kostova, A., 8 Sep 2017, In : Scientific Reports. 7, p. 1-12 12 p., 11023.

Research output: Contribution to journalArticle

Open Access
File
23 Citations (Scopus)
198 Downloads (Pure)

Whole-exome sequencing validates a preclinical mouse model for the prevention and treatment of cutaneous squamous cell carcinoma

Knatko, E. V., Praslicka, B., Higgins, M., Evans, A., Purdie, K. J., Harwood, C. A., Proby, C. M., Ooi, A. & Dinkova-Kostova, A. T., Jan 2017, In : Cancer Prevention Research. 10, 1, p. 67-75 9 p.

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
138 Downloads (Pure)
2016

Bioactive polymethoxylated flavonoids from Chiliadenus montanus

Hamed, A. R., Mohamed, T. A., Tawfik, W. A., Hassan, E. M., Higgins, M., El-Toumy, S. A. & Dinkova-Kostova, A. T., 31 Mar 2016, In : Journal of Chemical and Pharmaceutical Research. 8, 3, p. 788-793 6 p.

Research output: Contribution to journalArticle

Open Access
File
105 Downloads (Pure)

Chemical constituents and NAD(P)H:Quinone oxidoreductase 1 (NQO1) inducer activity of Teucrium oliverianum Ging. ex Benth

Shahat, A. A., Alsaid, M. S., Khan, J. A., Higgins, M. & Dinkova-Kostova, A. T., Apr 2016, In : Indian Journal of Traditional Knowledge. 15, 2, p. 232-236 5 p.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
37 Downloads (Pure)

Electron affinity of tricyclic, bicyclic, and monocyclic compounds containing cyanoenones correlates with their potency as inducers of a cytoprotective enzyme

Bensasson, R. V., Dinkova-Kostova, A. T., Zheng, S., Saito, A., Li, W., Zoete, V. & Honda, T., 1 Sep 2016, In : Bioorganic & Medicinal Chemistry Letters. 26, 17, p. 4345-4349 5 p.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
148 Downloads (Pure)

Filaggrin genotype does not determine the skin's threshold to UV-induced erythema

Forbes, D., Johnston, L., Gardner, J., MacCallum, S. F., Campbell, L. E., Dinkova-Kostova, A. T., McLean, W. H. I., Ibbotson, S. H., Dawe, R. S. & Brown, S. J., Apr 2016, In : Journal of Allergy and Clinical Immunology. 137, 4, p. 1280-1282.e3 6 p.

Research output: Contribution to journalLetter

Open Access
File
6 Citations (Scopus)
122 Downloads (Pure)

Glucosinolates from the Brassica Vegetables and Their Health Effects

Johnson, T. L., Dinkova-Kostova, A. T. & Fahey, J. W., 2016, Encyclopedia of Food and Health. Caballero, B., Finglas, P. M. & Toldrá, F. (eds.). Elsevier Inc., p. 248-255 8 p. (Reference Module in Food Science).

Research output: Chapter in Book/Report/Conference proceedingEntry for encyclopedia/dictionary

4 Citations (Scopus)

Heat Shock Factor 1 is a Substrate for p38 Mitogen-Activated Protein Kinases

Dayalan Naidu, S., Sutherland, C., Zhang, Y., Risco, A., de la Vega, L., Caunt, C. J., Hastie, C. J., Lamont, D. J., Torrente, L., Chowdhry, S., Benjamin, I. J., Keyse, S. M., Cuenda, A. & Dinkova-Kostova, A. T., 15 Sep 2016, In : Molecular and Cellular Biology. 36, 18, p. 2403-2417 15 p.

Research output: Contribution to journalArticle

Open Access
File
26 Citations (Scopus)
225 Downloads (Pure)
Open Access
File
17 Citations (Scopus)
182 Downloads (Pure)

NAD(P)H: quinone oxidoreductase 1 inducer activity of some novel anilinoquinazoline derivatives

Ghorab, M. M., Alsaid, M. S., Higgins, M., Dinkova-Kostova, A. T., Shahat, A. A., Elghazawy, N. H. & Arafa, R. K., 8 Aug 2016, In : Drug Design, Development and Therapy. 10, p. 2515-2524 10 p.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
155 Downloads (Pure)

NAD(P)H: Quinone oxidoreductase 1 inducer activity of novel 4-aminoquinazoline derivatives

Ghorab, M. M., Alsaid, M. S., El-Gazzar, M. G., Higgins, M., Dinkova-Kostova, A. T. & Shahat, A. A., 2016, In : Journal of Enzyme Inhibition and Medicinal Chemistry. 31, 6, p. 1369-1374 7 p.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
152 Downloads (Pure)

Nrf2 activation in the treatment of neurodegenerative diseases: A focus on its role in mitochondrial bioenergetics and function

Esteras, N., Dinkova-Kostova, A. T. & Abramov, A. Y., May 2016, In : Biological Chemistry. 397, 5, p. 383-400 18 p.

Research output: Contribution to journalArticle

Open Access
File
56 Citations (Scopus)
246 Downloads (Pure)
Open Access
File
15 Citations (Scopus)
137 Downloads (Pure)