Find Research Outputs — Discovery - the University of Dundee Research Portal

Activation of Nrf2 signaling as a common treatment of neurodegenerative diseases

Dinkova-Kostova, A. T. & Kazantsev, A. G., Apr 2017, In : Neurodegenerative Disease Management. 7, 2, p. 97-100 4 p.

Research output: Contribution to journal › Editorial

Open Access

File

175 Downloads (Pure)

Activation of Nrf2 signaling augments Vesicular Stomatitis Virus Oncolysis via Autophagy-Driven Suppression of Antiviral Immunity

Olagnier, D., Lababidi, R. R., Bel Hadj, S., Sze, A., Liu, Y., Dayalan Naidu, S., Ferrari, M., Jiang, Y., Chiang, C., Beljanski, V., Goulet, M-L., Knatko, E. V., Dinkova-Kostova, A. T., Hiscott, J. & Lin, R., 2 Aug 2017, In : Molecular Therapy. 25, 8, p. 1900-1916 17 p.

Research output: Contribution to journal › Article

Open Access

File

26 Citations (Scopus)

158 Downloads (Pure)

Arthur Neish Young Investigator Award Lecture a Novel Role for Sulfhydryl-Reactive Activators of Transcription Factor NRF2: HSF1-Dependent Upregulation of Hsp70

Zhang, Y., Ahn, Y-H., Calabrese, V., Cole, P. A. & Dinkova-Kostova, A. T., May 2012, In : Pharmaceutical Biology. 50, 5, p. 625-625 1 p.

Research output: Contribution to journal › Special issue

Bioactive polymethoxylated flavonoids from Chiliadenus montanus

Hamed, A. R., Mohamed, T. A., Tawfik, W. A., Hassan, E. M., Higgins, M., El-Toumy, S. A. & Dinkova-Kostova, A. T., 31 Mar 2016, In : Journal of Chemical and Pharmaceutical Research. 8, 3, p. 788-793 6 p.

Research output: Contribution to journal › Article

Open Access

File

102 Downloads (Pure)

Broccoli or Sulforaphane: Is It the Source or Dose That Matters?

Yagishita, Y., Fahey, J. W., Dinkova-Kostova, A. T. & Kensler, T. W., Oct 2019, In : Molecules and Cells. 24, 19, p. 1-38 38 p., 3593.

Research output: Contribution to journal › Review article

Open Access

File

10 Citations (Scopus)

192 Downloads (Pure)

Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity

Calabrese, V., Cornelius, C., Dinkova-Kostova, A. T., Iavicoli, I., Di Paola, R., Koverech, A., Cuzzocrea, S., Rizzarelli, E. & Calabrese, E. J., May 2012, In : Biochimica et Biophysica Acta. Molecular Basis of Disease. 1822, 5, p. 753-783 31 p.

Research output: Contribution to journal › Review article

244 Citations (Scopus)

Chemical constituents and NAD(P)H:Quinone oxidoreductase 1 (NQO1) inducer activity of Teucrium oliverianum Ging. ex Benth

Shahat, A. A., Alsaid, M. S., Khan, J. A., Higgins, M. & Dinkova-Kostova, A. T., Apr 2016, In : Indian Journal of Traditional Knowledge. 15, 2, p. 232-236 5 p.

Research output: Contribution to journal › Article

Open Access

File

3 Citations (Scopus)

37 Downloads (Pure)

Chemical tuning enhances both potency toward Nrf2 and in vitro therapeutic index of triterpenoids

Copple, I. M., Shelton, L. M., Walsh, J., Kratschmar, D. V., Lister, A., Odermatt, A., Goldring, C. E., Dinkova-Kostova, A. T., Honda, T. & Park, B. K., Aug 2014, In : Toxicological Sciences. 140, 2, p. 462-469 8 p.

Research output: Contribution to journal › Article

Open Access

File

12 Citations (Scopus)

552 Downloads (Pure)

Chemoprotection Against Cancer by Isothiocyanates: A Focus on the Animal Models and the Protective Mechanisms

Dinkova-Kostova, A. T., 2013, Natural Products in Cancer Prevention and Therapy. Pezzuto, J. M. & Suh, N. (eds.). Berlin: Springer , p. 179-201 23 p. (Topics in Current Chemistry; vol. 329).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

30 Citations (Scopus)

Crosstalk between NRF2 and HIPK2 shapes cytoprotective responses

Torrente, L., Sanchez, C., Moreno Dorta, R., Chowdhry, S., Cabello, P., Isono, K., Koseki, H., Honda, T., Hayes, J., Dinkova-Kostova, A. & de la Vega, L., 2 Nov 2017, In : Oncogene. 36, 44, p. 6204-6212 9 p.

Research output: Contribution to journal › Article

Open Access

File

24 Citations (Scopus)

214 Downloads (Pure)

Design, synthesis, and evaluation of triazole derivatives that induce Nrf2 dependent gene products and inhibit the Keap1-Nrf2 protein-protein interaction

Bertrand, H. C., Schaap, M., Baird, L., Georgakopoulos, N. D., Fowkes, A., Thiollier, C., Kachi, H., Dinkova-Kostova, A. T. & Wells, G., 24 Sep 2015, In : Journal of Medicinal Chemistry. 58, 18, p. 7186-7194 9 p.

Research output: Contribution to journal › Article

57 Citations (Scopus)

Diffusion dynamics of the Keap1-Cullin3 interaction in single live cells

Baird, L. & Dinkova-Kostova, A. T., 2013, In : Biochemical and Biophysical Research Communications. 433, 1, p. 58-65 8 p.

Research output: Contribution to journal › Article

27 Citations (Scopus)

Dual regulation of transcription factor Nrf2 by Keap1 and by the combined actions of β-TrCP and GSK-3

Hayes, J. D., Chowdhry, S., Dinkova-Kostova, A. T. & Sutherland, C., Aug 2015, In : Biochemical Society Transactions. 43, 4, p. 611-620 10 p.

Research output: Contribution to journal › Article

54 Citations (Scopus)

Effects of chemoprotective agent HBB-2 on cell survival in SH-SY5Y neuroblastoma cells

Scuto, M. C., Cavallaro, M. M., Luca, M., Cornelius, C., Cambria, M. T., Rizza, S., Salinaro, A. T., Dinkova-Kostova, A. & Calabrese, V., 2011, In : FEBS Journal. 278, S1, p. 268 1 p., P14.37.

Research output: Contribution to journal › Meeting abstract

Electron affinity of tricyclic, bicyclic, and monocyclic compounds containing cyanoenones correlates with their potency as inducers of a cytoprotective enzyme

Bensasson, R. V., Dinkova-Kostova, A. T., Zheng, S., Saito, A., Li, W., Zoete, V. & Honda, T., 1 Sep 2016, In : Bioorganic & Medicinal Chemistry Letters. 26, 17, p. 4345-4349 5 p.

Research output: Contribution to journal › Article

Open Access

File

3 Citations (Scopus)

146 Downloads (Pure)

Epigenetic Control of NRF2-Directed Cellular Antioxidant Status in Dictating Life-Death Decisions

Hayes, J. D. & Dinkova-Kostova, A. T., 5 Oct 2017, In : Molecular Cell. 68, 1, p. 5-7 3 p.

Research output: Contribution to journal › Article

Open Access

File

5 Citations (Scopus)

268 Downloads (Pure)

Filaggrin genotype does not determine the skin's threshold to UV-induced erythema

Forbes, D., Johnston, L., Gardner, J., MacCallum, S. F., Campbell, L. E., Dinkova-Kostova, A. T., McLean, W. H. I., Ibbotson, S. H., Dawe, R. S. & Brown, S. J., Apr 2016, In : Journal of Allergy and Clinical Immunology. 137, 4, p. 1280-1282.e3 6 p.

Research output: Contribution to journal › Letter

Open Access

File

6 Citations (Scopus)

118 Downloads (Pure)

Flavonolignan 2,3-dehydrosilydianin activates Nrf2 and upregulates NAD(P)H: quinone oxidoreductase 1 in Hepa1c1c7 cells

Roubalová, L., Dinkova-Kostova, A. T., Biedermann, D., Křen, V., Ulrichová, J. & Vrba, J., Jun 2017, In : Fitoterapia. 119, p. 115-120 6 p.

Research output: Contribution to journal › Article

Open Access

File

13 Citations (Scopus)

166 Downloads (Pure)

Glucosinolates and isothiocyanates in health and disease

Dinkova-Kostova, A. T. & Kostov, R. V., 2012, In : Trends in Molecular Medicine. 18, 6, p. 337-347 11 p.

Research output: Contribution to journal › Article

302 Citations (Scopus)

Glucosinolates from the Brassica Vegetables and Their Health Effects

Johnson, T. L., Dinkova-Kostova, A. T. & Fahey, J. W., 2016, Encyclopedia of Food and Health. Caballero, B., Finglas, P. M. & Toldrá, F. (eds.). Elsevier Inc., p. 248-255 8 p. (Reference Module in Food Science).

Research output: Chapter in Book/Report/Conference proceeding › Entry for encyclopedia/dictionary

4 Citations (Scopus)

Glutathione S-transferase genotype is associated with sensitivity to psoralen-ultraviolet A photochemotherapy

Ibbotson, S. H., Dawe, R. S., Dinkova-Kostova, A. T., Weidlich, S., Farr, P. M., Ferguson, J., Wolf, C. R. & Smith, G., Feb 2012, In : British Journal of Dermatology. 166, 2, p. 380-388 9 p.

Research output: Contribution to journal › Article

17 Citations (Scopus)

Heat Shock Factor 1 is a Substrate for p38 Mitogen-Activated Protein Kinases

Dayalan Naidu, S., Sutherland, C., Zhang, Y., Risco, A., de la Vega, L., Caunt, C. J., Hastie, C. J., Lamont, D. J., Torrente, L., Chowdhry, S., Benjamin, I. J., Keyse, S. M., Cuenda, A. & Dinkova-Kostova, A. T., 15 Sep 2016, In : Molecular and Cellular Biology. 36, 18, p. 2403-2417 15 p.

Research output: Contribution to journal › Article

Open Access

File

24 Citations (Scopus)

222 Downloads (Pure)

Highly potent activation of Nrf2 by topical tricyclic bis(cyano enone): Implications for protection against UV radiation during thiopurine therapy

Kalra, S., Knatko, E. V., Zhang, Y., Honda, T., Yamamoto, M. & Dinkova-Kostova, A. T., 2012, In : Cancer Prevention Research. 5, 7, p. 973-981 9 p.

Research output: Contribution to journal › Article

28 Citations (Scopus)

HSF1-Dependent Upregulation of Hsp70 by Sulfhydryl-Reactive Inducers of the KEAP1/NRF2/ARE Pathway

Zhang, Y., Ahn, Y-H., Benjamin, I. J., Honda, T., Hicks, R. J., Calabrese, V., Cole, P. A. & Dinkova-Kostova, A. T., 23 Nov 2011, In : Chemistry & Biology. 18, 11, p. 1355-1361 7 p.

Research output: Contribution to journal › Article

62 Citations (Scopus)

Induction of the Keapl/Nrf2/ARE pathway by oxidizable diphenols

Dinkova-Kostova, A. T. & Wang, X. J., 30 Jun 2011, In : Chemico-Biological Interactions. 192, 1-2, p. 101-106 6 p.

Research output: Contribution to journal › Article

47 Citations (Scopus)

Investigation into the use of histone deacetylase inhibitor MS-275 as a topical agent for the prevention and treatment of cutaneous squamous cell carcinoma in an SKH-1 hairless mouse model

Kalin, J. H., Eroglu, A., Liu, H., Holtzclaw, W. D., Leigh, I., Proby, C. M., Fahey, J. W., Cole, P. A. & Dinkova-Kostova, A. T., 13 Mar 2019, In : PLoS ONE. 14, 3, p. 1-13 13 p., e0213095.

Research output: Contribution to journal › Article

Open Access

File

1 Citation (Scopus)

112 Downloads (Pure)

Keap1, the cysteine-based mammalian intracellular sensor for electrophiles and oxidants

Dinkova-Kostova, A. T., Kostov, R. V. & Canning, P., 1 Mar 2017, In : Archives of Biochemistry and Biophysics. 617, p. 84-93 10 p.

Research output: Contribution to journal › Article

Open Access

File

80 Citations (Scopus)

156 Downloads (Pure)

KEAP1 and done? Targeting the NRF2 pathway with sulforaphane: Targeting the NRF2 Pathway with Sulforaphane

Dinkova-Kostova, A. T., Fahey, J. W., Kostov, R. V. & Kensler, T. W., Nov 2017, In : Trends in Food Science and Technology. 69, B, p. 257-269 13 p.

Research output: Contribution to journal › Review article

Open Access

File

66 Citations (Scopus)

372 Downloads (Pure)

KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients

Quinti, L., Dayalan Naidu, S., Träge, U., Chen, X., Kegel-Gleason, K., Lleres, D., Connolly, C., Chopra, V., Low, C., Moniot, S., Sapp, E., Tousley, A. R., Vodicka, P., Van Kanegan, M. J., Kaltenbach, L. S., Crawford, L. A., Fuszard, M., Higgins, M., Miller, J. R. C., Farmer, R. E. & 19 others, Potluri, V., Samajdar, S., Meisel, L., Zhang, N., Snyder, A., Stein, R., Hersch, S. M., Ellerby, L. M., Weerapana, E., Schwarzschild, M. A., Steegborn, C., Leavitt, B. R., Degterev, A., Tabrizi, S. J., Lo, D. C., DiFiglia, M., Thompson, L. M., Dinkova-Kostova, A. & Kazantsev, A. G., 6 Jun 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 23, p. e4676-e4685 10 p.

Research output: Contribution to journal › Article

Open Access

File

26 Citations (Scopus)

155 Downloads (Pure)

Loss of Nrf2 abrogates the protective effect of Keap1 down regulation in a preclinical model of cutaneous squamous cell carcinoma

Knatko, E. V., Higgins, M., Fahey, J. W. & Dinkova-Kostova, A., 24 May 2016, In : Scientific Reports. 6, 7 p., 25804.

Research output: Contribution to journal › Article

Open Access

File

17 Citations (Scopus)

180 Downloads (Pure)

Measuring the Interaction of Transcription Factor Nrf2 with Its Negative Regulator Keap1 in Single Live Cells by an Improved FRET/FLIM Analysis

Dikovskaya, D., Appleton, P., Bento-Pereira, C. & Dinkova-Kostova, A., 18 Mar 2019, In : Chemical Research in Toxicology. 32, 3, p. 500-512 13 p.

Research output: Contribution to journal › Article

Open Access

File

1 Citation (Scopus)

135 Downloads (Pure)

Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease

Tebay, L. E., Robertson, H., Durant, S. T., Vitale, S. R., Penning, T. M., Dinkova-Kostova, A. T. & Hayes, J. D., Nov 2015, In : Free Radical Biology and Medicine. 88, Part B, p. 108-146 39 p.

Research output: Contribution to journal › Article

300 Citations (Scopus)

Metabolic and Homeostatic Changes in Seizures and Acquired Epilepsy-Mitochondria, Calcium Dynamics and Reactive Oxygen Species

Kovac, S., Dinkova Kostova, A. T., Herrmann, A. M., Melzer, N., Meuth, S. G. & Gorji, A., 8 Sep 2017, In : International Journal of Molecular Sciences. 18, 9, p. 1-19 19 p., 1935.

Research output: Contribution to journal › Review article

Open Access

File

21 Citations (Scopus)

165 Downloads (Pure)

Monitoring Keap1-Nrf2 interactions in single live cells

Baird, L., Swift, S., Llères, D. & Dinkova-Kostova, A. T., 1 Nov 2014, In : Biotechnology Advances. 32, 6, p. 1133-1144 12 p.

Research output: Contribution to journal › Article

Open Access

File

75 Citations (Scopus)

341 Downloads (Pure)

NAD(P)H: Quinone oxidoreductase 1 inducer activity of novel 4-aminoquinazoline derivatives

Ghorab, M. M., Alsaid, M. S., El-Gazzar, M. G., Higgins, M., Dinkova-Kostova, A. T. & Shahat, A. A., 2016, In : Journal of Enzyme Inhibition and Medicinal Chemistry. 31, 6, p. 1369-1374 7 p.

Research output: Contribution to journal › Article

Open Access

File

3 Citations (Scopus)

148 Downloads (Pure)

NAD(P)H: quinone oxidoreductase 1 inducer activity of some novel anilinoquinazoline derivatives

Ghorab, M. M., Alsaid, M. S., Higgins, M., Dinkova-Kostova, A. T., Shahat, A. A., Elghazawy, N. H. & Arafa, R. K., 8 Aug 2016, In : Drug Design, Development and Therapy. 10, p. 2515-2524 10 p.

Research output: Contribution to journal › Article

Open Access

File

3 Citations (Scopus)

151 Downloads (Pure)

NAD(P)H: Quinone oxidoreductase 1 inducer activity of some Saudi Arabian medicinal plants

Shahat, A. A., Alsaid, M. S., Alyahya, M. A., Higgins, M. & Dinkova-Kostova, A. T., Apr 2013, In : Planta Medica. 79, 6, p. 459-464 6 p.

Research output: Contribution to journal › Article

9 Citations (Scopus)

NAD(P)H: Quinone oxidoreductase 1 inducer activity of some enaminone derivatives

Alsaid, M. S., Ghorab, M. M., Higgins, M., Dinkova-Kostova, A. T. & Shahat, A. A., 2015, In : Biomedical Research. 26, 1, p. 7-12 6 p.

Research output: Contribution to journal › Article

5 Citations (Scopus)

Neuroprotective effects of sulforaphane after contusive spinal cord injury

Benedict, A. L., Mountney, A., Hurtado, A., Bryan, K. E., Schnaar, R. L., Dinkova-Kostova, A. T. & Talalay, P., 2012, In : Journal of Neurotrauma. 29, 16, p. 2576-2586 11 p.

Research output: Contribution to journal › Article

43 Citations (Scopus)

New monocyclic, bicyclic, and tricyclic ethynylcyanodienones as activators of the Keap1/Nrf2/ARE pathway and inhibitors of inducible nitric oxide synthase

Li, W., Zheng, S., Higgins, M., Morra, R. P., Mendis, A. T., Chien, C-W., Ojima, I., Mierke, D. F., Dinkova-Kostova, A. T. & Honda, T., 11 Jun 2015, In : Journal of Medicinal Chemistry. 58, 11, p. 4738-4748 11 p.

Research output: Contribution to journal › Article

22 Citations (Scopus)

Novel Thioureido Derivatives Carrying Thione and Sulfonamide Moieties Induce the Cytoprotective Enzyme NAD(P)H:Quione Oxidoreductase 1: Quinone oxidoreductase 1

Ghorab, M. M., Higgins, M., Dinkova-Kostova, A. T., Alsaid, M. S. & Shahat, A. A., 1 Dec 2014, In : Asian Journal of Chemistry. 26, 24, p. 8501-8504 4 p.

Research output: Contribution to journal › Article

2 Citations (Scopus)

Nrf2 activation in the treatment of neurodegenerative diseases: A focus on its role in mitochondrial bioenergetics and function

Esteras, N., Dinkova-Kostova, A. T. & Abramov, A. Y., May 2016, In : Biological Chemistry. 397, 5, p. 383-400 18 p.

Research output: Contribution to journal › Article

Open Access

File

55 Citations (Scopus)

239 Downloads (Pure)

Nrf2 activation protects against solar-simulated ultraviolet radiation in mice and humans

Knatko, E. V., Ibbotson, S. H., Zhang, Y., Higgins, M., Fahey, J. W., Talalay, P., Dawe, R. S., Ferguson, J., Huang, J. T-J., Clarke, R., Zheng, S., Saito, A., Kalra, S., Benedict, A. L., Honda, T., Proby, C. M. & Dinkova-Kostova, A. T., Jun 2015, In : Cancer Prevention Research. 8, 6, p. 475-486 12 p.

Research output: Contribution to journal › Article

47 Citations (Scopus)

Nrf2 affects the efficiency of mitochondrial fatty acid oxidation

Ludtmann, M. H. R., Angelova, P. R., Zhang, Y., Abramov, A. Y. & Dinkova-Kostova, A. T., 1 Feb 2014, In : Biochemical Journal. 457, 3, p. 415-424 10 p.

Research output: Contribution to journal › Article

95 Citations (Scopus)

NRF2 as an emerging therapeutic target

Copple, I. M., Dinkova-Kostova, A. T., Kensler, T. W., Liby, K. T. & Wigley, W. C., 31 Jan 2017, In : Oxidative Medicine and Cellular Longevity. 2017, p. 1-2 2 p., 8165458.

Research output: Contribution to journal › Editorial

Open Access

File

19 Citations (Scopus)

174 Downloads (Pure)

Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration

Holmström, K. M., Baird, L., Zhang, Y., Hargreaves, I., Chalasani, A., Land, J. M., Stanyer, L., Yamamoto, M., Dinkova-Kostova, A. T. & Abramov, A. Y., 15 Aug 2013, In : Open Biology. 2, 8, p. 761-770 10 p.

Research output: Contribution to journal › Article

Open Access

File