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Author

  • Carol MacKintosh
2020

A PKB-SPEG signaling nexus links insulin resistance with diabetic cardiomyopathy by regulating calcium homeostasis

Quan, C., Du, Q., Li, M., Wang, R., Ouyang, Q., Su, S., Zhu, S., Chen, Q., Sheng, Y., Chen, L., Campbell, D. G., MacKintosh, C., Yang, Z., Ouyang, K., Wang, H. Y. & Chen, S., 4 May 2020, In : Nature Communications. 11, p. 1-14 14 p., 2186.

Research output: Contribution to journalArticle

Open Access
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19 Downloads (Pure)
2019

SPEG Controls Calcium Re-Uptake into the Sarcoplasmic Reticulum Through Regulating SERCA2a by Its Second Kinase-Domain

Quan, C., Li, M., Du, Q., Chen, Q., Wang, H., Campbell, D. G., Fang, L., Xue, B., MacKintosh, C., Gao, X., Ouyang, K., Wang, H. & Chen, S., 1 Mar 2019, In : Circulation Research. 124, 5, p. 712-726 15 p.

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
210 Downloads (Pure)
2017

A Tbc1d1Ser231Ala-knockin mutation partially impairs AICAR- but not exercise-induced muscle glucose uptake in mice

Chen, Q., Xie, B., Zhu, S., Rong, P., Sheng, Y., Ducommun, S., Chen, L., Quan, C., Li, M., Sakamoto, K., MacKintosh, C., Chen, S. & Wang, H. Y., Feb 2017, In : Diabetologia. 60, 2, p. 336-345 10 p.

Research output: Contribution to journalArticle

Open Access
File
11 Citations (Scopus)
211 Downloads (Pure)

Recent advances in understanding the roles of whole genome duplications in evolution

MacKintosh, C. & Ferrier, D. E. K., 31 Aug 2017, In : F1000 Research. 6, 9 p., 1623.

Research output: Contribution to journalReview article

Open Access
File
5 Citations (Scopus)
201 Downloads (Pure)
2016

AMP-activated protein kinase: a cellular energy sensor that comes in twelve flavours

Ross, F. A., MacKintosh, C. & Hardie, D. G., 24 Mar 2016, In : FEBS Journal. 283, 16, p. 2987-3001 15 p.

Research output: Contribution to journalArticle

Open Access
File
120 Citations (Scopus)
96 Downloads (Pure)

Disruption of the AMPK-TBC1D1 nexus increases lipogenic gene expression and causes obesity in mice via promoting IGF1 secretion

Chen, L., Chen, Q., Xie, B., Quan, C., Sheng, Y., Zhu, S., Rong, P., Zhou, S., Sakamoto, K., MacKintosh, C., Wang, H. Y. & Chen, S., 28 Jun 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 26, p. 7219-7224 6 p.

Research output: Contribution to journalArticle

Open Access
File
21 Citations (Scopus)
385 Downloads (Pure)

The E3 ubiquitin ligase ZNRF2 is a substrate of mTORC1 and regulates its activation by amino acids

Hoxhaj, G., Caddye, E., Najafov, A., Houde, V. P., Johnson, C., Dissanayake, K., Toth, R., Campbell, D. G., Prescott, A. R. & MacKintosh, C., 22 Apr 2016, In : eLife. 5, p. 1-18 18 p., e12278.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
140 Downloads (Pure)
2015

14-3-3-Pred: Improved methods to predict 14-3-3-binding phosphopeptides

Madeira, F., Tinti, M., Murugesan, G., Berrett, E., Stafford, M., Toth, R., Cole, C., MacKintosh, C. & Barton, G. J., 2015, In : Bioinformatics.

Research output: Contribution to journalArticle

Open Access
File
58 Citations (Scopus)
315 Downloads (Pure)

Fasting and systemic insulin signaling regulate phosphorylation of brain proteins that modulate cell morphology and link to neurological disorders

Li, M., Quan, C., Toth, R., Campbell, D. G., MacKintosh, C., Wang, H. Y. & Chen, S., 11 Dec 2015, In : Journal of Biological Chemistry. 290, p. 30030-30041 12 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
167 Downloads (Pure)
2014

ANIA: ANnotation and Integrated Analysis of the 14-3-3 interactome

Tinti, M., Madeira, F., Murugesan, G., Hoxhaj, G., Toth, R. & Mackintosh, C., 2014, In : Database: the Journal of Biological Databases and Curation. 2014, 15 p., bat085.

Research output: Contribution to journalArticle

Open Access
File
27 Citations (Scopus)
186 Downloads (Pure)

GARNL1, a major RalGAP α subunit in skeletal muscle, regulates insulin-stimulated RalA activation and GLUT4 trafficking via interaction with 14-3-3 proteins

Chen, Q., Quan, C., Xie, B., Chen, L., Zhou, S., Toth, R., Campbell, D. G., Lu, S., Shirakawa, R., Horiuchi, H., Li, C., Yang, Z., MacKintosh, C., Wang, H. Y. & Chen, S., 2014, In : Cellular Signalling. 26, 8, p. 1636-1648 13 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Identification of 2R-ohnologue gene families displaying the same mutation-load skew in multiple cancers

Tinti, M., Dissanayake, K., Synowsky, S., Albergante, L. & Mackintosh, C., 7 May 2014, In : Open Biology. 4, May, 16 p., 140029.

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
184 Downloads (Pure)

Phosphoproteomics combined with quantitative 14-3-3-affinity capture identifies SIRT1 and RAI as novel regulators of cytosolic double-stranded RNA recognition pathway

Öhman, T., Söderholm, S., Hintsanen, P., Välimäki, E., Lietzén, N., MacKintosh, C., Aittokallio, T., Matikainen, S. & Nyman, T. A., Oct 2014, In : Molecular & Cellular Proteomics. 13, 10, p. 2604-2617 14 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2013

AS160 deficiency causes whole-body insulin resistance via composite effects in multiple tissues.

Chen, H-Y., Ducommun, S., Quan, C., Xie, B., Li, M., Wasserman, D. H., Sakamoto, K., MacKintosh, C. & Chen, S., 15 Jan 2013, In : Biochemical Journal. 449, 2, p. 479-489 11 p.

Research output: Contribution to journalArticle

Open Access
File
47 Citations (Scopus)
148 Downloads (Pure)

Effect of IRS4 levels on PI 3-kinase signalling.

Hoxhaj, G., Dissanayake, K. & MacKintosh, C., 10 Sep 2013, In : PLoS ONE. 8, 9, p. e73327 9 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)
2012

Evolution of signal multiplexing by 14-3-3-binding 2R-ohnologue protein families in the vertebrates

Tinti, M., Johnson, C., Toth, R., Ferrier, D. E. K. & MacKintosh, C., 2012, In : Open Biology. 2, 7, 120103.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Identification of the Amino Acids 300-600 of IRS-2 as 14-3-3 Binding Region with the Importance of IGF-1/Insulin-Regulated Phosphorylation of Ser-573

Neukamm, S. S., Toth, R., Morrice, N., Campbell, D. G., Mackintosh, C., Lehmann, R., Haering, H-U., Schleicher, E. D. & Weigert, C., 2012, In : PLoS ONE. 7, 8, p. e43296

Research output: Contribution to journalArticle

6 Citations (Scopus)

Thr(649)Ala-AS160 knock-in mutation does not impair contraction/AICAR-induced glucose transport in mouse muscle

Ducommun, S., Wang, H. Y., Sakamoto, K., MacKintosh, C. & Chen, S., May 2012, In : American Journal of Physiology, Endocrinology and Metabolism. 302, 9, p. E1036-E1043 8 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

ZNRF2 is released from membranes by growth factors and with ZNRF1 regulates the Na+/K+ATPase

Hoxhaj, G., Najafov, A., Toth, R., Campbell, D. G., Prescott, A. R. & MacKintosh, C., 1 Oct 2012, In : Journal of Cell Science. 125, 19, p. 4662-4675 14 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Mice with AS160/TBC1D4-Thr649Ala Knockin Mutation Are Glucose Intolerant with Reduced Insulin Sensitivity and Altered GLUT4 Trafficking

Chen, S., Wasserman, D. H., MacKintosh, C. & Sakamoto, K., 5 Jan 2011, In : Cell Metabolism. 13, 1, p. 68-79 12 p.

Research output: Contribution to journalArticle

98 Citations (Scopus)

The capture of phosphoproteins by 14-3-3 proteins mediates actions of insulin

Chen, S., Synowsky, S., Tinti, M. & MacKintosh, C., Nov 2011, In : Trends in Endocrinology and Metabolism. 22, 11, p. 429-436 8 p.

Research output: Contribution to journalReview article

36 Citations (Scopus)

Visualization and biochemical analyses of the emerging mammalian 14-3-3-phosphoproteome

Johnson, C., Tinti, M., Wood, N. T., Campbell, D. G., Toth, R., Dubois, F., Geraghty, K. M., Wong, B. H. C., Brown, L. J., Tyler, J., Gernez, A., Chen, S., Synowsky, S. & MacKintosh, C., Oct 2011, In : Molecular & Cellular Proteomics. 10, 10, p. - 15 p.

Research output: Contribution to journalArticle

48 Citations (Scopus)