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  • Paul Davies
2019

CDK1 and CDK2 regulate NICD1 turnover and the periodicity of the segmentation clock

Carrieri, F., Murray, P., Ditsova, D., Ferris, M. A., Davies, P. & Dale, K., 1 Jul 2019, In : EMBO Reports. 20, 7, p. 1-22 22 p., e46436.

Research output: Contribution to journalArticle

Open Access
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5 Citations (Scopus)
126 Downloads (Pure)
2018

Development of phospho-specific Rab protein antibodies to monitor in vivo activity of the LRRK2 Parkinson’s disease kinase

Lis, P., Burel, S., Steger, M., Mann, M., Brown, F., Diez, F., Tonelli, F., Holton, J. L., Winglok Ho, P., Ho, S-L., Chou, M-Y., Polinski, N. K., Martinez, T. N., Davies, P. & Alessi, D. R., 2 Jan 2018, In : Biochemical Journal. 475, 1, p. 1-22 22 p.

Research output: Contribution to journalArticle

Open Access
File
26 Citations (Scopus)
280 Downloads (Pure)

LRRK2 is a negative regulator of Mycobacterium tuberculosis phagosome maturation in macrophages

Härtlova, A., Herbst, S., Peltier, J., Rodgers, A., Bilkei-Gorzo, O., Fearns, A., Dill, B. D., Lee, H., Flynn, R., Cowley, S. A., Davies, P., Lewis, P. A., Ganley, I. G., Martinez, J., Alessi, D. R., Reith, A. D., Trost, M. & Gutierrez, M. G., 15 Jun 2018, In : The EMBO Journal. 37, 12, p. 1-17 17 p., e98694.

Research output: Contribution to journalArticle

Open Access
File
42 Citations (Scopus)
167 Downloads (Pure)
2016

Functional kinomics establishes a critical node of volume-sensitive cation-Cl- cotransporter regulation in the mammalian brain

Zhang, J., Gao, G., Begum, G., Wang, J., Khanna, A. R., Shmukler, B. E., Daubner, G. M., De Los Heros, P., Davies, P., Varghese, J., Bhuiyan, M. I. H., Duan, J., Zhang, J., Duran, D., Alper, S. L., Sun, D., Elledge, S. J., Alessi, D. R. & Kahle, K. T., 26 Oct 2016, In : Scientific Reports. 6, p. 1-19 19 p., 35986.

Research output: Contribution to journalArticle

Open Access
File
14 Citations (Scopus)
140 Downloads (Pure)

Phosphoproteomics reveals that Parkinson’s disease kinase LRRK2 regulates a subset of Rab GTPases

Steger, M., Tonelli, F., Ito, G., Davies, P., Trost, M., Vetter, M., Wachter, S., Lorentzen, E., Duddy, G., Wilson, S., Baptista, M. A. S., Fiske, B. K., Fell, M. J., Morrow, J. A., Reith, A. D., Alessi, D. R. & Mann, M., 29 Jan 2016, In : eLife. 5, p. 1-28 28 p., e12813.

Research output: Contribution to journalArticle

Open Access
File
287 Citations (Scopus)
224 Downloads (Pure)
2015

Photoactivatable prodrugs of antimelanoma agent Vemurafenib

Horbert, R., Pinchuk, B., Davies, P., Alessi, D. & Peifer, C., 18 Sep 2015, In : ACS Chemical Biology. 10, 9, p. 2099-2107 9 p.

Research output: Contribution to journalArticle

Open Access
File
29 Citations (Scopus)
332 Downloads (Pure)

Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock in mice

Yue, M., Hinkle, K., Davies, P., Trushina, E., Fiesel, F., Christenson, T., Schroeder, A., Zhang, L., Bowles, E., Behrouz, B., Lincoln, S., Beevers, J., Milnerwood, A., Kurti, A., McLean, P. J., Fryer, J. D., Springer, W., Dickson, D., Farrer, M. & Melrose, H., Jun 2015, In : Neurobiology of Disease. 78, p. 172-195 24 p.

Research output: Contribution to journalArticle

81 Citations (Scopus)
2014
Open Access
File
104 Citations (Scopus)
172 Downloads (Pure)

Investigation of LKB1 Ser431 phosphorylation and Cys433 farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity

Houde, V. P., Ritorto, M. S., Gourlay, R., Davies, P., Shpiro, N., Sakamoto, K. & Alessi, D. R., 15 Feb 2014, In : Biochemical Journal. 458, 1, p. 41-56 16 p.

Research output: Contribution to journalArticle

Open Access
File
30 Citations (Scopus)
145 Downloads (Pure)
2013

Comprehensive characterization and optimization of anti-LRRK2 (leucine-rich repeat kinase 2) monoclonal antibodies

Davies, P., Hinkle, K. M., Sukar, N. N., Sepulveda, B., Mesias, R., Serrano, G., Alessi, D. R., Beach, T. G., Benson, D. L., White, C. L., Cowell, R. M., Das, S. S., West, A. B. & Melrose, H. L., 1 Jul 2013, In : Biochemical Journal. 453, 1, p. 101-113 13 p.

Research output: Contribution to journalArticle

50 Citations (Scopus)
2011

Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2

Deng, X., Dzamko, N., Prescott, A., Davies, P., Liu, Q., Yang, Q., Lee, J-D., Patricelli, M. P., Nomanbhoy, T. K., Alessi, D. R. & Gray, N. S., Apr 2011, In : Nature Chemical Biology. 7, 4, p. 203-205 3 p.

Research output: Contribution to journalArticle

243 Citations (Scopus)