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• 2020

  Activation of transcription factor Nrf2 to counteract mitochondrial dysfunction in Parkinson’s disease

  Bento-Pereira, C. & Dinkova-Kostova, A., 18 Jul 2020, In: Medicinal Research Reviews. 18 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Parkinson Disease
  • Transcription Factors
  • NF-E2 Transcription Factor
  • Names
  • Neurodegenerative Diseases
  1 Citation (Scopus)

  29 Downloads (Pure)

• Biomarker Exploration in Human Peripheral Blood Mononuclear Cells for Monitoring Sulforaphane Treatment Responses in Autism Spectrum Disorder

  Liu, H., Zimmerman, A. W., Singh, K., Connors, S. L., Diggins, E., Stephenson, K. K., Dinkova-Kostova, A. & Fahey, J. W., 2 Apr 2020, In: Scientific Reports. 10, 11 p., 5822.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • sulforafan
  • Autism Spectrum Disorder
  • Blood Cells
  • Biomarkers
  • Messenger RNA
  8 Citations (Scopus)

  43 Downloads (Pure)

• Can activation of NRF2 be a strategy against COVID-19?

  Cuadrado, A., Pajares, M., Benito, C., Jiménez-Villegas, J., Escoll, M., Fernández-Ginés, R., Garcia Yagüe, A. J., Lastra, D., Manda, G., Rojo, A. I. & Dinkova-Kostova, A. T., Sep 2020, In: Trends in Pharmacological Sciences. 41, 9, p. 598-610 13 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Alveolar Epithelial Cells
  • Chemical activation
  • methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate
  • Anti-Inflammatory Agents
  • T-cells
  18 Citations (Scopus)

  124 Downloads (Pure)

• Downregulation of Keap1 confers features of a fasted metabolic state

  Knatko, E. V., Tatham, M. H., Zhang, Y., Castro, C., Higgins, M., Dayalan Naidu, S., Leonardi, C., de la Vega, L., Honda, T., Griffin, J. L., Hay, R. T. & Dinkova-Kostova, A. T., 23 Oct 2020, In: iScience. 23, 10, 48 p., 101638.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Kelch-Like ECH-Associated Protein 1
  • Mouse Keap1 protein
  • Down-Regulation
  • Oxidation-Reduction
  • NF-E2 Transcription Factor
  19 Downloads (Pure)

• High NRF2 Levels Correlate with Poor Prognosis in Colorectal Cancer Patients and with Sensitivity to the Kinase Inhibitor AT9283 In Vitro

  Torrente Fernandez, L., Maan, G., Rezig, A. O., Quinn, J., Jackson, A., Grilli, A., Casares, L., Zhang, Y., Kulesskiy, E., Saarela, J., Bicciato, S., Edwards, J., Dinkova-Kostova, A. & de la Vega, L., Oct 2020, In: Biomolecules. 10, 10, 16 p., 1365.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • 1-cyclopropyl-3-(3-(5-morpholin-4-ylmethyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl)urea
  • NF-E2-Related Factor 2
  • Colorectal Neoplasms
  • Phosphotransferases
  • In Vitro Techniques
  2 Citations (Scopus)

  12 Downloads (Pure)

• Isomeric O-methyl cannabidiolquinones with dual BACH1/NRF2 activity

  Casares Perez, L., Unciti-Broceta, J. D., Prados, M. E., Caprioglio, D., Mattoteia, D., Higgins, M., Apendino, G., Dinkova-Kostova, A. T., Muñoz, E. & de la Vega, L., Oct 2020, In: Redox Biology. 37, p. 1-10 10 p., 101689.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cannabidiol
  • Neurodegenerative diseases
  • Neurodegenerative Diseases
  • Oxidative stress
  • Derivatives
  1 Citation (Scopus)

  32 Downloads (Pure)

• KEAP1, a cysteine-based sensor and a drug target for the prevention and treatment of chronic disease: KEAP1, a sensor and a drug target

  Dayalan Naidu, S. & Dinkova-Kostova, A., Jun 2020, In: Open Biology. 10, 6, p. 1-13 13 p., 200105.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Kelch-Like ECH-Associated Protein 1
  • Oxidation-Reduction
  • Cysteine
  • Chronic Disease
  • Sensors
  6 Citations (Scopus)

  22 Downloads (Pure)

• Measuring Changes in Keap1‐Nrf2 Protein Complex Conformation in Individual Cells by FLIM‐FRET

  Dikovskaya, D. & Dinkova-Kostova, A., Sep 2020, In: Current Protocols in Toxicology. 85, 1, p. 1-34 34 p., e96.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Kelch-Like ECH-Associated Protein 1
  • Protein Conformation
  • Conformations
  • Fluorescence
  • Photons
  37 Downloads (Pure)

• NRF2 and the Ambiguous Consequences of Its Activation during Initiation and the Subsequent Stages of Tumourigenesis

  Robertson, H., Dinkova-Kostova, A. T. & Hayes, J. D., 2 Dec 2020, In: Cancers. 12, 12, 48 p., 3609.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Kelch-Like ECH-Associated Protein 1
  • Cullin Proteins
  • Neoplasms
  • Mutation
  • Sulfhydryl Compounds
  14 Downloads (Pure)

• Nrf2 is activated by disruption of mitochondrial thiol homeostasis but not by enhanced mitochondrial superoxide production

  Cvetko, F., Caldwell, S. T., Higgins, M., Suzuki, T., Yamamoto, M., Prag, H. A., Hartley, R. C., Dinkova-Kostova, A. & Murphy, M. P., 20 Dec 2020, In: Journal of Biological Chemistry. 296, 14 p., 100169.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Sulfhydryl Compounds
  • Hydrogen Peroxide
  • Superoxides
  • Oxidation-Reduction
  • Homeostasis
  36 Downloads (Pure)

• Obesity and NRF2-mediated cytoprotection: Where is the missing link?

  Vasileva, L. V., Savova, M. S., Amirova, K. M., Dinkova-Kostova, A. & Georgiev, M. I., Jun 2020, In: Pharmacological Research. 156, p. 1-9 9 p., 104760.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Cytoprotection
  • Obesity
  • NF-E2 Transcription Factor
  • Oxidative Stress
  • Reactive Nitrogen Species
  16 Citations (Scopus)

  135 Downloads (Pure)

• Oxidative Stress in Cancer

  Hayes, J., Dinkova-Kostova, A. & Tew, K. D., 10 Aug 2020, In: Cancer Cell. 38, 31 p.

  Research output: Contribution to journal › Review article › peer-review

  • NADP
  • Oxidative Stress
  • Pentose Phosphate Pathway
  • Reactive Oxygen Species
  • Antioxidants
  28 Citations (Scopus)

• Radiomodulatory effect of a non-electrophilic NQO1 inducer identified in a screen of new 6, 8-diiodoquinazolin-4(3H)-ones carrying a sulfonamide moiety

  Soliman, A. M., Karam, H. M., Mekkawy, M. H., Higgins, M., Dinkova-Kostova, A. & Ghorab, M. M., 15 Aug 2020, In: European Journal of Medicinal Chemistry. 200, 12 p., 112467.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • acetamide
  • Sulfonamides
  • Quinazolinones
  • benzenesulfonamide
  • compound 18
  4 Citations (Scopus)

  30 Downloads (Pure)

• Sulfoxythiocarbamate S-4 inhibits HSP90 in human cutaneous squamous cell carcinoma cells

  Zhang, Y., VanHecke, G. C., Ahn, Y-H., Proby, C. M. & Dinkova-Kostova, A. T., 15 Dec 2020, In: European Journal of Pharmacology. 889, 9 p., 173609.

  Research output: Contribution to journal › Article › peer-review

  • HSP90 Heat-Shock Proteins
  • Squamous Cell Carcinoma
  • Skin
  • E2F Transcription Factors
  • Cyclin D

• The chemopreventive power of isothiocyanates

  Naidu, S. D., Brodziak-Jarosz, L., Gerhäuser, C. & Dinkova-Kostova, A. T., 2020, Natural Products for Cancer Chemoprevention: Single Compounds and Combinations. Pezzuto, J. M. & Vang, O. (eds.). Switzerland: Springer , p. 271-318 48 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Isothiocyanates
  • benzyl isothiocyanate
  • Glucosinolates
  • phenethyl isothiocyanate
  • sulforafan

• The stress-responsive kinase DYRK2 activates heat shock factor 1 promoting resistance to proteotoxic stress

  Moreno Dorta, R., Banerjee, S., Jackson, A. W., Quinn, J., Baillie, G., Dixon, J. E., Dinkova-Kostova, A., Edwards, J. & de la Vega, L., 2 Dec 2020, In: Cell Death & Differentiation. 0, p. 1-16 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • TYK2 Kinase
  • Heat-Shock Response
  • Triple Negative Breast Neoplasms
  • Phosphotransferases
  • Heat Shock Transcription Factors
  27 Downloads (Pure)
• 2019

  Broccoli or Sulforaphane: Is It the Source or Dose That Matters?

  Yagishita, Y., Fahey, J. W., Dinkova-Kostova, A. T. & Kensler, T. W., Oct 2019, In: Molecules and Cells. 24, 19, p. 1-38 38 p., 3593.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • sulforafan
  • Brassica
  • glucoraphanin
  • thioglucosidase
  • Pharmacodynamics
  35 Citations (Scopus)

  289 Downloads (Pure)

• Investigation into the use of histone deacetylase inhibitor MS-275 as a topical agent for the prevention and treatment of cutaneous squamous cell carcinoma in an SKH-1 hairless mouse model

  Kalin, J. H., Eroglu, A., Liu, H., Holtzclaw, W. D., Leigh, I., Proby, C. M., Fahey, J. W., Cole, P. A. & Dinkova-Kostova, A. T., 13 Mar 2019, In: PLoS ONE. 14, 3, p. 1-13 13 p., e0213095.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • entinostat
  • Epithelial Cells
  • squamous cell carcinoma
  • histone deacetylase
  • Hairless Mouse
  2 Citations (Scopus)

  137 Downloads (Pure)

• Measuring the Interaction of Transcription Factor Nrf2 with Its Negative Regulator Keap1 in Single Live Cells by an Improved FRET/FLIM Analysis

  Dikovskaya, D., Appleton, P., Bento-Pereira, C. & Dinkova-Kostova, A., 18 Mar 2019, In: Chemical Research in Toxicology. 32, 3, p. 500-512 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Kelch-Like ECH-Associated Protein 1
  • NF-E2 Transcription Factor
  • Forster resonance energy transfer
  • NF-E2-Related Factor 2
  • Transcription Factors
  4 Citations (Scopus)

  163 Downloads (Pure)

• The isothiocyanate sulforaphane inhibits mTOR in an NRF2-independent manner

  Zhang, Y., Gilmour, A., Ahn, Y-H., de la Vega, L. & Dinkova-Kostova, A., 5 Aug 2019, In: Phytomedicine. 153062.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • sulforafan
  • isothiocyanic acid
  • Sirolimus
  • Histone Deacetylase 6
  • Inhibition (Psychology)
  4 Citations (Scopus)

  119 Downloads (Pure)

• Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases

  Cuadrado, A., Rojo, A. I., Wells, G., Hayes, J., Cousin, S. P., Rumsey, W. L., Attucks, O. C., Franklin, S., Levonen, A-L., Kensler, T. W. & Dinkova-Kostova, A., Apr 2019, In: Nature Reviews Drug Discovery. 18, 4, p. 295-317 23 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Kelch-Like ECH-Associated Protein 1
  • Chronic Disease
  • NF-E2-Related Factor 2
  • Proteostasis
  • Cytoprotection
  229 Citations (Scopus)

  259 Downloads (Pure)
• 2018

  A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia

  Baardman, J., Verberk, S. G. S., Prange, K. H. M., van Weeghel, M., van der Velden, S., Ryan, D. G., Wüst, R. C. I., Neele, A. E., Speijer, D., Denis, S. W., Witte, M. E., Houtkooper, R. H., O'neill, L. A., Knatko, E. V., Dinkova-Kostova, A. T., Lutgens, E., de Winther, M. P. J. & Van den Bossche, J., 20 Nov 2018, In: Cell Reports. 25, 8, p. 2044-2052.e5 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Macrophages
  • Pentoses
  • Pentose Phosphate Pathway
  • Metabolism
  • Hypercholesterolemia
  40 Citations (Scopus)

  219 Downloads (Pure)

• Author Correction: Pathogenic p62/SQSTM1 mutations impair energy metabolism through limitation of mitochondrial substrates (Scientific Reports DOI: 10.1038/s41598-017-01678-4)

  Bartolome, F., Esteras, N., Martin-Requero, A., Boutoleau-Bretonniere, C., Vercelletto, M., Gabelle, A., Ber, I. L., Honda, T., Dinkova-Kostova, A. T., Hardy, J., Carro, E. & Abramov, A. Y., 1 Dec 2018, In: Scientific Reports. 8, p. 1-2 2 p., 4064.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  File

  • Energy Metabolism
  • Mutation
  166 Downloads (Pure)

• C151 in KEAP1 is the main cysteine sensor for the cyanoenone class of NRF2 activators, irrespective of molecular size or shape

  Dayalan Naidu, S., Muramatsu, A., Saito, R., Asami, S., Honda, T., Hosoya, T., Itoh, K., Yamamoto, M., Suzuki, T. & Dinkova-Kostova, A., 23 May 2018, In: Scientific Reports. 8, 1, p. 1-12 12 p., 8037.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Kelch-Like ECH-Associated Protein 1
  • Cysteine
  • TBE 31
  • Lipopolysaccharides
  • Interleukin-6
  17 Citations (Scopus)

  156 Downloads (Pure)

• Experimental Nonalcoholic Steatohepatitis and Liver Fibrosis Are Ameliorated by Pharmacologic Activation of Nrf2 (NF-E2 p45-Related Factor 2)

  Sharma, R. S., Harrison, D. J., Kisielewski, D., Cassidy, D. M., McNeilly, A. D., Gallagher, J. R., Walsh, S. V., Honda, T., McCrimmon, R. J., Dinkova-Kostova, A. T., Ashford, M. L. J., Dillon, J. F. & Hayes, J. D., 1 Mar 2018, In: CMGH: Cellular and Molecular Gastroenterology and Hepatology. 5, 3, p. 367-398 32 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • TBE 31
  • NF-E2-Related Factor 2
  • Fructose
  • Non-alcoholic Fatty Liver Disease
  • Liver Cirrhosis
  63 Citations (Scopus)

  171 Downloads (Pure)

• Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

  Mills, E. L., Ryan, D. G., Prag, H. A., Dikovskaya, D., Menon, D., Zaslona, Z., Jedrychowski, M. P., Costa, A. S. H., Higgins, M., Hams, E., Szpyt, J., Runtsch, M. C., King, M. S., McGouran, J. F., Fischer, R., Kessler, B. M., McGettrick, A. F., Hughes, M. M., Carroll, R. G., Booty, L. M. & 15 others, Knatko, E. V., Meakin, P. J., Ashford, M. L. J., Modis, L. K., Brunori, G., Sévin, D. C., Fallon, P. G., Caldwell, S. T., Kunji, E. R. S., Chouchani, E. T., Frezza, C., Dinkova-Kostova, A. T., Hartley, R. C., Murphy, M. P. & O'Neill, L. A., 5 Apr 2018, In: Nature. 556, 7699, p. 113-117 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • itaconic acid
  • Alkylation
  • Anti-Inflammatory Agents
  • Interferon Type I
  • Cysteine
  348 Citations (Scopus)

  827 Downloads (Pure)

• KEAP₁ inhibition is neuroprotective and suppresses the development of epilepsy

  Shekh-Ahmad, T., Eckel, R., Dayalan Naidu, S., Higgins, M., Yamamoto, M., Dinkova-Kostova, A., Kovac, S., Abramov, A. Y. & Walker, M. C., May 2018, In: Brain. 141, 5, p. 1390-1403 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • N-(11-cyano-2,2,6a,6b,9,9,12a-heptmethyl-10,14-dioxo-1,3,4,5,6a,6b,7,8,8a,9,10,12a,14,14a,14b-hexadecahydro-2H-picen-4a-yl)-2-2-difluoropropionamide
  • Kelch-Like ECH-Associated Protein 1
  • Status Epilepticus
  • Epilepsy
  • Reactive Oxygen Species
  39 Citations (Scopus)

  202 Downloads (Pure)

• Phenethyl isothiocyanate, a dual activator of transcription factors NRF2 and HSF1

  Dayalan Naidu, S., Suzuki, T., Yamamoto, M., Fahey, J. W. & Dinkova-Kostova, A., 1 Sep 2018, In: Molecular Nutrition & Food Research. 62, 18, p. e1700908 9 p., 1700908.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • phenethyl isothiocyanate
  • Heat Shock Transcription Factors
  • isothiocyanates
  • heat stress
  • transcription factors
  13 Citations (Scopus)

  190 Downloads (Pure)

• Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors

  Kalin, J. H., Wu, M., Gomez, A. V., Song, Y., Das, J., Hayward, D., Adejola, N., Wu, M., Panova, I., Chung, H. J., Kim, E., Roberts, H. J., Roberts, J. M., Prusevich, P., Jeliazkov, J. R., Burman, S. S. R., Fairall, L., Milano, C., Eroglu, A., Proby, C. & 14 others, Dinkova-Kostova, A., Hancock, W. W., Gray, J. J., Bradner, J. E., Valente, S., Mai, A., Anders, N. M., Rudek, M. A., Hu, Y., Ryu, B., Schwabe, J. W. R., Mattevi, A., Alani, R. M. & Cole, P. A., 4 Jan 2018, In: Nature Communications. 9, 1, p. 1-13 13 p., 53.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • entinostat
  • Histone Demethylases
  • Histone Deacetylase Inhibitors
  • Histone Deacetylases
  • inhibitors
  82 Citations (Scopus)

  198 Downloads (Pure)

• The role of Nrf2 signaling in counteracting neurodegenerative diseases

  Dinkova-Kostova, A. T., Kostov, R. V. & Kazantsev, A. G., 1 Oct 2018, In: FEBS Journal. 285, 19, p. 3576-3590 15 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Neurodegenerative diseases
  • Neurodegenerative Diseases
  • Detoxification
  • Antioxidants
  • Oxidation-Reduction
  82 Citations (Scopus)

  273 Downloads (Pure)
• 2017

  Activation of Nrf2 signaling as a common treatment of neurodegenerative diseases

  Dinkova-Kostova, A. T. & Kazantsev, A. G., Apr 2017, In: Neurodegenerative Disease Management. 7, 2, p. 97-100 4 p.

  Research output: Contribution to journal › Editorial

  Open Access

  File
  11 Citations (Scopus)

  202 Downloads (Pure)

• Activation of Nrf2 signaling augments Vesicular Stomatitis Virus Oncolysis via Autophagy-Driven Suppression of Antiviral Immunity

  Olagnier, D., Lababidi, R. R., Bel Hadj, S., Sze, A., Liu, Y., Dayalan Naidu, S., Ferrari, M., Jiang, Y., Chiang, C., Beljanski, V., Goulet, M-L., Knatko, E. V., Dinkova-Kostova, A. T., Hiscott, J. & Lin, R., 2 Aug 2017, In: Molecular Therapy. 25, 8, p. 1900-1916 17 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Vesicular Stomatitis
  • Autophagy
  • Antiviral Agents
  • Immunity
  • Oncolytic Viruses
  36 Citations (Scopus)

  195 Downloads (Pure)

• Crosstalk between NRF2 and HIPK2 shapes cytoprotective responses

  Torrente, L., Sanchez, C., Moreno Dorta, R., Chowdhry, S., Cabello, P., Isono, K., Koseki, H., Honda, T., Hayes, J., Dinkova-Kostova, A. & de la Vega, L., 2 Nov 2017, In: Oncogene. 36, 44, p. 6204-6212 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Homeodomain Proteins
  • Protein Kinases
  • Neoplasms
  • Phosphotransferases
  • Oncogenes
  32 Citations (Scopus)

  241 Downloads (Pure)

• Epigenetic Control of NRF2-Directed Cellular Antioxidant Status in Dictating Life-Death Decisions

  Hayes, J. D. & Dinkova-Kostova, A. T., 5 Oct 2017, In: Molecular Cell. 68, 1, p. 5-7 3 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Epigenomics
  • Antioxidants
  • Tumor Suppressor Proteins
  • Acetylation
  • Oxidation-Reduction
  8 Citations (Scopus)

  315 Downloads (Pure)

• Flavonolignan 2,3-dehydrosilydianin activates Nrf2 and upregulates NAD(P)H: quinone oxidoreductase 1 in Hepa1c1c7 cells

  Roubalová, L., Dinkova-Kostova, A. T., Biedermann, D., Křen, V., Ulrichová, J. & Vrba, J., Jun 2017, In: Fitoterapia. 119, p. 115-120 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Flavonolignans
  • quinone
  • Milk Thistle
  • NAD
  • Oxidoreductases
  17 Citations (Scopus)

  197 Downloads (Pure)

• Keap1, the cysteine-based mammalian intracellular sensor for electrophiles and oxidants

  Dinkova-Kostova, A. T., Kostov, R. V. & Canning, P., 1 Mar 2017, In: Archives of Biochemistry and Biophysics. 617, p. 84-93 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Kelch-Like ECH-Associated Protein 1
  • Oxidants
  • Cysteine
  • NF-E2-Related Factor 2
  • Sensors
  109 Citations (Scopus)

  181 Downloads (Pure)

• KEAP1 and done? Targeting the NRF2 pathway with sulforaphane: Targeting the NRF2 Pathway with Sulforaphane

  Dinkova-Kostova, A. T., Fahey, J. W., Kostov, R. V. & Kensler, T. W., Nov 2017, In: Trends in Food Science and Technology. 69, B, p. 257-269 13 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • sulforaphane
  • sulforafan
  • Brassica
  • broccoli
  • clinical trials
  88 Citations (Scopus)

  433 Downloads (Pure)

• KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients

  Quinti, L., Dayalan Naidu, S., Träge, U., Chen, X., Kegel-Gleason, K., Lleres, D., Connolly, C., Chopra, V., Low, C., Moniot, S., Sapp, E., Tousley, A. R., Vodicka, P., Van Kanegan, M. J., Kaltenbach, L. S., Crawford, L. A., Fuszard, M., Higgins, M., Miller, J. R. C., Farmer, R. E. & 19 others, Potluri, V., Samajdar, S., Meisel, L., Zhang, N., Snyder, A., Stein, R., Hersch, S. M., Ellerby, L. M., Weerapana, E., Schwarzschild, M. A., Steegborn, C., Leavitt, B. R., Degterev, A., Tabrizi, S. J., Lo, D. C., DiFiglia, M., Thompson, L. M., Dinkova-Kostova, A. & Kazantsev, A. G., 6 Jun 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 23, p. e4676-e4685 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Kelch-Like ECH-Associated Protein 1
  • Neural Stem Cells
  • Huntington Disease
  • NF-E2 Transcription Factor
  • Interleukin-6
  41 Citations (Scopus)

  183 Downloads (Pure)

• Metabolic and Homeostatic Changes in Seizures and Acquired Epilepsy-Mitochondria, Calcium Dynamics and Reactive Oxygen Species

  Kovac, S., Dinkova Kostova, A. T., Herrmann, A. M., Melzer, N., Meuth, S. G. & Gorji, A., 8 Sep 2017, In: International Journal of Molecular Sciences. 18, 9, p. 1-19 19 p., 1935.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Mitochondria
  • epilepsy
  • seizures
  • mitochondria
  • Metabolism
  26 Citations (Scopus)

  199 Downloads (Pure)

• NRF2 as an emerging therapeutic target

  Copple, I. M., Dinkova-Kostova, A. T., Kensler, T. W., Liby, K. T. & Wigley, W. C., 31 Jan 2017, In: Oxidative Medicine and Cellular Longevity. 2017, p. 1-2 2 p., 8165458.

  Research output: Contribution to journal › Editorial › peer-review

  Open Access

  File
  20 Citations (Scopus)

  201 Downloads (Pure)

• Oncogene-Stimulated Congestion at the KEAP1 Stress Signaling Hub Allows Bypass of NRF2 and Induction of NRF2-Target Genes that Promote Tumor Survival

  Hayes, J. D. & Dinkova-Kostova, A. T., Nov 2017, In: Cancer Cell. 32, 5, p. 539-541 3 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Oncogenes
  • Oncogene Proteins
  • Ligases
  • Genes
  • Neoplasms
  12 Citations (Scopus)

  246 Downloads (Pure)

• Oxidative stress and chronic inflammation in osteoarthritis: can Nrf2 counteract these partners in crime?

  Marchev, A. S., Dimitrova, P. A., Burns, A. J., Kostov, R., Dinkova-Kostova, A. & Georgiev, M. I., 11 Sep 2017, In: Annals of the New York Academy of Sciences. 1401, p. 114-135 22 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Oxidative stress
  • Osteoarthritis
  • Crime
  • Inflammation
  • Bone
  58 Citations (Scopus)

  442 Downloads (Pure)

• Oxidative stress management in the hair follicle: Could targeting NRF2 counter age-related hair disorders and beyond?

  Jadkauskaite, L., Coulombe, P. A., Schäfer, M., Dinkova-Kostova, A. T., Paus, R. & Haslam, I. S., 27 Jul 2017, In: BioEssays. 39, 8, p. 1-9 9 p., 1700029.

  Research output: Contribution to journal › Article › peer-review

  • Oxidative stress
  • Oxidation-Reduction
  • Hair Follicle
  • Oxidative Stress
  • Chemical activation
  16 Citations (Scopus)

• Pathogenic p62/SQSTM1 mutations impair energy metabolism through limitation of mitochondrial substrates

  Bartolome, F., Esteras, N., Martin-Requero, A., Boutoleau-Bretonniere, C., Vercelletto, M., Gabelle, A., Le Ber, I., Honda, T., Dinkova-Kostova, A. T., Hardy, J., Carro, E. & Abramov, A. Y., 10 May 2017, In: Scientific Reports. 7, p. 1-14 14 p., 1666.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Frontotemporal Dementia With Motor Neuron Disease
  • Mitochondrial Membrane Potential
  • NAD
  • Energy Metabolism
  • Fibroblasts
  33 Citations (Scopus)

  310 Downloads (Pure)

• Regulation of the mammalian heat shock factor 1

  Dayalan Naidu, S. & Dinkova-Kostova, A. T., Jun 2017, In: FEBS Journal. 284, 11, p. 1606-1627 22 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Heat-Shock Response
  • Machinery
  • Acetylation
  • Phosphorylation
  • Heat Shock Transcription Factors
  60 Citations (Scopus)

  267 Downloads (Pure)

• Transcription factors NRF2 and HSF1 have opposing functions in autophagy

  Dayalan Naidu, S., Dikovskaya, D., Gaurilcikaite, E., Knatko, E., Healy, Z. R., Mohan, H., Koh, G., Laurell, A., Ball, G., Olagnier, D., de la Vega, L., Ganley, I., Talalay, P. & Dinkova-Kostova, A., 8 Sep 2017, In: Scientific Reports. 7, p. 1-12 12 p., 11023.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Heat Shock Transcription Factors
  • Autophagy
  • Heat-Shock Response
  • Sequestosome-1 Protein
  • GATA1 Transcription Factor
  25 Citations (Scopus)

  220 Downloads (Pure)

• Whole-exome sequencing validates a preclinical mouse model for the prevention and treatment of cutaneous squamous cell carcinoma

  Knatko, E. V., Praslicka, B., Higgins, M., Evans, A., Purdie, K. J., Harwood, C. A., Proby, C. M., Ooi, A. & Dinkova-Kostova, A. T., Jan 2017, In: Cancer Prevention Research. 10, 1, p. 67-75 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Whole Exome Sequencing
  • Squamous Cell Carcinoma
  • Single Nucleotide Polymorphism
  • Skin
  • Mutation Rate
  9 Citations (Scopus)

  160 Downloads (Pure)
• 2015

  Design, synthesis, and evaluation of triazole derivatives that induce Nrf2 dependent gene products and inhibit the Keap1-Nrf2 protein-protein interaction

  Bertrand, H. C., Schaap, M., Baird, L., Georgakopoulos, N. D., Fowkes, A., Thiollier, C., Kachi, H., Dinkova-Kostova, A. T. & Wells, G., 24 Sep 2015, In: Journal of Medicinal Chemistry. 58, 18, p. 7186-7194 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Triazoles
  • 1,4-diphenyl-1,2,3-triazole
  • Genes
  • Proteins
  • Metabolic Networks and Pathways
  71 Citations (Scopus)

• Dual regulation of transcription factor Nrf2 by Keap1 and by the combined actions of β-TrCP and GSK-3

  Hayes, J. D., Chowdhry, S., Dinkova-Kostova, A. T. & Sutherland, C., Aug 2015, In: Biochemical Society Transactions. 43, 4, p. 611-620 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Kelch-Like ECH-Associated Protein 1
  • NF-E2 Transcription Factor
  • NF-E2-Related Factor 2
  • Glycogen Synthase Kinase 3
  • Phosphorylation
  67 Citations (Scopus)

• Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease

  Tebay, L. E., Robertson, H., Durant, S. T., Vitale, S. R., Penning, T. M., Dinkova-Kostova, A. T. & Hayes, J. D., Nov 2015, In: Free Radical Biology and Medicine. 88, Part B, p. 108-146 39 p.

  Research output: Contribution to journal › Article › peer-review

  • Cullin 1
  • SKP Cullin F-Box Protein Ligases
  • Kelch-Like ECH-Associated Protein 1
  • F-Box Proteins
  • Oxidation-Reduction
  355 Citations (Scopus)