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• Activation of transcription factor Nrf2 to counteract mitochondrial dysfunction in Parkinson’s disease

  Bento-Pereira, C. & Dinkova-Kostova, A., 18 Jul 2020, In: Medicinal Research Reviews. 18 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Parkinson Disease
  • Transcription Factors
  • NF-E2 Transcription Factor
  • Names
  • Neurodegenerative Diseases
  1 Citation (Scopus)

  29 Downloads (Pure)

• A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia

  Baardman, J., Verberk, S. G. S., Prange, K. H. M., van Weeghel, M., van der Velden, S., Ryan, D. G., Wüst, R. C. I., Neele, A. E., Speijer, D., Denis, S. W., Witte, M. E., Houtkooper, R. H., O'neill, L. A., Knatko, E. V., Dinkova-Kostova, A. T., Lutgens, E., de Winther, M. P. J. & Van den Bossche, J., 20 Nov 2018, In: Cell Reports. 25, 8, p. 2044-2052.e5 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Macrophages
  • Pentoses
  • Pentose Phosphate Pathway
  • Metabolism
  • Hypercholesterolemia
  40 Citations (Scopus)

  219 Downloads (Pure)

• Arthur Neish Young Investigator Award Lecture a Novel Role for Sulfhydryl-Reactive Activators of Transcription Factor NRF2: HSF1-Dependent Upregulation of Hsp70

  Zhang, Y., Ahn, Y-H., Calabrese, V., Cole, P. A. & Dinkova-Kostova, A. T., May 2012, In: Pharmaceutical Biology. 50, 5, p. 625-625 1 p.

  Research output: Contribution to journal › Special issue › peer-review

• Author Correction: Pathogenic p62/SQSTM1 mutations impair energy metabolism through limitation of mitochondrial substrates (Scientific Reports DOI: 10.1038/s41598-017-01678-4)

  Bartolome, F., Esteras, N., Martin-Requero, A., Boutoleau-Bretonniere, C., Vercelletto, M., Gabelle, A., Ber, I. L., Honda, T., Dinkova-Kostova, A. T., Hardy, J., Carro, E. & Abramov, A. Y., 1 Dec 2018, In: Scientific Reports. 8, p. 1-2 2 p., 4064.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  File

  • Energy Metabolism
  • Mutation
  165 Downloads (Pure)

• Biomarker Exploration in Human Peripheral Blood Mononuclear Cells for Monitoring Sulforaphane Treatment Responses in Autism Spectrum Disorder

  Liu, H., Zimmerman, A. W., Singh, K., Connors, S. L., Diggins, E., Stephenson, K. K., Dinkova-Kostova, A. & Fahey, J. W., 2 Apr 2020, In: Scientific Reports. 10, 11 p., 5822.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • sulforafan
  • Autism Spectrum Disorder
  • Blood Cells
  • Biomarkers
  • Messenger RNA
  8 Citations (Scopus)

  43 Downloads (Pure)

• Broccoli or Sulforaphane: Is It the Source or Dose That Matters?

  Yagishita, Y., Fahey, J. W., Dinkova-Kostova, A. T. & Kensler, T. W., Oct 2019, In: Molecules and Cells. 24, 19, p. 1-38 38 p., 3593.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • sulforafan
  • Brassica
  • glucoraphanin
  • thioglucosidase
  • Pharmacodynamics
  34 Citations (Scopus)

  289 Downloads (Pure)

• C151 in KEAP1 is the main cysteine sensor for the cyanoenone class of NRF2 activators, irrespective of molecular size or shape

  Dayalan Naidu, S., Muramatsu, A., Saito, R., Asami, S., Honda, T., Hosoya, T., Itoh, K., Yamamoto, M., Suzuki, T. & Dinkova-Kostova, A., 23 May 2018, In: Scientific Reports. 8, 1, p. 1-12 12 p., 8037.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Kelch-Like ECH-Associated Protein 1
  • Cysteine
  • TBE 31
  • Lipopolysaccharides
  • Interleukin-6
  17 Citations (Scopus)

  156 Downloads (Pure)

• Can activation of NRF2 be a strategy against COVID-19?

  Cuadrado, A., Pajares, M., Benito, C., Jiménez-Villegas, J., Escoll, M., Fernández-Ginés, R., Garcia Yagüe, A. J., Lastra, D., Manda, G., Rojo, A. I. & Dinkova-Kostova, A. T., Sep 2020, In: Trends in Pharmacological Sciences. 41, 9, p. 598-610 13 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Alveolar Epithelial Cells
  • Chemical activation
  • methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate
  • Anti-Inflammatory Agents
  • T-cells
  16 Citations (Scopus)

  123 Downloads (Pure)

• Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity

  Calabrese, V., Cornelius, C., Dinkova-Kostova, A. T., Iavicoli, I., Di Paola, R., Koverech, A., Cuzzocrea, S., Rizzarelli, E. & Calabrese, E. J., May 2012, In: Biochimica et Biophysica Acta. Molecular Basis of Disease. 1822, 5, p. 753-783 31 p.

  Research output: Contribution to journal › Review article › peer-review
  266 Citations (Scopus)

• Chemical tuning enhances both potency toward Nrf2 and in vitro therapeutic index of triterpenoids

  Copple, I. M., Shelton, L. M., Walsh, J., Kratschmar, D. V., Lister, A., Odermatt, A., Goldring, C. E., Dinkova-Kostova, A. T., Honda, T. & Park, B. K., Aug 2014, In: Toxicological Sciences. 140, 2, p. 462-469 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate
  • Therapeutic Index
  • Toxicity
  • Tuning
  • Molecules
  12 Citations (Scopus)

  583 Downloads (Pure)

• Chemoprotection Against Cancer by Isothiocyanates: A Focus on the Animal Models and the Protective Mechanisms

  Dinkova-Kostova, A. T., 2013, Natural Products in Cancer Prevention and Therapy. Pezzuto, J. M. & Suh, N. (eds.). Berlin: Springer , p. 179-201 23 p. (Topics in Current Chemistry; vol. 329).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter
  32 Citations (Scopus)

• Design, synthesis, and evaluation of triazole derivatives that induce Nrf2 dependent gene products and inhibit the Keap1-Nrf2 protein-protein interaction

  Bertrand, H. C., Schaap, M., Baird, L., Georgakopoulos, N. D., Fowkes, A., Thiollier, C., Kachi, H., Dinkova-Kostova, A. T. & Wells, G., 24 Sep 2015, In: Journal of Medicinal Chemistry. 58, 18, p. 7186-7194 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Triazoles
  • 1,4-diphenyl-1,2,3-triazole
  • Genes
  • Proteins
  • Metabolic Networks and Pathways
  71 Citations (Scopus)

• Diffusion dynamics of the Keap1-Cullin3 interaction in single live cells

  Baird, L. & Dinkova-Kostova, A. T., 2013, In: Biochemical and Biophysical Research Communications. 433, 1, p. 58-65 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Kelch-Like ECH-Associated Protein 1
  • NF-E2-Related Factor 2
  • Molecules
  • Cysteine
  • Gene encoding
  34 Citations (Scopus)

• Downregulation of Keap1 confers features of a fasted metabolic state

  Knatko, E. V., Tatham, M. H., Zhang, Y., Castro, C., Higgins, M., Dayalan Naidu, S., Leonardi, C., de la Vega, L., Honda, T., Griffin, J. L., Hay, R. T. & Dinkova-Kostova, A. T., 23 Oct 2020, In: iScience. 23, 10, 48 p., 101638.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Kelch-Like ECH-Associated Protein 1
  • Mouse Keap1 protein
  • Down-Regulation
  • Oxidation-Reduction
  • NF-E2 Transcription Factor
  18 Downloads (Pure)

• Dual regulation of transcription factor Nrf2 by Keap1 and by the combined actions of β-TrCP and GSK-3

  Hayes, J. D., Chowdhry, S., Dinkova-Kostova, A. T. & Sutherland, C., Aug 2015, In: Biochemical Society Transactions. 43, 4, p. 611-620 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Kelch-Like ECH-Associated Protein 1
  • NF-E2 Transcription Factor
  • NF-E2-Related Factor 2
  • Glycogen Synthase Kinase 3
  • Phosphorylation
  66 Citations (Scopus)

• Effects of chemoprotective agent HBB-2 on cell survival in SH-SY5Y neuroblastoma cells

  Scuto, M. C., Cavallaro, M. M., Luca, M., Cornelius, C., Cambria, M. T., Rizza, S., Salinaro, A. T., Dinkova-Kostova, A. & Calabrese, V., 2011, In: FEBS Journal. 278, S1, p. 268 1 p., P14.37.

  Research output: Contribution to journal › Meeting abstract › peer-review

• Experimental Nonalcoholic Steatohepatitis and Liver Fibrosis Are Ameliorated by Pharmacologic Activation of Nrf2 (NF-E2 p45-Related Factor 2)

  Sharma, R. S., Harrison, D. J., Kisielewski, D., Cassidy, D. M., McNeilly, A. D., Gallagher, J. R., Walsh, S. V., Honda, T., McCrimmon, R. J., Dinkova-Kostova, A. T., Ashford, M. L. J., Dillon, J. F. & Hayes, J. D., 1 Mar 2018, In: CMGH: Cellular and Molecular Gastroenterology and Hepatology. 5, 3, p. 367-398 32 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • TBE 31
  • NF-E2-Related Factor 2
  • Fructose
  • Non-alcoholic Fatty Liver Disease
  • Liver Cirrhosis
  63 Citations (Scopus)

  171 Downloads (Pure)

• Glucosinolates and isothiocyanates in health and disease

  Dinkova-Kostova, A. T. & Kostov, R. V., 2012, In: Trends in Molecular Medicine. 18, 6, p. 337-347 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Glucosinolates
  • Isothiocyanates
  • sulforafan
  • Brassica
  • isothiocyanic acid
  329 Citations (Scopus)

• Glutathione S-transferase genotype is associated with sensitivity to psoralen-ultraviolet A photochemotherapy

  Ibbotson, S. H., Dawe, R. S., Dinkova-Kostova, A. T., Weidlich, S., Farr, P. M., Ferguson, J., Wolf, C. R. & Smith, G., Feb 2012, In: British Journal of Dermatology. 166, 2, p. 380-388 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Ficusin
  • Photochemotherapy
  • Glutathione Transferase
  • Methoxsalen
  • Genotype
  17 Citations (Scopus)

• Highly potent activation of Nrf2 by topical tricyclic bis(cyano enone): Implications for protection against UV radiation during thiopurine therapy

  Kalra, S., Knatko, E. V., Zhang, Y., Honda, T., Yamamoto, M. & Dinkova-Kostova, A. T., 2012, In: Cancer Prevention Research. 5, 7, p. 973-981 9 p.

  Research output: Contribution to journal › Article › peer-review
  30 Citations (Scopus)

• High NRF2 Levels Correlate with Poor Prognosis in Colorectal Cancer Patients and with Sensitivity to the Kinase Inhibitor AT9283 In Vitro

  Torrente Fernandez, L., Maan, G., Rezig, A. O., Quinn, J., Jackson, A., Grilli, A., Casares, L., Zhang, Y., Kulesskiy, E., Saarela, J., Bicciato, S., Edwards, J., Dinkova-Kostova, A. & de la Vega, L., Oct 2020, In: Biomolecules. 10, 10, 16 p., 1365.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • 1-cyclopropyl-3-(3-(5-morpholin-4-ylmethyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl)urea
  • NF-E2-Related Factor 2
  • Colorectal Neoplasms
  • Phosphotransferases
  • In Vitro Techniques
  2 Citations (Scopus)

  12 Downloads (Pure)

• HSF1-Dependent Upregulation of Hsp70 by Sulfhydryl-Reactive Inducers of the KEAP1/NRF2/ARE Pathway

  Zhang, Y., Ahn, Y-H., Benjamin, I. J., Honda, T., Hicks, R. J., Calabrese, V., Cole, P. A. & Dinkova-Kostova, A. T., 23 Nov 2011, In: Chemistry & Biology. 18, 11, p. 1355-1361 7 p.

  Research output: Contribution to journal › Article › peer-review
  70 Citations (Scopus)

• Induction of the Keapl/Nrf2/ARE pathway by oxidizable diphenols

  Dinkova-Kostova, A. T. & Wang, X. J., 30 Jun 2011, In: Chemico-Biological Interactions. 192, 1-2, p. 101-106 6 p.

  Research output: Contribution to journal › Article › peer-review
  50 Citations (Scopus)

• Investigation into the use of histone deacetylase inhibitor MS-275 as a topical agent for the prevention and treatment of cutaneous squamous cell carcinoma in an SKH-1 hairless mouse model

  Kalin, J. H., Eroglu, A., Liu, H., Holtzclaw, W. D., Leigh, I., Proby, C. M., Fahey, J. W., Cole, P. A. & Dinkova-Kostova, A. T., 13 Mar 2019, In: PLoS ONE. 14, 3, p. 1-13 13 p., e0213095.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • entinostat
  • Epithelial Cells
  • squamous cell carcinoma
  • histone deacetylase
  • Hairless Mouse
  2 Citations (Scopus)

  137 Downloads (Pure)

• Isomeric O-methyl cannabidiolquinones with dual BACH1/NRF2 activity

  Casares Perez, L., Unciti-Broceta, J. D., Prados, M. E., Caprioglio, D., Mattoteia, D., Higgins, M., Apendino, G., Dinkova-Kostova, A. T., Muñoz, E. & de la Vega, L., Oct 2020, In: Redox Biology. 37, p. 1-10 10 p., 101689.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cannabidiol
  • Neurodegenerative diseases
  • Neurodegenerative Diseases
  • Oxidative stress
  • Derivatives
  1 Citation (Scopus)

  29 Downloads (Pure)

• Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

  Mills, E. L., Ryan, D. G., Prag, H. A., Dikovskaya, D., Menon, D., Zaslona, Z., Jedrychowski, M. P., Costa, A. S. H., Higgins, M., Hams, E., Szpyt, J., Runtsch, M. C., King, M. S., McGouran, J. F., Fischer, R., Kessler, B. M., McGettrick, A. F., Hughes, M. M., Carroll, R. G., Booty, L. M. & 15 others, Knatko, E. V., Meakin, P. J., Ashford, M. L. J., Modis, L. K., Brunori, G., Sévin, D. C., Fallon, P. G., Caldwell, S. T., Kunji, E. R. S., Chouchani, E. T., Frezza, C., Dinkova-Kostova, A. T., Hartley, R. C., Murphy, M. P. & O'Neill, L. A., 5 Apr 2018, In: Nature. 556, 7699, p. 113-117 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • itaconic acid
  • Alkylation
  • Anti-Inflammatory Agents
  • Interferon Type I
  • Cysteine
  348 Citations (Scopus)

  822 Downloads (Pure)

• KEAP1, a cysteine-based sensor and a drug target for the prevention and treatment of chronic disease: KEAP1, a sensor and a drug target

  Dayalan Naidu, S. & Dinkova-Kostova, A., Jun 2020, In: Open Biology. 10, 6, p. 1-13 13 p., 200105.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Kelch-Like ECH-Associated Protein 1
  • Oxidation-Reduction
  • Cysteine
  • Chronic Disease
  • Sensors
  6 Citations (Scopus)

  22 Downloads (Pure)

• KEAP₁ inhibition is neuroprotective and suppresses the development of epilepsy

  Shekh-Ahmad, T., Eckel, R., Dayalan Naidu, S., Higgins, M., Yamamoto, M., Dinkova-Kostova, A., Kovac, S., Abramov, A. Y. & Walker, M. C., May 2018, In: Brain. 141, 5, p. 1390-1403 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • N-(11-cyano-2,2,6a,6b,9,9,12a-heptmethyl-10,14-dioxo-1,3,4,5,6a,6b,7,8,8a,9,10,12a,14,14a,14b-hexadecahydro-2H-picen-4a-yl)-2-2-difluoropropionamide
  • Kelch-Like ECH-Associated Protein 1
  • Status Epilepticus
  • Epilepsy
  • Reactive Oxygen Species
  39 Citations (Scopus)

  202 Downloads (Pure)

• Measuring Changes in Keap1‐Nrf2 Protein Complex Conformation in Individual Cells by FLIM‐FRET

  Dikovskaya, D. & Dinkova-Kostova, A., Sep 2020, In: Current Protocols in Toxicology. 85, 1, p. 1-34 34 p., e96.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Kelch-Like ECH-Associated Protein 1
  • Protein Conformation
  • Conformations
  • Fluorescence
  • Photons
  37 Downloads (Pure)

• Measuring the Interaction of Transcription Factor Nrf2 with Its Negative Regulator Keap1 in Single Live Cells by an Improved FRET/FLIM Analysis

  Dikovskaya, D., Appleton, P., Bento-Pereira, C. & Dinkova-Kostova, A., 18 Mar 2019, In: Chemical Research in Toxicology. 32, 3, p. 500-512 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Kelch-Like ECH-Associated Protein 1
  • NF-E2 Transcription Factor
  • Forster resonance energy transfer
  • NF-E2-Related Factor 2
  • Transcription Factors
  4 Citations (Scopus)

  163 Downloads (Pure)

• Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease

  Tebay, L. E., Robertson, H., Durant, S. T., Vitale, S. R., Penning, T. M., Dinkova-Kostova, A. T. & Hayes, J. D., Nov 2015, In: Free Radical Biology and Medicine. 88, Part B, p. 108-146 39 p.

  Research output: Contribution to journal › Article › peer-review

  • Cullin 1
  • SKP Cullin F-Box Protein Ligases
  • Kelch-Like ECH-Associated Protein 1
  • F-Box Proteins
  • Oxidation-Reduction
  353 Citations (Scopus)

• Monitoring Keap1-Nrf2 interactions in single live cells

  Baird, L., Swift, S., Llères, D. & Dinkova-Kostova, A. T., 1 Nov 2014, In: Biotechnology Advances. 32, 6, p. 1133-1144 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Kelch-Like ECH-Associated Protein 1
  • NF-E2-Related Factor 2
  • Proteins
  • Monitoring
  • sulforafan
  82 Citations (Scopus)

  405 Downloads (Pure)

• NAD(P)H: Quinone oxidoreductase 1 inducer activity of some Saudi Arabian medicinal plants

  Shahat, A. A., Alsaid, M. S., Alyahya, M. A., Higgins, M. & Dinkova-Kostova, A. T., Apr 2013, In: Planta Medica. 79, 6, p. 459-464 6 p.

  Research output: Contribution to journal › Article › peer-review
  11 Citations (Scopus)

• NAD(P)H: Quinone oxidoreductase 1 inducer activity of some enaminone derivatives

  Alsaid, M. S., Ghorab, M. M., Higgins, M., Dinkova-Kostova, A. T. & Shahat, A. A., 2015, In: Biomedical Research. 26, 1, p. 7-12 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Carbon-13 Magnetic Resonance Spectroscopy
  • quinone
  • Nuclear magnetic resonance
  • NAD
  • Oxidoreductases
  5 Citations (Scopus)

• Neuroprotective effects of sulforaphane after contusive spinal cord injury

  Benedict, A. L., Mountney, A., Hurtado, A., Bryan, K. E., Schnaar, R. L., Dinkova-Kostova, A. T. & Talalay, P., 2012, In: Journal of Neurotrauma. 29, 16, p. 2576-2586 11 p.

  Research output: Contribution to journal › Article › peer-review

  • sulforafan
  • Neuroprotective Agents
  • Spinal Cord Injuries
  • Contusions
  • Antioxidants
  48 Citations (Scopus)

• New monocyclic, bicyclic, and tricyclic ethynylcyanodienones as activators of the Keap1/Nrf2/ARE pathway and inhibitors of inducible nitric oxide synthase

  Li, W., Zheng, S., Higgins, M., Morra, R. P., Mendis, A. T., Chien, C-W., Ojima, I., Mierke, D. F., Dinkova-Kostova, A. T. & Honda, T., 11 Jun 2015, In: Journal of Medicinal Chemistry. 58, 11, p. 4738-4748 11 p.

  Research output: Contribution to journal › Article › peer-review

  • 3-ethynyl-3-methyl-6-oxocyclohexa-1,4-dienecarbonitrile
  • Nitric Oxide Synthase Type II
  • Synthetic Drugs
  • Pharmaceutical Preparations
  • Carcinogenesis
  23 Citations (Scopus)

• Novel Thioureido Derivatives Carrying Thione and Sulfonamide Moieties Induce the Cytoprotective Enzyme NAD(P)H:Quione Oxidoreductase 1: Quinone oxidoreductase 1

  Ghorab, M. M., Higgins, M., Dinkova-Kostova, A. T., Alsaid, M. S. & Shahat, A. A., 1 Dec 2014, In: Asian Journal of Chemistry. 26, 24, p. 8501-8504 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Thiones
  • Sulfonamides
  • quinone
  • Quinazolines
  • NAD
  2 Citations (Scopus)

• Nrf2 activation protects against solar-simulated ultraviolet radiation in mice and humans

  Knatko, E. V., Ibbotson, S. H., Zhang, Y., Higgins, M., Fahey, J. W., Talalay, P., Dawe, R. S., Ferguson, J., Huang, J. T-J., Clarke, R., Zheng, S., Saito, A., Kalra, S., Benedict, A. L., Honda, T., Proby, C. M. & Dinkova-Kostova, A. T., Jun 2015, In: Cancer Prevention Research. 8, 6, p. 475-486 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Ultraviolet Rays
  • TBE 31
  • Skin Neoplasms
  • Carcinogens
  • Carcinogenesis
  54 Citations (Scopus)

• Nrf2 affects the efficiency of mitochondrial fatty acid oxidation

  Ludtmann, M. H. R., Angelova, P. R., Zhang, Y., Abramov, A. Y. & Dinkova-Kostova, A. T., 1 Feb 2014, In: Biochemical Journal. 457, 3, p. 415-424 10 p.

  Research output: Contribution to journal › Article › peer-review

  • NF-E2-Related Factor 2
  • Oxidation
  • Fatty Acids
  • 1,5-dihydro-FAD
  • Kelch-Like ECH-Associated Protein 1
  118 Citations (Scopus)

• NRF2 and the Ambiguous Consequences of Its Activation during Initiation and the Subsequent Stages of Tumourigenesis

  Robertson, H., Dinkova-Kostova, A. T. & Hayes, J. D., 2 Dec 2020, In: Cancers. 12, 12, 48 p., 3609.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Kelch-Like ECH-Associated Protein 1
  • Cullin Proteins
  • Neoplasms
  • Mutation
  • Sulfhydryl Compounds
  14 Downloads (Pure)

• Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration

  Holmström, K. M., Baird, L., Zhang, Y., Hargreaves, I., Chalasani, A., Land, J. M., Stanyer, L., Yamamoto, M., Dinkova-Kostova, A. T. & Abramov, A. Y., 15 Aug 2013, In: Open Biology. 2, 8, p. 761-770 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Energy Metabolism
  • Genes
  • Respiration
  • Adenosine Triphosphate
  • Mitochondrial Membrane Potential
  209 Citations (Scopus)

  218 Downloads (Pure)

• Nrf2 is activated by disruption of mitochondrial thiol homeostasis but not by enhanced mitochondrial superoxide production

  Cvetko, F., Caldwell, S. T., Higgins, M., Suzuki, T., Yamamoto, M., Prag, H. A., Hartley, R. C., Dinkova-Kostova, A. & Murphy, M. P., 20 Dec 2020, In: Journal of Biological Chemistry. 296, 14 p., 100169.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Sulfhydryl Compounds
  • Hydrogen Peroxide
  • Superoxides
  • Oxidation-Reduction
  • Homeostasis
  36 Downloads (Pure)

• Nrf2 regulates ROS production by mitochondria and NADPH oxidase

  Kovac, S., Angelova, P. R., Holmström, K. M., Zhang, Y., Dinkova-Kostova, A. T. & Abramov, A. Y., Apr 2015, In: Biochimica et Biophysica Acta: General Subjects. 1850, 4, p. 794-801 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Kelch-Like ECH-Associated Protein 1
  • Mitochondria
  • NADPH Oxidases
  • Antioxidants
  • Tissue
  232 Citations (Scopus)

• Obesity and NRF2-mediated cytoprotection: Where is the missing link?

  Vasileva, L. V., Savova, M. S., Amirova, K. M., Dinkova-Kostova, A. & Georgiev, M. I., Jun 2020, In: Pharmacological Research. 156, p. 1-9 9 p., 104760.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Cytoprotection
  • Obesity
  • NF-E2 Transcription Factor
  • Oxidative Stress
  • Reactive Nitrogen Species
  15 Citations (Scopus)

  133 Downloads (Pure)

• Oral Azathioprine Leads to Higher Incorporation of 6-Thioguanine in DNA of Skin than Liver: The Protective Role of the Keap1/Nrf2/ARE Pathway

  Kalra, S., Zhang, Y., Knatko, E. V., Finlayson, S., Yamamoto, M. & Dinkova-Kostova, A. T., Oct 2011, In: Cancer Prevention Research. 4, 10, p. 1665-1674 10 p.

  Research output: Contribution to journal › Article › peer-review
  13 Citations (Scopus)

• Oxidative Stress in Cancer

  Hayes, J., Dinkova-Kostova, A. & Tew, K. D., 10 Aug 2020, In: Cancer Cell. 38, 31 p.

  Research output: Contribution to journal › Review article › peer-review

  • NADP
  • Oxidative Stress
  • Pentose Phosphate Pathway
  • Reactive Oxygen Species
  • Antioxidants
  27 Citations (Scopus)

• Pharmacokinetics and pharmacodynamics of orally administered acetylenic tricyclic bis(cyanoenone), a highly potent Nrf2 activator with a reversible covalent mode of action

  Kostov, R. V., Knatko, E. V., McLaughlin, L. A., Henderson, C. J., Zheng, S., Huang, J. T. J., Honda, T. & Dinkova-Kostova, A. T., 25 Sep 2015, In: Biochemical and Biophysical Research Communications. 465, 3, p. 402-407 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • TBE 31
  • Pharmacodynamics
  • Pharmacokinetics
  • Kelch-Like ECH-Associated Protein 1
  • Cysteine
  11 Citations (Scopus)

  164 Downloads (Pure)

• Phenethyl isothiocyanate, a dual activator of transcription factors NRF2 and HSF1

  Dayalan Naidu, S., Suzuki, T., Yamamoto, M., Fahey, J. W. & Dinkova-Kostova, A., 1 Sep 2018, In: Molecular Nutrition & Food Research. 62, 18, p. e1700908 9 p., 1700908.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • phenethyl isothiocyanate
  • Heat Shock Transcription Factors
  • isothiocyanates
  • heat stress
  • transcription factors
  13 Citations (Scopus)

  189 Downloads (Pure)

• Radiomodulatory effect of a non-electrophilic NQO1 inducer identified in a screen of new 6, 8-diiodoquinazolin-4(3H)-ones carrying a sulfonamide moiety

  Soliman, A. M., Karam, H. M., Mekkawy, M. H., Higgins, M., Dinkova-Kostova, A. & Ghorab, M. M., 15 Aug 2020, In: European Journal of Medicinal Chemistry. 200, 12 p., 112467.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • acetamide
  • Sulfonamides
  • Quinazolinones
  • benzenesulfonamide
  • compound 18
  4 Citations (Scopus)

  30 Downloads (Pure)

• Regulatory flexibility in the Nrf2-mediated stress response is conferred by conformational cycling of the Keap1-Nrf2 protein complex

  Baird, L., Llères, D., Swift, S. & Dinkova-Kostova, A. T., 17 Sep 2013, In: Proceedings of the National Academy of Sciences of the United States of America. 110, 38, p. 15259-15264 6 p.

  Research output: Contribution to journal › Article › peer-review

  • NF-E2-Related Factor 2
  • Proteins
  • Energy Transfer
  • Ubiquitin-Protein Ligases
  • Optical Imaging
  174 Citations (Scopus)