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  • Albena Dinkova-Kostova

Broccoli or Sulforaphane: Is It the Source or Dose That Matters?

Yagishita, Y., Fahey, J. W., Dinkova-Kostova, A. T. & Kensler, T. W., Oct 2019, In : Molecules and Cells. 24, 19, p. 1-38 38 p., 3593.

Research output: Contribution to journalReview article

Open Access
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19 Citations (Scopus)
224 Downloads (Pure)

Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity

Calabrese, V., Cornelius, C., Dinkova-Kostova, A. T., Iavicoli, I., Di Paola, R., Koverech, A., Cuzzocrea, S., Rizzarelli, E. & Calabrese, E. J., May 2012, In : Biochimica et Biophysica Acta. Molecular Basis of Disease. 1822, 5, p. 753-783 31 p.

Research output: Contribution to journalReview article

254 Citations (Scopus)

Chemical tuning enhances both potency toward Nrf2 and in vitro therapeutic index of triterpenoids

Copple, I. M., Shelton, L. M., Walsh, J., Kratschmar, D. V., Lister, A., Odermatt, A., Goldring, C. E., Dinkova-Kostova, A. T., Honda, T. & Park, B. K., Aug 2014, In : Toxicological Sciences. 140, 2, p. 462-469 8 p.

Research output: Contribution to journalArticle

Open Access
File
12 Citations (Scopus)
561 Downloads (Pure)

Chemoprotection Against Cancer by Isothiocyanates: A Focus on the Animal Models and the Protective Mechanisms

Dinkova-Kostova, A. T., 2013, Natural Products in Cancer Prevention and Therapy. Pezzuto, J. M. & Suh, N. (eds.). Berlin: Springer , p. 179-201 23 p. (Topics in Current Chemistry; vol. 329).

Research output: Chapter in Book/Report/Conference proceedingChapter

30 Citations (Scopus)

Design, synthesis, and evaluation of triazole derivatives that induce Nrf2 dependent gene products and inhibit the Keap1-Nrf2 protein-protein interaction

Bertrand, H. C., Schaap, M., Baird, L., Georgakopoulos, N. D., Fowkes, A., Thiollier, C., Kachi, H., Dinkova-Kostova, A. T. & Wells, G., 24 Sep 2015, In : Journal of Medicinal Chemistry. 58, 18, p. 7186-7194 9 p.

Research output: Contribution to journalArticle

64 Citations (Scopus)

Diffusion dynamics of the Keap1-Cullin3 interaction in single live cells

Baird, L. & Dinkova-Kostova, A. T., 2013, In : Biochemical and Biophysical Research Communications. 433, 1, p. 58-65 8 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)
56 Citations (Scopus)

Effects of chemoprotective agent HBB-2 on cell survival in SH-SY5Y neuroblastoma cells

Scuto, M. C., Cavallaro, M. M., Luca, M., Cornelius, C., Cambria, M. T., Rizza, S., Salinaro, A. T., Dinkova-Kostova, A. & Calabrese, V., 2011, In : FEBS Journal. 278, S1, p. 268 1 p., P14.37.

Research output: Contribution to journalMeeting abstract

Glucosinolates and isothiocyanates in health and disease

Dinkova-Kostova, A. T. & Kostov, R. V., 2012, In : Trends in Molecular Medicine. 18, 6, p. 337-347 11 p.

Research output: Contribution to journalArticle

309 Citations (Scopus)

Glutathione S-transferase genotype is associated with sensitivity to psoralen-ultraviolet A photochemotherapy

Ibbotson, S. H., Dawe, R. S., Dinkova-Kostova, A. T., Weidlich, S., Farr, P. M., Ferguson, J., Wolf, C. R. & Smith, G., Feb 2012, In : British Journal of Dermatology. 166, 2, p. 380-388 9 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)
29 Citations (Scopus)

HSF1-Dependent Upregulation of Hsp70 by Sulfhydryl-Reactive Inducers of the KEAP1/NRF2/ARE Pathway

Zhang, Y., Ahn, Y-H., Benjamin, I. J., Honda, T., Hicks, R. J., Calabrese, V., Cole, P. A. & Dinkova-Kostova, A. T., 23 Nov 2011, In : Chemistry & Biology. 18, 11, p. 1355-1361 7 p.

Research output: Contribution to journalArticle

65 Citations (Scopus)

Induction of the Keapl/Nrf2/ARE pathway by oxidizable diphenols

Dinkova-Kostova, A. T. & Wang, X. J., 30 Jun 2011, In : Chemico-Biological Interactions. 192, 1-2, p. 101-106 6 p.

Research output: Contribution to journalArticle

49 Citations (Scopus)

Investigation into the use of histone deacetylase inhibitor MS-275 as a topical agent for the prevention and treatment of cutaneous squamous cell carcinoma in an SKH-1 hairless mouse model

Kalin, J. H., Eroglu, A., Liu, H., Holtzclaw, W. D., Leigh, I., Proby, C. M., Fahey, J. W., Cole, P. A. & Dinkova-Kostova, A. T., 13 Mar 2019, In : PLoS ONE. 14, 3, p. 1-13 13 p., e0213095.

Research output: Contribution to journalArticle

Open Access
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1 Citation (Scopus)
120 Downloads (Pure)
Open Access
File
3 Citations (Scopus)
144 Downloads (Pure)

Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease

Tebay, L. E., Robertson, H., Durant, S. T., Vitale, S. R., Penning, T. M., Dinkova-Kostova, A. T. & Hayes, J. D., Nov 2015, In : Free Radical Biology and Medicine. 88, Part B, p. 108-146 39 p.

Research output: Contribution to journalArticle

315 Citations (Scopus)

Monitoring Keap1-Nrf2 interactions in single live cells

Baird, L., Swift, S., Llères, D. & Dinkova-Kostova, A. T., 1 Nov 2014, In : Biotechnology Advances. 32, 6, p. 1133-1144 12 p.

Research output: Contribution to journalArticle

Open Access
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82 Citations (Scopus)
350 Downloads (Pure)

NAD(P)H: Quinone oxidoreductase 1 inducer activity of some enaminone derivatives

Alsaid, M. S., Ghorab, M. M., Higgins, M., Dinkova-Kostova, A. T. & Shahat, A. A., 2015, In : Biomedical Research. 26, 1, p. 7-12 6 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

NAD(P)H: Quinone oxidoreductase 1 inducer activity of some Saudi Arabian medicinal plants

Shahat, A. A., Alsaid, M. S., Alyahya, M. A., Higgins, M. & Dinkova-Kostova, A. T., Apr 2013, In : Planta Medica. 79, 6, p. 459-464 6 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Neuroprotective effects of sulforaphane after contusive spinal cord injury

Benedict, A. L., Mountney, A., Hurtado, A., Bryan, K. E., Schnaar, R. L., Dinkova-Kostova, A. T. & Talalay, P., 2012, In : Journal of Neurotrauma. 29, 16, p. 2576-2586 11 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)

New monocyclic, bicyclic, and tricyclic ethynylcyanodienones as activators of the Keap1/Nrf2/ARE pathway and inhibitors of inducible nitric oxide synthase

Li, W., Zheng, S., Higgins, M., Morra, R. P., Mendis, A. T., Chien, C-W., Ojima, I., Mierke, D. F., Dinkova-Kostova, A. T. & Honda, T., 11 Jun 2015, In : Journal of Medicinal Chemistry. 58, 11, p. 4738-4748 11 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Novel Thioureido Derivatives Carrying Thione and Sulfonamide Moieties Induce the Cytoprotective Enzyme NAD(P)H:Quione Oxidoreductase 1: Quinone oxidoreductase 1

Ghorab, M. M., Higgins, M., Dinkova-Kostova, A. T., Alsaid, M. S. & Shahat, A. A., 1 Dec 2014, In : Asian Journal of Chemistry. 26, 24, p. 8501-8504 4 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Nrf2 activation protects against solar-simulated ultraviolet radiation in mice and humans

Knatko, E. V., Ibbotson, S. H., Zhang, Y., Higgins, M., Fahey, J. W., Talalay, P., Dawe, R. S., Ferguson, J., Huang, J. T-J., Clarke, R., Zheng, S., Saito, A., Kalra, S., Benedict, A. L., Honda, T., Proby, C. M. & Dinkova-Kostova, A. T., Jun 2015, In : Cancer Prevention Research. 8, 6, p. 475-486 12 p.

Research output: Contribution to journalArticle

50 Citations (Scopus)

Nrf2 affects the efficiency of mitochondrial fatty acid oxidation

Ludtmann, M. H. R., Angelova, P. R., Zhang, Y., Abramov, A. Y. & Dinkova-Kostova, A. T., 1 Feb 2014, In : Biochemical Journal. 457, 3, p. 415-424 10 p.

Research output: Contribution to journalArticle

103 Citations (Scopus)

Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration

Holmström, K. M., Baird, L., Zhang, Y., Hargreaves, I., Chalasani, A., Land, J. M., Stanyer, L., Yamamoto, M., Dinkova-Kostova, A. T. & Abramov, A. Y., 15 Aug 2013, In : Open Biology. 2, 8, p. 761-770 10 p.

Research output: Contribution to journalArticle

Open Access
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186 Citations (Scopus)
201 Downloads (Pure)

Nrf2 regulates ROS production by mitochondria and NADPH oxidase

Kovac, S., Angelova, P. R., Holmström, K. M., Zhang, Y., Dinkova-Kostova, A. T. & Abramov, A. Y., Apr 2015, In : Biochimica et Biophysica Acta: General Subjects. 1850, 4, p. 794-801 8 p.

Research output: Contribution to journalArticle

209 Citations (Scopus)
13 Citations (Scopus)
Open Access
File
10 Citations (Scopus)
148 Downloads (Pure)
159 Citations (Scopus)

Sulphoxythiocarbamates modify cysteine residues in HSP90 causing degradation of client proteins and inhibition of cancer cell proliferation

Zhang, Y., Dayalan Naidu, S., Samarasinghe, K., Van Hecke, G. C., Pheely, A., Boronina, T. N., Cole, R. N., Benjamin, I. J., Cole, P. A., Ahn, Y-H. & Dinkova-Kostova, A. T., 7 Jan 2014, In : British Journal of Cancer. 110, 1, p. 71-82 12 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)
97 Citations (Scopus)
269 Downloads (Pure)

Synthesis, chemical reactivity as Michael acceptors, and biological potency of monocyclic cyanoenones, novel and highly potent anti-inflammatory and cytoprotective agents

Zheng, S., Laxmi, Y. R. S., David, E., Dinkova-Kostova, A. T., Shiavoni, K. H., Ren, Y., Zheng, Y., Trevino, I., Bumeister, R., Ojima, I., Wigley, W. C., Bliska, J. B., Mierke, D. F. & Honda, T., 24 May 2012, In : Journal of Medicinal Chemistry. 55, 10, p. 4837-4846 10 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)
7 Citations (Scopus)

Synthesis and biological evaluation of 1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]-4-ethynylimidazole. A novel and highly potent anti-inflammatory and cytoprotective agent

Honda, T., Dinkova-Kostova, A. T., David, E., Padegimas, E. M., Sundararajan, C., Visnick, M., Bumeister, R. & Wigley, W. C., 15 Apr 2011, In : Bioorganic & Medicinal Chemistry Letters. 21, 8, p. 2188-2191 4 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)
4 Citations (Scopus)

The cytoprotective role of the Keap1-Nrf2 pathway

Baird, L. & Dinkova-Kostova, A. T., Apr 2011, In : Archives of Toxicology. 85, 4, p. 241-272 32 p.

Research output: Contribution to journalReview article

578 Citations (Scopus)

The emerging role of Nrf2 in mitochondrial function

Dinkova-Kostova, A. T. & Abramov, A. Y., Nov 2015, In : Free Radical Biology and Medicine. 88, Part B, p. 179-188 10 p.

Research output: Contribution to journalArticle

Open Access
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307 Citations (Scopus)
265 Downloads (Pure)

The indirect antioxidant sulforaphane protects against thiopurine-mediated photooxidative stress

Benedict, A. L., Knatko, E. V. & Dinkova-Kostova, A. T., Dec 2012, In : Carcinogenesis. 33, 12, p. 2457-2466 10 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

The isothiocyanate sulforaphane inhibits mTOR in an NRF2-independent manner

Zhang, Y., Gilmour, A., Ahn, Y-H., de la Vega, L. & Dinkova-Kostova, A., 5 Aug 2019, In : Phytomedicine. 153062.

Research output: Contribution to journalArticle

Open Access
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3 Citations (Scopus)
100 Downloads (Pure)
797 Citations (Scopus)

Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases

Cuadrado, A., Rojo, A. I., Wells, G., Hayes, J., Cousin, S. P., Rumsey, W. L., Attucks, O. C., Franklin, S., Levonen, A-L., Kensler, T. W. & Dinkova-Kostova, A., Apr 2019, In : Nature Reviews Drug Discovery. 18, 4, p. 295-317 23 p.

Research output: Contribution to journalReview article

Open Access
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159 Citations (Scopus)
216 Downloads (Pure)

The spatiotemporal regulation of the Keap1-Nrf2 pathway and its importance in cellular bioenergetics

Dinkova-Kostova, A. T., Baird, L., Holmström, K. M., Meyer, C. J. & Abramov, A. Y., Aug 2015, In : Biochemical Society Transactions. 43, 4, p. 602-610 9 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)

Transcription factors Hsf1 and Nrf2 engage in crosstalk for cytoprotection

Dayalan Naidu, S., Kostov, R. V. & Dinkova-Kostova, A. T., Jan 2015, In : Trends in Pharmacological Sciences. 36, 1, p. 6-14 9 p.

Research output: Contribution to journalArticle

59 Citations (Scopus)