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Author

  • Albena Dinkova-Kostova
2011

Effects of chemoprotective agent HBB-2 on cell survival in SH-SY5Y neuroblastoma cells

Scuto, M. C., Cavallaro, M. M., Luca, M., Cornelius, C., Cambria, M. T., Rizza, S., Salinaro, A. T., Dinkova-Kostova, A. & Calabrese, V., 2011, In : FEBS Journal. 278, S1, p. 268 1 p., P14.37.

Research output: Contribution to journalMeeting abstract

HSF1-Dependent Upregulation of Hsp70 by Sulfhydryl-Reactive Inducers of the KEAP1/NRF2/ARE Pathway

Zhang, Y., Ahn, Y-H., Benjamin, I. J., Honda, T., Hicks, R. J., Calabrese, V., Cole, P. A. & Dinkova-Kostova, A. T., 23 Nov 2011, In : Chemistry & Biology. 18, 11, p. 1355-1361 7 p.

Research output: Contribution to journalArticle

65 Citations (Scopus)

Induction of the Keapl/Nrf2/ARE pathway by oxidizable diphenols

Dinkova-Kostova, A. T. & Wang, X. J., 30 Jun 2011, In : Chemico-Biological Interactions. 192, 1-2, p. 101-106 6 p.

Research output: Contribution to journalArticle

49 Citations (Scopus)
13 Citations (Scopus)

Synthesis and biological evaluation of 1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]-4-ethynylimidazole. A novel and highly potent anti-inflammatory and cytoprotective agent

Honda, T., Dinkova-Kostova, A. T., David, E., Padegimas, E. M., Sundararajan, C., Visnick, M., Bumeister, R. & Wigley, W. C., 15 Apr 2011, In : Bioorganic & Medicinal Chemistry Letters. 21, 8, p. 2188-2191 4 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

The cytoprotective role of the Keap1-Nrf2 pathway

Baird, L. & Dinkova-Kostova, A. T., Apr 2011, In : Archives of Toxicology. 85, 4, p. 241-272 32 p.

Research output: Contribution to journalReview article

573 Citations (Scopus)
2012

Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity

Calabrese, V., Cornelius, C., Dinkova-Kostova, A. T., Iavicoli, I., Di Paola, R., Koverech, A., Cuzzocrea, S., Rizzarelli, E. & Calabrese, E. J., May 2012, In : Biochimica et Biophysica Acta. Molecular Basis of Disease. 1822, 5, p. 753-783 31 p.

Research output: Contribution to journalReview article

254 Citations (Scopus)

Glucosinolates and isothiocyanates in health and disease

Dinkova-Kostova, A. T. & Kostov, R. V., 2012, In : Trends in Molecular Medicine. 18, 6, p. 337-347 11 p.

Research output: Contribution to journalArticle

306 Citations (Scopus)

Glutathione S-transferase genotype is associated with sensitivity to psoralen-ultraviolet A photochemotherapy

Ibbotson, S. H., Dawe, R. S., Dinkova-Kostova, A. T., Weidlich, S., Farr, P. M., Ferguson, J., Wolf, C. R. & Smith, G., Feb 2012, In : British Journal of Dermatology. 166, 2, p. 380-388 9 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)
28 Citations (Scopus)

Neuroprotective effects of sulforaphane after contusive spinal cord injury

Benedict, A. L., Mountney, A., Hurtado, A., Bryan, K. E., Schnaar, R. L., Dinkova-Kostova, A. T. & Talalay, P., 2012, In : Journal of Neurotrauma. 29, 16, p. 2576-2586 11 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)

Synthesis, chemical reactivity as Michael acceptors, and biological potency of monocyclic cyanoenones, novel and highly potent anti-inflammatory and cytoprotective agents

Zheng, S., Laxmi, Y. R. S., David, E., Dinkova-Kostova, A. T., Shiavoni, K. H., Ren, Y., Zheng, Y., Trevino, I., Bumeister, R., Ojima, I., Wigley, W. C., Bliska, J. B., Mierke, D. F. & Honda, T., 24 May 2012, In : Journal of Medicinal Chemistry. 55, 10, p. 4837-4846 10 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

The indirect antioxidant sulforaphane protects against thiopurine-mediated photooxidative stress

Benedict, A. L., Knatko, E. V. & Dinkova-Kostova, A. T., Dec 2012, In : Carcinogenesis. 33, 12, p. 2457-2466 10 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)
2013

Chemoprotection Against Cancer by Isothiocyanates: A Focus on the Animal Models and the Protective Mechanisms

Dinkova-Kostova, A. T., 2013, Natural Products in Cancer Prevention and Therapy. Pezzuto, J. M. & Suh, N. (eds.). Berlin: Springer , p. 179-201 23 p. (Topics in Current Chemistry; vol. 329).

Research output: Chapter in Book/Report/Conference proceedingChapter

30 Citations (Scopus)

Diffusion dynamics of the Keap1-Cullin3 interaction in single live cells

Baird, L. & Dinkova-Kostova, A. T., 2013, In : Biochemical and Biophysical Research Communications. 433, 1, p. 58-65 8 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

NAD(P)H: Quinone oxidoreductase 1 inducer activity of some Saudi Arabian medicinal plants

Shahat, A. A., Alsaid, M. S., Alyahya, M. A., Higgins, M. & Dinkova-Kostova, A. T., Apr 2013, In : Planta Medica. 79, 6, p. 459-464 6 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration

Holmström, K. M., Baird, L., Zhang, Y., Hargreaves, I., Chalasani, A., Land, J. M., Stanyer, L., Yamamoto, M., Dinkova-Kostova, A. T. & Abramov, A. Y., 15 Aug 2013, In : Open Biology. 2, 8, p. 761-770 10 p.

Research output: Contribution to journalArticle

Open Access
File
181 Citations (Scopus)
198 Downloads (Pure)
159 Citations (Scopus)
4 Citations (Scopus)
2014

Chemical tuning enhances both potency toward Nrf2 and in vitro therapeutic index of triterpenoids

Copple, I. M., Shelton, L. M., Walsh, J., Kratschmar, D. V., Lister, A., Odermatt, A., Goldring, C. E., Dinkova-Kostova, A. T., Honda, T. & Park, B. K., Aug 2014, In : Toxicological Sciences. 140, 2, p. 462-469 8 p.

Research output: Contribution to journalArticle

Open Access
File
12 Citations (Scopus)
561 Downloads (Pure)

Monitoring Keap1-Nrf2 interactions in single live cells

Baird, L., Swift, S., Llères, D. & Dinkova-Kostova, A. T., 1 Nov 2014, In : Biotechnology Advances. 32, 6, p. 1133-1144 12 p.

Research output: Contribution to journalArticle

Open Access
File
79 Citations (Scopus)
350 Downloads (Pure)

Novel Thioureido Derivatives Carrying Thione and Sulfonamide Moieties Induce the Cytoprotective Enzyme NAD(P)H:Quione Oxidoreductase 1: Quinone oxidoreductase 1

Ghorab, M. M., Higgins, M., Dinkova-Kostova, A. T., Alsaid, M. S. & Shahat, A. A., 1 Dec 2014, In : Asian Journal of Chemistry. 26, 24, p. 8501-8504 4 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Nrf2 affects the efficiency of mitochondrial fatty acid oxidation

Ludtmann, M. H. R., Angelova, P. R., Zhang, Y., Abramov, A. Y. & Dinkova-Kostova, A. T., 1 Feb 2014, In : Biochemical Journal. 457, 3, p. 415-424 10 p.

Research output: Contribution to journalArticle

100 Citations (Scopus)

Sulphoxythiocarbamates modify cysteine residues in HSP90 causing degradation of client proteins and inhibition of cancer cell proliferation

Zhang, Y., Dayalan Naidu, S., Samarasinghe, K., Van Hecke, G. C., Pheely, A., Boronina, T. N., Cole, R. N., Benjamin, I. J., Cole, P. A., Ahn, Y-H. & Dinkova-Kostova, A. T., 7 Jan 2014, In : British Journal of Cancer. 110, 1, p. 71-82 12 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)
96 Citations (Scopus)
267 Downloads (Pure)
7 Citations (Scopus)
785 Citations (Scopus)
2019

Broccoli or Sulforaphane: Is It the Source or Dose That Matters?

Yagishita, Y., Fahey, J. W., Dinkova-Kostova, A. T. & Kensler, T. W., Oct 2019, In : Molecules and Cells. 24, 19, p. 1-38 38 p., 3593.

Research output: Contribution to journalReview article

Open Access
File
16 Citations (Scopus)
219 Downloads (Pure)

Investigation into the use of histone deacetylase inhibitor MS-275 as a topical agent for the prevention and treatment of cutaneous squamous cell carcinoma in an SKH-1 hairless mouse model

Kalin, J. H., Eroglu, A., Liu, H., Holtzclaw, W. D., Leigh, I., Proby, C. M., Fahey, J. W., Cole, P. A. & Dinkova-Kostova, A. T., 13 Mar 2019, In : PLoS ONE. 14, 3, p. 1-13 13 p., e0213095.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
120 Downloads (Pure)
Open Access
File
3 Citations (Scopus)
143 Downloads (Pure)

The isothiocyanate sulforaphane inhibits mTOR in an NRF2-independent manner

Zhang, Y., Gilmour, A., Ahn, Y-H., de la Vega, L. & Dinkova-Kostova, A., 5 Aug 2019, In : Phytomedicine. 153062.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
100 Downloads (Pure)

Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases

Cuadrado, A., Rojo, A. I., Wells, G., Hayes, J., Cousin, S. P., Rumsey, W. L., Attucks, O. C., Franklin, S., Levonen, A-L., Kensler, T. W. & Dinkova-Kostova, A., Apr 2019, In : Nature Reviews Drug Discovery. 18, 4, p. 295-317 23 p.

Research output: Contribution to journalReview article

Open Access
File
150 Citations (Scopus)
213 Downloads (Pure)
2020

Activation of transcription factor Nrf2 to counteract mitochondrial dysfunction in Parkinson’s disease

Bento-Pereira, C. & Dinkova-Kostova, A., 18 Jul 2020, In : Medicinal Research Reviews. 18 p.

Research output: Contribution to journalReview article

Open Access
File
12 Downloads (Pure)

Biomarker Exploration in Human Peripheral Blood Mononuclear Cells for Monitoring Sulforaphane Treatment Responses in Autism Spectrum Disorder

Liu, H., Zimmerman, A. W., Singh, K., Connors, S. L., Diggins, E., Stephenson, K. K., Dinkova-Kostova, A. & Fahey, J. W., 2 Apr 2020, In : Scientific Reports. 10, 1, p. 1-11 11 p., 5822.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
26 Downloads (Pure)

Can activation of NRF2 be a strategy against COVID-19?

Cuadrado, A., Pajares, M., Benito, C., Jiménez-Villegas, J., Escoll, M., Fernández-Ginés, R., Garcia Yagüe, A. J., Lastra, D., Manda, G., Rojo, A. I. & Dinkova-Kostova, A. T., Sep 2020, In : Trends in Pharmacological Sciences. 41, 9, p. 598-610 13 p.

Research output: Contribution to journalReview article

Open Access
File
1 Citation (Scopus)
18 Downloads (Pure)

Isomeric O-methyl cannabidiolquinones with dual BACH1/NRF2 activity

Casares Perez, L., Unciti-Broceta, J. D., Prados, M. E., Caprioglio, D., Mattoteia, D., Higgins, M., Apendino, G., Dinkova-Kostova, A. T., Muñoz, E. & de la Vega, L., 22 Aug 2020, In : Redox Biology. 37, p. 1-10 10 p., 101689.

Research output: Contribution to journalArticle

Open Access
File
4 Downloads (Pure)

KEAP1, a cysteine-based sensor and a drug target for the prevention and treatment of chronic disease

Dayalan Naidu, S. & Dinkova-Kostova, A., Jun 2020, In : Open Biology. 10, 6, p. 1-13 13 p., 200105.

Research output: Contribution to journalArticle

Open Access
File
14 Downloads (Pure)
Open Access
File
9 Downloads (Pure)

Obesity and NRF2-mediated cytoprotection: Where is the missing link?

Vasileva, L. V., Savova, M. S., Amirova, K. M., Dinkova-Kostova, A. & Georgiev, M. I., Jun 2020, In : Pharmacological Research. 156, p. 1-9 9 p., 104760.

Research output: Contribution to journalReview article

Open Access
File
5 Citations (Scopus)
70 Downloads (Pure)

Oxidative Stress in Cancer

Hayes, J., Dinkova-Kostova, A. & Tew, K. D., 10 Aug 2020, In : Cancer Cell. 38, 31 p.

Research output: Contribution to journalReview article

1 Citation (Scopus)

Radiomodulatory effect of a non-electrophilic NQO1 inducer identified in a screen of new 6, 8-diiodoquinazolin-4(3H)-ones carrying a sulfonamide moiety

Soliman, A. M., Karam, H. M., Mekkawy, M. H., Higgins, M., Dinkova-Kostova, A. & Ghorab, M. M., 15 Aug 2020, In : European Journal of Medicinal Chemistry. 200, 12 p., 112467.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
8 Downloads (Pure)

The chemopreventive power of isothiocyanates

Naidu, S. D., Brodziak-Jarosz, L., Gerhäuser, C. & Dinkova-Kostova, A. T., 2020, Natural Products for Cancer Chemoprevention: Single Compounds and Combinations. Pezzuto, J. M. & Vang, O. (eds.). Switzerland: Springer , p. 271-318 48 p.

Research output: Chapter in Book/Report/Conference proceedingChapter