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  • Lindsay Spender
2020

Multifaceted transforming growth factor-beta (TGFβ) signalling in glioblastoma

Birch, J. L., Coull, B. J., Spender, L. C., Watt, C., Willison, A., Syed, N., Chalmers, A. J., Hossain-Ibrahim, M. K. & Inman, G. J., 19 Apr 2020, In : Cellular Signalling. 72, p. 1-12 12 p., 109638.

Research output: Contribution to journalReview article

2019

Preclinical Evaluation of AZ12601011 and AZ12799734, Inhibitors of Transforming Growth Factor β Superfamily Type 1 Receptors.

Spender, L. C., Ferguson, G. J., Hughes, G. D., Davies, B. R., Goldberg, F. W., Herrera, B., Taylor, R. G., Strathearn, L., Sansom, O. J., Barry, S. T. & Inman, G., 1 Feb 2019, In : Molecular Pharmacology. 95, 2, p. 222-234 13 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
198 Downloads (Pure)
2018

Reduced SMAD2/3 activation independently predicts increased depth of human cutaneous squamous cell carcinoma

Rose, A. M., Spender, L. C., Stephen, C., Mitchell, A., Rickaby, W., Bray, S., Evans, A. T., Dayal, J., Purdie, K. J., Harwood, C. A., Proby, C. M., Leigh, I. M., Coates, P. J. . & Inman, G. J., 6 Mar 2018, In : Oncotarget. 9, 18, p. 14552-14566 15 p.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
181 Downloads (Pure)

The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature

Inman, G. J., Wang, J., Nagano, A., Alexandrov, L. B., Purdie, K. J., Taylor, R. G., Sherwood, V., Thomson, J., Hogan, S., Spender, L. C., South, A. P., Stratton, M., Chelala, C., Harwood, C. A., Proby, C. M. & Leigh, I. M., 10 Sep 2018, In : Nature Communications. 9, 1, p. 1-14 14 p., 3667.

Research output: Contribution to journalArticle

Open Access
File
33 Citations (Scopus)
139 Downloads (Pure)
2017

Targeting BRAF-mutant tumours with TGFBR1 inhibitors

Spender, L. C. & Inman, G. J., 31 Jan 2017, In : Aging-US. 9, 1, p. 5-6 2 p.

Research output: Contribution to journalEditorial

Open Access
File
159 Downloads (Pure)
2016
Open Access
File
130 Downloads (Pure)

Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma

Cammareri, P., Rose, A., Vincent, D. F., Wang, J., Nagano, A., Libertini, S., Ridgway, R. A., Athineos, D., Coates, P. J. ., McHugh, A., Pourreyron, C., Dayal, J., Larsson, J., Weidlich, S., Spender, L., Sapkota, G., Purdie, K. J., Proby, C., Harwood, C. A., Leigh, I. & 9 others, Clevers, H., Barker, N., Karlsson, S., Pritchard, C., Marais, R., Chelala, C., South, A., Sansom, O. J. & Inman, G., 25 Aug 2016, In : Nature Communications. 7, p. 1-7 7 p., 12493.

Research output: Contribution to journalArticle

Open Access
File
41 Citations (Scopus)
124 Downloads (Pure)

Mutational activation of BRAF confers sensitivity to transforming growth factor beta inhibitors in human cancer cells

Spender, L. C., Ferguson, G. J., Liu, S., Cui, C., Girotti, M. R., Sibbet, G., Higgs, E. B., Shuttleworth, M. K., Hamilton, T., Lorigan, P., Weller, M., Vincent, D. F., Sansom, O. J., Frame, M., Ten Dijke, P., Marais, R. & Inman, G. J., 13 Dec 2016, In : Oncotarget. 7, 50, p. 81995-82012 18 p.

Research output: Contribution to journalArticle

Open Access
File
9 Citations (Scopus)
234 Downloads (Pure)
2012
34 Citations (Scopus)

Transforming Growth Factor-β directly induces PUMA during the rapid induction of apoptosis in Myc-driven B-cell lymphomas.

Spender, L. C., Carter, M. J., O'Brien, D. I., Clark, L. J., Yu, J., Michalak, E. M., Happo, L., Cragg, M. S. & Inman, G. J., 2012, In : Journal of Biological Chemistry.

Research output: Contribution to journalArticle

25 Citations (Scopus)
2011

Inhibition of germinal centre apoptotic programmes by epstein-barr virus

Spender, L. C. & Inman, G. J., 2011, In : Advances in Hematology. 2011, p. 829525

Research output: Contribution to journalArticle

8 Citations (Scopus)