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Activation of Nrf2 signaling as a common treatment of neurodegenerative diseases
Dinkova-Kostova, A. T. & Kazantsev, A. G., Apr 2017, In: Neurodegenerative Disease Management. 7, 2, p. 97-100 4 p.Research output: Contribution to journal › Editorial
Open AccessFile11 Citations (Scopus)207 Downloads (Pure) -
Activation of Nrf2 signaling augments Vesicular Stomatitis Virus Oncolysis via Autophagy-Driven Suppression of Antiviral Immunity
Olagnier, D., Lababidi, R. R., Bel Hadj, S., Sze, A., Liu, Y., Dayalan Naidu, S., Ferrari, M., Jiang, Y., Chiang, C., Beljanski, V., Goulet, M-L., Knatko, E. V., Dinkova-Kostova, A. T., Hiscott, J. & Lin, R., 2 Aug 2017, In: Molecular Therapy. 25, 8, p. 1900-1916 17 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile37 Citations (Scopus)204 Downloads (Pure) -
Activation of transcription factor Nrf2 to counteract mitochondrial dysfunction in Parkinson’s disease
Bento-Pereira, C. & Dinkova-Kostova, A., 18 Jul 2020, In: Medicinal Research Reviews. 18 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile3 Citations (Scopus)39 Downloads (Pure) -
Arthur Neish Young Investigator Award Lecture a Novel Role for Sulfhydryl-Reactive Activators of Transcription Factor NRF2: HSF1-Dependent Upregulation of Hsp70
Zhang, Y., Ahn, Y-H., Calabrese, V., Cole, P. A. & Dinkova-Kostova, A. T., May 2012, In: Pharmaceutical Biology. 50, 5, p. 625-625 1 p.Research output: Contribution to journal › Special issue › peer-review
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Bioactive polymethoxylated flavonoids from Chiliadenus montanus
Hamed, A. R., Mohamed, T. A., Tawfik, W. A., Hassan, E. M., Higgins, M., El-Toumy, S. A. & Dinkova-Kostova, A. T., 31 Mar 2016, In: Journal of Chemical and Pharmaceutical Research. 8, 3, p. 788-793 6 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile142 Downloads (Pure) -
Biomarker Exploration in Human Peripheral Blood Mononuclear Cells for Monitoring Sulforaphane Treatment Responses in Autism Spectrum Disorder
Liu, H., Zimmerman, A. W., Singh, K., Connors, S. L., Diggins, E., Stephenson, K. K., Dinkova-Kostova, A. & Fahey, J. W., 2 Apr 2020, In: Scientific Reports. 10, 11 p., 5822.Research output: Contribution to journal › Article › peer-review
Open AccessFile9 Citations (Scopus)48 Downloads (Pure) -
Broccoli or Sulforaphane: Is It the Source or Dose That Matters?
Yagishita, Y., Fahey, J. W., Dinkova-Kostova, A. T. & Kensler, T. W., Oct 2019, In: Molecules and Cells. 24, 19, p. 1-38 38 p., 3593.Research output: Contribution to journal › Review article › peer-review
Open AccessFile40 Citations (Scopus)314 Downloads (Pure) -
Can activation of NRF2 be a strategy against COVID-19?
Cuadrado, A., Pajares, M., Benito, C., Jiménez-Villegas, J., Escoll, M., Fernández-Ginés, R., Garcia Yagüe, A. J., Lastra, D., Manda, G., Rojo, A. I. & Dinkova-Kostova, A. T., Sep 2020, In: Trends in Pharmacological Sciences. 41, 9, p. 598-610 13 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile23 Citations (Scopus)135 Downloads (Pure) -
Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity
Calabrese, V., Cornelius, C., Dinkova-Kostova, A. T., Iavicoli, I., Di Paola, R., Koverech, A., Cuzzocrea, S., Rizzarelli, E. & Calabrese, E. J., May 2012, In: Biochimica et Biophysica Acta. Molecular Basis of Disease. 1822, 5, p. 753-783 31 p.Research output: Contribution to journal › Review article › peer-review
268 Citations (Scopus) -
Chemical constituents and NAD(P)H:Quinone oxidoreductase 1 (NQO1) inducer activity of Teucrium oliverianum Ging. ex Benth
Shahat, A. A., Alsaid, M. S., Khan, J. A., Higgins, M. & Dinkova-Kostova, A. T., Apr 2016, In: Indian Journal of Traditional Knowledge. 15, 2, p. 232-236 5 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)43 Downloads (Pure) -
Chemoprotection Against Cancer by Isothiocyanates: A Focus on the Animal Models and the Protective Mechanisms
Dinkova-Kostova, A. T., 2013, Natural Products in Cancer Prevention and Therapy. Pezzuto, J. M. & Suh, N. (eds.). Berlin: Springer , p. 179-201 23 p. (Topics in Current Chemistry; vol. 329).Research output: Chapter in Book/Report/Conference proceeding › Chapter
32 Citations (Scopus) -
Crosstalk between NRF2 and HIPK2 shapes cytoprotective responses
Torrente, L., Sanchez, C., Moreno Dorta, R., Chowdhry, S., Cabello, P., Isono, K., Koseki, H., Honda, T., Hayes, J., Dinkova-Kostova, A. & de la Vega, L., 2 Nov 2017, In: Oncogene. 36, 44, p. 6204-6212 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile33 Citations (Scopus)246 Downloads (Pure) -
Design, synthesis, and evaluation of triazole derivatives that induce Nrf2 dependent gene products and inhibit the Keap1-Nrf2 protein-protein interaction
Bertrand, H. C., Schaap, M., Baird, L., Georgakopoulos, N. D., Fowkes, A., Thiollier, C., Kachi, H., Dinkova-Kostova, A. T. & Wells, G., 24 Sep 2015, In: Journal of Medicinal Chemistry. 58, 18, p. 7186-7194 9 p.Research output: Contribution to journal › Article › peer-review
71 Citations (Scopus) -
Diffusion dynamics of the Keap1-Cullin3 interaction in single live cells
Baird, L. & Dinkova-Kostova, A. T., 2013, In: Biochemical and Biophysical Research Communications. 433, 1, p. 58-65 8 p.Research output: Contribution to journal › Article › peer-review
34 Citations (Scopus) -
Downregulation of Keap1 confers features of a fasted metabolic state
Knatko, E. V., Tatham, M. H., Zhang, Y., Castro, C., Higgins, M., Dayalan Naidu, S., Leonardi, C., de la Vega, L., Honda, T., Griffin, J. L., Hay, R. T. & Dinkova-Kostova, A. T., 23 Oct 2020, In: iScience. 23, 10, 48 p., 101638.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)24 Downloads (Pure) -
Dual regulation of transcription factor Nrf2 by Keap1 and by the combined actions of β-TrCP and GSK-3
Hayes, J. D., Chowdhry, S., Dinkova-Kostova, A. T. & Sutherland, C., Aug 2015, In: Biochemical Society Transactions. 43, 4, p. 611-620 10 p.Research output: Contribution to journal › Article › peer-review
69 Citations (Scopus) -
Effects of chemoprotective agent HBB-2 on cell survival in SH-SY5Y neuroblastoma cells
Scuto, M. C., Cavallaro, M. M., Luca, M., Cornelius, C., Cambria, M. T., Rizza, S., Salinaro, A. T., Dinkova-Kostova, A. & Calabrese, V., 2011, In: FEBS Journal. 278, S1, p. 268 1 p., P14.37.Research output: Contribution to journal › Meeting abstract › peer-review
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Electron affinity of tricyclic, bicyclic, and monocyclic compounds containing cyanoenones correlates with their potency as inducers of a cytoprotective enzyme
Bensasson, R. V., Dinkova-Kostova, A. T., Zheng, S., Saito, A., Li, W., Zoete, V. & Honda, T., 1 Sep 2016, In: Bioorganic & Medicinal Chemistry Letters. 26, 17, p. 4345-4349 5 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)174 Downloads (Pure) -
Epigenetic Control of NRF2-Directed Cellular Antioxidant Status in Dictating Life-Death Decisions
Hayes, J. D. & Dinkova-Kostova, A. T., 5 Oct 2017, In: Molecular Cell. 68, 1, p. 5-7 3 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile9 Citations (Scopus)327 Downloads (Pure) -
Filaggrin genotype does not determine the skin's threshold to UV-induced erythema
Forbes, D., Johnston, L., Gardner, J., MacCallum, S. F., Campbell, L. E., Dinkova-Kostova, A. T., McLean, W. H. I., Ibbotson, S. H., Dawe, R. S. & Brown, S. J., Apr 2016, In: Journal of Allergy and Clinical Immunology. 137, 4, p. 1280-1282.e3 6 p.Research output: Contribution to journal › Letter › peer-review
Open AccessFile6 Citations (Scopus)148 Downloads (Pure) -
Flavonolignan 2,3-dehydrosilydianin activates Nrf2 and upregulates NAD(P)H: quinone oxidoreductase 1 in Hepa1c1c7 cells
Roubalová, L., Dinkova-Kostova, A. T., Biedermann, D., Křen, V., Ulrichová, J. & Vrba, J., Jun 2017, In: Fitoterapia. 119, p. 115-120 6 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile18 Citations (Scopus)199 Downloads (Pure) -
Glucosinolates and isothiocyanates in health and disease
Dinkova-Kostova, A. T. & Kostov, R. V., 2012, In: Trends in Molecular Medicine. 18, 6, p. 337-347 11 p.Research output: Contribution to journal › Article › peer-review
337 Citations (Scopus) -
Glucosinolates from the Brassica Vegetables and Their Health Effects
Johnson, T. L., Dinkova-Kostova, A. T. & Fahey, J. W., 2016, Encyclopedia of Food and Health. Caballero, B., Finglas, P. M. & Toldrá, F. (eds.). Elsevier Inc., p. 248-255 8 p. (Reference Module in Food Science).Research output: Chapter in Book/Report/Conference proceeding › Entry for encyclopedia/dictionary
5 Citations (Scopus) -
Glutathione S-transferase genotype is associated with sensitivity to psoralen-ultraviolet A photochemotherapy
Ibbotson, S. H., Dawe, R. S., Dinkova-Kostova, A. T., Weidlich, S., Farr, P. M., Ferguson, J., Wolf, C. R. & Smith, G., Feb 2012, In: British Journal of Dermatology. 166, 2, p. 380-388 9 p.Research output: Contribution to journal › Article › peer-review
17 Citations (Scopus) -
Heat Shock Factor 1 is a Substrate for p38 Mitogen-Activated Protein Kinases
Dayalan Naidu, S., Sutherland, C., Zhang, Y., Risco, A., de la Vega, L., Caunt, C. J., Hastie, C. J., Lamont, D. J., Torrente, L., Chowdhry, S., Benjamin, I. J., Keyse, S. M., Cuenda, A. & Dinkova-Kostova, A. T., 15 Sep 2016, In: Molecular and Cellular Biology. 36, 18, p. 2403-2417 15 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile28 Citations (Scopus)297 Downloads (Pure) -
Highly potent activation of Nrf2 by topical tricyclic bis(cyano enone): Implications for protection against UV radiation during thiopurine therapy
Kalra, S., Knatko, E. V., Zhang, Y., Honda, T., Yamamoto, M. & Dinkova-Kostova, A. T., 2012, In: Cancer Prevention Research. 5, 7, p. 973-981 9 p.Research output: Contribution to journal › Article › peer-review
30 Citations (Scopus) -
High NRF2 Levels Correlate with Poor Prognosis in Colorectal Cancer Patients and with Sensitivity to the Kinase Inhibitor AT9283 In Vitro
Torrente Fernandez, L., Maan, G., Rezig, A. O., Quinn, J., Jackson, A., Grilli, A., Casares, L., Zhang, Y., Kulesskiy, E., Saarela, J., Bicciato, S., Edwards, J., Dinkova-Kostova, A. & de la Vega, L., Oct 2020, In: Biomolecules. 10, 10, 16 p., 1365.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)25 Downloads (Pure) -
HSF1-Dependent Upregulation of Hsp70 by Sulfhydryl-Reactive Inducers of the KEAP1/NRF2/ARE Pathway
Zhang, Y., Ahn, Y-H., Benjamin, I. J., Honda, T., Hicks, R. J., Calabrese, V., Cole, P. A. & Dinkova-Kostova, A. T., 23 Nov 2011, In: Chemistry & Biology. 18, 11, p. 1355-1361 7 p.Research output: Contribution to journal › Article › peer-review
70 Citations (Scopus) -
Induction of the Keapl/Nrf2/ARE pathway by oxidizable diphenols
Dinkova-Kostova, A. T. & Wang, X. J., 30 Jun 2011, In: Chemico-Biological Interactions. 192, 1-2, p. 101-106 6 p.Research output: Contribution to journal › Article › peer-review
51 Citations (Scopus) -
Investigation into the use of histone deacetylase inhibitor MS-275 as a topical agent for the prevention and treatment of cutaneous squamous cell carcinoma in an SKH-1 hairless mouse model
Kalin, J. H., Eroglu, A., Liu, H., Holtzclaw, W. D., Leigh, I., Proby, C. M., Fahey, J. W., Cole, P. A. & Dinkova-Kostova, A. T., 13 Mar 2019, In: PLoS ONE. 14, 3, p. 1-13 13 p., e0213095.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)142 Downloads (Pure) -
Isomeric O-methyl cannabidiolquinones with dual BACH1/NRF2 activity
Casares Perez, L., Unciti-Broceta, J. D., Prados, M. E., Caprioglio, D., Mattoteia, D., Higgins, M., Apendino, G., Dinkova-Kostova, A. T., Muñoz, E. & de la Vega, L., Oct 2020, In: Redox Biology. 37, p. 1-10 10 p., 101689.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)37 Downloads (Pure) -
KEAP1, a cysteine-based sensor and a drug target for the prevention and treatment of chronic disease: KEAP1, a sensor and a drug target
Dayalan Naidu, S. & Dinkova-Kostova, A., Jun 2020, In: Open Biology. 10, 6, p. 1-13 13 p., 200105.Research output: Contribution to journal › Review article › peer-review
Open AccessFile8 Citations (Scopus)30 Downloads (Pure) -
Keap1, the cysteine-based mammalian intracellular sensor for electrophiles and oxidants
Dinkova-Kostova, A. T., Kostov, R. V. & Canning, P., 1 Mar 2017, In: Archives of Biochemistry and Biophysics. 617, p. 84-93 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile111 Citations (Scopus)193 Downloads (Pure) -
KEAP1 and done? Targeting the NRF2 pathway with sulforaphane: Targeting the NRF2 Pathway with Sulforaphane
Dinkova-Kostova, A. T., Fahey, J. W., Kostov, R. V. & Kensler, T. W., Nov 2017, In: Trends in Food Science and Technology. 69, B, p. 257-269 13 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile92 Citations (Scopus)444 Downloads (Pure) -
KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients
Quinti, L., Dayalan Naidu, S., Träge, U., Chen, X., Kegel-Gleason, K., Lleres, D., Connolly, C., Chopra, V., Low, C., Moniot, S., Sapp, E., Tousley, A. R., Vodicka, P., Van Kanegan, M. J., Kaltenbach, L. S., Crawford, L. A., Fuszard, M., Higgins, M., Miller, J. R. C., Farmer, R. E. & 19 others, , 6 Jun 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 23, p. e4676-e4685 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile41 Citations (Scopus)193 Downloads (Pure) -
Loss of Nrf2 abrogates the protective effect of Keap1 down regulation in a preclinical model of cutaneous squamous cell carcinoma
Knatko, E. V., Higgins, M., Fahey, J. W. & Dinkova-Kostova, A., 24 May 2016, In: Scientific Reports. 6, 7 p., 25804.Research output: Contribution to journal › Article › peer-review
Open AccessFile21 Citations (Scopus)208 Downloads (Pure) -
Measuring Changes in Keap1‐Nrf2 Protein Complex Conformation in Individual Cells by FLIM‐FRET
Dikovskaya, D. & Dinkova-Kostova, A., Sep 2020, In: Current Protocols in Toxicology. 85, 1, p. 1-34 34 p., e96.Research output: Contribution to journal › Article › peer-review
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Measuring the Interaction of Transcription Factor Nrf2 with Its Negative Regulator Keap1 in Single Live Cells by an Improved FRET/FLIM Analysis
Dikovskaya, D., Appleton, P., Bento-Pereira, C. & Dinkova-Kostova, A., 18 Mar 2019, In: Chemical Research in Toxicology. 32, 3, p. 500-512 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)169 Downloads (Pure) -
Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease
Tebay, L. E., Robertson, H., Durant, S. T., Vitale, S. R., Penning, T. M., Dinkova-Kostova, A. T. & Hayes, J. D., Nov 2015, In: Free Radical Biology and Medicine. 88, Part B, p. 108-146 39 p.Research output: Contribution to journal › Article › peer-review
370 Citations (Scopus) -
Metabolic and Homeostatic Changes in Seizures and Acquired Epilepsy-Mitochondria, Calcium Dynamics and Reactive Oxygen Species
Kovac, S., Dinkova Kostova, A. T., Herrmann, A. M., Melzer, N., Meuth, S. G. & Gorji, A., 8 Sep 2017, In: International Journal of Molecular Sciences. 18, 9, p. 1-19 19 p., 1935.Research output: Contribution to journal › Review article › peer-review
Open AccessFile27 Citations (Scopus)213 Downloads (Pure) -
NAD(P)H: Quinone oxidoreductase 1 inducer activity of some Saudi Arabian medicinal plants
Shahat, A. A., Alsaid, M. S., Alyahya, M. A., Higgins, M. & Dinkova-Kostova, A. T., Apr 2013, In: Planta Medica. 79, 6, p. 459-464 6 p.Research output: Contribution to journal › Article › peer-review
11 Citations (Scopus) -
NAD(P)H: Quinone oxidoreductase 1 inducer activity of novel 4-aminoquinazoline derivatives
Ghorab, M. M., Alsaid, M. S., El-Gazzar, M. G., Higgins, M., Dinkova-Kostova, A. T. & Shahat, A. A., 2016, In: Journal of Enzyme Inhibition and Medicinal Chemistry. 31, 6, p. 1369-1374 7 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)205 Downloads (Pure) -
NAD(P)H: quinone oxidoreductase 1 inducer activity of some novel anilinoquinazoline derivatives
Ghorab, M. M., Alsaid, M. S., Higgins, M., Dinkova-Kostova, A. T., Shahat, A. A., Elghazawy, N. H. & Arafa, R. K., 8 Aug 2016, In: Drug Design, Development and Therapy. 10, p. 2515-2524 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)191 Downloads (Pure) -
NAD(P)H: Quinone oxidoreductase 1 inducer activity of some enaminone derivatives
Alsaid, M. S., Ghorab, M. M., Higgins, M., Dinkova-Kostova, A. T. & Shahat, A. A., 2015, In: Biomedical Research. 26, 1, p. 7-12 6 p.Research output: Contribution to journal › Article › peer-review
5 Citations (Scopus) -
Neuroprotective effects of sulforaphane after contusive spinal cord injury
Benedict, A. L., Mountney, A., Hurtado, A., Bryan, K. E., Schnaar, R. L., Dinkova-Kostova, A. T. & Talalay, P., 2012, In: Journal of Neurotrauma. 29, 16, p. 2576-2586 11 p.Research output: Contribution to journal › Article › peer-review
49 Citations (Scopus) -
New monocyclic, bicyclic, and tricyclic ethynylcyanodienones as activators of the Keap1/Nrf2/ARE pathway and inhibitors of inducible nitric oxide synthase
Li, W., Zheng, S., Higgins, M., Morra, R. P., Mendis, A. T., Chien, C-W., Ojima, I., Mierke, D. F., Dinkova-Kostova, A. T. & Honda, T., 11 Jun 2015, In: Journal of Medicinal Chemistry. 58, 11, p. 4738-4748 11 p.Research output: Contribution to journal › Article › peer-review
23 Citations (Scopus) -
Nrf2 activation in the treatment of neurodegenerative diseases: A focus on its role in mitochondrial bioenergetics and function
Esteras, N., Dinkova-Kostova, A. T. & Abramov, A. Y., May 2016, In: Biological Chemistry. 397, 5, p. 383-400 18 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile67 Citations (Scopus)310 Downloads (Pure) -
Nrf2 activation protects against solar-simulated ultraviolet radiation in mice and humans
Knatko, E. V., Ibbotson, S. H., Zhang, Y., Higgins, M., Fahey, J. W., Talalay, P., Dawe, R. S., Ferguson, J., Huang, J. T-J., Clarke, R., Zheng, S., Saito, A., Kalra, S., Benedict, A. L., Honda, T., Proby, C. M. & Dinkova-Kostova, A. T., Jun 2015, In: Cancer Prevention Research. 8, 6, p. 475-486 12 p.Research output: Contribution to journal › Article › peer-review
56 Citations (Scopus) -
NRF2 and the Ambiguous Consequences of Its Activation during Initiation and the Subsequent Stages of Tumourigenesis
Robertson, H., Dinkova-Kostova, A. T. & Hayes, J. D., 2 Dec 2020, In: Cancers. 12, 12, 48 p., 3609.Research output: Contribution to journal › Review article › peer-review
Open AccessFile1 Citation (Scopus)23 Downloads (Pure) -
NRF2 as an emerging therapeutic target
Copple, I. M., Dinkova-Kostova, A. T., Kensler, T. W., Liby, K. T. & Wigley, W. C., 31 Jan 2017, In: Oxidative Medicine and Cellular Longevity. 2017, p. 1-2 2 p., 8165458.Research output: Contribution to journal › Editorial › peer-review
Open AccessFile23 Citations (Scopus)205 Downloads (Pure)