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  • 2019
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Author

  • Julian Blow
2019

Defects in the origin licensing checkpoint stresses cells exiting G0

Blow, J. J., 1 Jul 2019, In : Journal of Cell Biology. 218, 7, p. 2080-2081 2 p.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
79 Downloads (Pure)
2017

Reversal of DDK-mediated MCM phosphorylation by Rif1-PP1 regulates replication initiation and replisome stability independently of ATR/Chk1

Alver, R. C., Chadha, G. S., Gillespie, P. J. & Blow, J. J., 7 Mar 2017, In : Cell Reports. 18, 10, p. 2508-2520 13 p.

Research output: Contribution to journalArticle

Open Access
File
36 Citations (Scopus)
163 Downloads (Pure)

The High-Affinity Interaction between ORC and DNA that Is Required for Replication Licensing Is Inhibited by 2-Arylquinolin-4-Amines

Gardner, N. J., Gillespie, P. J., Carrington, J. T., Shanks, E. J., McElroy, S. P., Haagensen, E. J., Frearson, J. A., Woodland, A. & Blow, J. J., 17 Aug 2017, In : Cell Chemical Biology. 24, 8, p. 981-992.e4 16 p.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
142 Downloads (Pure)
2016

Cell cycle synchronization in xenopus egg extracts

Gillespie, P. J., Neusiedler, J., Creavin, K., Chadha, G. S. & Blow, J., 2016, Cell cycle oscillators: methods and protocols. Coutts, A. S. & Weston, L. (eds.). New York: Humana Press, p. 101-147 47 p. (Methods in Molecular Biology; vol. 1342).

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

5 Citations (Scopus)

Chronic p53-independent p21 expression causes genomic instability by deregulating replication licensing

Galanos, P., Vougas, K., Walter, D., Polyzos, A., Maya-Mendoza, A., Haagensen, E. J., Kokkalis, A., Roumelioti, F-M., Gagos, S., Tzetis, M., Canovas, B., Igea, A., Ahuja, A. K., Zellweger, R., Havaki, S., Kanavakis, E., Kletsas, D., Roninson, I. B., Garbis, S. D., Lopes, M. & 7 others, Nebreda, A., Thanos, D., Blow, J. J., Townsend, P., Sørensen, C. S., Bartek, J. & Gorgoulis, V. G., Jul 2016, In : Nature Cell Biology. 18, 7, p. 777-789 13 p.

Research output: Contribution to journalArticle

Open Access
File
105 Citations (Scopus)
594 Downloads (Pure)

Direct non transcriptional role of NF-Y in DNA replication

Benatti, P., Belluti, S., Miotto, B., Neusiedler, J., Dolfini, D., Drac, M., Basile, V., Schwob, E., Mantovani, R., Blow, J. J. & Imbriano, C., 1 Apr 2016, In : Biochimica et Biophysica Acta. Molecular Cell Research. 1863, 4, p. 673-685 13 p.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
138 Downloads (Pure)

Inevitability and containment of replication errors for eukaryotic genome lengths spanning Megabase to Gigabase

Al Mamun, M., Albergante, L., Moreno, A., Carrington, J. T., Blow, J. & Newman, T. J., 27 Sep 2016, In : Proceedings of the National Academy of Sciences. 113, 39, p. E5765-E5774 10 p.

Research output: Contribution to journalArticle

Open Access
File
13 Citations (Scopus)
446 Downloads (Pure)

The KRAB Zinc Finger Protein Roma/Zfp157 Is a Critical Regulator of Cell-Cycle Progression and Genomic Stability

Ho, T. L. F., Guilbaud, G., Blow, J. J., Sale, J. E. & Watson, C. J., 26 Apr 2016, In : Cell Reports. 15, 4, p. 724-734 11 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
147 Downloads (Pure)
Open Access
File
11 Citations (Scopus)
284 Downloads (Pure)

Ubiquitinated Fancd2 recruits Fan1 to stalled replication forks to prevent genome instability

Lachaud, C., Moreno, A., Marchesi, F., Toth, R., Blow, J. J. & Rouse, J., 19 Feb 2016, In : Science. 351, 6275, p. 846-849 4 p.

Research output: Contribution to journalArticle

Open Access
60 Citations (Scopus)

Unreplicated DNA remaining from unperturbed S phases passes through mitosis for resolution in daughter cells

Moreno, A., Carrington, J. T., Albergante, L., Al Mamun, M., Haagensen, E. J., Komseli, E-S., Gorgoulis, V. G., Newman, T. J. & Blow, J., 27 Sep 2016, In : Proceedings of the National Academy of Sciences. 113, 39, p. E5757-E5764 8 p.

Research output: Contribution to journalArticle

Open Access
File
48 Citations (Scopus)
366 Downloads (Pure)
Open Access
File
3 Citations (Scopus)
175 Downloads (Pure)

Xenopus Mcm10 is a CDK-substrate required for replication fork stability

Chadha, G. S., Gambus, A., Gillespie, P. J. & Blow, J., 2016, In : Cell Cycle. 15, 16, p. 2183-2195 13 p.

Research output: Contribution to journalArticle

Open Access
File
13 Citations (Scopus)
225 Downloads (Pure)
2013

Combinatorial regulation of meiotic holliday junction resolution in C. elegans by HIM-6 (BLM) helicase, SLX-4, and the SLX-1, MUS-81 and XPF-1 nucleases

Agostinho, A., Meier, B., Sonneville, R., Jagut, M., Woglar, A., Blow, J., Jantsch, V. & Gartner, A., 18 Jul 2013, In : PLoS Genetics. 9, 7, e1003591.

Research output: Contribution to journalArticle

53 Citations (Scopus)

Deregulated origin licensing leads to chromosomal breaks by rereplication of a gapped DNA template

Neelsen, K. J., Zanini, I. M. Y., Mijic, S., Herrador, R., Zellweger, R., Chaudhuri, A. R., Creavin, K., Blow, J. J. & Lopes, M., 1 Dec 2013, In : Genes and Development. 27, 23, p. 2537-2542 6 p.

Research output: Contribution to journalArticle

48 Citations (Scopus)

Kinetochores coordinate pericentromeric cohesion and early DNA replication by Cdc7-Dbf4 kinase recruitment

Natsume, T., Müller, C. A., Katou, Y., Retkute, R., Gierlinski, M., Araki, H., Blow, J. J., Shirahige, K., Nieduszynski, C. A. & Tanaka, T. U., 6 Jun 2013, In : Molecular Cell. 50, 5, p. 661-674 14 p.

Research output: Contribution to journalArticle

85 Citations (Scopus)

Mcm8 and Mcm9 form a dimeric complex in Xenopus laevis egg extract that is not essential for DNA replication initiation

Gambus, A. & Blow, J. J., 15 Apr 2013, In : Cell Cycle. 12, 8, p. 1225-1232 8 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

PHD1 links cell-cycle progression to oxygen sensing through hydroxylation of the centrosomal protein Cep192

Moser, S. C., Bensaddek, D., Ortmann, B., Maure, J-F., Mudie, S., Blow, J. J., Lamond, A. I., Swedlow, J. R. & Rocha, S., 26 Aug 2013, In : Developmental Cell. 26, 4, p. 381-392 12 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)

Replisome stall events have shaped the distribution of replication origins in the genomes of yeasts

Newman, T. J., Mamun, M. A., Nieduszynski, C. A. & Blow, J. J., Nov 2013, In : Nucleic Acids Research. 41, 21, p. 9705-9718 14 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Stochastic association of neighboring replicons creates replication factories in budding yeast

Saner, N., Karschau, J., Natsume, T., Gierlinski, M., Retkute, R., Hawkins, M., Nieduszynski, C. A., Blow, J. J., de Moura, A. P. S. & Tanaka, T. U., 2013, In : Journal of Cell Biology. 202, 7, p. 1001-1012 12 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

The Geminin and Idas coiled coils preferentially form a heterodimer that inhibits Geminin function in DNA replication licensing

Caillat, C., Pefani, D-E., Gillespie, P. J., Taraviras, S., Blow, J. J., Lygerou, Z. & Perrakis, A., Nov 2013, In : Journal of Biological Chemistry. 288, 44, p. 31624-31634 11 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
2012

Dormant Origins, the Licensing Checkpoint, and the Response to Replicative Stresses

McIntosh, D. & Blow, J. J., Oct 2012, In : Cold spring harbor perspectives in biology. 4, 10, 10 p., 012955.

Research output: Contribution to journalArticle

69 Citations (Scopus)

Dynamic interactions of high Cdt1 and geminin levels regulate S phase in early Xenopus embryos

Kisielewska, J. & Blow, J. J., 1 Jan 2012, In : Development. 139, 1, p. 63-74 12 p.

Research output: Contribution to journalArticle

Open Access
18 Citations (Scopus)

Optimal Placement of Origins for DNA Replication

Karschau, J., Blow, J. J. & de Moura, A. P. S., 30 Jan 2012, In : Physical Review Letters. 108, 5, p. - 5 p., 058101.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Preparation and use of Xenopus egg extracts to study DNA replication and chromatin associated proteins

Gillespie, P. J., Gambus, A. & Blow, J. J., Jun 2012, In : Methods. 57, 2, p. 203-13 11 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Re-replication induced by geminin depletion occurs from G2 and is enhanced by checkpoint activation

Klotz-Noack, K., McIntosh, D., Schurch, N., Pratt, N. & Blow, J. J., 15 May 2012, In : Journal of Cell Science. 125, 10, p. 2436-2445 10 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

The dynamics of replication licensing in live Caenorhabditis elegans embryos

Sonneville, R., Querenet, M., Craig, A., Gartner, A. & Blow, J. J., 23 Jan 2012, In : Journal of Cell Biology. 196, 2, p. 233-246 14 p.

Research output: Contribution to journalArticle

Open Access
File
48 Citations (Scopus)
180 Downloads (Pure)
2011

A Role for Dormant Origins in Tumor Suppression

Klotz-Noack, K. & Blow, J. J., 4 Mar 2011, In : Molecular Cell. 41, 5, p. 495-496 2 p.

Research output: Contribution to journalEditorial

6 Citations (Scopus)

Biphasic chromatin binding of histone chaperone FACT during eukaryotic chromatin DNA replication

Kundu, L. R., Seki, M., Watanabe, N., Murofushi, H., Furukohri, A., Waga, S., Score, A. J., Blow, J. J., Horikoshi, M., Enomoto, T. & Tada, S., Jun 2011, In : Biochimica et Biophysica Acta. Molecular Cell Research. 1813, 6, p. 1129-1136 8 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

CDC-48/p97 Coordinates CDT-1 Degradation with GINS Chromatin Dissociation to Ensure Faithful DNA Replication

Franz, A., Orth, M., Pirson, P. A., Sonneville, R., Blow, J. J., Gartner, A., Stemmann, O. & Hoppe, T., 7 Oct 2011, In : Molecular Cell. 44, 1, p. 85-96 12 p.

Research output: Contribution to journalArticle

60 Citations (Scopus)

Evidence for a mammalian late-G1 phase inhibitor of replication licensing distinct from geminin or Cdk activity

Sasaki, T., Li, A., Gillespie, P. J., Blow, J. J. & Gilbert, D. M., Sep 2011, In : Nucleus. 2, 5, p. 455-464

Research output: Contribution to journalArticle

4 Citations (Scopus)

How dormant origins promote complete genome replication

Blow, J. J., Ge, X. Q. & Jackson, D. A., Aug 2011, In : Trends in Biochemical Sciences. 36, 8, p. 405-414 10 p.

Research output: Contribution to journalReview article

138 Citations (Scopus)

MCM2-7 Form Double Hexamers at Licensed Origins in Xenopus Egg Extract

Gambus, A., Khoudoli, G. A., Jones, R. C. & Blow, J. J., 1 Apr 2011, In : Journal of Biological Chemistry. 286, 13, p. 11855-11864 10 p.

Research output: Contribution to journalArticle

95 Citations (Scopus)