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  • Albena Dinkova-Kostova

Activation of transcription factor Nrf2 to counteract mitochondrial dysfunction in Parkinson’s disease

Bento-Pereira, C. & Dinkova-Kostova, A., 18 Jul 2020, In : Medicinal Research Reviews. 18 p.

Research output: Contribution to journalReview article

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18 Downloads (Pure)

Bioactive polymethoxylated flavonoids from Chiliadenus montanus

Hamed, A. R., Mohamed, T. A., Tawfik, W. A., Hassan, E. M., Higgins, M., El-Toumy, S. A. & Dinkova-Kostova, A. T., 31 Mar 2016, In : Journal of Chemical and Pharmaceutical Research. 8, 3, p. 788-793 6 p.

Research output: Contribution to journalArticle

Open Access
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117 Downloads (Pure)

Biomarker Exploration in Human Peripheral Blood Mononuclear Cells for Monitoring Sulforaphane Treatment Responses in Autism Spectrum Disorder

Liu, H., Zimmerman, A. W., Singh, K., Connors, S. L., Diggins, E., Stephenson, K. K., Dinkova-Kostova, A. & Fahey, J. W., 2 Apr 2020, In : Scientific Reports. 10, 1, p. 1-11 11 p., 5822.

Research output: Contribution to journalArticle

Open Access
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4 Citations (Scopus)
26 Downloads (Pure)

Broccoli or Sulforaphane: Is It the Source or Dose That Matters?

Yagishita, Y., Fahey, J. W., Dinkova-Kostova, A. T. & Kensler, T. W., Oct 2019, In : Molecules and Cells. 24, 19, p. 1-38 38 p., 3593.

Research output: Contribution to journalReview article

Open Access
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22 Citations (Scopus)
238 Downloads (Pure)

Can activation of NRF2 be a strategy against COVID-19?

Cuadrado, A., Pajares, M., Benito, C., Jiménez-Villegas, J., Escoll, M., Fernández-Ginés, R., Garcia Yagüe, A. J., Lastra, D., Manda, G., Rojo, A. I. & Dinkova-Kostova, A. T., Sep 2020, In : Trends in Pharmacological Sciences. 41, 9, p. 598-610 13 p.

Research output: Contribution to journalReview article

Open Access
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4 Citations (Scopus)
103 Downloads (Pure)

Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity

Calabrese, V., Cornelius, C., Dinkova-Kostova, A. T., Iavicoli, I., Di Paola, R., Koverech, A., Cuzzocrea, S., Rizzarelli, E. & Calabrese, E. J., May 2012, In : Biochimica et Biophysica Acta. Molecular Basis of Disease. 1822, 5, p. 753-783 31 p.

Research output: Contribution to journalReview article

255 Citations (Scopus)

Chemical constituents and NAD(P)H:Quinone oxidoreductase 1 (NQO1) inducer activity of Teucrium oliverianum Ging. ex Benth

Shahat, A. A., Alsaid, M. S., Khan, J. A., Higgins, M. & Dinkova-Kostova, A. T., Apr 2016, In : Indian Journal of Traditional Knowledge. 15, 2, p. 232-236 5 p.

Research output: Contribution to journalArticle

Open Access
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3 Citations (Scopus)
37 Downloads (Pure)

Chemical tuning enhances both potency toward Nrf2 and in vitro therapeutic index of triterpenoids

Copple, I. M., Shelton, L. M., Walsh, J., Kratschmar, D. V., Lister, A., Odermatt, A., Goldring, C. E., Dinkova-Kostova, A. T., Honda, T. & Park, B. K., Aug 2014, In : Toxicological Sciences. 140, 2, p. 462-469 8 p.

Research output: Contribution to journalArticle

Open Access
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12 Citations (Scopus)
564 Downloads (Pure)

Downregulation of Keap1 confers features of a fasted metabolic state

Knatko, E. V., Tatham, M. H., Zhang, Y., Castro, C., Higgins, M., Dayalan Naidu, S., Leonardi, C., de la Vega, L., Honda, T., Griffin, J. L., Hay, R. T. & Dinkova-Kostova, A. T., 23 Oct 2020, In : iScience. 23, 10, 48 p., 101638.

Research output: Contribution to journalArticle

Open Access
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10 Downloads (Pure)

Effects of chemoprotective agent HBB-2 on cell survival in SH-SY5Y neuroblastoma cells

Scuto, M. C., Cavallaro, M. M., Luca, M., Cornelius, C., Cambria, M. T., Rizza, S., Salinaro, A. T., Dinkova-Kostova, A. & Calabrese, V., 2011, In : FEBS Journal. 278, S1, p. 268 1 p., P14.37.

Research output: Contribution to journalMeeting abstract

Electron affinity of tricyclic, bicyclic, and monocyclic compounds containing cyanoenones correlates with their potency as inducers of a cytoprotective enzyme

Bensasson, R. V., Dinkova-Kostova, A. T., Zheng, S., Saito, A., Li, W., Zoete, V. & Honda, T., 1 Sep 2016, In : Bioorganic & Medicinal Chemistry Letters. 26, 17, p. 4345-4349 5 p.

Research output: Contribution to journalArticle

Open Access
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3 Citations (Scopus)
158 Downloads (Pure)

Filaggrin genotype does not determine the skin's threshold to UV-induced erythema

Forbes, D., Johnston, L., Gardner, J., MacCallum, S. F., Campbell, L. E., Dinkova-Kostova, A. T., McLean, W. H. I., Ibbotson, S. H., Dawe, R. S. & Brown, S. J., Apr 2016, In : Journal of Allergy and Clinical Immunology. 137, 4, p. 1280-1282.e3 6 p.

Research output: Contribution to journalLetter

Open Access
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6 Citations (Scopus)
128 Downloads (Pure)

Glucosinolates and isothiocyanates in health and disease

Dinkova-Kostova, A. T. & Kostov, R. V., 2012, In : Trends in Molecular Medicine. 18, 6, p. 337-347 11 p.

Research output: Contribution to journalArticle

316 Citations (Scopus)

Glucosinolates from the Brassica Vegetables and Their Health Effects

Johnson, T. L., Dinkova-Kostova, A. T. & Fahey, J. W., 2016, Encyclopedia of Food and Health. Caballero, B., Finglas, P. M. & Toldrá, F. (eds.). Elsevier Inc., p. 248-255 8 p. (Reference Module in Food Science).

Research output: Chapter in Book/Report/Conference proceedingEntry for encyclopedia/dictionary

5 Citations (Scopus)

Glutathione S-transferase genotype is associated with sensitivity to psoralen-ultraviolet A photochemotherapy

Ibbotson, S. H., Dawe, R. S., Dinkova-Kostova, A. T., Weidlich, S., Farr, P. M., Ferguson, J., Wolf, C. R. & Smith, G., Feb 2012, In : British Journal of Dermatology. 166, 2, p. 380-388 9 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Heat Shock Factor 1 is a Substrate for p38 Mitogen-Activated Protein Kinases

Dayalan Naidu, S., Sutherland, C., Zhang, Y., Risco, A., de la Vega, L., Caunt, C. J., Hastie, C. J., Lamont, D. J., Torrente, L., Chowdhry, S., Benjamin, I. J., Keyse, S. M., Cuenda, A. & Dinkova-Kostova, A. T., 15 Sep 2016, In : Molecular and Cellular Biology. 36, 18, p. 2403-2417 15 p.

Research output: Contribution to journalArticle

Open Access
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26 Citations (Scopus)
260 Downloads (Pure)
29 Citations (Scopus)

High NRF2 Levels Correlate with Poor Prognosis in Colorectal Cancer Patients and with Sensitivity to the Kinase Inhibitor AT9283 In Vitro

Torrente Fernandez, L., Maan, G., Rezig, A. O., Quinn, J., Jackson, A., Grilli, A., Casares, L., Zhang, Y., Kulesskiy, E., Saarela, J., Bicciato, S., Edwards, J., Dinkova-Kostova, A. & de la Vega, L., Oct 2020, In : Biomolecules. 10, 10, 16 p., 1365.

Research output: Contribution to journalArticle

Open Access
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5 Downloads (Pure)

HSF1-Dependent Upregulation of Hsp70 by Sulfhydryl-Reactive Inducers of the KEAP1/NRF2/ARE Pathway

Zhang, Y., Ahn, Y-H., Benjamin, I. J., Honda, T., Hicks, R. J., Calabrese, V., Cole, P. A. & Dinkova-Kostova, A. T., 23 Nov 2011, In : Chemistry & Biology. 18, 11, p. 1355-1361 7 p.

Research output: Contribution to journalArticle

68 Citations (Scopus)

Induction of the Keapl/Nrf2/ARE pathway by oxidizable diphenols

Dinkova-Kostova, A. T. & Wang, X. J., 30 Jun 2011, In : Chemico-Biological Interactions. 192, 1-2, p. 101-106 6 p.

Research output: Contribution to journalArticle

49 Citations (Scopus)

Investigation into the use of histone deacetylase inhibitor MS-275 as a topical agent for the prevention and treatment of cutaneous squamous cell carcinoma in an SKH-1 hairless mouse model

Kalin, J. H., Eroglu, A., Liu, H., Holtzclaw, W. D., Leigh, I., Proby, C. M., Fahey, J. W., Cole, P. A. & Dinkova-Kostova, A. T., 13 Mar 2019, In : PLoS ONE. 14, 3, p. 1-13 13 p., e0213095.

Research output: Contribution to journalArticle

Open Access
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2 Citations (Scopus)
126 Downloads (Pure)

Isomeric O-methyl cannabidiolquinones with dual BACH1/NRF2 activity

Casares Perez, L., Unciti-Broceta, J. D., Prados, M. E., Caprioglio, D., Mattoteia, D., Higgins, M., Apendino, G., Dinkova-Kostova, A. T., Muñoz, E. & de la Vega, L., Oct 2020, In : Redox Biology. 37, p. 1-10 10 p., 101689.

Research output: Contribution to journalArticle

Open Access
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5 Downloads (Pure)
Open Access
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2 Citations (Scopus)
16 Downloads (Pure)
Open Access
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19 Citations (Scopus)
190 Downloads (Pure)
Open Access
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9 Downloads (Pure)
Open Access
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3 Citations (Scopus)
147 Downloads (Pure)

Monitoring Keap1-Nrf2 interactions in single live cells

Baird, L., Swift, S., Llères, D. & Dinkova-Kostova, A. T., 1 Nov 2014, In : Biotechnology Advances. 32, 6, p. 1133-1144 12 p.

Research output: Contribution to journalArticle

Open Access
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82 Citations (Scopus)
353 Downloads (Pure)

NAD(P)H: quinone oxidoreductase 1 inducer activity of some novel anilinoquinazoline derivatives

Ghorab, M. M., Alsaid, M. S., Higgins, M., Dinkova-Kostova, A. T., Shahat, A. A., Elghazawy, N. H. & Arafa, R. K., 8 Aug 2016, In : Drug Design, Development and Therapy. 10, p. 2515-2524 10 p.

Research output: Contribution to journalArticle

Open Access
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3 Citations (Scopus)
167 Downloads (Pure)

NAD(P)H: Quinone oxidoreductase 1 inducer activity of novel 4-aminoquinazoline derivatives

Ghorab, M. M., Alsaid, M. S., El-Gazzar, M. G., Higgins, M., Dinkova-Kostova, A. T. & Shahat, A. A., 2016, In : Journal of Enzyme Inhibition and Medicinal Chemistry. 31, 6, p. 1369-1374 7 p.

Research output: Contribution to journalArticle

Open Access
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3 Citations (Scopus)
165 Downloads (Pure)

Neuroprotective effects of sulforaphane after contusive spinal cord injury

Benedict, A. L., Mountney, A., Hurtado, A., Bryan, K. E., Schnaar, R. L., Dinkova-Kostova, A. T. & Talalay, P., 2012, In : Journal of Neurotrauma. 29, 16, p. 2576-2586 11 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)

Novel Thioureido Derivatives Carrying Thione and Sulfonamide Moieties Induce the Cytoprotective Enzyme NAD(P)H:Quione Oxidoreductase 1: Quinone oxidoreductase 1

Ghorab, M. M., Higgins, M., Dinkova-Kostova, A. T., Alsaid, M. S. & Shahat, A. A., 1 Dec 2014, In : Asian Journal of Chemistry. 26, 24, p. 8501-8504 4 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Nrf2 activation in the treatment of neurodegenerative diseases: A focus on its role in mitochondrial bioenergetics and function

Esteras, N., Dinkova-Kostova, A. T. & Abramov, A. Y., May 2016, In : Biological Chemistry. 397, 5, p. 383-400 18 p.

Research output: Contribution to journalArticle

Open Access
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58 Citations (Scopus)
268 Downloads (Pure)

Nrf2 affects the efficiency of mitochondrial fatty acid oxidation

Ludtmann, M. H. R., Angelova, P. R., Zhang, Y., Abramov, A. Y. & Dinkova-Kostova, A. T., 1 Feb 2014, In : Biochemical Journal. 457, 3, p. 415-424 10 p.

Research output: Contribution to journalArticle

107 Citations (Scopus)
Open Access
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16 Citations (Scopus)
144 Downloads (Pure)

Obesity and NRF2-mediated cytoprotection: Where is the missing link?

Vasileva, L. V., Savova, M. S., Amirova, K. M., Dinkova-Kostova, A. & Georgiev, M. I., Jun 2020, In : Pharmacological Research. 156, p. 1-9 9 p., 104760.

Research output: Contribution to journalReview article

Open Access
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9 Citations (Scopus)
94 Downloads (Pure)
13 Citations (Scopus)

Oxidative Stress in Cancer

Hayes, J., Dinkova-Kostova, A. & Tew, K. D., 10 Aug 2020, In : Cancer Cell. 38, 31 p.

Research output: Contribution to journalReview article

7 Citations (Scopus)

Potency of extracts from selected Egyptian plants as inducers of the Nrf2-dependent chemopreventive enzyme NQO1

Hamed, A. R., Hegazy, M-E. F., Higgins, M., Mohamed, T. A., Abdel-Azim, N. S., Pare, P. W. & Dinkova-Kostova, A. T., Jul 2016, In : Journal of Natural Medicines. 70, 3, p. 683-688 6 p.

Research output: Contribution to journalArticle

Open Access
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6 Citations (Scopus)
212 Downloads (Pure)

Radiomodulatory effect of a non-electrophilic NQO1 inducer identified in a screen of new 6, 8-diiodoquinazolin-4(3H)-ones carrying a sulfonamide moiety

Soliman, A. M., Karam, H. M., Mekkawy, M. H., Higgins, M., Dinkova-Kostova, A. & Ghorab, M. M., 15 Aug 2020, In : European Journal of Medicinal Chemistry. 200, 12 p., 112467.

Research output: Contribution to journalArticle

Open Access
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1 Citation (Scopus)
10 Downloads (Pure)

Regulation of the CNC-bZIP transcription factor Nrf2 by Keap1 and the axis between GSK-3 and β-TrCP

Hayes, J. D., Ebisine, K., Sharma, R. S., Chowdhry, S., Dinkova-Kostova, A. T. & Sutherland, C., Dec 2016, In : Current Opinion in Toxicology. 1, p. 92-103 12 p.

Research output: Contribution to journalReview article

Open Access
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9 Citations (Scopus)
330 Downloads (Pure)

Rhodiola rosea L. from golden root to green cell factories

Marchev, A. S., Dinkova-Kostova, A. T., György, Z., Mirmazloum, I., Aneva, I. Y. & Georgiev, M. I., Aug 2016, In : Phytochemistry Reviews. 15, 4, p. 515-536 22 p.

Research output: Contribution to journalArticle

Open Access
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17 Citations (Scopus)
400 Downloads (Pure)

Semisynthetic flavonoid 7-O-galloylquercetin activates Nrf2 and induces Nrf2-dependent gene expression in RAW264.7 and Hepa1c1c7 cells

Roubalová, L., Biedermann, D., Papoušková, B., Vacek, J., Kuzma, M., Křen, V., Ulrichová, J., Dinkova-Kostova, A. T. & Vrba, J., 25 Dec 2016, In : Chemico-Biological Interactions. 260, p. 58-66 9 p.

Research output: Contribution to journalArticle

Open Access
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6 Citations (Scopus)
159 Downloads (Pure)

SIRT2- and NRF2-Targeting Thiazole-Containing Compound with Therapeutic Activity in Huntington's Disease Models

Quinti, L., Casale, M., Moniot, S., Pais, T. F., Van Kanegan, M. J., Kaltenbach, L. S., Pallos, J., Lim, R. G., Naidu, S. D., Runne, H., Meisel, L., Rauf, N. A., Leyfer, D., Maxwell, M. M., Saiah, E., Landers, J. E., Luthi-Carter, R., Abagyan, R., Dinkova-Kostova, A. T., Steegborn, C. & 4 others, Marsh, J. L., Lo, D. C., Thompson, L. M. & Kazantsev, A. G., 21 Jul 2016, In : Cell Chemical Biology. 23, 7, p. 849-861 13 p.

Research output: Contribution to journalArticle

Open Access
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35 Citations (Scopus)
186 Downloads (Pure)

Sulfoxythiocarbamate S-4 inhibits HSP90 in human cutaneous squamous cell carcinoma cells

Zhang, Y., VanHecke, G. C., Ahn, Y-H., Proby, C. M. & Dinkova-Kostova, A. T., 6 Oct 2020, In : European Journal of Pharmacology. 889, 9 p., 173609.

Research output: Contribution to journalArticle

Sulphoxythiocarbamates modify cysteine residues in HSP90 causing degradation of client proteins and inhibition of cancer cell proliferation

Zhang, Y., Dayalan Naidu, S., Samarasinghe, K., Van Hecke, G. C., Pheely, A., Boronina, T. N., Cole, R. N., Benjamin, I. J., Cole, P. A., Ahn, Y-H. & Dinkova-Kostova, A. T., 7 Jan 2014, In : British Journal of Cancer. 110, 1, p. 71-82 12 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)
102 Citations (Scopus)
282 Downloads (Pure)

Synthesis, chemical reactivity as Michael acceptors, and biological potency of monocyclic cyanoenones, novel and highly potent anti-inflammatory and cytoprotective agents

Zheng, S., Laxmi, Y. R. S., David, E., Dinkova-Kostova, A. T., Shiavoni, K. H., Ren, Y., Zheng, Y., Trevino, I., Bumeister, R., Ojima, I., Wigley, W. C., Bliska, J. B., Mierke, D. F. & Honda, T., 24 May 2012, In : Journal of Medicinal Chemistry. 55, 10, p. 4837-4846 10 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

Synthesis, molecular modeling and NAD(P)H: quinone oxidoreductase 1 inducer activity of novel 2-phenylquinazolin-4-amine derivatives

Ghorab, M. M., Alsaid, M. S., Higgins, M., Dinkova-Kostova, A. T., Shahat, A. A., Elghazawy, N. H. & Arafa, R. K., Apr 2016, In : Journal of Enzyme Inhibition and Medicinal Chemistry. 31, 6, p. 1612-1618 7 p.

Research output: Contribution to journalArticle

Open Access
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3 Citations (Scopus)
147 Downloads (Pure)
7 Citations (Scopus)