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  Synthesis, full chemical characterisation and development of validated methods for the quantification of (±)-4′-methylmethcathinone (mephedrone): A new "legal high"

  Santali, E. Y., Cadogan, A-K., Nic Daeid, N., Savage, K. A. & Sutcliffe, O. B., 10 Sept 2011, In: Journal of Pharmaceutical and Biomedical Analysis. 56, 2, p. 246-255 10 p.

  Research output: Contribution to journal › Article › peer-review
  47 Citations (Scopus)

• Synthesis, full chemical characterisation and development of validated methods for the quantification of the components found in the evolved "legal high" NRG-2

  Khreit, O. I. G., Irving, C., Schimdt, E., Parkinson, J. A., Nic Daeid, N. & Sutcliffe, O. B., 5 Mar 2012, In: Journal of Pharmaceutical and Biomedical Analysis. 61, p. 122-135 14 p.

  Research output: Contribution to journal › Article › peer-review
  25 Citations (Scopus)

• Synthesis, Kinase Inhibitory Potencies, and in Vitro Antiproliferative Evaluation of New Pim Kinase Inhibitors

  Akue-Gedu, R., Rossignol, E., Azzaro, S., Knapp, S., Filippakopoulos, P., Bullock, A. N., Bain, J., Cohen, P., Prudhomme, M., Anizon, F. & Moreau, P., 22 Oct 2009, In: Journal of Medicinal Chemistry. 52, 20, p. 6369-6381 13 p.

  Research output: Contribution to journal › Article › peer-review
  93 Citations (Scopus)

• Synthesis, molecular modeling and NAD(P)H: quinone oxidoreductase 1 inducer activity of novel 2-phenylquinazolin-4-amine derivatives

  Ghorab, M. M., Alsaid, M. S., Higgins, M., Dinkova-Kostova, A. T., Shahat, A. A., Elghazawy, N. H. & Arafa, R. K., Apr 2016, In: Journal of Enzyme Inhibition and Medicinal Chemistry. 31, 6, p. 1612-1618 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  4 Citations (Scopus)

  143 Downloads (Pure)

• Synthesis, molecular modeling and NAD(P)H:quinone oxidoreductase 1 inducer activity of novel cyanoenone and enone benzenesulfonamides: quinone oxidoreductase 1 inducer activity of novel cyanoenone and enone benzenesulfonamides

  Ghorab, M. M., Higgins, M., Alsaid, M. S., Arafa, R. K., Shahat, A. A. & Dinkova-Kostova, A. T., Dec 2014, In: Journal of Enzyme Inhibition and Medicinal Chemistry. 29, 6, p. 840-845 6 p.

  Research output: Contribution to journal › Article › peer-review
  8 Citations (Scopus)

• Synthesis, Pim kinase inhibitory potencies and in vitro antiproliferative activities of diversely substituted pyrrolo[2,3-a]carbazoles

  Akue-Gedu, R., Nauton, L., Thery, V., Bain, J., Cohen, P., Anizon, F. & Moreau, P., 15 Sept 2010, In: Bioorganic & Medicinal Chemistry. 18, 18, p. 6865-6873 9 p.

  Research output: Contribution to journal › Article › peer-review
  35 Citations (Scopus)

• Synthesis, Structure–Activity Relationships, and Antiviral Profiling of 1-Heteroaryl-2-Alkoxyphenyl Analogs as Inhibitors of SARS-CoV-2 Replication

  Bardiot, D., Vangeel, L., Koukni, M., Arzel, P., Zwaagstra, M., Lyoo, H., Wanningen, P., Ahmad, S., Zhang, L., Sun, X., Delpal, A., Eydoux, C., Guillemot, J. C., Lescrinier, E., Klaassen, H., Leyssen, P., Jochmans, D., Castermans, K., Hilgenfeld, R., Robinson, C., & 9 othersDecroly, E., Canard, B., Snijder, E. J., van Hemert, M. J., van Kuppeveld, F., Chaltin, P., Neyts, J., De Jonghe, S. & Marchand, A., 4 Feb 2022, In: Molecules. 27, 3, 26 p., 1052.

  Research output: Contribution to journal › Article › peer-review

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  3 Citations (Scopus)

  63 Downloads (Pure)

• Synthesis and Anti-Inflammatory Activity of 2-Amino-4,5,6,7-tetrahydrobenzo[b]thiophene-Derived NRF2 Activators

  Mak, K-K., Shiming, Z., Epemolu, O., Dinkova-Kostova, A. T., Wells, G., Gazaryan, I. G., Sakirolla, R., Mohd, Z. & Pichika, M. R., Oct 2022, In: ChemistryOpen. 11, 10, 11 p., e202200181.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  2 Citations (Scopus)

  25 Downloads (Pure)

• Synthesis and antitrypanosomal evaluation of some thiazole-containing amino acids and peptides

  Van Bogaert, I., Haemers, A., Bollaert, W., Van Meirvenne, N., Brun, R., Smith, K. & Fairlamb, AH., 1993, In: European Journal of Medicinal Chemistry. 28, 5, p. 387-397 11 p.

  Research output: Contribution to journal › Article › peer-review
  5 Citations (Scopus)

• Synthesis and applications of oligoribonucleotides with selected 2′-o-methylation using the 2′-o-[1-(2-fluorophenyl)-4-methoxypiperidin-4-yl] protecting group

  Beijer, B., Sulston, I., Sproat, B. S., Rider, P., Lamond, A. I. & Neuner, P., 11 Sept 1990, In: Nucleic Acids Research. 18, 17, p. 5143-5151 9 p.

  Research output: Contribution to journal › Article › peer-review
  30 Citations (Scopus)

• Synthesis and biological activity of conjugates between paclitaxel and the cell delivery vector penetratin

  Wang, S., Zhelev, N. Z., Duff, S. & Fischer, P. M., 15 May 2006, In: Bioorganic and Medicinal Chemistry Letters. 16, 10, p. 2628-2631 4 p.

  Research output: Contribution to journal › Article › peer-review
  15 Citations (Scopus)

• Synthesis and biological evaluation of 1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]-4-ethynylimidazole. A novel and highly potent anti-inflammatory and cytoprotective agent

  Honda, T., Dinkova-Kostova, A. T., David, E., Padegimas, E. M., Sundararajan, C., Visnick, M., Bumeister, R. & Wigley, W. C., 15 Apr 2011, In: Bioorganic & Medicinal Chemistry Letters. 21, 8, p. 2188-2191 4 p.

  Research output: Contribution to journal › Article › peer-review
  20 Citations (Scopus)

• Synthesis and biological evaluation of biotin conjugates of (±)-(4bS,8aR,10aS)-10a-ethynyl-4b,8,8-trimethyl-3,7-dioxo-3,4b,7,8,8a,9,10,10a-octahydro-phenanthrene-2,6-dicarbonitrile, an activator of the Keap1/Nrf2/ARE pathway, for the isolation of its protein targets

  Saito, A., Higgins, M., Zheng, S., Li, W., Ojima, I., Dinkova-Kostova, A. T. & Honda, T., 15 Oct 2013, In: Bioorganic & Medicinal Chemistry Letters. 23, 20, p. 5540-5543 4 p.

  Research output: Contribution to journal › Article › peer-review
  5 Citations (Scopus)

• Synthesis and biological evaluation of novel 2-phenylquinazoline-4-amine derivatives: identification of 6-phenyl-8H-benzo[g]quinazolino[4,3-b]quinazolin-8-one as a highly potent inducer of NAD(P)H quinone oxidoreductase 1

  Ghorab, M. M., Alsaid, M. S., El-Gazzar, M. G., Higgins, M., Dinkova-Kostova, A. T. & Shahat, A. A., 2016, In: Journal of Enzyme Inhibition and Medicinal Chemistry. 31, Suppl. 1, p. 34-49 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  5 Citations (Scopus)

  208 Downloads (Pure)

• Synthesis and biological evaluation of phosphate Prodrugs of 4-Phospho-D-erythronohydroxamic acid, an inhibitor of 6-phosphogluconate dehydrogenase

  Ruda, G. F., Alibu, V. P., Mitsos, C., Bidet, O., Kaiser, M., Brun, R., Barrett, M. P. & Gilbert, I. H., Aug 2007, In: ChemMedChem. 2, 8, p. 1169-1180 12 p.

  Research output: Contribution to journal › Article › peer-review
  25 Citations (Scopus)

  9 Downloads (Pure)

• Synthesis and Biological Investigation of (+)-JD1, an Organometallic BET Bromodomain Inhibitor

  Hassell-Hart, S., Runcie, A., Krojer, T., Doyle, J., Lineham, E., Ocasio, C. A., Neto, B. A. D., Fedorov, O., Marsh, G., Maple, H., Felix, R., Banks, R., Ciulli, A., Picaud, S., Filippakopoulos, P., Von Delft, F., Brennan, P., Stewart, H. J. S., Chevassut, T. J., Walker, M., & 3 othersAustin, C., Morley, S. & Spencer, J., 10 Feb 2020, In: Organometallics. 39, 3

  Research output: Contribution to journal › Article › peer-review
  5 Citations (Scopus)

• Synthesis and biological properties of bioreductively targeted nitrothienyl prodrugs of combretastatin A-4

  Thomson, P., Naylor, M. A., Everett, S. A., Stratford, M. R. L., Lewis, G., Hill, S., Patel, K. B., Wardman, P. & Davis, P. D., Nov 2006, In: Molecular Cancer Therapeutics. 5, 11, p. 2886-2894 9 p.

  Research output: Contribution to journal › Article › peer-review
  36 Citations (Scopus)

• Synthesis and characterisation of nanosized TiO₂-ZrO₂ binary system prepared by an aqueous sol-gel process: Physical and sensing properties

  Mohammadi, M. R. & Fray, D. J., 20 Jul 2011, In: Sensors and Actuators, B: Chemical. 155, 2, p. 568-576 9 p.

  Research output: Contribution to journal › Article › peer-review
  39 Citations (Scopus)

• Synthesis and characterisation of nanostructured neodymium titanium oxides by sol-gel process: Controlling the phase composition, crystal structure and grain size

  Mohammadi, M. R. & Fray, D. J., 1 Aug 2010, In: Materials Chemistry and Physics. 122, 2-3, p. 512-523 12 p.

  Research output: Contribution to journal › Article › peer-review
  14 Citations (Scopus)

• Synthesis and characterization of an iodinated bile-salt derivative for photoaffinity-labeling

  Henderson, C. J. & Percy-Robb, I. W., 12 Sept 1984, In: Biochimica et Biophysica Acta. Lipids and Lipid Metabolism. 795, 2, p. 257-264 8 p.

  Research output: Contribution to journal › Article › peer-review

• Synthesis and characterization of quantum dots designed for biomedical use

  Kuzyniak, W., Adegoke, O., Sekhosana, K., D'Souza, S., Tshangana, S. C., Hoffmann, B., Ermilov, E. A., Nyokong, T. & Höpfner, M., 15 May 2014, In: International Journal of Pharmaceutics. 466, 1-2, p. 382-389 8 p.

  Research output: Contribution to journal › Article › peer-review
  31 Citations (Scopus)

• Synthesis and crystallization of lead-zirconium-titanate (PZT) nanotubes at the low temperature using carbon nanotubes (CNTs) as sacrificial templates

  Mohammadi, M. R., Tabei, S. A., Nemati, A., Eder, D. & Pradeep, T., Sept 2012, In: Advanced Powder Technology. 23, 5, p. 647-654 8 p.

  Research output: Contribution to journal › Article › peer-review
  9 Citations (Scopus)

• Synthesis and enzymology of modified N-benzyloxycarbonyl-L-cysteinylglycyl-3,3-dimethylaminopropylamide disulphides as alternative substrates for trypanothione reductase from Trypanosoma cruzi: Part 3

  Yuen, C. T., Garforth, J., Besheya, T., Jaouhari, R., McKie, J. H., Fairlamb, A. H. & Douglas, K. T., Jun 1999, In: Amino Acids. 17, 2, p. 175-183 9 p.

  Research output: Contribution to journal › Article › peer-review
  3 Citations (Scopus)

• Synthesis and Evaluation of 1-(1-(Benzo[b]thiophen-2-yl)cyclohexyl)piperidine (BTCP) Analogues as Inhibitors of Trypanothione Reductase

  Patterson, S., Jones, D. C., Shanks, E. J., Frearson, J. A., Gilbert, I. H., Wyatt, P. G. & Fairlamb, A. H., Aug 2009, In: ChemMedChem. 4, 8, p. 1341-1353 13 p.

  Research output: Contribution to journal › Article › peer-review
  50 Citations (Scopus)

• Synthesis and evaluation of 9,9-dimethylxanthene tricyclics against trypanothione reductase, Trypanosoma brucei, Trypanosoma cruzi and Leishmania donovani

  Chibale, K., Visser, M., Yardley, V., Croft, S. L. & Fairlamb, A. H., 5 Jun 2000, In: Bioorganic and Medicinal Chemistry Letters. 10, 11, p. 1147-1150 4 p.

  Research output: Contribution to journal › Article › peer-review
  16 Citations (Scopus)

• Synthesis and evaluation of analogues of congo red as potential compounds against transmissible spongiform. encephalopathies

  Rudyk, H., Knaggs, M. H., Vasiljevic, S., Hope, J., Birkett, C. & Gilbert, I. H., 2003, In: European Journal of Medicinal Chemistry. 38, 6, p. 567-579 13 p.

  Research output: Contribution to journal › Article › peer-review
  45 Citations (Scopus)

• Synthesis and Evaluation of Indatraline-Based Inhibitors for Trypanothione Reductase

  Walton, J. G. A., Jones, D. C., Kiuru, P., Durie, A. J., Westwood, N. J. & Fairlamb, A. H., 7 Feb 2011, In: ChemMedChem. 6, 2, p. 321-328 8 p.

  Research output: Contribution to journal › Article › peer-review
  22 Citations (Scopus)

• Synthesis and Evaluation of α-Thymidine Analogues as Novel Antimalarials

  Cui, H., Carrero-Lérida, J., Silva, A. P. G., Whittingham, J. L., Brannigan, J. A., Ruiz-Pérez, L. M., Read, K. D., Wilson, K. S., González-Pacanowska, D. & Gilbert, I. H., 2012, In: Journal of Medicinal Chemistry. 55, 24, p. 10948-57 10 p.

  Research output: Contribution to journal › Article › peer-review
  34 Citations (Scopus)

• Synthesis and inclusion study of a novel γ-cyclodextrin derivative as a potential thermo-sensitive carrier for doxorubicin

  Xu, D., Wang, L., Gourevich, D., Kabha, E., Arditti, F., Athamna, M., Cochran, S., Melzer, A. & Gnaim, J. M., Jul 2014, In: Chemical and Pharmaceutical Bulletin. 62, 7, p. 627-635 9 p.

  Research output: Contribution to journal › Article › peer-review
  6 Citations (Scopus)

• Synthesis and in vitro biochemical evaluation of oxime bond-linked daunorubicin-GnRH-III conjugates developed for targeted drug delivery

  Schuster, S., Biri-Kovács, B., Szeder, B., Farkas, V., Buday, L., Szabó, Z., Halmos, G. & Mező, G., 4 Apr 2018, In: Beilstein Journal of Organic Chemistry. 14, p. 756-771 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  18 Citations (Scopus)

  35 Downloads (Pure)

• Synthesis and NAD(P)H: Quinone oxidoreductase 1 inducer activity of acetamide and pyridine-3-carbonitrile derivatives

  Ghorab, M. M., Shahat, A. A., Alsaid, M. S., Higgins, M., Dinkova-Kostova, A. T. & Naser, A. A., 2016, In: Biomedical Research. 27, 4, p. 1045-1048 4 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  51 Downloads (Pure)

• Synthesis and preliminary assessment of the anticancer and Wnt/β-catenin inhibitory activity of small amide libraries of fenamates and profens

  Mathew, B., Hobrath, J. V., Lu, W., Li, Y. & Reynolds, R. C., Nov 2017, In: Medicinal Chemistry Research. 26, 11, p. 3038-3045 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  11 Citations (Scopus)

  166 Downloads (Pure)

• Synthesis and structure-activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKε kinases

  McIver, E. G., Bryans, J., Birchall, K., Chugh, J., Drake, T., Lewis, S. J., Osborne, J., Smiljanic-Hurley, E., Tsang, W., Kamal, A., Levy, A., Newman, M., Taylor, D., Arthur, J. S. C., Clark, K. & Cohen, P., Dec 2012, In: Bioorganic & Medicinal Chemistry Letters. 22, 23, p. 7169-7173 5 p.

  Research output: Contribution to journal › Article › peer-review
  32 Citations (Scopus)

• Synthesis and testing of 5-benzyl-2,4-diaminopyrimidines as potential inhibitors of leishmanial and trypanosomal dihydrofolate reductase

  Chowdhury, S. F., Hurtado Guerrero, R., Brun, R., Ruiz-Perez, L. M., Gonzalez Pacanowska, D. & Gilbert, I. H., 2002, In: Journal of Enzyme Inhibition and Medicinal Chemistry. 17, 5, p. 293-302 10 p.

  Research output: Contribution to journal › Article › peer-review
  23 Citations (Scopus)

• Synthesis and testing of peptides for anti-prion activity

  Sellarajah, S., Boussard, C., Lekishvili, T., Brown, D. R. & Gilbert, I. H., Nov 2008, In: European Journal of Medicinal Chemistry. 43, 11, p. 2418-2427 10 p.

  Research output: Contribution to journal › Article › peer-review
  3 Citations (Scopus)

• Synthesis of (-)-(S, S)-clemastine by invertive N → C aryl migration in a lithiated carbamate

  Fournier, A. M., Brown, R. A., Farnaby, W., Miyatake-Ondozabal, H. & Clayden, J., 21 May 2010, In: Organic Letters. 12, 10, p. 2222-2225 4 p.

  Research output: Contribution to journal › Article › peer-review
  52 Citations (Scopus)

• Synthesis of (R)-2-methyl-4-deoxy and (R)-2-methyl-4,5-dideoxy analogues of 6-phosphogluconate as potential inhibitors of 6-phosphogluconate dehydrogenase

  Dardonville, C. & Gilbert, I. H., 2003, In: Organic and Biomolecular Chemistry. 1, 3, p. 552-559 8 p.

  Research output: Contribution to journal › Article › peer-review
  11 Citations (Scopus)

• Synthesis of ¹³C₂¹⁵N₂-labeled anti-inflammatory and cytoprotective tricyclic bis(cyanoenone) ([¹³C₂¹⁵N₂]-TBE-31) as an internal standard for quantification by stable isotope dilution LC-MS method

  Zheng, S., Huang, J. T. -J., Knatko, E. V., Sharp, S., Higgins, M., Ojima, I., Dinkova-Kostova, A. T. & Honda, T., Aug 2014, In: Journal of Labelled Compounds and Radiopharmaceuticals. 57, 10, p. 606-610 5 p.

  Research output: Contribution to journal › Article › peer-review
  3 Citations (Scopus)

• Synthesis of 1-D-6-O-[2-(N-hydroxyaminocarbonyl)amino-2-deoxy-alpha-D-glucopyranosyl]-myo-inositol 1-(n-octadecyl phosphate): a potential metalloenzyme inhibitor of glycosylphosphatidylinositol biosynthesis

  Crossman, A. T., Urbaniak, M. D. & Ferguson, M. A. J., 7 Jul 2008, In: Carbohydrate Research. 343, 9, p. 1478-1481 4 p.

  Research output: Contribution to journal › Article › peer-review
  7 Citations (Scopus)

• Synthesis of 2-quinuclidonium by eliminating water: experimental quantification of the high basicity of extremely twisted amides

  Ly, T., Krout, M., Pham, D. K., Tani, K., Stoltz, B. M. & Julian, R. R., 21 Feb 2007, In: Journal of the American Chemical Society. 129, 7, p. 1864-1865 2 p.

  Research output: Contribution to journal › Article › peer-review
  31 Citations (Scopus)

• Synthesis of 3,3-disubstituted heterocycles by Pd-catalyzed arylallylation of unactivated alkenes

  Phillips, D., Hewitt, J. F. M. & France, D. J., 31 Jul 2018, In: ACS Omega. 3, 7, p. 8451-8459 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  4 Citations (Scopus)

  57 Downloads (Pure)

• Synthesis of 3 '-, 4 '- and 6 '-deoxy and other analogues of D-glucosaminylphosphatidylinositol

  Borissow, C. N., Smith, T. K., Ferguson, M. A. J. & Brimacombe, J. S., 1 Jan 2001, In: Tetrahedron Letters. 42, 1, p. 121-123 3 p.

  Research output: Contribution to journal › Article › peer-review
  1 Citation (Scopus)

• Synthesis of 3-alkyl naphthalenes as novel estrogen receptor ligands

  Fang, J., Akwabi-Ameyaw, A., Britton, J. E., Katamreddy, S. R., Navas III, F., Miller, A. B., Williams, S. P., Gray, D. W., Orband-Miller, L. A., Shearin, J. & Heyer, D., 15 Sept 2008, In: Bioorganic & Medicinal Chemistry Letters. 18, 18, p. 5075-5077 3 p.

  Research output: Contribution to journal › Article › peer-review
  24 Citations (Scopus)

• Synthesis of 6-N-biotinylaminohexyl isopropyl phosphorofluoridate: a potent tool for the inhibition/isolation of serine esterases and proteases

  Higson, A. P., Ferguson, M. A. J. & Nikolaev, A. V., Mar 1999, In: Synthesis-Stuttgart. 3, p. 407-409 3 p.

  Research output: Contribution to journal › Article › peer-review
  6 Citations (Scopus)

• Synthesis of a cell-permeable analogue of a glycosylphosphatidylinositol (GPI) intermediate that is toxic to the living bloodstream form of Trypanosoma brucei

  Crossman, A., Smith, T. K., Ferguson, M. A. J. & Brimacombe, J. S., 24 Oct 2005, In: Tetrahedron Letters. 46, 43, p. 7419-7421 3 p.

  Research output: Contribution to journal › Article › peer-review
  6 Citations (Scopus)

• Synthesis of allylamines in enantiomerically pure form

  Concellón, J. M., Baragaña, B. & Riego, E., 8 Jun 2000, In: Tetrahedron Letters. 41, 22, p. 4361-4362 2 p.

  Research output: Contribution to journal › Article › peer-review
  7 Citations (Scopus)

• Synthesis of analogues of Congo red and evaluation of their anti-prion activity

  Sellarajah, S., Lekishvili, T., Bowring, C., Thompsett, A. R., Rudyk, H., Birkett, C. R., Brown, D. R. & Gilbert, I. H., 2004, In: Journal of Medicinal Chemistry. 47, 22, p. 5515-5534 20 p.

  Research output: Contribution to journal › Article › peer-review
  62 Citations (Scopus)

• Synthesis of an azido-tagged low affinity ratiometric calcium sensor

  Caldwell, S. T., Cairns, A. G., Olson, M., Chalmers, S., Sandison, M., Mullen, W., McCarron, J. G. & Hartley, R. C., 23 Dec 2015, In: Tetrahedron. 71, 51, p. 9571-9578 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  4 Citations (Scopus)

  33 Downloads (Pure)

• Synthesis of an IGD peptidomimetic with motogenic activity

  Shpiro, N., Ellis, I. R., Dines, T. J., Schor, A. M., Schor, S. L., Norman, D. G. & Marquez, R., 2005, In: Molecular BioSystems. 1, 4, p. 318-320 3 p.

  Research output: Contribution to journal › Article › peer-review
  5 Citations (Scopus)

• Synthesis of a partially protected 1D-6-O-(2-azido-2-deoxy-α-D-glucopyranosyl)-myo-inositol: a useful precursor of glycosylphosphatidylinositols and related compounds

  Cottaz, S., Brimacombe, J. S. & Ferguson, M. A. J., 1 Jan 1995, In: Carbohydrate Research. 270, 1, p. 85-91 7 p.

  Research output: Contribution to journal › Article › peer-review
  4 Citations (Scopus)