Find Research Outputs

Search results

• 2020

  Activation of transcription factor Nrf2 to counteract mitochondrial dysfunction in Parkinson’s disease

  Bento-Pereira, C. & Dinkova-Kostova, A., 18 Jul 2020, In: Medicinal Research Reviews. 18 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Parkinson Disease
  • Transcription Factors
  • NF-E2 Transcription Factor
  • Names
  • Neurodegenerative Diseases
  25 Downloads (Pure)

• Application of the in vivo oxidative stress reporter Hmox1 as mechanistic biomarker of arsenic toxicity

  Inesta-Vaquera, F., Navasumrit, P., Henderson, C. J., Frangova, T. G., Honda, T., Dinkova-Kostova, A. T., Ruchirawat, M. & Wolf, C. R., 9 Nov 2020, In: Environmental Pollution. 12 p., 116053.

  Research output: Contribution to journal › Article › peer-review

  • Oxidative stress
  • Arsenic
  • Biomarkers
  • Toxicity
  • Oxidative Stress

• Biomarker Exploration in Human Peripheral Blood Mononuclear Cells for Monitoring Sulforaphane Treatment Responses in Autism Spectrum Disorder

  Liu, H., Zimmerman, A. W., Singh, K., Connors, S. L., Diggins, E., Stephenson, K. K., Dinkova-Kostova, A. & Fahey, J. W., 2 Apr 2020, In: Scientific Reports. 10, 11 p., 5822.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • sulforafan
  • Autism Spectrum Disorder
  • Blood Cells
  • Biomarkers
  • Messenger RNA
  7 Citations (Scopus)

  41 Downloads (Pure)

• Can activation of NRF2 be a strategy against COVID-19?

  Cuadrado, A., Pajares, M., Benito, C., Jiménez-Villegas, J., Escoll, M., Fernández-Ginés, R., Garcia Yagüe, A. J., Lastra, D., Manda, G., Rojo, A. I. & Dinkova-Kostova, A. T., Sep 2020, In: Trends in Pharmacological Sciences. 41, 9, p. 598-610 13 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Alveolar Epithelial Cells
  • Chemical activation
  • methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate
  • Anti-Inflammatory Agents
  • T-cells
  14 Citations (Scopus)

  118 Downloads (Pure)

• Downregulation of Keap1 confers features of a fasted metabolic state

  Knatko, E. V., Tatham, M. H., Zhang, Y., Castro, C., Higgins, M., Dayalan Naidu, S., Leonardi, C., de la Vega, L., Honda, T., Griffin, J. L., Hay, R. T. & Dinkova-Kostova, A. T., 23 Oct 2020, In: iScience. 23, 10, 48 p., 101638.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Kelch-Like ECH-Associated Protein 1
  • Mouse Keap1 protein
  • Down-Regulation
  • Oxidation-Reduction
  • NF-E2 Transcription Factor
  18 Downloads (Pure)

• High NRF2 Levels Correlate with Poor Prognosis in Colorectal Cancer Patients and with Sensitivity to the Kinase Inhibitor AT9283 In Vitro

  Torrente Fernandez, L., Maan, G., Rezig, A. O., Quinn, J., Jackson, A., Grilli, A., Casares, L., Zhang, Y., Kulesskiy, E., Saarela, J., Bicciato, S., Edwards, J., Dinkova-Kostova, A. & de la Vega, L., Oct 2020, In: Biomolecules. 10, 10, 16 p., 1365.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • 1-cyclopropyl-3-(3-(5-morpholin-4-ylmethyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl)urea
  • NF-E2-Related Factor 2
  • Colorectal Neoplasms
  • Phosphotransferases
  • In Vitro Techniques
  1 Citation (Scopus)

  12 Downloads (Pure)

• Isomeric O-methyl cannabidiolquinones with dual BACH1/NRF2 activity

  Casares Perez, L., Unciti-Broceta, J. D., Prados, M. E., Caprioglio, D., Mattoteia, D., Higgins, M., Apendino, G., Dinkova-Kostova, A. T., Muñoz, E. & de la Vega, L., Oct 2020, In: Redox Biology. 37, p. 1-10 10 p., 101689.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cannabidiol
  • Neurodegenerative diseases
  • Neurodegenerative Diseases
  • Oxidative stress
  • Derivatives
  1 Citation (Scopus)

  22 Downloads (Pure)

• KEAP1, a cysteine-based sensor and a drug target for the prevention and treatment of chronic disease: KEAP1, a sensor and a drug target

  Dayalan Naidu, S. & Dinkova-Kostova, A., Jun 2020, In: Open Biology. 10, 6, p. 1-13 13 p., 200105.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Kelch-Like ECH-Associated Protein 1
  • Oxidation-Reduction
  • Cysteine
  • Chronic Disease
  • Sensors
  5 Citations (Scopus)

  20 Downloads (Pure)

• Measuring Changes in Keap1‐Nrf2 Protein Complex Conformation in Individual Cells by FLIM‐FRET

  Dikovskaya, D. & Dinkova-Kostova, A., Sep 2020, In: Current Protocols in Toxicology. 85, 1, p. 1-34 34 p., e96.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Kelch-Like ECH-Associated Protein 1
  • Protein Conformation
  • Conformations
  • Fluorescence
  • Photons
  16 Downloads (Pure)

• NRF2 and the Ambiguous Consequences of Its Activation during Initiation and the Subsequent Stages of Tumourigenesis

  Robertson, H., Dinkova-Kostova, A. T. & Hayes, J. D., 2 Dec 2020, In: Cancers. 12, 12, 48 p., 3609.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Kelch-Like ECH-Associated Protein 1
  • Cullin Proteins
  • Neoplasms
  • Mutation
  • Sulfhydryl Compounds
  13 Downloads (Pure)

• Nrf2 is activated by disruption of mitochondrial thiol homeostasis but not by enhanced mitochondrial superoxide production

  Cvetko, F., Caldwell, S. T., Higgins, M., Suzuki, T., Yamamoto, M., Prag, H. A., Hartley, R. C., Dinkova-Kostova, A. & Murphy, M. P., 9 Dec 2020, In: Journal of Biological Chemistry.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Sulfhydryl Compounds
  • Hydrogen Peroxide
  • Superoxides
  • Oxidation-Reduction
  • Homeostasis
  26 Downloads (Pure)

• Obesity and NRF2-mediated cytoprotection: Where is the missing link?

  Vasileva, L. V., Savova, M. S., Amirova, K. M., Dinkova-Kostova, A. & Georgiev, M. I., Jun 2020, In: Pharmacological Research. 156, p. 1-9 9 p., 104760.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Cytoprotection
  • Obesity
  • NF-E2 Transcription Factor
  • Oxidative Stress
  • Reactive Nitrogen Species
  12 Citations (Scopus)

  127 Downloads (Pure)

• Oxidative Stress in Cancer

  Hayes, J., Dinkova-Kostova, A. & Tew, K. D., 10 Aug 2020, In: Cancer Cell. 38, 31 p.

  Research output: Contribution to journal › Review article › peer-review

  • NADP
  • Oxidative Stress
  • Pentose Phosphate Pathway
  • Reactive Oxygen Species
  • Antioxidants
  18 Citations (Scopus)

• Radiomodulatory effect of a non-electrophilic NQO1 inducer identified in a screen of new 6, 8-diiodoquinazolin-4(3H)-ones carrying a sulfonamide moiety

  Soliman, A. M., Karam, H. M., Mekkawy, M. H., Higgins, M., Dinkova-Kostova, A. & Ghorab, M. M., 15 Aug 2020, In: European Journal of Medicinal Chemistry. 200, 12 p., 112467.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • acetamide
  • Sulfonamides
  • Quinazolinones
  • benzenesulfonamide
  • compound 18
  3 Citations (Scopus)

  28 Downloads (Pure)

• Sulfoxythiocarbamate S-4 inhibits HSP90 in human cutaneous squamous cell carcinoma cells

  Zhang, Y., VanHecke, G. C., Ahn, Y-H., Proby, C. M. & Dinkova-Kostova, A. T., 15 Dec 2020, In: European Journal of Pharmacology. 889, 9 p., 173609.

  Research output: Contribution to journal › Article › peer-review

  • HSP90 Heat-Shock Proteins
  • Squamous Cell Carcinoma
  • Skin
  • E2F Transcription Factors
  • Cyclin D

• The chemopreventive power of isothiocyanates

  Naidu, S. D., Brodziak-Jarosz, L., Gerhäuser, C. & Dinkova-Kostova, A. T., 2020, Natural Products for Cancer Chemoprevention: Single Compounds and Combinations. Pezzuto, J. M. & Vang, O. (eds.). Switzerland: Springer , p. 271-318 48 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Isothiocyanates
  • benzyl isothiocyanate
  • Glucosinolates
  • phenethyl isothiocyanate
  • sulforafan

• The stress-responsive kinase DYRK2 activates heat shock factor 1 promoting resistance to proteotoxic stress

  Moreno Dorta, R., Banerjee, S., Jackson, A. W., Quinn, J., Baillie, G., Dixon, J. E., Dinkova-Kostova, A., Edwards, J. & de la Vega, L., 2 Dec 2020, In: Cell Death & Differentiation. 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • TYK2 Kinase
  • Heat-Shock Response
  • Triple Negative Breast Neoplasms
  • Phosphotransferases
  • Heat Shock Transcription Factors
  24 Downloads (Pure)
• 2016

  Bioactive polymethoxylated flavonoids from Chiliadenus montanus

  Hamed, A. R., Mohamed, T. A., Tawfik, W. A., Hassan, E. M., Higgins, M., El-Toumy, S. A. & Dinkova-Kostova, A. T., 31 Mar 2016, In: Journal of Chemical and Pharmaceutical Research. 8, 3, p. 788-793 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Flavonoids
  • vitamin B 12 factor III
  • Phytochemicals
  • Biological Assay
  • NAD
  134 Downloads (Pure)

• Chemical constituents and NAD(P)H:Quinone oxidoreductase 1 (NQO1) inducer activity of Teucrium oliverianum Ging. ex Benth

  Shahat, A. A., Alsaid, M. S., Khan, J. A., Higgins, M. & Dinkova-Kostova, A. T., Apr 2016, In: Indian Journal of Traditional Knowledge. 15, 2, p. 232-236 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • eupatorin
  • Teucrium
  • quinone
  • 8-O-acetylharpagide
  • NAD
  3 Citations (Scopus)

  41 Downloads (Pure)

• Electron affinity of tricyclic, bicyclic, and monocyclic compounds containing cyanoenones correlates with their potency as inducers of a cytoprotective enzyme

  Bensasson, R. V., Dinkova-Kostova, A. T., Zheng, S., Saito, A., Li, W., Zoete, V. & Honda, T., 1 Sep 2016, In: Bioorganic & Medicinal Chemistry Letters. 26, 17, p. 4345-4349 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Electron affinity
  • Density Functional Theory
  • Molecular orbitals
  • Density functional theory
  • Electrons
  3 Citations (Scopus)

  165 Downloads (Pure)

• Filaggrin genotype does not determine the skin's threshold to UV-induced erythema

  Forbes, D., Johnston, L., Gardner, J., MacCallum, S. F., Campbell, L. E., Dinkova-Kostova, A. T., McLean, W. H. I., Ibbotson, S. H., Dawe, R. S. & Brown, S. J., Apr 2016, In: Journal of Allergy and Clinical Immunology. 137, 4, p. 1280-1282.e3 6 p.

  Research output: Contribution to journal › Letter › peer-review

  Open Access

  File
  6 Citations (Scopus)

  140 Downloads (Pure)

• Glucosinolates from the Brassica Vegetables and Their Health Effects

  Johnson, T. L., Dinkova-Kostova, A. T. & Fahey, J. W., 2016, Encyclopedia of Food and Health. Caballero, B., Finglas, P. M. & Toldrá, F. (eds.). Elsevier Inc., p. 248-255 8 p. (Reference Module in Food Science).

  Research output: Chapter in Book/Report/Conference proceeding › Entry for encyclopedia/dictionary

  • Glucosinolates
  • Brassica
  • Vegetables
  • Thioglucosides
  • Magnoliopsida
  5 Citations (Scopus)

• Heat Shock Factor 1 is a Substrate for p38 Mitogen-Activated Protein Kinases

  Dayalan Naidu, S., Sutherland, C., Zhang, Y., Risco, A., de la Vega, L., Caunt, C. J., Hastie, C. J., Lamont, D. J., Torrente, L., Chowdhry, S., Benjamin, I. J., Keyse, S. M., Cuenda, A. & Dinkova-Kostova, A. T., 15 Sep 2016, In: Molecular and Cellular Biology. 36, 18, p. 2403-2417 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Heat-Shock Response
  • p38 Mitogen-Activated Protein Kinases
  • Phosphorylation
  • phenethyl isothiocyanate
  • Heat Shock Transcription Factors
  27 Citations (Scopus)

  278 Downloads (Pure)

• Loss of Nrf2 abrogates the protective effect of Keap1 down regulation in a preclinical model of cutaneous squamous cell carcinoma

  Knatko, E. V., Higgins, M., Fahey, J. W. & Dinkova-Kostova, A., 24 May 2016, In: Scientific Reports. 6, 7 p., 25804.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Kelch-Like ECH-Associated Protein 1
  • NF-E2-Related Factor 2
  • Squamous Cell Carcinoma
  • Down-Regulation
  • Skin
  20 Citations (Scopus)

  199 Downloads (Pure)

• NAD(P)H: Quinone oxidoreductase 1 inducer activity of novel 4-aminoquinazoline derivatives

  Ghorab, M. M., Alsaid, M. S., El-Gazzar, M. G., Higgins, M., Dinkova-Kostova, A. T. & Shahat, A. A., 2016, In: Journal of Enzyme Inhibition and Medicinal Chemistry. 31, 6, p. 1369-1374 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • 4-aminoquinazoline
  • quinone
  • NAD
  • Oxidoreductases
  • Aptitude
  3 Citations (Scopus)

  198 Downloads (Pure)

• NAD(P)H: quinone oxidoreductase 1 inducer activity of some novel anilinoquinazoline derivatives

  Ghorab, M. M., Alsaid, M. S., Higgins, M., Dinkova-Kostova, A. T., Shahat, A. A., Elghazawy, N. H. & Arafa, R. K., 8 Aug 2016, In: Drug Design, Development and Therapy. 10, p. 2515-2524 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • anilinoquinazoline
  • Kelch-Like ECH-Associated Protein 1
  • quinone
  • NAD
  • Oxidoreductases
  3 Citations (Scopus)

  176 Downloads (Pure)

• Nrf2 activation in the treatment of neurodegenerative diseases: A focus on its role in mitochondrial bioenergetics and function

  Esteras, N., Dinkova-Kostova, A. T. & Abramov, A. Y., May 2016, In: Biological Chemistry. 397, 5, p. 383-400 18 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Neurodegenerative diseases
  • NF-E2-Related Factor 2
  • Energy Metabolism
  • Chemical activation
  • Neurodegenerative Diseases
  64 Citations (Scopus)

  288 Downloads (Pure)

• Nrf2-mediated neuroprotection response to recurrent hypoglycemia is insufficient to prevent cognitive impairment in a rodent model of type 1 diabetes

  McNeilly, A. D., Gallagher, J. R., Dinkova-Kostova, A. T., Hayes, J. D., Sharkey, J., Ashford, M. L. J. & McCrimmon, R. J., 1 Oct 2016, In: Diabetes. 65, 10, p. 3151-3160 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Neuroprotection
  • Hypoglycemia
  • Type 1 Diabetes Mellitus
  • Cognitive Dysfunction
  • Rodentia
  18 Citations (Scopus)

  157 Downloads (Pure)

• Potency of extracts from selected Egyptian plants as inducers of the Nrf2-dependent chemopreventive enzyme NQO1

  Hamed, A. R., Hegazy, M-E. F., Higgins, M., Mohamed, T. A., Abdel-Azim, N. S., Pare, P. W. & Dinkova-Kostova, A. T., Jul 2016, In: Journal of Natural Medicines. 70, 3, p. 683-688 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Chemoprevention
  • NF-E2-Related Factor 2
  • NF-E2 Transcription Factor
  • quinone
  • Heme Oxygenase-1
  6 Citations (Scopus)

  226 Downloads (Pure)

• Regulation of the CNC-bZIP transcription factor Nrf2 by Keap1 and the axis between GSK-3 and β-TrCP

  Hayes, J. D., Ebisine, K., Sharma, R. S., Chowdhry, S., Dinkova-Kostova, A. T. & Sutherland, C., Dec 2016, In: Current Opinion in Toxicology. 1, p. 92-103 12 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Kelch-Like ECH-Associated Protein 1
  • Basic-Leucine Zipper Transcription Factors
  • NF-E2-Related Factor 2
  • Mouse Keap1 protein
  • Glycogen Synthase Kinase 3
  10 Citations (Scopus)

  355 Downloads (Pure)

• Rhodiola rosea L. from golden root to green cell factories

  Marchev, A. S., Dinkova-Kostova, A. T., György, Z., Mirmazloum, I., Aneva, I. Y. & Georgiev, M. I., Aug 2016, In: Phytochemistry Reviews. 15, 4, p. 515-536 22 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Rhodiola
  • Rhodiola rosea
  • factories
  • secondary metabolites
  • Plant Roots
  17 Citations (Scopus)

  434 Downloads (Pure)

• Semisynthetic flavonoid 7-O-galloylquercetin activates Nrf2 and induces Nrf2-dependent gene expression in RAW264.7 and Hepa1c1c7 cells

  Roubalová, L., Biedermann, D., Papoušková, B., Vacek, J., Kuzma, M., Křen, V., Ulrichová, J., Dinkova-Kostova, A. T. & Vrba, J., 25 Dec 2016, In: Chemico-Biological Interactions. 260, p. 58-66 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Quercetin
  • Gene expression
  • Flavonoids
  • Heme Oxygenase-1
  • Gene Expression
  7 Citations (Scopus)

  171 Downloads (Pure)

• SIRT2- and NRF2-Targeting Thiazole-Containing Compound with Therapeutic Activity in Huntington's Disease Models

  Quinti, L., Casale, M., Moniot, S., Pais, T. F., Van Kanegan, M. J., Kaltenbach, L. S., Pallos, J., Lim, R. G., Naidu, S. D., Runne, H., Meisel, L., Rauf, N. A., Leyfer, D., Maxwell, M. M., Saiah, E., Landers, J. E., Luthi-Carter, R., Abagyan, R., Dinkova-Kostova, A. T., Steegborn, C. & 4 others, Marsh, J. L., Lo, D. C., Thompson, L. M. & Kazantsev, A. G., 21 Jul 2016, In: Cell Chemical Biology. 23, 7, p. 849-861 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Sirtuin 2
  • Thiazoles
  • Huntington Disease
  • Lead compounds
  • Systems Biology
  37 Citations (Scopus)

  199 Downloads (Pure)

• Synthesis, molecular modeling and NAD(P)H: quinone oxidoreductase 1 inducer activity of novel 2-phenylquinazolin-4-amine derivatives

  Ghorab, M. M., Alsaid, M. S., Higgins, M., Dinkova-Kostova, A. T., Shahat, A. A., Elghazawy, N. H. & Arafa, R. K., Apr 2016, In: Journal of Enzyme Inhibition and Medicinal Chemistry. 31, 6, p. 1612-1618 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • quinone
  • Amines
  • NAD
  • Oxidoreductases
  • Reactive Oxygen Species
  3 Citations (Scopus)

  155 Downloads (Pure)

• Synthesis and biological evaluation of novel 2-phenylquinazoline-4-amine derivatives: identification of 6-phenyl-8H-benzo[g]quinazolino[4,3-b]quinazolin-8-one as a highly potent inducer of NAD(P)H quinone oxidoreductase 1

  Ghorab, M. M., Alsaid, M. S., El-Gazzar, M. G., Higgins, M., Dinkova-Kostova, A. T. & Shahat, A. A., 2016, In: Journal of Enzyme Inhibition and Medicinal Chemistry. 31, Suppl. 1, p. 34-49 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • quinone
  • NAD
  • Oxidoreductases
  • Kelch Repeat
  • Quinazolines
  4 Citations (Scopus)

  196 Downloads (Pure)

• Synthesis and NAD(P)H: Quinone oxidoreductase 1 inducer activity of acetamide and pyridine-3-carbonitrile derivatives

  Ghorab, M. M., Shahat, A. A., Alsaid, M. S., Higgins, M., Dinkova-Kostova, A. T. & Naser, A. A., 2016, In: Biomedical Research. 27, 4, p. 1045-1048 4 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • pyridine-3-carbonitrile
  • Pyridones
  • acetamide
  • quinone
  • NAD
  47 Downloads (Pure)

• The multifaceted role of Nrf2 in mitochondrial function

  Holmström, K. M., Kostov, R. V. & Dinkova-Kostova, A. T., Dec 2016, In: Current Opinion in Toxicology. 1, p. 80-91 12 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Stem cells
  • Mitochondria
  • NF-E2 Transcription Factor
  • Antioxidants
  • Stem Cells
  128 Citations (Scopus)

  215 Downloads (Pure)

• The multifaceted role of sulforaphane in protection against uv radiation-mediated skin damage

  Benedict, A. L., Knatko, E. V., Kostov, R. V., Zhang, Y., Higgins, M., Kalra, S., Fahey, J. W., Ibbotson, S. H., Proby, C. M., Talalay, P. & Dinkova-Kostova, A. T., Jan 2016, Broccoli: Cultivation, Nutritional Properties and Effects on Health. Nova Science Publishers, p. 185-208 24 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • sulforafan
  • Ultraviolet Rays
  • Radiation
  • Skin
  • isothiocyanic acid
  1 Citation (Scopus)
• 2012

  Arthur Neish Young Investigator Award Lecture a Novel Role for Sulfhydryl-Reactive Activators of Transcription Factor NRF2: HSF1-Dependent Upregulation of Hsp70

  Zhang, Y., Ahn, Y-H., Calabrese, V., Cole, P. A. & Dinkova-Kostova, A. T., May 2012, In: Pharmaceutical Biology. 50, 5, p. 625-625 1 p.

  Research output: Contribution to journal › Special issue › peer-review

• Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity

  Calabrese, V., Cornelius, C., Dinkova-Kostova, A. T., Iavicoli, I., Di Paola, R., Koverech, A., Cuzzocrea, S., Rizzarelli, E. & Calabrese, E. J., May 2012, In: Biochimica et Biophysica Acta. Molecular Basis of Disease. 1822, 5, p. 753-783 31 p.

  Research output: Contribution to journal › Review article › peer-review
  265 Citations (Scopus)

• Glucosinolates and isothiocyanates in health and disease

  Dinkova-Kostova, A. T. & Kostov, R. V., 2012, In: Trends in Molecular Medicine. 18, 6, p. 337-347 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Glucosinolates
  • Isothiocyanates
  • sulforafan
  • Brassica
  • isothiocyanic acid
  326 Citations (Scopus)

• Glutathione S-transferase genotype is associated with sensitivity to psoralen-ultraviolet A photochemotherapy

  Ibbotson, S. H., Dawe, R. S., Dinkova-Kostova, A. T., Weidlich, S., Farr, P. M., Ferguson, J., Wolf, C. R. & Smith, G., Feb 2012, In: British Journal of Dermatology. 166, 2, p. 380-388 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Ficusin
  • Photochemotherapy
  • Glutathione Transferase
  • Methoxsalen
  • Genotype
  17 Citations (Scopus)

• Highly potent activation of Nrf2 by topical tricyclic bis(cyano enone): Implications for protection against UV radiation during thiopurine therapy

  Kalra, S., Knatko, E. V., Zhang, Y., Honda, T., Yamamoto, M. & Dinkova-Kostova, A. T., 2012, In: Cancer Prevention Research. 5, 7, p. 973-981 9 p.

  Research output: Contribution to journal › Article › peer-review
  30 Citations (Scopus)

• Neuroprotective effects of sulforaphane after contusive spinal cord injury

  Benedict, A. L., Mountney, A., Hurtado, A., Bryan, K. E., Schnaar, R. L., Dinkova-Kostova, A. T. & Talalay, P., 2012, In: Journal of Neurotrauma. 29, 16, p. 2576-2586 11 p.

  Research output: Contribution to journal › Article › peer-review

  • sulforafan
  • Neuroprotective Agents
  • Spinal Cord Injuries
  • Contusions
  • Antioxidants
  46 Citations (Scopus)

• Synthesis, chemical reactivity as Michael acceptors, and biological potency of monocyclic cyanoenones, novel and highly potent anti-inflammatory and cytoprotective agents

  Zheng, S., Laxmi, Y. R. S., David, E., Dinkova-Kostova, A. T., Shiavoni, K. H., Ren, Y., Zheng, Y., Trevino, I., Bumeister, R., Ojima, I., Wigley, W. C., Bliska, J. B., Mierke, D. F. & Honda, T., 24 May 2012, In: Journal of Medicinal Chemistry. 55, 10, p. 4837-4846 10 p.

  Research output: Contribution to journal › Article › peer-review

  • methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate
  • TBE 31
  • Anti-Inflammatory Agents
  • Phase III Clinical Trials
  • Sulfhydryl Compounds
  42 Citations (Scopus)

• The indirect antioxidant sulforaphane protects against thiopurine-mediated photooxidative stress

  Benedict, A. L., Knatko, E. V. & Dinkova-Kostova, A. T., Dec 2012, In: Carcinogenesis. 33, 12, p. 2457-2466 10 p.

  Research output: Contribution to journal › Article › peer-review

  • sulforafan
  • Thioguanine
  • Antioxidants
  • Azathioprine
  • Glutathione
  32 Citations (Scopus)
• 2011

  Effects of chemoprotective agent HBB-2 on cell survival in SH-SY5Y neuroblastoma cells

  Scuto, M. C., Cavallaro, M. M., Luca, M., Cornelius, C., Cambria, M. T., Rizza, S., Salinaro, A. T., Dinkova-Kostova, A. & Calabrese, V., 2011, In: FEBS Journal. 278, S1, p. 268 1 p., P14.37.

  Research output: Contribution to journal › Meeting abstract › peer-review

• HSF1-Dependent Upregulation of Hsp70 by Sulfhydryl-Reactive Inducers of the KEAP1/NRF2/ARE Pathway

  Zhang, Y., Ahn, Y-H., Benjamin, I. J., Honda, T., Hicks, R. J., Calabrese, V., Cole, P. A. & Dinkova-Kostova, A. T., 23 Nov 2011, In: Chemistry & Biology. 18, 11, p. 1355-1361 7 p.

  Research output: Contribution to journal › Article › peer-review
  70 Citations (Scopus)

• Induction of the Keapl/Nrf2/ARE pathway by oxidizable diphenols

  Dinkova-Kostova, A. T. & Wang, X. J., 30 Jun 2011, In: Chemico-Biological Interactions. 192, 1-2, p. 101-106 6 p.

  Research output: Contribution to journal › Article › peer-review
  49 Citations (Scopus)

• Oral Azathioprine Leads to Higher Incorporation of 6-Thioguanine in DNA of Skin than Liver: The Protective Role of the Keap1/Nrf2/ARE Pathway

  Kalra, S., Zhang, Y., Knatko, E. V., Finlayson, S., Yamamoto, M. & Dinkova-Kostova, A. T., Oct 2011, In: Cancer Prevention Research. 4, 10, p. 1665-1674 10 p.

  Research output: Contribution to journal › Article › peer-review
  13 Citations (Scopus)