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• Activation of Nrf2 signaling as a common treatment of neurodegenerative diseases

  Dinkova-Kostova, A. T. & Kazantsev, A. G., Apr 2017, In: Neurodegenerative Disease Management. 7, 2, p. 97-100 4 p.

  Research output: Contribution to journal › Editorial

  Open Access

  File
  11 Citations (Scopus)

  198 Downloads (Pure)

• Activation of Nrf2 signaling augments Vesicular Stomatitis Virus Oncolysis via Autophagy-Driven Suppression of Antiviral Immunity

  Olagnier, D., Lababidi, R. R., Bel Hadj, S., Sze, A., Liu, Y., Dayalan Naidu, S., Ferrari, M., Jiang, Y., Chiang, C., Beljanski, V., Goulet, M-L., Knatko, E. V., Dinkova-Kostova, A. T., Hiscott, J. & Lin, R., 2 Aug 2017, In: Molecular Therapy. 25, 8, p. 1900-1916 17 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Vesicular Stomatitis
  • Autophagy
  • Antiviral Agents
  • Immunity
  • Oncolytic Viruses
  35 Citations (Scopus)

  191 Downloads (Pure)

• Arthur Neish Young Investigator Award Lecture a Novel Role for Sulfhydryl-Reactive Activators of Transcription Factor NRF2: HSF1-Dependent Upregulation of Hsp70

  Zhang, Y., Ahn, Y-H., Calabrese, V., Cole, P. A. & Dinkova-Kostova, A. T., May 2012, In: Pharmaceutical Biology. 50, 5, p. 625-625 1 p.

  Research output: Contribution to journal › Special issue › peer-review

• Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity

  Calabrese, V., Cornelius, C., Dinkova-Kostova, A. T., Iavicoli, I., Di Paola, R., Koverech, A., Cuzzocrea, S., Rizzarelli, E. & Calabrese, E. J., May 2012, In: Biochimica et Biophysica Acta. Molecular Basis of Disease. 1822, 5, p. 753-783 31 p.

  Research output: Contribution to journal › Review article › peer-review
  265 Citations (Scopus)

• Crosstalk between NRF2 and HIPK2 shapes cytoprotective responses

  Torrente, L., Sanchez, C., Moreno Dorta, R., Chowdhry, S., Cabello, P., Isono, K., Koseki, H., Honda, T., Hayes, J., Dinkova-Kostova, A. & de la Vega, L., 2 Nov 2017, In: Oncogene. 36, 44, p. 6204-6212 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Homeodomain Proteins
  • Protein Kinases
  • Neoplasms
  • Phosphotransferases
  • Oncogenes
  30 Citations (Scopus)

  237 Downloads (Pure)

• Effects of chemoprotective agent HBB-2 on cell survival in SH-SY5Y neuroblastoma cells

  Scuto, M. C., Cavallaro, M. M., Luca, M., Cornelius, C., Cambria, M. T., Rizza, S., Salinaro, A. T., Dinkova-Kostova, A. & Calabrese, V., 2011, In: FEBS Journal. 278, S1, p. 268 1 p., P14.37.

  Research output: Contribution to journal › Meeting abstract › peer-review

• Epigenetic Control of NRF2-Directed Cellular Antioxidant Status in Dictating Life-Death Decisions

  Hayes, J. D. & Dinkova-Kostova, A. T., 5 Oct 2017, In: Molecular Cell. 68, 1, p. 5-7 3 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Epigenomics
  • Antioxidants
  • Tumor Suppressor Proteins
  • Acetylation
  • Oxidation-Reduction
  8 Citations (Scopus)

  310 Downloads (Pure)

• Flavonolignan 2,3-dehydrosilydianin activates Nrf2 and upregulates NAD(P)H: quinone oxidoreductase 1 in Hepa1c1c7 cells

  Roubalová, L., Dinkova-Kostova, A. T., Biedermann, D., Křen, V., Ulrichová, J. & Vrba, J., Jun 2017, In: Fitoterapia. 119, p. 115-120 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Flavonolignans
  • quinone
  • Milk Thistle
  • NAD
  • Oxidoreductases
  16 Citations (Scopus)

  190 Downloads (Pure)

• Glucosinolates and isothiocyanates in health and disease

  Dinkova-Kostova, A. T. & Kostov, R. V., 2012, In: Trends in Molecular Medicine. 18, 6, p. 337-347 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Glucosinolates
  • Isothiocyanates
  • sulforafan
  • Brassica
  • isothiocyanic acid
  326 Citations (Scopus)

• Glutathione S-transferase genotype is associated with sensitivity to psoralen-ultraviolet A photochemotherapy

  Ibbotson, S. H., Dawe, R. S., Dinkova-Kostova, A. T., Weidlich, S., Farr, P. M., Ferguson, J., Wolf, C. R. & Smith, G., Feb 2012, In: British Journal of Dermatology. 166, 2, p. 380-388 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Ficusin
  • Photochemotherapy
  • Glutathione Transferase
  • Methoxsalen
  • Genotype
  17 Citations (Scopus)

• Highly potent activation of Nrf2 by topical tricyclic bis(cyano enone): Implications for protection against UV radiation during thiopurine therapy

  Kalra, S., Knatko, E. V., Zhang, Y., Honda, T., Yamamoto, M. & Dinkova-Kostova, A. T., 2012, In: Cancer Prevention Research. 5, 7, p. 973-981 9 p.

  Research output: Contribution to journal › Article › peer-review
  30 Citations (Scopus)

• HSF1-Dependent Upregulation of Hsp70 by Sulfhydryl-Reactive Inducers of the KEAP1/NRF2/ARE Pathway

  Zhang, Y., Ahn, Y-H., Benjamin, I. J., Honda, T., Hicks, R. J., Calabrese, V., Cole, P. A. & Dinkova-Kostova, A. T., 23 Nov 2011, In: Chemistry & Biology. 18, 11, p. 1355-1361 7 p.

  Research output: Contribution to journal › Article › peer-review
  70 Citations (Scopus)

• Induction of the Keapl/Nrf2/ARE pathway by oxidizable diphenols

  Dinkova-Kostova, A. T. & Wang, X. J., 30 Jun 2011, In: Chemico-Biological Interactions. 192, 1-2, p. 101-106 6 p.

  Research output: Contribution to journal › Article › peer-review
  49 Citations (Scopus)

• Keap1, the cysteine-based mammalian intracellular sensor for electrophiles and oxidants

  Dinkova-Kostova, A. T., Kostov, R. V. & Canning, P., 1 Mar 2017, In: Archives of Biochemistry and Biophysics. 617, p. 84-93 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Kelch-Like ECH-Associated Protein 1
  • Oxidants
  • Cysteine
  • NF-E2-Related Factor 2
  • Sensors
  103 Citations (Scopus)

  178 Downloads (Pure)

• KEAP1 and done? Targeting the NRF2 pathway with sulforaphane: Targeting the NRF2 Pathway with Sulforaphane

  Dinkova-Kostova, A. T., Fahey, J. W., Kostov, R. V. & Kensler, T. W., Nov 2017, In: Trends in Food Science and Technology. 69, B, p. 257-269 13 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • sulforaphane
  • sulforafan
  • Brassica
  • broccoli
  • clinical trials
  86 Citations (Scopus)

  422 Downloads (Pure)

• KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients

  Quinti, L., Dayalan Naidu, S., Träge, U., Chen, X., Kegel-Gleason, K., Lleres, D., Connolly, C., Chopra, V., Low, C., Moniot, S., Sapp, E., Tousley, A. R., Vodicka, P., Van Kanegan, M. J., Kaltenbach, L. S., Crawford, L. A., Fuszard, M., Higgins, M., Miller, J. R. C., Farmer, R. E. & 19 others, Potluri, V., Samajdar, S., Meisel, L., Zhang, N., Snyder, A., Stein, R., Hersch, S. M., Ellerby, L. M., Weerapana, E., Schwarzschild, M. A., Steegborn, C., Leavitt, B. R., Degterev, A., Tabrizi, S. J., Lo, D. C., DiFiglia, M., Thompson, L. M., Dinkova-Kostova, A. & Kazantsev, A. G., 6 Jun 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 23, p. e4676-e4685 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Kelch-Like ECH-Associated Protein 1
  • Neural Stem Cells
  • Huntington Disease
  • NF-E2 Transcription Factor
  • Interleukin-6
  41 Citations (Scopus)

  182 Downloads (Pure)

• Metabolic and Homeostatic Changes in Seizures and Acquired Epilepsy-Mitochondria, Calcium Dynamics and Reactive Oxygen Species

  Kovac, S., Dinkova Kostova, A. T., Herrmann, A. M., Melzer, N., Meuth, S. G. & Gorji, A., 8 Sep 2017, In: International Journal of Molecular Sciences. 18, 9, p. 1-19 19 p., 1935.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Mitochondria
  • epilepsy
  • seizures
  • mitochondria
  • Metabolism
  26 Citations (Scopus)

  196 Downloads (Pure)

• Neuroprotective effects of sulforaphane after contusive spinal cord injury

  Benedict, A. L., Mountney, A., Hurtado, A., Bryan, K. E., Schnaar, R. L., Dinkova-Kostova, A. T. & Talalay, P., 2012, In: Journal of Neurotrauma. 29, 16, p. 2576-2586 11 p.

  Research output: Contribution to journal › Article › peer-review

  • sulforafan
  • Neuroprotective Agents
  • Spinal Cord Injuries
  • Contusions
  • Antioxidants
  46 Citations (Scopus)

• NRF2 as an emerging therapeutic target

  Copple, I. M., Dinkova-Kostova, A. T., Kensler, T. W., Liby, K. T. & Wigley, W. C., 31 Jan 2017, In: Oxidative Medicine and Cellular Longevity. 2017, p. 1-2 2 p., 8165458.

  Research output: Contribution to journal › Editorial › peer-review

  Open Access

  File
  20 Citations (Scopus)

  199 Downloads (Pure)

• Oncogene-Stimulated Congestion at the KEAP1 Stress Signaling Hub Allows Bypass of NRF2 and Induction of NRF2-Target Genes that Promote Tumor Survival

  Hayes, J. D. & Dinkova-Kostova, A. T., Nov 2017, In: Cancer Cell. 32, 5, p. 539-541 3 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Oncogenes
  • Oncogene Proteins
  • Ligases
  • Genes
  • Neoplasms
  11 Citations (Scopus)

  244 Downloads (Pure)

• Oral Azathioprine Leads to Higher Incorporation of 6-Thioguanine in DNA of Skin than Liver: The Protective Role of the Keap1/Nrf2/ARE Pathway

  Kalra, S., Zhang, Y., Knatko, E. V., Finlayson, S., Yamamoto, M. & Dinkova-Kostova, A. T., Oct 2011, In: Cancer Prevention Research. 4, 10, p. 1665-1674 10 p.

  Research output: Contribution to journal › Article › peer-review
  13 Citations (Scopus)

• Oxidative stress and chronic inflammation in osteoarthritis: can Nrf2 counteract these partners in crime?

  Marchev, A. S., Dimitrova, P. A., Burns, A. J., Kostov, R., Dinkova-Kostova, A. & Georgiev, M. I., 11 Sep 2017, In: Annals of the New York Academy of Sciences. 1401, p. 114-135 22 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Oxidative stress
  • Osteoarthritis
  • Crime
  • Inflammation
  • Bone
  57 Citations (Scopus)

  429 Downloads (Pure)

• Oxidative stress management in the hair follicle: Could targeting NRF2 counter age-related hair disorders and beyond?

  Jadkauskaite, L., Coulombe, P. A., Schäfer, M., Dinkova-Kostova, A. T., Paus, R. & Haslam, I. S., 27 Jul 2017, In: BioEssays. 39, 8, p. 1-9 9 p., 1700029.

  Research output: Contribution to journal › Article › peer-review

  • Oxidative stress
  • Oxidation-Reduction
  • Hair Follicle
  • Oxidative Stress
  • Chemical activation
  16 Citations (Scopus)

• Pathogenic p62/SQSTM1 mutations impair energy metabolism through limitation of mitochondrial substrates

  Bartolome, F., Esteras, N., Martin-Requero, A., Boutoleau-Bretonniere, C., Vercelletto, M., Gabelle, A., Le Ber, I., Honda, T., Dinkova-Kostova, A. T., Hardy, J., Carro, E. & Abramov, A. Y., 10 May 2017, In: Scientific Reports. 7, p. 1-14 14 p., 1666.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Frontotemporal Dementia With Motor Neuron Disease
  • Mitochondrial Membrane Potential
  • NAD
  • Energy Metabolism
  • Fibroblasts
  32 Citations (Scopus)

  305 Downloads (Pure)

• Regulation of the mammalian heat shock factor 1

  Dayalan Naidu, S. & Dinkova-Kostova, A. T., Jun 2017, In: FEBS Journal. 284, 11, p. 1606-1627 22 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Heat-Shock Response
  • Machinery
  • Acetylation
  • Phosphorylation
  • Heat Shock Transcription Factors
  59 Citations (Scopus)

  252 Downloads (Pure)

• Synthesis, chemical reactivity as Michael acceptors, and biological potency of monocyclic cyanoenones, novel and highly potent anti-inflammatory and cytoprotective agents

  Zheng, S., Laxmi, Y. R. S., David, E., Dinkova-Kostova, A. T., Shiavoni, K. H., Ren, Y., Zheng, Y., Trevino, I., Bumeister, R., Ojima, I., Wigley, W. C., Bliska, J. B., Mierke, D. F. & Honda, T., 24 May 2012, In: Journal of Medicinal Chemistry. 55, 10, p. 4837-4846 10 p.

  Research output: Contribution to journal › Article › peer-review

  • methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate
  • TBE 31
  • Anti-Inflammatory Agents
  • Phase III Clinical Trials
  • Sulfhydryl Compounds
  42 Citations (Scopus)

• Synthesis and biological evaluation of 1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]-4-ethynylimidazole. A novel and highly potent anti-inflammatory and cytoprotective agent

  Honda, T., Dinkova-Kostova, A. T., David, E., Padegimas, E. M., Sundararajan, C., Visnick, M., Bumeister, R. & Wigley, W. C., 15 Apr 2011, In: Bioorganic & Medicinal Chemistry Letters. 21, 8, p. 2188-2191 4 p.

  Research output: Contribution to journal › Article › peer-review
  18 Citations (Scopus)

• The cytoprotective role of the Keap1-Nrf2 pathway

  Baird, L. & Dinkova-Kostova, A. T., Apr 2011, In: Archives of Toxicology. 85, 4, p. 241-272 32 p.

  Research output: Contribution to journal › Review article › peer-review
  601 Citations (Scopus)

• The indirect antioxidant sulforaphane protects against thiopurine-mediated photooxidative stress

  Benedict, A. L., Knatko, E. V. & Dinkova-Kostova, A. T., Dec 2012, In: Carcinogenesis. 33, 12, p. 2457-2466 10 p.

  Research output: Contribution to journal › Article › peer-review

  • sulforafan
  • Thioguanine
  • Antioxidants
  • Azathioprine
  • Glutathione
  32 Citations (Scopus)

• Transcription factors NRF2 and HSF1 have opposing functions in autophagy

  Dayalan Naidu, S., Dikovskaya, D., Gaurilcikaite, E., Knatko, E., Healy, Z. R., Mohan, H., Koh, G., Laurell, A., Ball, G., Olagnier, D., de la Vega, L., Ganley, I., Talalay, P. & Dinkova-Kostova, A., 8 Sep 2017, In: Scientific Reports. 7, p. 1-12 12 p., 11023.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Heat Shock Transcription Factors
  • Autophagy
  • Heat-Shock Response
  • Sequestosome-1 Protein
  • GATA1 Transcription Factor
  25 Citations (Scopus)

  218 Downloads (Pure)

• Whole-exome sequencing validates a preclinical mouse model for the prevention and treatment of cutaneous squamous cell carcinoma

  Knatko, E. V., Praslicka, B., Higgins, M., Evans, A., Purdie, K. J., Harwood, C. A., Proby, C. M., Ooi, A. & Dinkova-Kostova, A. T., Jan 2017, In: Cancer Prevention Research. 10, 1, p. 67-75 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Whole Exome Sequencing
  • Squamous Cell Carcinoma
  • Single Nucleotide Polymorphism
  • Skin
  • Mutation Rate
  9 Citations (Scopus)

  155 Downloads (Pure)