Search concepts
|
Selected filters |
- 1 - 50 out of 92 results
- Export search results
Search results
-
2020
Activation of transcription factor Nrf2 to counteract mitochondrial dysfunction in Parkinson’s disease
Bento-Pereira, C. & Dinkova-Kostova, A., 18 Jul 2020, In: Medicinal Research Reviews. 18 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile -
Application of the in vivo oxidative stress reporter Hmox1 as mechanistic biomarker of arsenic toxicity
Inesta-Vaquera, F., Navasumrit, P., Henderson, C. J., Frangova, T. G., Honda, T., Dinkova-Kostova, A. T., Ruchirawat, M. & Wolf, C. R., 9 Nov 2020, In: Environmental Pollution. 12 p., 116053.Research output: Contribution to journal › Article › peer-review
-
Biomarker Exploration in Human Peripheral Blood Mononuclear Cells for Monitoring Sulforaphane Treatment Responses in Autism Spectrum Disorder
Liu, H., Zimmerman, A. W., Singh, K., Connors, S. L., Diggins, E., Stephenson, K. K., Dinkova-Kostova, A. & Fahey, J. W., 2 Apr 2020, In: Scientific Reports. 10, 11 p., 5822.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)41 Downloads (Pure) -
Can activation of NRF2 be a strategy against COVID-19?
Cuadrado, A., Pajares, M., Benito, C., Jiménez-Villegas, J., Escoll, M., Fernández-Ginés, R., Garcia Yagüe, A. J., Lastra, D., Manda, G., Rojo, A. I. & Dinkova-Kostova, A. T., Sep 2020, In: Trends in Pharmacological Sciences. 41, 9, p. 598-610 13 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile14 Citations (Scopus)117 Downloads (Pure) -
Downregulation of Keap1 confers features of a fasted metabolic state
Knatko, E. V., Tatham, M. H., Zhang, Y., Castro, C., Higgins, M., Dayalan Naidu, S., Leonardi, C., de la Vega, L., Honda, T., Griffin, J. L., Hay, R. T. & Dinkova-Kostova, A. T., 23 Oct 2020, In: iScience. 23, 10, 48 p., 101638.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
High NRF2 Levels Correlate with Poor Prognosis in Colorectal Cancer Patients and with Sensitivity to the Kinase Inhibitor AT9283 In Vitro
Torrente Fernandez, L., Maan, G., Rezig, A. O., Quinn, J., Jackson, A., Grilli, A., Casares, L., Zhang, Y., Kulesskiy, E., Saarela, J., Bicciato, S., Edwards, J., Dinkova-Kostova, A. & de la Vega, L., Oct 2020, In: Biomolecules. 10, 10, 16 p., 1365.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)12 Downloads (Pure) -
Isomeric O-methyl cannabidiolquinones with dual BACH1/NRF2 activity
Casares Perez, L., Unciti-Broceta, J. D., Prados, M. E., Caprioglio, D., Mattoteia, D., Higgins, M., Apendino, G., Dinkova-Kostova, A. T., Muñoz, E. & de la Vega, L., Oct 2020, In: Redox Biology. 37, p. 1-10 10 p., 101689.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)21 Downloads (Pure) -
KEAP1, a cysteine-based sensor and a drug target for the prevention and treatment of chronic disease: KEAP1, a sensor and a drug target
Dayalan Naidu, S. & Dinkova-Kostova, A., Jun 2020, In: Open Biology. 10, 6, p. 1-13 13 p., 200105.Research output: Contribution to journal › Review article › peer-review
Open AccessFile5 Citations (Scopus)20 Downloads (Pure) -
Measuring Changes in Keap1‐Nrf2 Protein Complex Conformation in Individual Cells by FLIM‐FRET
Dikovskaya, D. & Dinkova-Kostova, A., Sep 2020, In: Current Protocols in Toxicology. 85, 1, p. 1-34 34 p., e96.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
NRF2 and the Ambiguous Consequences of Its Activation during Initiation and the Subsequent Stages of Tumourigenesis
Robertson, H., Dinkova-Kostova, A. T. & Hayes, J. D., 2 Dec 2020, In: Cancers. 12, 12, 48 p., 3609.Research output: Contribution to journal › Review article › peer-review
Open AccessFile -
Nrf2 is activated by disruption of mitochondrial thiol homeostasis but not by enhanced mitochondrial superoxide production
Cvetko, F., Caldwell, S. T., Higgins, M., Suzuki, T., Yamamoto, M., Prag, H. A., Hartley, R. C., Dinkova-Kostova, A. & Murphy, M. P., 9 Dec 2020, In: Journal of Biological Chemistry.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Obesity and NRF2-mediated cytoprotection: Where is the missing link?
Vasileva, L. V., Savova, M. S., Amirova, K. M., Dinkova-Kostova, A. & Georgiev, M. I., Jun 2020, In: Pharmacological Research. 156, p. 1-9 9 p., 104760.Research output: Contribution to journal › Review article › peer-review
Open AccessFile12 Citations (Scopus)126 Downloads (Pure) -
Oxidative Stress in Cancer
Hayes, J., Dinkova-Kostova, A. & Tew, K. D., 10 Aug 2020, In: Cancer Cell. 38, 31 p.Research output: Contribution to journal › Review article › peer-review
18 Citations (Scopus) -
Radiomodulatory effect of a non-electrophilic NQO1 inducer identified in a screen of new 6, 8-diiodoquinazolin-4(3H)-ones carrying a sulfonamide moiety
Soliman, A. M., Karam, H. M., Mekkawy, M. H., Higgins, M., Dinkova-Kostova, A. & Ghorab, M. M., 15 Aug 2020, In: European Journal of Medicinal Chemistry. 200, 12 p., 112467.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)28 Downloads (Pure) -
Sulfoxythiocarbamate S-4 inhibits HSP90 in human cutaneous squamous cell carcinoma cells
Zhang, Y., VanHecke, G. C., Ahn, Y-H., Proby, C. M. & Dinkova-Kostova, A. T., 15 Dec 2020, In: European Journal of Pharmacology. 889, 9 p., 173609.Research output: Contribution to journal › Article › peer-review
-
The chemopreventive power of isothiocyanates
Naidu, S. D., Brodziak-Jarosz, L., Gerhäuser, C. & Dinkova-Kostova, A. T., 2020, Natural Products for Cancer Chemoprevention: Single Compounds and Combinations. Pezzuto, J. M. & Vang, O. (eds.). Switzerland: Springer , p. 271-318 48 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter
-
The stress-responsive kinase DYRK2 activates heat shock factor 1 promoting resistance to proteotoxic stress
Moreno Dorta, R., Banerjee, S., Jackson, A. W., Quinn, J., Baillie, G., Dixon, J. E., Dinkova-Kostova, A., Edwards, J. & de la Vega, L., 2 Dec 2020, In: Cell Death & Differentiation. 16 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
2019
Broccoli or Sulforaphane: Is It the Source or Dose That Matters?
Yagishita, Y., Fahey, J. W., Dinkova-Kostova, A. T. & Kensler, T. W., Oct 2019, In: Molecules and Cells. 24, 19, p. 1-38 38 p., 3593.Research output: Contribution to journal › Review article › peer-review
Open AccessFile29 Citations (Scopus)280 Downloads (Pure) -
Investigation into the use of histone deacetylase inhibitor MS-275 as a topical agent for the prevention and treatment of cutaneous squamous cell carcinoma in an SKH-1 hairless mouse model
Kalin, J. H., Eroglu, A., Liu, H., Holtzclaw, W. D., Leigh, I., Proby, C. M., Fahey, J. W., Cole, P. A. & Dinkova-Kostova, A. T., 13 Mar 2019, In: PLoS ONE. 14, 3, p. 1-13 13 p., e0213095.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)134 Downloads (Pure) -
Measuring the Interaction of Transcription Factor Nrf2 with Its Negative Regulator Keap1 in Single Live Cells by an Improved FRET/FLIM Analysis
Dikovskaya, D., Appleton, P., Bento-Pereira, C. & Dinkova-Kostova, A., 18 Mar 2019, In: Chemical Research in Toxicology. 32, 3, p. 500-512 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)157 Downloads (Pure) -
The isothiocyanate sulforaphane inhibits mTOR in an NRF2-independent manner
Zhang, Y., Gilmour, A., Ahn, Y-H., de la Vega, L. & Dinkova-Kostova, A., 5 Aug 2019, In: Phytomedicine. 153062.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)117 Downloads (Pure) -
Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases
Cuadrado, A., Rojo, A. I., Wells, G., Hayes, J., Cousin, S. P., Rumsey, W. L., Attucks, O. C., Franklin, S., Levonen, A-L., Kensler, T. W. & Dinkova-Kostova, A., Apr 2019, In: Nature Reviews Drug Discovery. 18, 4, p. 295-317 23 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile210 Citations (Scopus)248 Downloads (Pure) -
2017
Activation of Nrf2 signaling as a common treatment of neurodegenerative diseases
Dinkova-Kostova, A. T. & Kazantsev, A. G., Apr 2017, In: Neurodegenerative Disease Management. 7, 2, p. 97-100 4 p.Research output: Contribution to journal › Editorial
Open AccessFile11 Citations (Scopus)198 Downloads (Pure) -
Activation of Nrf2 signaling augments Vesicular Stomatitis Virus Oncolysis via Autophagy-Driven Suppression of Antiviral Immunity
Olagnier, D., Lababidi, R. R., Bel Hadj, S., Sze, A., Liu, Y., Dayalan Naidu, S., Ferrari, M., Jiang, Y., Chiang, C., Beljanski, V., Goulet, M-L., Knatko, E. V., Dinkova-Kostova, A. T., Hiscott, J. & Lin, R., 2 Aug 2017, In: Molecular Therapy. 25, 8, p. 1900-1916 17 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile35 Citations (Scopus)191 Downloads (Pure) -
Crosstalk between NRF2 and HIPK2 shapes cytoprotective responses
Torrente, L., Sanchez, C., Moreno Dorta, R., Chowdhry, S., Cabello, P., Isono, K., Koseki, H., Honda, T., Hayes, J., Dinkova-Kostova, A. & de la Vega, L., 2 Nov 2017, In: Oncogene. 36, 44, p. 6204-6212 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile30 Citations (Scopus)237 Downloads (Pure) -
Epigenetic Control of NRF2-Directed Cellular Antioxidant Status in Dictating Life-Death Decisions
Hayes, J. D. & Dinkova-Kostova, A. T., 5 Oct 2017, In: Molecular Cell. 68, 1, p. 5-7 3 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Citations (Scopus)310 Downloads (Pure) -
Flavonolignan 2,3-dehydrosilydianin activates Nrf2 and upregulates NAD(P)H: quinone oxidoreductase 1 in Hepa1c1c7 cells
Roubalová, L., Dinkova-Kostova, A. T., Biedermann, D., Křen, V., Ulrichová, J. & Vrba, J., Jun 2017, In: Fitoterapia. 119, p. 115-120 6 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile16 Citations (Scopus)190 Downloads (Pure) -
Keap1, the cysteine-based mammalian intracellular sensor for electrophiles and oxidants
Dinkova-Kostova, A. T., Kostov, R. V. & Canning, P., 1 Mar 2017, In: Archives of Biochemistry and Biophysics. 617, p. 84-93 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile103 Citations (Scopus)178 Downloads (Pure) -
KEAP1 and done? Targeting the NRF2 pathway with sulforaphane: Targeting the NRF2 Pathway with Sulforaphane
Dinkova-Kostova, A. T., Fahey, J. W., Kostov, R. V. & Kensler, T. W., Nov 2017, In: Trends in Food Science and Technology. 69, B, p. 257-269 13 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile86 Citations (Scopus)420 Downloads (Pure) -
KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients
Quinti, L., Dayalan Naidu, S., Träge, U., Chen, X., Kegel-Gleason, K., Lleres, D., Connolly, C., Chopra, V., Low, C., Moniot, S., Sapp, E., Tousley, A. R., Vodicka, P., Van Kanegan, M. J., Kaltenbach, L. S., Crawford, L. A., Fuszard, M., Higgins, M., Miller, J. R. C., Farmer, R. E. & 19 others, , 6 Jun 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 23, p. e4676-e4685 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile41 Citations (Scopus)181 Downloads (Pure) -
Metabolic and Homeostatic Changes in Seizures and Acquired Epilepsy-Mitochondria, Calcium Dynamics and Reactive Oxygen Species
Kovac, S., Dinkova Kostova, A. T., Herrmann, A. M., Melzer, N., Meuth, S. G. & Gorji, A., 8 Sep 2017, In: International Journal of Molecular Sciences. 18, 9, p. 1-19 19 p., 1935.Research output: Contribution to journal › Review article › peer-review
Open AccessFile26 Citations (Scopus)196 Downloads (Pure) -
NRF2 as an emerging therapeutic target
Copple, I. M., Dinkova-Kostova, A. T., Kensler, T. W., Liby, K. T. & Wigley, W. C., 31 Jan 2017, In: Oxidative Medicine and Cellular Longevity. 2017, p. 1-2 2 p., 8165458.Research output: Contribution to journal › Editorial › peer-review
Open AccessFile20 Citations (Scopus)199 Downloads (Pure) -
Oncogene-Stimulated Congestion at the KEAP1 Stress Signaling Hub Allows Bypass of NRF2 and Induction of NRF2-Target Genes that Promote Tumor Survival
Hayes, J. D. & Dinkova-Kostova, A. T., Nov 2017, In: Cancer Cell. 32, 5, p. 539-541 3 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile11 Citations (Scopus)244 Downloads (Pure) -
Oxidative stress and chronic inflammation in osteoarthritis: can Nrf2 counteract these partners in crime?
Marchev, A. S., Dimitrova, P. A., Burns, A. J., Kostov, R., Dinkova-Kostova, A. & Georgiev, M. I., 11 Sep 2017, In: Annals of the New York Academy of Sciences. 1401, p. 114-135 22 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile57 Citations (Scopus)428 Downloads (Pure) -
Oxidative stress management in the hair follicle: Could targeting NRF2 counter age-related hair disorders and beyond?
Jadkauskaite, L., Coulombe, P. A., Schäfer, M., Dinkova-Kostova, A. T., Paus, R. & Haslam, I. S., 27 Jul 2017, In: BioEssays. 39, 8, p. 1-9 9 p., 1700029.Research output: Contribution to journal › Article › peer-review
16 Citations (Scopus) -
Pathogenic p62/SQSTM1 mutations impair energy metabolism through limitation of mitochondrial substrates
Bartolome, F., Esteras, N., Martin-Requero, A., Boutoleau-Bretonniere, C., Vercelletto, M., Gabelle, A., Le Ber, I., Honda, T., Dinkova-Kostova, A. T., Hardy, J., Carro, E. & Abramov, A. Y., 10 May 2017, In: Scientific Reports. 7, p. 1-14 14 p., 1666.Research output: Contribution to journal › Article › peer-review
Open AccessFile32 Citations (Scopus)305 Downloads (Pure) -
Regulation of the mammalian heat shock factor 1
Dayalan Naidu, S. & Dinkova-Kostova, A. T., Jun 2017, In: FEBS Journal. 284, 11, p. 1606-1627 22 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile59 Citations (Scopus)252 Downloads (Pure) -
Transcription factors NRF2 and HSF1 have opposing functions in autophagy
Dayalan Naidu, S., Dikovskaya, D., Gaurilcikaite, E., Knatko, E., Healy, Z. R., Mohan, H., Koh, G., Laurell, A., Ball, G., Olagnier, D., de la Vega, L., Ganley, I., Talalay, P. & Dinkova-Kostova, A., 8 Sep 2017, In: Scientific Reports. 7, p. 1-12 12 p., 11023.Research output: Contribution to journal › Article › peer-review
Open AccessFile25 Citations (Scopus)218 Downloads (Pure) -
Whole-exome sequencing validates a preclinical mouse model for the prevention and treatment of cutaneous squamous cell carcinoma
Knatko, E. V., Praslicka, B., Higgins, M., Evans, A., Purdie, K. J., Harwood, C. A., Proby, C. M., Ooi, A. & Dinkova-Kostova, A. T., Jan 2017, In: Cancer Prevention Research. 10, 1, p. 67-75 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile9 Citations (Scopus)155 Downloads (Pure) -
2016
Bioactive polymethoxylated flavonoids from Chiliadenus montanus
Hamed, A. R., Mohamed, T. A., Tawfik, W. A., Hassan, E. M., Higgins, M., El-Toumy, S. A. & Dinkova-Kostova, A. T., 31 Mar 2016, In: Journal of Chemical and Pharmaceutical Research. 8, 3, p. 788-793 6 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile134 Downloads (Pure) -
Chemical constituents and NAD(P)H:Quinone oxidoreductase 1 (NQO1) inducer activity of Teucrium oliverianum Ging. ex Benth
Shahat, A. A., Alsaid, M. S., Khan, J. A., Higgins, M. & Dinkova-Kostova, A. T., Apr 2016, In: Indian Journal of Traditional Knowledge. 15, 2, p. 232-236 5 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)41 Downloads (Pure) -
Electron affinity of tricyclic, bicyclic, and monocyclic compounds containing cyanoenones correlates with their potency as inducers of a cytoprotective enzyme
Bensasson, R. V., Dinkova-Kostova, A. T., Zheng, S., Saito, A., Li, W., Zoete, V. & Honda, T., 1 Sep 2016, In: Bioorganic & Medicinal Chemistry Letters. 26, 17, p. 4345-4349 5 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)165 Downloads (Pure) -
Filaggrin genotype does not determine the skin's threshold to UV-induced erythema
Forbes, D., Johnston, L., Gardner, J., MacCallum, S. F., Campbell, L. E., Dinkova-Kostova, A. T., McLean, W. H. I., Ibbotson, S. H., Dawe, R. S. & Brown, S. J., Apr 2016, In: Journal of Allergy and Clinical Immunology. 137, 4, p. 1280-1282.e3 6 p.Research output: Contribution to journal › Letter › peer-review
Open AccessFile6 Citations (Scopus)140 Downloads (Pure) -
Glucosinolates from the Brassica Vegetables and Their Health Effects
Johnson, T. L., Dinkova-Kostova, A. T. & Fahey, J. W., 2016, Encyclopedia of Food and Health. Caballero, B., Finglas, P. M. & Toldrá, F. (eds.). Elsevier Inc., p. 248-255 8 p. (Reference Module in Food Science).Research output: Chapter in Book/Report/Conference proceeding › Entry for encyclopedia/dictionary
5 Citations (Scopus) -
Heat Shock Factor 1 is a Substrate for p38 Mitogen-Activated Protein Kinases
Dayalan Naidu, S., Sutherland, C., Zhang, Y., Risco, A., de la Vega, L., Caunt, C. J., Hastie, C. J., Lamont, D. J., Torrente, L., Chowdhry, S., Benjamin, I. J., Keyse, S. M., Cuenda, A. & Dinkova-Kostova, A. T., 15 Sep 2016, In: Molecular and Cellular Biology. 36, 18, p. 2403-2417 15 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile27 Citations (Scopus)277 Downloads (Pure) -
Loss of Nrf2 abrogates the protective effect of Keap1 down regulation in a preclinical model of cutaneous squamous cell carcinoma
Knatko, E. V., Higgins, M., Fahey, J. W. & Dinkova-Kostova, A., 24 May 2016, In: Scientific Reports. 6, 7 p., 25804.Research output: Contribution to journal › Article › peer-review
Open AccessFile20 Citations (Scopus)199 Downloads (Pure) -
NAD(P)H: Quinone oxidoreductase 1 inducer activity of novel 4-aminoquinazoline derivatives
Ghorab, M. M., Alsaid, M. S., El-Gazzar, M. G., Higgins, M., Dinkova-Kostova, A. T. & Shahat, A. A., 2016, In: Journal of Enzyme Inhibition and Medicinal Chemistry. 31, 6, p. 1369-1374 7 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)198 Downloads (Pure) -
NAD(P)H: quinone oxidoreductase 1 inducer activity of some novel anilinoquinazoline derivatives
Ghorab, M. M., Alsaid, M. S., Higgins, M., Dinkova-Kostova, A. T., Shahat, A. A., Elghazawy, N. H. & Arafa, R. K., 8 Aug 2016, In: Drug Design, Development and Therapy. 10, p. 2515-2524 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)176 Downloads (Pure) -
Nrf2 activation in the treatment of neurodegenerative diseases: A focus on its role in mitochondrial bioenergetics and function
Esteras, N., Dinkova-Kostova, A. T. & Abramov, A. Y., May 2016, In: Biological Chemistry. 397, 5, p. 383-400 18 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile64 Citations (Scopus)287 Downloads (Pure) -
Nrf2-mediated neuroprotection response to recurrent hypoglycemia is insufficient to prevent cognitive impairment in a rodent model of type 1 diabetes
McNeilly, A. D., Gallagher, J. R., Dinkova-Kostova, A. T., Hayes, J. D., Sharkey, J., Ashford, M. L. J. & McCrimmon, R. J., 1 Oct 2016, In: Diabetes. 65, 10, p. 3151-3160 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile18 Citations (Scopus)157 Downloads (Pure)