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• Activation of Nrf2 signaling as a common treatment of neurodegenerative diseases

  Dinkova-Kostova, A. T. & Kazantsev, A. G., Apr 2017, In: Neurodegenerative Disease Management. 7, 2, p. 97-100 4 p.

  Research output: Contribution to journal › Editorial

  Open Access

  File
  11 Citations (Scopus)

  202 Downloads (Pure)

• Activation of Nrf2 signaling augments Vesicular Stomatitis Virus Oncolysis via Autophagy-Driven Suppression of Antiviral Immunity

  Olagnier, D., Lababidi, R. R., Bel Hadj, S., Sze, A., Liu, Y., Dayalan Naidu, S., Ferrari, M., Jiang, Y., Chiang, C., Beljanski, V., Goulet, M-L., Knatko, E. V., Dinkova-Kostova, A. T., Hiscott, J. & Lin, R., 2 Aug 2017, In: Molecular Therapy. 25, 8, p. 1900-1916 17 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Vesicular Stomatitis
  • Autophagy
  • Antiviral Agents
  • Immunity
  • Oncolytic Viruses
  36 Citations (Scopus)

  195 Downloads (Pure)

• Activation of transcription factor Nrf2 to counteract mitochondrial dysfunction in Parkinson’s disease

  Bento-Pereira, C. & Dinkova-Kostova, A., 18 Jul 2020, In: Medicinal Research Reviews. 18 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Parkinson Disease
  • Transcription Factors
  • NF-E2 Transcription Factor
  • Names
  • Neurodegenerative Diseases
  1 Citation (Scopus)

  29 Downloads (Pure)

• A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia

  Baardman, J., Verberk, S. G. S., Prange, K. H. M., van Weeghel, M., van der Velden, S., Ryan, D. G., Wüst, R. C. I., Neele, A. E., Speijer, D., Denis, S. W., Witte, M. E., Houtkooper, R. H., O'neill, L. A., Knatko, E. V., Dinkova-Kostova, A. T., Lutgens, E., de Winther, M. P. J. & Van den Bossche, J., 20 Nov 2018, In: Cell Reports. 25, 8, p. 2044-2052.e5 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Macrophages
  • Pentoses
  • Pentose Phosphate Pathway
  • Metabolism
  • Hypercholesterolemia
  40 Citations (Scopus)

  219 Downloads (Pure)

• Author Correction: Pathogenic p62/SQSTM1 mutations impair energy metabolism through limitation of mitochondrial substrates (Scientific Reports DOI: 10.1038/s41598-017-01678-4)

  Bartolome, F., Esteras, N., Martin-Requero, A., Boutoleau-Bretonniere, C., Vercelletto, M., Gabelle, A., Ber, I. L., Honda, T., Dinkova-Kostova, A. T., Hardy, J., Carro, E. & Abramov, A. Y., 1 Dec 2018, In: Scientific Reports. 8, p. 1-2 2 p., 4064.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  File

  • Energy Metabolism
  • Mutation
  166 Downloads (Pure)

• Bioactive polymethoxylated flavonoids from Chiliadenus montanus

  Hamed, A. R., Mohamed, T. A., Tawfik, W. A., Hassan, E. M., Higgins, M., El-Toumy, S. A. & Dinkova-Kostova, A. T., 31 Mar 2016, In: Journal of Chemical and Pharmaceutical Research. 8, 3, p. 788-793 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Flavonoids
  • vitamin B 12 factor III
  • Phytochemicals
  • Biological Assay
  • NAD
  137 Downloads (Pure)

• Biomarker Exploration in Human Peripheral Blood Mononuclear Cells for Monitoring Sulforaphane Treatment Responses in Autism Spectrum Disorder

  Liu, H., Zimmerman, A. W., Singh, K., Connors, S. L., Diggins, E., Stephenson, K. K., Dinkova-Kostova, A. & Fahey, J. W., 2 Apr 2020, In: Scientific Reports. 10, 11 p., 5822.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • sulforafan
  • Autism Spectrum Disorder
  • Blood Cells
  • Biomarkers
  • Messenger RNA
  8 Citations (Scopus)

  43 Downloads (Pure)

• Broccoli or Sulforaphane: Is It the Source or Dose That Matters?

  Yagishita, Y., Fahey, J. W., Dinkova-Kostova, A. T. & Kensler, T. W., Oct 2019, In: Molecules and Cells. 24, 19, p. 1-38 38 p., 3593.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • sulforafan
  • Brassica
  • glucoraphanin
  • thioglucosidase
  • Pharmacodynamics
  35 Citations (Scopus)

  289 Downloads (Pure)

• C151 in KEAP1 is the main cysteine sensor for the cyanoenone class of NRF2 activators, irrespective of molecular size or shape

  Dayalan Naidu, S., Muramatsu, A., Saito, R., Asami, S., Honda, T., Hosoya, T., Itoh, K., Yamamoto, M., Suzuki, T. & Dinkova-Kostova, A., 23 May 2018, In: Scientific Reports. 8, 1, p. 1-12 12 p., 8037.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Kelch-Like ECH-Associated Protein 1
  • Cysteine
  • TBE 31
  • Lipopolysaccharides
  • Interleukin-6
  17 Citations (Scopus)

  156 Downloads (Pure)

• Can activation of NRF2 be a strategy against COVID-19?

  Cuadrado, A., Pajares, M., Benito, C., Jiménez-Villegas, J., Escoll, M., Fernández-Ginés, R., Garcia Yagüe, A. J., Lastra, D., Manda, G., Rojo, A. I. & Dinkova-Kostova, A. T., Sep 2020, In: Trends in Pharmacological Sciences. 41, 9, p. 598-610 13 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Alveolar Epithelial Cells
  • Chemical activation
  • methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate
  • Anti-Inflammatory Agents
  • T-cells
  18 Citations (Scopus)

  124 Downloads (Pure)

• Chemical constituents and NAD(P)H:Quinone oxidoreductase 1 (NQO1) inducer activity of Teucrium oliverianum Ging. ex Benth

  Shahat, A. A., Alsaid, M. S., Khan, J. A., Higgins, M. & Dinkova-Kostova, A. T., Apr 2016, In: Indian Journal of Traditional Knowledge. 15, 2, p. 232-236 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • eupatorin
  • Teucrium
  • quinone
  • 8-O-acetylharpagide
  • NAD
  3 Citations (Scopus)

  43 Downloads (Pure)

• Chemical tuning enhances both potency toward Nrf2 and in vitro therapeutic index of triterpenoids

  Copple, I. M., Shelton, L. M., Walsh, J., Kratschmar, D. V., Lister, A., Odermatt, A., Goldring, C. E., Dinkova-Kostova, A. T., Honda, T. & Park, B. K., Aug 2014, In: Toxicological Sciences. 140, 2, p. 462-469 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate
  • Therapeutic Index
  • Toxicity
  • Tuning
  • Molecules
  12 Citations (Scopus)

  583 Downloads (Pure)

• Chemoprotection Against Cancer by Isothiocyanates: A Focus on the Animal Models and the Protective Mechanisms

  Dinkova-Kostova, A. T., 2013, Natural Products in Cancer Prevention and Therapy. Pezzuto, J. M. & Suh, N. (eds.). Berlin: Springer , p. 179-201 23 p. (Topics in Current Chemistry; vol. 329).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter
  32 Citations (Scopus)

• Crosstalk between NRF2 and HIPK2 shapes cytoprotective responses

  Torrente, L., Sanchez, C., Moreno Dorta, R., Chowdhry, S., Cabello, P., Isono, K., Koseki, H., Honda, T., Hayes, J., Dinkova-Kostova, A. & de la Vega, L., 2 Nov 2017, In: Oncogene. 36, 44, p. 6204-6212 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Homeodomain Proteins
  • Protein Kinases
  • Neoplasms
  • Phosphotransferases
  • Oncogenes
  32 Citations (Scopus)

  241 Downloads (Pure)

• Diffusion dynamics of the Keap1-Cullin3 interaction in single live cells

  Baird, L. & Dinkova-Kostova, A. T., 2013, In: Biochemical and Biophysical Research Communications. 433, 1, p. 58-65 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Kelch-Like ECH-Associated Protein 1
  • NF-E2-Related Factor 2
  • Molecules
  • Cysteine
  • Gene encoding
  34 Citations (Scopus)

• Downregulation of Keap1 confers features of a fasted metabolic state

  Knatko, E. V., Tatham, M. H., Zhang, Y., Castro, C., Higgins, M., Dayalan Naidu, S., Leonardi, C., de la Vega, L., Honda, T., Griffin, J. L., Hay, R. T. & Dinkova-Kostova, A. T., 23 Oct 2020, In: iScience. 23, 10, 48 p., 101638.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Kelch-Like ECH-Associated Protein 1
  • Mouse Keap1 protein
  • Down-Regulation
  • Oxidation-Reduction
  • NF-E2 Transcription Factor
  19 Downloads (Pure)

• Effects of chemoprotective agent HBB-2 on cell survival in SH-SY5Y neuroblastoma cells

  Scuto, M. C., Cavallaro, M. M., Luca, M., Cornelius, C., Cambria, M. T., Rizza, S., Salinaro, A. T., Dinkova-Kostova, A. & Calabrese, V., 2011, In: FEBS Journal. 278, S1, p. 268 1 p., P14.37.

  Research output: Contribution to journal › Meeting abstract › peer-review

• Electron affinity of tricyclic, bicyclic, and monocyclic compounds containing cyanoenones correlates with their potency as inducers of a cytoprotective enzyme

  Bensasson, R. V., Dinkova-Kostova, A. T., Zheng, S., Saito, A., Li, W., Zoete, V. & Honda, T., 1 Sep 2016, In: Bioorganic & Medicinal Chemistry Letters. 26, 17, p. 4345-4349 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Electron affinity
  • Density Functional Theory
  • Molecular orbitals
  • Density functional theory
  • Electrons
  3 Citations (Scopus)

  171 Downloads (Pure)

• Epigenetic Control of NRF2-Directed Cellular Antioxidant Status in Dictating Life-Death Decisions

  Hayes, J. D. & Dinkova-Kostova, A. T., 5 Oct 2017, In: Molecular Cell. 68, 1, p. 5-7 3 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Epigenomics
  • Antioxidants
  • Tumor Suppressor Proteins
  • Acetylation
  • Oxidation-Reduction
  8 Citations (Scopus)

  315 Downloads (Pure)

• Experimental Nonalcoholic Steatohepatitis and Liver Fibrosis Are Ameliorated by Pharmacologic Activation of Nrf2 (NF-E2 p45-Related Factor 2)

  Sharma, R. S., Harrison, D. J., Kisielewski, D., Cassidy, D. M., McNeilly, A. D., Gallagher, J. R., Walsh, S. V., Honda, T., McCrimmon, R. J., Dinkova-Kostova, A. T., Ashford, M. L. J., Dillon, J. F. & Hayes, J. D., 1 Mar 2018, In: CMGH: Cellular and Molecular Gastroenterology and Hepatology. 5, 3, p. 367-398 32 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • TBE 31
  • NF-E2-Related Factor 2
  • Fructose
  • Non-alcoholic Fatty Liver Disease
  • Liver Cirrhosis
  63 Citations (Scopus)

  171 Downloads (Pure)

• Filaggrin genotype does not determine the skin's threshold to UV-induced erythema

  Forbes, D., Johnston, L., Gardner, J., MacCallum, S. F., Campbell, L. E., Dinkova-Kostova, A. T., McLean, W. H. I., Ibbotson, S. H., Dawe, R. S. & Brown, S. J., Apr 2016, In: Journal of Allergy and Clinical Immunology. 137, 4, p. 1280-1282.e3 6 p.

  Research output: Contribution to journal › Letter › peer-review

  Open Access

  File
  6 Citations (Scopus)

  143 Downloads (Pure)

• Flavonolignan 2,3-dehydrosilydianin activates Nrf2 and upregulates NAD(P)H: quinone oxidoreductase 1 in Hepa1c1c7 cells

  Roubalová, L., Dinkova-Kostova, A. T., Biedermann, D., Křen, V., Ulrichová, J. & Vrba, J., Jun 2017, In: Fitoterapia. 119, p. 115-120 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Flavonolignans
  • quinone
  • Milk Thistle
  • NAD
  • Oxidoreductases
  17 Citations (Scopus)

  197 Downloads (Pure)

• Glucosinolates from the Brassica Vegetables and Their Health Effects

  Johnson, T. L., Dinkova-Kostova, A. T. & Fahey, J. W., 2016, Encyclopedia of Food and Health. Caballero, B., Finglas, P. M. & Toldrá, F. (eds.). Elsevier Inc., p. 248-255 8 p. (Reference Module in Food Science).

  Research output: Chapter in Book/Report/Conference proceeding › Entry for encyclopedia/dictionary

  • Glucosinolates
  • Brassica
  • Vegetables
  • Thioglucosides
  • Magnoliopsida
  5 Citations (Scopus)

• Heat Shock Factor 1 is a Substrate for p38 Mitogen-Activated Protein Kinases

  Dayalan Naidu, S., Sutherland, C., Zhang, Y., Risco, A., de la Vega, L., Caunt, C. J., Hastie, C. J., Lamont, D. J., Torrente, L., Chowdhry, S., Benjamin, I. J., Keyse, S. M., Cuenda, A. & Dinkova-Kostova, A. T., 15 Sep 2016, In: Molecular and Cellular Biology. 36, 18, p. 2403-2417 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Heat-Shock Response
  • p38 Mitogen-Activated Protein Kinases
  • Phosphorylation
  • phenethyl isothiocyanate
  • Heat Shock Transcription Factors
  27 Citations (Scopus)

  285 Downloads (Pure)

• High NRF2 Levels Correlate with Poor Prognosis in Colorectal Cancer Patients and with Sensitivity to the Kinase Inhibitor AT9283 In Vitro

  Torrente Fernandez, L., Maan, G., Rezig, A. O., Quinn, J., Jackson, A., Grilli, A., Casares, L., Zhang, Y., Kulesskiy, E., Saarela, J., Bicciato, S., Edwards, J., Dinkova-Kostova, A. & de la Vega, L., Oct 2020, In: Biomolecules. 10, 10, 16 p., 1365.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • 1-cyclopropyl-3-(3-(5-morpholin-4-ylmethyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl)urea
  • NF-E2-Related Factor 2
  • Colorectal Neoplasms
  • Phosphotransferases
  • In Vitro Techniques
  2 Citations (Scopus)

  12 Downloads (Pure)

• HSF1-Dependent Upregulation of Hsp70 by Sulfhydryl-Reactive Inducers of the KEAP1/NRF2/ARE Pathway

  Zhang, Y., Ahn, Y-H., Benjamin, I. J., Honda, T., Hicks, R. J., Calabrese, V., Cole, P. A. & Dinkova-Kostova, A. T., 23 Nov 2011, In: Chemistry & Biology. 18, 11, p. 1355-1361 7 p.

  Research output: Contribution to journal › Article › peer-review
  70 Citations (Scopus)

• Induction of the Keapl/Nrf2/ARE pathway by oxidizable diphenols

  Dinkova-Kostova, A. T. & Wang, X. J., 30 Jun 2011, In: Chemico-Biological Interactions. 192, 1-2, p. 101-106 6 p.

  Research output: Contribution to journal › Article › peer-review
  50 Citations (Scopus)

• Investigation into the use of histone deacetylase inhibitor MS-275 as a topical agent for the prevention and treatment of cutaneous squamous cell carcinoma in an SKH-1 hairless mouse model

  Kalin, J. H., Eroglu, A., Liu, H., Holtzclaw, W. D., Leigh, I., Proby, C. M., Fahey, J. W., Cole, P. A. & Dinkova-Kostova, A. T., 13 Mar 2019, In: PLoS ONE. 14, 3, p. 1-13 13 p., e0213095.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • entinostat
  • Epithelial Cells
  • squamous cell carcinoma
  • histone deacetylase
  • Hairless Mouse
  2 Citations (Scopus)

  137 Downloads (Pure)

• Isomeric O-methyl cannabidiolquinones with dual BACH1/NRF2 activity

  Casares Perez, L., Unciti-Broceta, J. D., Prados, M. E., Caprioglio, D., Mattoteia, D., Higgins, M., Apendino, G., Dinkova-Kostova, A. T., Muñoz, E. & de la Vega, L., Oct 2020, In: Redox Biology. 37, p. 1-10 10 p., 101689.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cannabidiol
  • Neurodegenerative diseases
  • Neurodegenerative Diseases
  • Oxidative stress
  • Derivatives
  1 Citation (Scopus)

  32 Downloads (Pure)

• Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

  Mills, E. L., Ryan, D. G., Prag, H. A., Dikovskaya, D., Menon, D., Zaslona, Z., Jedrychowski, M. P., Costa, A. S. H., Higgins, M., Hams, E., Szpyt, J., Runtsch, M. C., King, M. S., McGouran, J. F., Fischer, R., Kessler, B. M., McGettrick, A. F., Hughes, M. M., Carroll, R. G., Booty, L. M. & 15 others, Knatko, E. V., Meakin, P. J., Ashford, M. L. J., Modis, L. K., Brunori, G., Sévin, D. C., Fallon, P. G., Caldwell, S. T., Kunji, E. R. S., Chouchani, E. T., Frezza, C., Dinkova-Kostova, A. T., Hartley, R. C., Murphy, M. P. & O'Neill, L. A., 5 Apr 2018, In: Nature. 556, 7699, p. 113-117 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • itaconic acid
  • Alkylation
  • Anti-Inflammatory Agents
  • Interferon Type I
  • Cysteine
  348 Citations (Scopus)

  827 Downloads (Pure)

• KEAP1, a cysteine-based sensor and a drug target for the prevention and treatment of chronic disease: KEAP1, a sensor and a drug target

  Dayalan Naidu, S. & Dinkova-Kostova, A., Jun 2020, In: Open Biology. 10, 6, p. 1-13 13 p., 200105.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Kelch-Like ECH-Associated Protein 1
  • Oxidation-Reduction
  • Cysteine
  • Chronic Disease
  • Sensors
  6 Citations (Scopus)

  22 Downloads (Pure)

• Keap1, the cysteine-based mammalian intracellular sensor for electrophiles and oxidants

  Dinkova-Kostova, A. T., Kostov, R. V. & Canning, P., 1 Mar 2017, In: Archives of Biochemistry and Biophysics. 617, p. 84-93 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Kelch-Like ECH-Associated Protein 1
  • Oxidants
  • Cysteine
  • NF-E2-Related Factor 2
  • Sensors
  109 Citations (Scopus)

  181 Downloads (Pure)

• KEAP1 and done? Targeting the NRF2 pathway with sulforaphane: Targeting the NRF2 Pathway with Sulforaphane

  Dinkova-Kostova, A. T., Fahey, J. W., Kostov, R. V. & Kensler, T. W., Nov 2017, In: Trends in Food Science and Technology. 69, B, p. 257-269 13 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • sulforaphane
  • sulforafan
  • Brassica
  • broccoli
  • clinical trials
  88 Citations (Scopus)

  433 Downloads (Pure)

• KEAP₁ inhibition is neuroprotective and suppresses the development of epilepsy

  Shekh-Ahmad, T., Eckel, R., Dayalan Naidu, S., Higgins, M., Yamamoto, M., Dinkova-Kostova, A., Kovac, S., Abramov, A. Y. & Walker, M. C., May 2018, In: Brain. 141, 5, p. 1390-1403 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • N-(11-cyano-2,2,6a,6b,9,9,12a-heptmethyl-10,14-dioxo-1,3,4,5,6a,6b,7,8,8a,9,10,12a,14,14a,14b-hexadecahydro-2H-picen-4a-yl)-2-2-difluoropropionamide
  • Kelch-Like ECH-Associated Protein 1
  • Status Epilepticus
  • Epilepsy
  • Reactive Oxygen Species
  39 Citations (Scopus)

  202 Downloads (Pure)

• KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients

  Quinti, L., Dayalan Naidu, S., Träge, U., Chen, X., Kegel-Gleason, K., Lleres, D., Connolly, C., Chopra, V., Low, C., Moniot, S., Sapp, E., Tousley, A. R., Vodicka, P., Van Kanegan, M. J., Kaltenbach, L. S., Crawford, L. A., Fuszard, M., Higgins, M., Miller, J. R. C., Farmer, R. E. & 19 others, Potluri, V., Samajdar, S., Meisel, L., Zhang, N., Snyder, A., Stein, R., Hersch, S. M., Ellerby, L. M., Weerapana, E., Schwarzschild, M. A., Steegborn, C., Leavitt, B. R., Degterev, A., Tabrizi, S. J., Lo, D. C., DiFiglia, M., Thompson, L. M., Dinkova-Kostova, A. & Kazantsev, A. G., 6 Jun 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 23, p. e4676-e4685 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Kelch-Like ECH-Associated Protein 1
  • Neural Stem Cells
  • Huntington Disease
  • NF-E2 Transcription Factor
  • Interleukin-6
  41 Citations (Scopus)

  183 Downloads (Pure)

• Loss of Nrf2 abrogates the protective effect of Keap1 down regulation in a preclinical model of cutaneous squamous cell carcinoma

  Knatko, E. V., Higgins, M., Fahey, J. W. & Dinkova-Kostova, A., 24 May 2016, In: Scientific Reports. 6, 7 p., 25804.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Kelch-Like ECH-Associated Protein 1
  • NF-E2-Related Factor 2
  • Squamous Cell Carcinoma
  • Down-Regulation
  • Skin
  20 Citations (Scopus)

  205 Downloads (Pure)

• Measuring Changes in Keap1‐Nrf2 Protein Complex Conformation in Individual Cells by FLIM‐FRET

  Dikovskaya, D. & Dinkova-Kostova, A., Sep 2020, In: Current Protocols in Toxicology. 85, 1, p. 1-34 34 p., e96.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Kelch-Like ECH-Associated Protein 1
  • Protein Conformation
  • Conformations
  • Fluorescence
  • Photons
  37 Downloads (Pure)

• Measuring the Interaction of Transcription Factor Nrf2 with Its Negative Regulator Keap1 in Single Live Cells by an Improved FRET/FLIM Analysis

  Dikovskaya, D., Appleton, P., Bento-Pereira, C. & Dinkova-Kostova, A., 18 Mar 2019, In: Chemical Research in Toxicology. 32, 3, p. 500-512 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Kelch-Like ECH-Associated Protein 1
  • NF-E2 Transcription Factor
  • Forster resonance energy transfer
  • NF-E2-Related Factor 2
  • Transcription Factors
  4 Citations (Scopus)

  163 Downloads (Pure)

• Metabolic and Homeostatic Changes in Seizures and Acquired Epilepsy-Mitochondria, Calcium Dynamics and Reactive Oxygen Species

  Kovac, S., Dinkova Kostova, A. T., Herrmann, A. M., Melzer, N., Meuth, S. G. & Gorji, A., 8 Sep 2017, In: International Journal of Molecular Sciences. 18, 9, p. 1-19 19 p., 1935.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Mitochondria
  • epilepsy
  • seizures
  • mitochondria
  • Metabolism
  26 Citations (Scopus)

  199 Downloads (Pure)

• Monitoring Keap1-Nrf2 interactions in single live cells

  Baird, L., Swift, S., Llères, D. & Dinkova-Kostova, A. T., 1 Nov 2014, In: Biotechnology Advances. 32, 6, p. 1133-1144 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Kelch-Like ECH-Associated Protein 1
  • NF-E2-Related Factor 2
  • Proteins
  • Monitoring
  • sulforafan
  82 Citations (Scopus)

  405 Downloads (Pure)

• NAD(P)H: quinone oxidoreductase 1 inducer activity of some novel anilinoquinazoline derivatives

  Ghorab, M. M., Alsaid, M. S., Higgins, M., Dinkova-Kostova, A. T., Shahat, A. A., Elghazawy, N. H. & Arafa, R. K., 8 Aug 2016, In: Drug Design, Development and Therapy. 10, p. 2515-2524 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • anilinoquinazoline
  • Kelch-Like ECH-Associated Protein 1
  • quinone
  • NAD
  • Oxidoreductases
  3 Citations (Scopus)

  180 Downloads (Pure)

• NAD(P)H: Quinone oxidoreductase 1 inducer activity of novel 4-aminoquinazoline derivatives

  Ghorab, M. M., Alsaid, M. S., El-Gazzar, M. G., Higgins, M., Dinkova-Kostova, A. T. & Shahat, A. A., 2016, In: Journal of Enzyme Inhibition and Medicinal Chemistry. 31, 6, p. 1369-1374 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • 4-aminoquinazoline
  • quinone
  • NAD
  • Oxidoreductases
  • Aptitude
  3 Citations (Scopus)

  203 Downloads (Pure)

• NAD(P)H: Quinone oxidoreductase 1 inducer activity of some Saudi Arabian medicinal plants

  Shahat, A. A., Alsaid, M. S., Alyahya, M. A., Higgins, M. & Dinkova-Kostova, A. T., Apr 2013, In: Planta Medica. 79, 6, p. 459-464 6 p.

  Research output: Contribution to journal › Article › peer-review
  11 Citations (Scopus)

• Novel Thioureido Derivatives Carrying Thione and Sulfonamide Moieties Induce the Cytoprotective Enzyme NAD(P)H:Quione Oxidoreductase 1: Quinone oxidoreductase 1

  Ghorab, M. M., Higgins, M., Dinkova-Kostova, A. T., Alsaid, M. S. & Shahat, A. A., 1 Dec 2014, In: Asian Journal of Chemistry. 26, 24, p. 8501-8504 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Thiones
  • Sulfonamides
  • quinone
  • Quinazolines
  • NAD
  2 Citations (Scopus)

• Nrf2 activation in the treatment of neurodegenerative diseases: A focus on its role in mitochondrial bioenergetics and function

  Esteras, N., Dinkova-Kostova, A. T. & Abramov, A. Y., May 2016, In: Biological Chemistry. 397, 5, p. 383-400 18 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Neurodegenerative diseases
  • NF-E2-Related Factor 2
  • Energy Metabolism
  • Chemical activation
  • Neurodegenerative Diseases
  66 Citations (Scopus)

  294 Downloads (Pure)

• Nrf2 affects the efficiency of mitochondrial fatty acid oxidation

  Ludtmann, M. H. R., Angelova, P. R., Zhang, Y., Abramov, A. Y. & Dinkova-Kostova, A. T., 1 Feb 2014, In: Biochemical Journal. 457, 3, p. 415-424 10 p.

  Research output: Contribution to journal › Article › peer-review

  • NF-E2-Related Factor 2
  • Oxidation
  • Fatty Acids
  • 1,5-dihydro-FAD
  • Kelch-Like ECH-Associated Protein 1
  119 Citations (Scopus)

• NRF2 and the Ambiguous Consequences of Its Activation during Initiation and the Subsequent Stages of Tumourigenesis

  Robertson, H., Dinkova-Kostova, A. T. & Hayes, J. D., 2 Dec 2020, In: Cancers. 12, 12, 48 p., 3609.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Kelch-Like ECH-Associated Protein 1
  • Cullin Proteins
  • Neoplasms
  • Mutation
  • Sulfhydryl Compounds
  14 Downloads (Pure)

• NRF2 as an emerging therapeutic target

  Copple, I. M., Dinkova-Kostova, A. T., Kensler, T. W., Liby, K. T. & Wigley, W. C., 31 Jan 2017, In: Oxidative Medicine and Cellular Longevity. 2017, p. 1-2 2 p., 8165458.

  Research output: Contribution to journal › Editorial › peer-review

  Open Access

  File
  20 Citations (Scopus)

  201 Downloads (Pure)

• Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration

  Holmström, K. M., Baird, L., Zhang, Y., Hargreaves, I., Chalasani, A., Land, J. M., Stanyer, L., Yamamoto, M., Dinkova-Kostova, A. T. & Abramov, A. Y., 15 Aug 2013, In: Open Biology. 2, 8, p. 761-770 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Energy Metabolism
  • Genes
  • Respiration
  • Adenosine Triphosphate
  • Mitochondrial Membrane Potential
  209 Citations (Scopus)

  218 Downloads (Pure)

• Nrf2 is activated by disruption of mitochondrial thiol homeostasis but not by enhanced mitochondrial superoxide production

  Cvetko, F., Caldwell, S. T., Higgins, M., Suzuki, T., Yamamoto, M., Prag, H. A., Hartley, R. C., Dinkova-Kostova, A. & Murphy, M. P., 20 Dec 2020, In: Journal of Biological Chemistry. 296, 14 p., 100169.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Sulfhydryl Compounds
  • Hydrogen Peroxide
  • Superoxides
  • Oxidation-Reduction
  • Homeostasis
  36 Downloads (Pure)