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• Structure of Trypanosoma brucei glutathione synthetase: domain and loop alterations in the catalytic cycle of a highly conserved enzyme

  Fyfe, P. K., Alphey, M. S. & Hunter, W. N., Apr 2010, In: Molecular and Biochemical Parasitology. 170, 2, p. 93-99 7 p.

  Research output: Contribution to journal › Article › peer-review
  11 Citations (Scopus)

• Structure of the three-way helical junction of the hepatitis C virus IRES element

  Ouellet, J., Melcher, S., Iqbal, A., Ding, Y. & Lilley, D. M. J., Aug 2010, In: RNA: a Publication of the RNA Society. 16, 8, p. 1597-1609 13 p.

  Research output: Contribution to journal › Article › peer-review
  27 Citations (Scopus)

• Structure of the TatC core of the twin-arginine protein transport system

  Rollauer, S. E., Tarry, M. J., Graham, J. E., Jääskeläinen, M., Jager, F., Johnson, S., Krehenbrink, M., Liu, S-M., Lukey, M. J., Marcoux, J., McDowell, M. A., Rodriguez, F., Roversi, P., Stansfeld, P. J., Robinson, C. V., Sansom, M. S. P., Palmer, T., Högbom, M., Berks, B. C. & Lea, S. M., 13 Dec 2012, In: Nature. 492, 7428, p. 210-214 5 p.

  Research output: Contribution to journal › Article › peer-review
  132 Citations (Scopus)

• Structure of the SCAN domain of human paternally expressed gene 3 protein

  Rimsa, V., Eadsforth, T. C. & Hunter, W. N., 23 Jul 2013, In: PLoS ONE. 8, 7, e69538.

  Research output: Contribution to journal › Article › peer-review
  9 Citations (Scopus)

• Structure of the phosphosaccharide-inositol core of the Leishmania donovani lipophosphoglycan

  Turco, S. J., Orlandi Jr., P. A., Homans, S. W., Ferguson, M. A. J., Dwek, R. A. & Rademacher, T. W., 25 Apr 1989, In: Journal of Biological Chemistry. 264, 12, p. 6711-6715 5 p.

  Research output: Contribution to journal › Article › peer-review
  91 Citations (Scopus)

• Structure of the OSR1 kinase, a hypertension drug target

  Villa, F., Deak, M., Alessi, D. R. & van Aalten, D. M. F., Dec 2008, In: Proteins: Structure, Function, and Bioinformatics. 73, 4, p. 1082-1087 6 p.

  Research output: Contribution to journal › Article › peer-review
  39 Citations (Scopus)

• Structure of the N-linked oligosaccharide of the main diagnostic antigen of the pathogenic fungus Paracoccidioides brasiliensis

  Almeida, I. C., Neville, D. C. A., Mehlert, A., Treumann, A., Ferguson, M. A. J., Previato, J. O. & Travassos, L. R., Jul 1996, In: Glycobiology. 6, 5, p. 507-515 9 p.

  Research output: Contribution to journal › Article › peer-review
  43 Citations (Scopus)

• Structure of the mouse calpain small subunit gene

  Arthur, J. S. C., Greer, P. A. & Elce, J. S., 14 Oct 1998, In: Biochimica et Biophysica Acta. Protein Structure and Molecular Enzymology. 1388, 1, p. 247-252 6 p.

  Research output: Contribution to journal › Article › peer-review
  17 Citations (Scopus)

• Structure of the MacAB-TolC ABC-type tripartite multidrug efflux pump

  Fitzpatrick, A. W. P., Llabres, S., Neuberger, A., Blaza, J. N., Bai, X-C., Okada, U., Murakami, S., van Veen, H. W., Zachariae, U., Scheres, S. H. W., Luisi, B. F. & Du, D., 15 May 2017, In: Nature Microbiology. 2, p. 1-8 8 p., 17070.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  99 Citations (Scopus)

  253 Downloads (Pure)

• Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation

  Zeqiraj, E., Filippi, B. M., Deak, M., Alessi, D. R. & van Aalten, D. M. F., 18 Dec 2009, In: Science. 326, 5960, p. 1707-1711 5 p.

  Research output: Contribution to journal › Article › peer-review
  240 Citations (Scopus)

• Structure of the lipophosphoglycan from Leishmania major

  McConville, M. J., Thomas-Oates, J. E., Ferguson, M. A. J. & Homans, S. W., 15 Nov 1990, In: Journal of Biological Chemistry. 265, 32, p. 19611-19623 13 p.

  Research output: Contribution to journal › Article › peer-review
  185 Citations (Scopus)

• Structure of the Human FANCL RING-Ube2T Complex Reveals Determinants of Cognate E3-E2 Selection

  Hodson, C., Purkiss, A., Miles, J. A. & Walden, H., Feb 2014, In: Structure. 22, 2, p. 337-344

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  56 Citations (Scopus)

  347 Downloads (Pure)

• Structure of the glycosyl-phosphatidylinositol membrane anchor of the Leishmania major promastigote surface protease.

  Schneider, P., Ferguson, M., McConville, M. J., Mehlert, A., Homans, S. W. & Bordier, C., 5 Oct 1990, In: Journal of Biological Chemistry. 265, 28, p. 16955-16964 10 p.

  Research output: Contribution to journal › Article › peer-review
  132 Citations (Scopus)

• Structure of the glycosylphosphatidylinositol membrane anchor of human placental alkaline phosphatase

  Redman, C. A., Thomas-Oates, J. E., Ogata, S., Ikehara, Y. & Ferguson, M. A. J., 1 Jan 1994, In: Biochemical Journal. 302, 3, p. 861-865 5 p.

  Research output: Contribution to journal › Article › peer-review
  54 Citations (Scopus)

• Structure of the glycosyl-phosphatidylinositol membrane anchor of acetylcholinesterase from the electric organ of the electric-fish, Torpedo californica

  Mehlert, A., Varon, L., Silman, I., Homans, S. W. & Ferguson, M. A. J., 1993, In: Biochemical Journal. 296 ( Pt 2), p. 473-479 7 p.

  Research output: Contribution to journal › Article › peer-review
  21 Citations (Scopus)

• Structure of the glycosylphosphatidylinositol membrane anchor glycan of a class-2 variant surface glycoprotein from Trypanosoma brucei

  Mehlert, A., Richardson, J. M. & Ferguson, M. A. J., 27 Mar 1998, In: Journal of Molecular Biology. 277, 2, p. 379-392 14 p.

  Research output: Contribution to journal › Article › peer-review
  66 Citations (Scopus)

• Structure of the glycosylphosphatidylinositol anchor of the Trypanosoma brucei transferrin receptor

  Mehlert, A. & Ferguson, M. A. J., Feb 2007, In: Molecular and Biochemical Parasitology. 151, 2, p. 220-223 4 p.

  Research output: Contribution to journal › Article › peer-review
  19 Citations (Scopus)

• Structure of the fibronectin type 1 module

  Baron, M., Norman, D., Willis, A. & Campbell, I. D., 14 Jun 1990, In: Nature. 345, 6276, p. 642-646 5 p.

  Research output: Contribution to journal › Article › peer-review
  92 Citations (Scopus)

• Structure of the chromatin remodelling enzyme Chd1 bound to a ubiquitinylated nucleosome

  Sundaramoorthy, R., Hughes, A., El-Mkami, H., Norman, D. & Owen-Hughes, T., 6 Aug 2018, In: eLife. 2018, 7, p. 1-28 28 p., e35720.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  43 Citations (Scopus)

  179 Downloads (Pure)

• Structure of the CAMPATH-1 antigen, a glycosylphosphatidylinositol-anchored glycoprotein which is an exceptionally good target for complement lysis

  Xia, M-Q., Hale, G., Lifely, M. R., Ferguson, M. A. J., Campbell, D., Packman, L. & Waldmann, H., 1993, In: Biochemical Journal. 293 ( Pt 3), p. 633-640 8 p.

  Research output: Contribution to journal › Article › peer-review
  189 Citations (Scopus)

• Structure of the band tails in amorphous selenium

  Benkhedir, M. L., Brinza, M., Adriaenssens, G. J. & Main, C., 28 May 2008, In: Journal of Physics: Condensed Matter. 20, 21, p. - 4 p., 215202.

  Research output: Contribution to journal › Article › peer-review
  10 Citations (Scopus)

• Structure of staphylococcus aureus EsxA suggests a contribution to virulence by action as a transport chaperone and/or adaptor protein

  Sundaramoorthy, R., Fyfe, P. K. & Hunter, W. N., 14 Nov 2008, In: Journal of Molecular Biology. 383, 3, p. 603-614 12 p.

  Research output: Contribution to journal › Article › peer-review
  56 Citations (Scopus)

• Structure of Staphylococcus aureus adenylosuccinate lyase (PurB) and assessment of its potential as a target for structure-based inhibitor discovery

  Fyfe, P. K., Dawson, A., Hutchison, M-T., Cameron, S. & Hunter, W. N., Aug 2010, In: Acta Crystallographica Section D: Biological Crystallography. 66, p. 881-888 8 p.

  Research output: Contribution to journal › Article › peer-review
  16 Citations (Scopus)

• Structure of Staphylococcus aureus 1,4-dihydroxy-2-naphthoyl-CoA synthase (MenB) in complex with acetoacetyl-CoA

  Ulaganathan, V., Agacan, M. F., Buetow, L., Tulloch, L. B. & Hunter, W. N., Nov 2007, In: Acta Crystallographica F-Structural Biology and Crystallization Communications. 63, p. 908-913 6 p.

  Research output: Contribution to journal › Article › peer-review
  18 Citations (Scopus)

• Structure of saccharomyces cerevisiae chitinase 1 and screening-based discovery of potent inhibitors

  Hurtado-Guerrero, R. & van Aalten, D. M. F., 29 May 2007, In: Chemistry & Biology. 14, 5, p. 589-599 11 p.

  Research output: Contribution to journal › Article › peer-review
  58 Citations (Scopus)

• Structure of recombinant Leishmania donovani pteridine reductase reveals a disordered active site

  Barrack, K. L., Tulloch, L. B., Burke, L-A., Fyfe, P. K. & Hunter, W. N., Jan 2011, In: Acta Crystallographica F-Structural Biology and Crystallization Communications. 67, p. 33-37 5 p.

  Research output: Contribution to journal › Article › peer-review
  22 Citations (Scopus)

• Structure of Pseudomonas aeruginosa inosine 5-monophosphate dehydrogenase

  Rao, V. A., Shepherd, S. M., Owen, R. & Hunter, W. N., 2013, In: Acta Crystallographica F-Structural Biology and Crystallization Communications. 69, 3, p. 243-247 5 p.

  Research output: Contribution to journal › Article › peer-review
  13 Citations (Scopus)

• Structure of PINK1 and mechanisms of Parkinson's disease associated mutations

  Kumar, A., Tamjar, J., Waddell, A. D., Woodroof, H. I., Raimi, O. G., Shaw, A. M., Peggie, M., Muqit, M. M. K. & van Aalten, D. M. F., 9 Nov 2017, In: eLife. 6, p. 1-16 16 p., e29985.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  53 Citations (Scopus)

  218 Downloads (Pure)

• Structure of Leishmania mexicana lipophosphoglycan

  Ilg, T., Etges, R., Overath, P., McConville, M. J., Thomas-Oates, J., Thomas, J., Homans, S. W. & Ferguson, M. A., 5 Apr 1992, In: Journal of Biological Chemistry. 267, 10, p. 6834-40 7 p.

  Research output: Contribution to journal › Article › peer-review
  109 Citations (Scopus)

• Structure of HHARI, a RING-IBR-RING ubiquitin ligase: autoinhibition of an Ariadne-family E3 and insights into ligation mechanism

  Duda, D. M., Olszewski, J. L., Schuermann, J. P., Kurinov, I., Miller, D. J., Nourse, A., Alpi, A. F. & Schulman, B. A., 4 Jun 2013, In: Structure. 21, 6, p. 1030-1041 12 p.

  Research output: Contribution to journal › Article › peer-review
  100 Citations (Scopus)

• Structure of diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase from Acinetobacter baumannii

  Dawson, A., Trumper, P., Chrysostomou, G. & Hunter, W. N., 2013, In: Acta Crystallographica F-Structural Biology and Crystallization Communications. 69, 6, p. 611-617 7 p.

  Research output: Contribution to journal › Article › peer-review
  1 Citation (Scopus)

• Structure of a RING E3 ligase and ubiquitin-loaded E2 primed for catalysis

  Plechanovová, A., Jaffray, E. G., Tatham, M. H., Naismith, J. H. & Hay, R. T., 2012, In: Nature. 489, 7414, p. 115-120 5 p.

  Research output: Contribution to journal › Article › peer-review
  370 Citations (Scopus)

• Structure of a rare non-standard sequence k-turn bound by L7Ae protein

  Huang, L. & Lilley, D. M. J., Apr 2014, In: Nucleic Acids Research. 42, 7, p. 4734-4740 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  12 Citations (Scopus)

  204 Downloads (Pure)

• Structure of an Insecticide Sequestering Carboxylesterase from the Disease Vector Culex quinquefasciatus: What Makes an Enzyme a Good Insecticide Sponge?

  Hopkins, D. H., Fraser, N. J., Mabbitt, P. D., Carr, P. D., Oakeshott, J. G. & Jackson, C. J., 17 Oct 2017, In: Biochemistry. 56, 41, p. 5512-5525 14 p.

  Research output: Contribution to journal › Article › peer-review
  16 Citations (Scopus)

• Structure of a complex phosphoglycan epitope from gp72 of Trypanosoma cruzi

  Allen, S., Richardson, J. M., Mehlert, A. & Ferguson, M. A. J., 19 Apr 2013, In: Journal of Biological Chemistry. 288, 16, p. 11093-11105 13 p.

  Research output: Contribution to journal › Article › peer-review
  21 Citations (Scopus)

• Structure of a calpain Ca²⁺-binding domain reveals a novel EF-hand and Ca²⁺-induced conformational changes

  Blanchard, H., Grochulski, P., Li, Y., Arthur, J. S. C., Davies, P. L., Elce, J. S. & Cygler, M., 1 Jul 1997, In: Nature Structural Biology. 4, 7, p. 532-538 7 p.

  Research output: Contribution to journal › Article › peer-review
  182 Citations (Scopus)

• Structure of a bacterial putative acetyltransferase defines the fold of the human O-GlcNAcase C-terminal domain

  Rao, F. V., Schüttelkopf, A. W., Dorfmueller, H. C., Ferenbach, A. T., Navratilova, I. & van Aalten, D. M. F., 2 Oct 2013, In: Open Biology. 3, 130021.

  Research output: Contribution to journal › Article › peer-review
  40 Citations (Scopus)

• Structure of 2C-methyl-d-erythritol 2,4- cyclodiphosphate synthase: an essential enzyme for isoprenoid biosynthesis and target for antimicrobial drug development

  Kemp, L. E., Bond, C. S., Hunter, W. N. & Deisenhofer, J. (ed.), 2002, In: Proceedings of the National Academy of Sciences of the United States of America. 99, 10, p. 6591-6596 6 p.

  Research output: Contribution to journal › Article › peer-review
  86 Citations (Scopus)

• Structure modification of 0-3 piezoelectric ceramic/polymer composites through dielectrophoresis

  Wilson, S., Maistros, G. M. & Whatmore, R. W., 21 Jan 2005, In: Journal of Physics D: Applied Physics. 38, 2, p. 175-182 8 p.

  Research output: Contribution to journal › Article › peer-review
  67 Citations (Scopus)

• Structure-kinetic relationship reveals the mechanism of selectivity of FAK inhibitors over PYK2

  Berger, B. T., Amaral, M., Kokh, D. B., Nunes-Alves, A., Musil, D., Heinrich, T., Schröder, M., Neil, R., Wang, J., Navratilova, I., Bomke, J., Elkins, J. M., Müller, S., Frech, M., Wade, R. C. & Knapp, S., 20 May 2021, In: Cell Chemical Biology. 28, 5, p. 686-698.e7 20 p.

  Research output: Contribution to journal › Article › peer-review
  22 Citations (Scopus)

• Structure-guided enhancement of selectivity of chemical probe inhibitors targeting bacterial seryl-tRNA synthetase

  Cain, R., Salimraj, R., Punekar, A., Belini, D., Fishwick, C. W. G., Czaplewski, L., Scott, D. J., Harris, G., Dowson, C. G., Lloyd, A. J. & Roper, D. I., 18 Oct 2019, In: Journal of Medicinal Chemistry. 62, 21, p. 9703-9717 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  2 Citations (Scopus)

  32 Downloads (Pure)

• Structure-guided design of peptides as tools to probe the protein-protein interaction between Cullin-2 and Elongin BC substrate adaptor in Cullin RING E3 ubiquitin ligases

  Cardote, T. & Ciulli, A., 21 Sep 2017, In: ChemMedChem. 12, 18, p. 1491-1496 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  6 Citations (Scopus)

  161 Downloads (Pure)

• Structure-guided design of a high affinity ligand for a riboswitch

  Huang, L., Wang, J., Wilson, T. & Lilley, D., Apr 2019, In: RNA: a Publication of the RNA Society. 25, 4, p. 423-430 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  7 Citations (Scopus)

  145 Downloads (Pure)

• Structure-guided design and optimization of small molecules targeting the protein-protein interaction between the von hippel-lindau (VHL) E3 ubiquitin ligase and the hypoxia inducible factor (HIF) alpha subunit with in vitro nanomolar affinities

  Galdeano, C., Gadd, M. S., Soares, P., Scaffidi, S., Van Molle, I., Birced, I., Hewitt, S., Dias, D. M. & Ciulli, A., 23 Oct 2014, In: Journal of Medicinal Chemistry. 57, 20, p. 8657-8663 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  223 Citations (Scopus)

  235 Downloads (Pure)

• Structure-function studies on recombinant calpain

  Davies, P. L., Arthur, J. S. C., Blanchard, H., Cygler, M., Elce, J. S., Gauthier, S., Grochulski, P., Hegadorn, C., Jia, Z. & Yi, L., 1997, In: FASEB Journal. 11, 9, p. A1400

  Research output: Contribution to journal › Article › peer-review

• Structure function studies on Leishmania surface membrane proteins.

  Olafson, R. W., Dwek, R. A., Rademacher, T. W., Chang, K-P. & Ferguson, M. A. J., 1989, Leishmaniasis : the current status and new strategies for control. Proceedings of the NATO Advanced Study Institute, Zakynthos (Greece), 1987. Hart, D. T. (ed.). New York: Plenum Press, p. 619-627 9 p. ( NATO ASI series. Series A: Life sciences; vol. 163).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

• Structure-driven nonlinear instability as the origin of the explosive reconnection dynamics in resistive double tearing modes

  Janvier, M., Kishimoto, Y. & Li, J. Q., 31 Oct 2011, In: Physical Review Letters. 107, 19, 5 p., 195001.

  Research output: Contribution to journal › Article › peer-review
  45 Citations (Scopus)

• Structured perceptual arrays and the modulation of Fitts's law: Examining saccadic eye movements

  Al-Aidroos, N., Fischer, M. H., Adam, J. J. & Pratt, J., Mar 2008, In: Journal of Motor Behavior. 40, 2, p. 155-164 10 p.

  Research output: Contribution to journal › Article › peer-review
  6 Citations (Scopus)

• Structured models of cell migration incorporating molecular binding processes

  Domschke, P., Trucu, D., Gerisch, A. & Chaplain, M. A. J., Dec 2017, In: Journal of Mathematical Biology. 75, 6-7, p. 1517-1561 45 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  20 Citations (Scopus)

  205 Downloads (Pure)

• Structured Models of Cell Migration Incorporating Membrane Reactions (Keynote Speaker Talk)

  Trucu, D., 2017.

  Research output: Contribution to conference › Paper