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• Structure of a rare non-standard sequence k-turn bound by L7Ae protein

  Huang, L. & Lilley, D. M. J., Apr 2014, In: Nucleic Acids Research. 42, 7, p. 4734-4740 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  12 Citations (Scopus)

  204 Downloads (Pure)

• Structure of an Insecticide Sequestering Carboxylesterase from the Disease Vector Culex quinquefasciatus: What Makes an Enzyme a Good Insecticide Sponge?

  Hopkins, D. H., Fraser, N. J., Mabbitt, P. D., Carr, P. D., Oakeshott, J. G. & Jackson, C. J., 17 Oct 2017, In: Biochemistry. 56, 41, p. 5512-5525 14 p.

  Research output: Contribution to journal › Article › peer-review
  16 Citations (Scopus)

• Structure of a complex phosphoglycan epitope from gp72 of Trypanosoma cruzi

  Allen, S., Richardson, J. M., Mehlert, A. & Ferguson, M. A. J., 19 Apr 2013, In: Journal of Biological Chemistry. 288, 16, p. 11093-11105 13 p.

  Research output: Contribution to journal › Article › peer-review
  21 Citations (Scopus)

• Structure of a calpain Ca²⁺-binding domain reveals a novel EF-hand and Ca²⁺-induced conformational changes

  Blanchard, H., Grochulski, P., Li, Y., Arthur, J. S. C., Davies, P. L., Elce, J. S. & Cygler, M., 1 Jul 1997, In: Nature Structural Biology. 4, 7, p. 532-538 7 p.

  Research output: Contribution to journal › Article › peer-review
  182 Citations (Scopus)

• Structure of a bacterial putative acetyltransferase defines the fold of the human O-GlcNAcase C-terminal domain

  Rao, F. V., Schüttelkopf, A. W., Dorfmueller, H. C., Ferenbach, A. T., Navratilova, I. & van Aalten, D. M. F., 2 Oct 2013, In: Open Biology. 3, 130021.

  Research output: Contribution to journal › Article › peer-review
  40 Citations (Scopus)

• Structure of 2C-methyl-d-erythritol 2,4- cyclodiphosphate synthase: an essential enzyme for isoprenoid biosynthesis and target for antimicrobial drug development

  Kemp, L. E., Bond, C. S., Hunter, W. N. & Deisenhofer, J. (ed.), 2002, In: Proceedings of the National Academy of Sciences of the United States of America. 99, 10, p. 6591-6596 6 p.

  Research output: Contribution to journal › Article › peer-review
  86 Citations (Scopus)

• Structure modification of 0-3 piezoelectric ceramic/polymer composites through dielectrophoresis

  Wilson, S., Maistros, G. M. & Whatmore, R. W., 21 Jan 2005, In: Journal of Physics D: Applied Physics. 38, 2, p. 175-182 8 p.

  Research output: Contribution to journal › Article › peer-review
  67 Citations (Scopus)

• Structure-kinetic relationship reveals the mechanism of selectivity of FAK inhibitors over PYK2

  Berger, B. T., Amaral, M., Kokh, D. B., Nunes-Alves, A., Musil, D., Heinrich, T., Schröder, M., Neil, R., Wang, J., Navratilova, I., Bomke, J., Elkins, J. M., Müller, S., Frech, M., Wade, R. C. & Knapp, S., 20 May 2021, In: Cell Chemical Biology. 28, 5, p. 686-698.e7 20 p.

  Research output: Contribution to journal › Article › peer-review
  23 Citations (Scopus)

• Structure-guided enhancement of selectivity of chemical probe inhibitors targeting bacterial seryl-tRNA synthetase

  Cain, R., Salimraj, R., Punekar, A., Belini, D., Fishwick, C. W. G., Czaplewski, L., Scott, D. J., Harris, G., Dowson, C. G., Lloyd, A. J. & Roper, D. I., 18 Oct 2019, In: Journal of Medicinal Chemistry. 62, 21, p. 9703-9717 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  2 Citations (Scopus)

  32 Downloads (Pure)

• Structure-guided design of peptides as tools to probe the protein-protein interaction between Cullin-2 and Elongin BC substrate adaptor in Cullin RING E3 ubiquitin ligases

  Cardote, T. & Ciulli, A., 21 Sep 2017, In: ChemMedChem. 12, 18, p. 1491-1496 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  6 Citations (Scopus)

  161 Downloads (Pure)

• Structure-guided design of a high affinity ligand for a riboswitch

  Huang, L., Wang, J., Wilson, T. & Lilley, D., Apr 2019, In: RNA: a Publication of the RNA Society. 25, 4, p. 423-430 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  7 Citations (Scopus)

  146 Downloads (Pure)

• Structure-guided design and optimization of small molecules targeting the protein-protein interaction between the von hippel-lindau (VHL) E3 ubiquitin ligase and the hypoxia inducible factor (HIF) alpha subunit with in vitro nanomolar affinities

  Galdeano, C., Gadd, M. S., Soares, P., Scaffidi, S., Van Molle, I., Birced, I., Hewitt, S., Dias, D. M. & Ciulli, A., 23 Oct 2014, In: Journal of Medicinal Chemistry. 57, 20, p. 8657-8663 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  224 Citations (Scopus)

  237 Downloads (Pure)

• Structure-function studies on recombinant calpain

  Davies, P. L., Arthur, J. S. C., Blanchard, H., Cygler, M., Elce, J. S., Gauthier, S., Grochulski, P., Hegadorn, C., Jia, Z. & Yi, L., 1997, In: FASEB Journal. 11, 9, p. A1400

  Research output: Contribution to journal › Article › peer-review

• Structure function studies on Leishmania surface membrane proteins.

  Olafson, R. W., Dwek, R. A., Rademacher, T. W., Chang, K-P. & Ferguson, M. A. J., 1989, Leishmaniasis : the current status and new strategies for control. Proceedings of the NATO Advanced Study Institute, Zakynthos (Greece), 1987. Hart, D. T. (ed.). New York: Plenum Press, p. 619-627 9 p. ( NATO ASI series. Series A: Life sciences; vol. 163).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

• Structure-driven nonlinear instability as the origin of the explosive reconnection dynamics in resistive double tearing modes

  Janvier, M., Kishimoto, Y. & Li, J. Q., 31 Oct 2011, In: Physical Review Letters. 107, 19, 5 p., 195001.

  Research output: Contribution to journal › Article › peer-review
  46 Citations (Scopus)

• Structured perceptual arrays and the modulation of Fitts's law: Examining saccadic eye movements

  Al-Aidroos, N., Fischer, M. H., Adam, J. J. & Pratt, J., Mar 2008, In: Journal of Motor Behavior. 40, 2, p. 155-164 10 p.

  Research output: Contribution to journal › Article › peer-review
  6 Citations (Scopus)

• Structured models of cell migration incorporating molecular binding processes

  Domschke, P., Trucu, D., Gerisch, A. & Chaplain, M. A. J., Dec 2017, In: Journal of Mathematical Biology. 75, 6-7, p. 1517-1561 45 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  20 Citations (Scopus)

  205 Downloads (Pure)

• Structured Models of Cell Migration Incorporating Membrane Reactions (Keynote Speaker Talk)

  Trucu, D., 2017.

  Research output: Contribution to conference › Paper

• Structured Models of Cell Migration Incorporating Membrane Reactions (Keynote Speaker Talk)

  Trucu, D., 2015.

  Research output: Contribution to conference › Paper

• Structured medical electives: a concept whose time has come?

  Willott, C., Khair, E., Worthington, R., Daniels, K. & Clarfield, A. M., 3 Dec 2019, In: BMJ Global Health. 15, p. 1-7 7 p., 84.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

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  12 Citations (Scopus)

  105 Downloads (Pure)

• Structured learning for clinical ethics in anaesthesia

  Logarajah, S. & Roff, S., 1 Dec 2016, In: Clinical Ethics. 11, 4, p. 200-209 10 p.

  Research output: Contribution to journal › Article › peer-review

• Structured-illumination microscopy of living cells

  Gustafsson, M. G. L., Kner, P., Chhun, B. B. & Griffis, E. R., 16 Aug 2009, In: Abstracts of Papers of the American Chemical Society. 238, 1 p.

  Research output: Contribution to journal › Book/Film/Article review › peer-review

• Structured illumination microscopy as a diagnostic tool for nephrotic disease

  Nylk, J., Pullman, J. M., Campbell, E. C., Gunn-Moore, F. J., Prystowsky, M. B. & Dholakia, K., 2017, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XV. Grundfest, W. S., Vo-Dinh, T. & Mahadevan-Jansen, A. (eds.). Bellingham, WA: SPIE-International Society for Optical Engineering, Vol. 10054. 7 p. 1005417. (Proceedings of SPIE).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

• Structured Expert Consensus on Actinic Keratosis: Treatment Algorithm Focusing on Daylight PDT

  Calzavara-Pinton, P., Hædersdal, M., Barber, K., Basset-Seguin, N., del Pino Flores, M. E., Foley, P., Galimberti, G., Gerritsen, R., Gilaberte, Y., Ibbotson, S., Peris, K., Sapra, S., Sotiriou, E., Torezan, L., Ulrich, C., Guillemot, J., Hendrich, J. & M. Szeimies, R-M., 1 May 2017, In: Journal of Cutaneous Medicine and Surgery. 21, 1, p. 3s-16s 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  29 Citations (Scopus)

  310 Downloads (Pure)

• Structured cost analysis of robotic TME resection for rectal cancer: a comparison between the da Vinci Si and Xi in a single surgeon's experience

  Morelli, L., Di Franco, G., Lorenzoni, V., Guadagni, S., Palmeri, M., Furbetta, N., Gianardi, D., Bianchini, M., Caprili, G., Mosca, F., Turchetti, G. & Cuschieri, A., Jun 2019, In: Surgical Endoscopy. 33, p. 1858-1869 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  37 Citations (Scopus)

  242 Downloads (Pure)

• Structured Co-spans: An algebra of interaction protocols

  Fiadeiro, J. L. & Schmitt, V., 2007, Algebra and Coalgebra in Computer Science: Second International Conference, CALCO 2007, Proceedings. Mossakowski, T., Montanari, U. & Haveraaen, M. (eds.). Berlin: Springer Verlag, p. 194-208 15 p. (Lecture Notes in Computer Science; vol. 4624).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
  8 Citations (Scopus)

• Structured clinical operative tests: Assessing invasive practical procedures

  Rennie, S. C., Mossey, P. A. & Crosby, J. R., 17 Nov 2001, In: Medical Education. 35, 11, p. 1083-1084 2 p.

  Research output: Contribution to journal › Article › peer-review
  1 Citation (Scopus)

• Structured arguments and their aggregation: A reply to selinger

  Reed, C., Aug 2014, In: Argumentation. 28, 3, p. 395-399 5 p.

  Research output: Contribution to journal › Article › peer-review

• Structured antibiotic 'time-out' audits as recommended by the CDC reduce antibiotic use and costs

  Davey, P. G., Jan 2016, In: Evidence-Based Nursing. 19, 1, p. 24 1 p.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

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  198 Downloads (Pure)

• Structure-based virtual screening for the identification of RNA-binding ligands

  Daldrop, P. & Brenk, R., 2014, Therapeutic applications of ribozymes and riboswitches: methods and protocols. Lafontaine, D. & Dubé, A. (eds.). Humana Press, p. 127-139 13 p. (Methods in Molecular Biology; vol. 1103).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed)
  5 Citations (Scopus)

• Structure-based optimization of potent PDK1 inhibitors

  Angiolini, M., Banfi, P., Casale, E., Casuscelli, F., Fiorelli, C., Saccardo, M. B., Silvagni, M. & Zuccotto, F., 15 Jul 2010, In: Bioorganic & Medicinal Chemistry Letters. 20, 14, p. 4095-4099 5 p.

  Research output: Contribution to journal › Article › peer-review
  17 Citations (Scopus)

• Structure-based ligand design and the promise held for antiprotozoan drug discovery

  Hunter, W. N., 1 May 2009, In: Journal of Biological Chemistry. 284, 18, p. 11749-11753 5 p.

  Research output: Contribution to journal › Review article › peer-review
  40 Citations (Scopus)

• Structure-based exploration of cyclic dipeptide chitinase inhibitors

  Houston, D. R., Synstad, B., Eijsink, V. G. H., Stark, M. J. R., Eggleston, I. M. & van Aalten, D. M. F., 2004, In: Journal of Medicinal Chemistry. 47, 23, p. 5713-20 8 p.

  Research output: Contribution to journal › Article › peer-review
  133 Citations (Scopus)

• Structure-based dissection of the natural product cyclopentapeptide chitinase inhibitor argifin

  Andersen, O. A., Nathubhai, A., Dixon, M. J., Eggleston, I. M. & van Aalten, D. M. F., Mar 2008, In: Chemistry & Biology. 15, 3, p. 295-301 7 p.

  Research output: Contribution to journal › Article › peer-review
  53 Citations (Scopus)

• Structure-based design of pteridine reductase inhibitors targeting African sleeping sickness and the Leishmaniases

  Tulloch, L. B., Martini, V. P., Iulek, J., Huggan, J. K., Lee, J. H., Gibson, C. L., Smith, T. K., Suckling, C. J. & Hunter, W. N., 14 Jan 2010, In: Journal of Medicinal Chemistry. 53, 1, p. 221-229 9 p.

  Research output: Contribution to journal › Article › peer-review
  68 Citations (Scopus)

• Structure-Based Design of Inhibitors Targeting PrfA, the Master Virulence Regulator of Listeria monocytogenes

  Kulén, M., Lindgren, M., Hansen, S., Cairns, A. G., Grundström, C., Begum, A., Van Der Lingen, I., Brännström, K., Hall, M., Sauer, U. H., Johansson, J., Sauer-Eriksson, A. E. & Almqvist, F., 10 May 2018, In: Journal of Medicinal Chemistry. 61, 9, p. 4165-4175 11 p.

  Research output: Contribution to journal › Article › peer-review
  17 Citations (Scopus)

• Structure-Based Design of a Macrocyclic PROTAC

  Testa, A., Hughes, S. J., Lucas, X., Wright, J. E. & Ciulli, A., 20 Jan 2020, In: Angewandte Chemie International Edition. 59, 4, p. 1727-1734 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  97 Citations (Scopus)

  284 Downloads (Pure)

• Structure-based design and synthesis of antiparasitic pyrrolopyrimidines targeting pteridine reductase 1

  Khalaf, A. I., Huggan, J. K., Suckling, C. J., Gibson, C. L., Stewart, K., Giordani, F., Barrett, M. P., Wong, P. E., Barrack, K. L. & Hunter, W. N., 14 Aug 2014, In: Journal of Medicinal Chemistry. 57, 15, p. 6479-6494 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  31 Citations (Scopus)

  286 Downloads (Pure)

• Structure‐based design, synthesis and biological evaluation of bis‐tetrahydropyran furan acetogenin mimics targeting the trypanosomatid F1 component of ATP synthase

  Zacharova, M. K., Tulloch, L. B., Gould, E. R., Fraser, A. L., King, E. F., Menzies, S. K., Smith, T. K. & Florence, G. J., 1 Sep 2019, In: European Journal of Organic Chemistry. 2019, 31-32, p. 5434-5440 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  2 Citations (Scopus)

  113 Downloads (Pure)

• Structure and regulation of enzymes for the degradation and resynthesis of glycogen

  Cohen, P., Antoniw, J. F., Nimmo, H. G. & Proud, C. G., 1 Dec 1975, In: Biochemical Society Transactions. 3, 6, p. 849-854 6 p.

  Research output: Contribution to journal › Article › peer-review
  11 Citations (Scopus)

• Structure and reactivity of Trypanosoma brucei pteridine reductase: inhibition by the archetypal antifolate methotrexate

  Dawson, A., Gibellini, F., Sienkiewicz, N., Tulloch, L. B., Fyfe, P. K., McLuskey, K., Fairlamb, A. H. & Hunter, W. N., Sep 2006, In: Molecular Microbiology. 61, 6, p. 1457-1468 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  53 Citations (Scopus)

  87 Downloads (Pure)

• Structure and reactivity of LpxD, the N-acyltransferase of lipid A biosynthesis

  Buetow, L., Smith, T. K., Dawson, A., Fyffe, S., Hunter, W. N. & Thornton, J. M. (ed.), 2007, In: Proceedings of the National Academy of Sciences of the United States of America. 104, 11, p. 4321-4326 6 p.

  Research output: Contribution to journal › Article › peer-review
  60 Citations (Scopus)

• Structure and reactivity of hydroxypropylphosphonic acid epoxidase in fosfomycin biosynthesis by a cation- and flavin-dependent mechanism

  McLuskey, K., Cameron, S., Hammerschmidt, F., Hunter, W. N. & Davies, D. R. (ed.), Oct 2005, In: Proceedings of the National Academy of Sciences of the United States of America. 102, 40, p. 14221-14226 6 p.

  Research output: Contribution to journal › Article › peer-review
  30 Citations (Scopus)

• Structure and reactivity of Bacillus subtilis MenD catalyzing the first committed step in menaquinone biosynthesis

  Dawson, A., Chen, M., Fyfe, P. K., Guo, Z. & Hunter, W. N., 13 Aug 2010, In: Journal of Molecular Biology. 401, 2, p. 253-264 12 p.

  Research output: Contribution to journal › Article › peer-review
  28 Citations (Scopus)

• Structure and optical properties of Cu_xO- and Cu_xSe-doped sol-gel silica glasses

  Gurin, V. S., Alexeenko, A. A., Yumashev, K. V., Prokoshin, P. V., Zolotovskaya, S. A. & Zhavnerko, G. A., 15 Dec 2003, In: Materials Science and Engineering: C. 23, 6-8, p. 1063-1067 5 p.

  Research output: Contribution to journal › Article › peer-review
  27 Citations (Scopus)

• Structure and operation of the DNA-translocating type I DNA restriction enzymes

  Kennaway, C. K., Taylor, J. E., Song, C. F., Potrzebowski, W., Nicholson, W., White, J. H., Swiderska, A., Obarska-Kosinska, A., Callow, P., Cooper, L. P., Roberts, G. A., Artero, J-B., Bujnicki, J. M., Trinick, J., Kneale, G. G. & Dryden, D. T. F., 2012, In: Genes and Development. 26, p. 92-104 13 p.

  Research output: Contribution to journal › Article › peer-review
  44 Citations (Scopus)

• Structure and metal-dependent mechanism of peptidoglycan deacetylase, a streptococcal virulence factor

  Blair, D. E., Schuettelkopf, A. W., MacRae, J. I., van Aalten, D. M. F. & Thornton, J. (ed.), 2005, In: Proceedings of the National Academy of Sciences of the United States of America. 102, 43, p. 15429-15434 6 p.

  Research output: Contribution to journal › Article › peer-review
  165 Citations (Scopus)

• Structure and mechanism of the type I-G CRISPR effector

  Shangguan, Q., Graham, S., Sundaramoorthy, R. & White, M. F., 28 Oct 2022, In: Nucleic Acids Research. 50, 19, p. 11214-11228 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  8 Downloads (Pure)

• Structure and mechanism of chitin deacetylase from the fungal pathogen colletotrichum lindemuthianum

  Blair, D. E., Hekmat, O., Schüttelkopf, A. W., Shrestha, B., Tokuyasu, K., Withers, S. G. & van Aalten, D. M. F., 8 Aug 2006, In: Biochemistry. 45, 31, p. 9416-9426 11 p.

  Research output: Contribution to journal › Article › peer-review
  124 Citations (Scopus)

• Structure and mechanism of a methyl transferase ribozyme

  Deng, J., Wilson, T. J., Wang, J., Peng, X., Li, M., Lin, X., Liao, W., Lilley, D. M. J. & Huang, L., May 2022, In: Nature Chemical Biology. 18, p. 556-564 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  3 Citations (Scopus)

  8 Downloads (Pure)