Search concepts
|
Selected filters |
Search results
-
2020
Activation of transcription factor Nrf2 to counteract mitochondrial dysfunction in Parkinson’s disease
Bento-Pereira, C. & Dinkova-Kostova, A., 18 Jul 2020, In: Medicinal Research Reviews. 18 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile -
Application of the in vivo oxidative stress reporter Hmox1 as mechanistic biomarker of arsenic toxicity
Inesta-Vaquera, F., Navasumrit, P., Henderson, C. J., Frangova, T. G., Honda, T., Dinkova-Kostova, A. T., Ruchirawat, M. & Wolf, C. R., 9 Nov 2020, In: Environmental Pollution. 12 p., 116053.Research output: Contribution to journal › Article › peer-review
-
Biomarker Exploration in Human Peripheral Blood Mononuclear Cells for Monitoring Sulforaphane Treatment Responses in Autism Spectrum Disorder
Liu, H., Zimmerman, A. W., Singh, K., Connors, S. L., Diggins, E., Stephenson, K. K., Dinkova-Kostova, A. & Fahey, J. W., 2 Apr 2020, In: Scientific Reports. 10, 11 p., 5822.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)42 Downloads (Pure) -
Can activation of NRF2 be a strategy against COVID-19?
Cuadrado, A., Pajares, M., Benito, C., Jiménez-Villegas, J., Escoll, M., Fernández-Ginés, R., Garcia Yagüe, A. J., Lastra, D., Manda, G., Rojo, A. I. & Dinkova-Kostova, A. T., Sep 2020, In: Trends in Pharmacological Sciences. 41, 9, p. 598-610 13 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile16 Citations (Scopus)120 Downloads (Pure) -
Downregulation of Keap1 confers features of a fasted metabolic state
Knatko, E. V., Tatham, M. H., Zhang, Y., Castro, C., Higgins, M., Dayalan Naidu, S., Leonardi, C., de la Vega, L., Honda, T., Griffin, J. L., Hay, R. T. & Dinkova-Kostova, A. T., 23 Oct 2020, In: iScience. 23, 10, 48 p., 101638.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
High NRF2 Levels Correlate with Poor Prognosis in Colorectal Cancer Patients and with Sensitivity to the Kinase Inhibitor AT9283 In Vitro
Torrente Fernandez, L., Maan, G., Rezig, A. O., Quinn, J., Jackson, A., Grilli, A., Casares, L., Zhang, Y., Kulesskiy, E., Saarela, J., Bicciato, S., Edwards, J., Dinkova-Kostova, A. & de la Vega, L., Oct 2020, In: Biomolecules. 10, 10, 16 p., 1365.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)12 Downloads (Pure) -
Isomeric O-methyl cannabidiolquinones with dual BACH1/NRF2 activity
Casares Perez, L., Unciti-Broceta, J. D., Prados, M. E., Caprioglio, D., Mattoteia, D., Higgins, M., Apendino, G., Dinkova-Kostova, A. T., Muñoz, E. & de la Vega, L., Oct 2020, In: Redox Biology. 37, p. 1-10 10 p., 101689.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)22 Downloads (Pure) -
KEAP1, a cysteine-based sensor and a drug target for the prevention and treatment of chronic disease: KEAP1, a sensor and a drug target
Dayalan Naidu, S. & Dinkova-Kostova, A., Jun 2020, In: Open Biology. 10, 6, p. 1-13 13 p., 200105.Research output: Contribution to journal › Review article › peer-review
Open AccessFile5 Citations (Scopus)20 Downloads (Pure) -
Measuring Changes in Keap1‐Nrf2 Protein Complex Conformation in Individual Cells by FLIM‐FRET
Dikovskaya, D. & Dinkova-Kostova, A., Sep 2020, In: Current Protocols in Toxicology. 85, 1, p. 1-34 34 p., e96.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
NRF2 and the Ambiguous Consequences of Its Activation during Initiation and the Subsequent Stages of Tumourigenesis
Robertson, H., Dinkova-Kostova, A. T. & Hayes, J. D., 2 Dec 2020, In: Cancers. 12, 12, 48 p., 3609.Research output: Contribution to journal › Review article › peer-review
Open AccessFile -
Nrf2 is activated by disruption of mitochondrial thiol homeostasis but not by enhanced mitochondrial superoxide production
Cvetko, F., Caldwell, S. T., Higgins, M., Suzuki, T., Yamamoto, M., Prag, H. A., Hartley, R. C., Dinkova-Kostova, A. & Murphy, M. P., 9 Dec 2020, In: Journal of Biological Chemistry.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Obesity and NRF2-mediated cytoprotection: Where is the missing link?
Vasileva, L. V., Savova, M. S., Amirova, K. M., Dinkova-Kostova, A. & Georgiev, M. I., Jun 2020, In: Pharmacological Research. 156, p. 1-9 9 p., 104760.Research output: Contribution to journal › Review article › peer-review
Open AccessFile12 Citations (Scopus)127 Downloads (Pure) -
Oxidative Stress in Cancer
Hayes, J., Dinkova-Kostova, A. & Tew, K. D., 10 Aug 2020, In: Cancer Cell. 38, 31 p.Research output: Contribution to journal › Review article › peer-review
20 Citations (Scopus) -
Radiomodulatory effect of a non-electrophilic NQO1 inducer identified in a screen of new 6, 8-diiodoquinazolin-4(3H)-ones carrying a sulfonamide moiety
Soliman, A. M., Karam, H. M., Mekkawy, M. H., Higgins, M., Dinkova-Kostova, A. & Ghorab, M. M., 15 Aug 2020, In: European Journal of Medicinal Chemistry. 200, 12 p., 112467.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)28 Downloads (Pure) -
Sulfoxythiocarbamate S-4 inhibits HSP90 in human cutaneous squamous cell carcinoma cells
Zhang, Y., VanHecke, G. C., Ahn, Y-H., Proby, C. M. & Dinkova-Kostova, A. T., 15 Dec 2020, In: European Journal of Pharmacology. 889, 9 p., 173609.Research output: Contribution to journal › Article › peer-review
-
The chemopreventive power of isothiocyanates
Naidu, S. D., Brodziak-Jarosz, L., Gerhäuser, C. & Dinkova-Kostova, A. T., 2020, Natural Products for Cancer Chemoprevention: Single Compounds and Combinations. Pezzuto, J. M. & Vang, O. (eds.). Switzerland: Springer , p. 271-318 48 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter
-
The stress-responsive kinase DYRK2 activates heat shock factor 1 promoting resistance to proteotoxic stress
Moreno Dorta, R., Banerjee, S., Jackson, A. W., Quinn, J., Baillie, G., Dixon, J. E., Dinkova-Kostova, A., Edwards, J. & de la Vega, L., 2 Dec 2020, In: Cell Death & Differentiation. 16 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
2019
Broccoli or Sulforaphane: Is It the Source or Dose That Matters?
Yagishita, Y., Fahey, J. W., Dinkova-Kostova, A. T. & Kensler, T. W., Oct 2019, In: Molecules and Cells. 24, 19, p. 1-38 38 p., 3593.Research output: Contribution to journal › Review article › peer-review
Open AccessFile31 Citations (Scopus)282 Downloads (Pure) -
Investigation into the use of histone deacetylase inhibitor MS-275 as a topical agent for the prevention and treatment of cutaneous squamous cell carcinoma in an SKH-1 hairless mouse model
Kalin, J. H., Eroglu, A., Liu, H., Holtzclaw, W. D., Leigh, I., Proby, C. M., Fahey, J. W., Cole, P. A. & Dinkova-Kostova, A. T., 13 Mar 2019, In: PLoS ONE. 14, 3, p. 1-13 13 p., e0213095.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)134 Downloads (Pure) -
Measuring the Interaction of Transcription Factor Nrf2 with Its Negative Regulator Keap1 in Single Live Cells by an Improved FRET/FLIM Analysis
Dikovskaya, D., Appleton, P., Bento-Pereira, C. & Dinkova-Kostova, A., 18 Mar 2019, In: Chemical Research in Toxicology. 32, 3, p. 500-512 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)157 Downloads (Pure) -
The isothiocyanate sulforaphane inhibits mTOR in an NRF2-independent manner
Zhang, Y., Gilmour, A., Ahn, Y-H., de la Vega, L. & Dinkova-Kostova, A., 5 Aug 2019, In: Phytomedicine. 153062.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)117 Downloads (Pure) -
Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases
Cuadrado, A., Rojo, A. I., Wells, G., Hayes, J., Cousin, S. P., Rumsey, W. L., Attucks, O. C., Franklin, S., Levonen, A-L., Kensler, T. W. & Dinkova-Kostova, A., Apr 2019, In: Nature Reviews Drug Discovery. 18, 4, p. 295-317 23 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile215 Citations (Scopus)251 Downloads (Pure) -
2013
Chemoprotection Against Cancer by Isothiocyanates: A Focus on the Animal Models and the Protective Mechanisms
Dinkova-Kostova, A. T., 2013, Natural Products in Cancer Prevention and Therapy. Pezzuto, J. M. & Suh, N. (eds.). Berlin: Springer , p. 179-201 23 p. (Topics in Current Chemistry; vol. 329).Research output: Chapter in Book/Report/Conference proceeding › Chapter
32 Citations (Scopus) -
Diffusion dynamics of the Keap1-Cullin3 interaction in single live cells
Baird, L. & Dinkova-Kostova, A. T., 2013, In: Biochemical and Biophysical Research Communications. 433, 1, p. 58-65 8 p.Research output: Contribution to journal › Article › peer-review
34 Citations (Scopus) -
NAD(P)H: Quinone oxidoreductase 1 inducer activity of some Saudi Arabian medicinal plants
Shahat, A. A., Alsaid, M. S., Alyahya, M. A., Higgins, M. & Dinkova-Kostova, A. T., Apr 2013, In: Planta Medica. 79, 6, p. 459-464 6 p.Research output: Contribution to journal › Article › peer-review
11 Citations (Scopus) -
Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration
Holmström, K. M., Baird, L., Zhang, Y., Hargreaves, I., Chalasani, A., Land, J. M., Stanyer, L., Yamamoto, M., Dinkova-Kostova, A. T. & Abramov, A. Y., 15 Aug 2013, In: Open Biology. 2, 8, p. 761-770 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile206 Citations (Scopus)215 Downloads (Pure) -
Regulatory flexibility in the Nrf2-mediated stress response is conferred by conformational cycling of the Keap1-Nrf2 protein complex
Baird, L., Llères, D., Swift, S. & Dinkova-Kostova, A. T., 17 Sep 2013, In: Proceedings of the National Academy of Sciences of the United States of America. 110, 38, p. 15259-15264 6 p.Research output: Contribution to journal › Article › peer-review
171 Citations (Scopus) -
Synthesis and biological evaluation of biotin conjugates of (±)-(4bS,8aR,10aS)-10a-ethynyl-4b,8,8-trimethyl-3,7-dioxo-3,4b,7,8,8a,9,10,10a-octahydro-phenanthrene-2,6-dicarbonitrile, an activator of the Keap1/Nrf2/ARE pathway, for the isolation of its protein targets
Saito, A., Higgins, M., Zheng, S., Li, W., Ojima, I., Dinkova-Kostova, A. T. & Honda, T., 15 Oct 2013, In: Bioorganic & Medicinal Chemistry Letters. 23, 20, p. 5540-5543 4 p.Research output: Contribution to journal › Article › peer-review
4 Citations (Scopus) -
2011
Effects of chemoprotective agent HBB-2 on cell survival in SH-SY5Y neuroblastoma cells
Scuto, M. C., Cavallaro, M. M., Luca, M., Cornelius, C., Cambria, M. T., Rizza, S., Salinaro, A. T., Dinkova-Kostova, A. & Calabrese, V., 2011, In: FEBS Journal. 278, S1, p. 268 1 p., P14.37.Research output: Contribution to journal › Meeting abstract › peer-review
-
HSF1-Dependent Upregulation of Hsp70 by Sulfhydryl-Reactive Inducers of the KEAP1/NRF2/ARE Pathway
Zhang, Y., Ahn, Y-H., Benjamin, I. J., Honda, T., Hicks, R. J., Calabrese, V., Cole, P. A. & Dinkova-Kostova, A. T., 23 Nov 2011, In: Chemistry & Biology. 18, 11, p. 1355-1361 7 p.Research output: Contribution to journal › Article › peer-review
70 Citations (Scopus) -
Induction of the Keapl/Nrf2/ARE pathway by oxidizable diphenols
Dinkova-Kostova, A. T. & Wang, X. J., 30 Jun 2011, In: Chemico-Biological Interactions. 192, 1-2, p. 101-106 6 p.Research output: Contribution to journal › Article › peer-review
49 Citations (Scopus) -
Oral Azathioprine Leads to Higher Incorporation of 6-Thioguanine in DNA of Skin than Liver: The Protective Role of the Keap1/Nrf2/ARE Pathway
Kalra, S., Zhang, Y., Knatko, E. V., Finlayson, S., Yamamoto, M. & Dinkova-Kostova, A. T., Oct 2011, In: Cancer Prevention Research. 4, 10, p. 1665-1674 10 p.Research output: Contribution to journal › Article › peer-review
13 Citations (Scopus) -
Synthesis and biological evaluation of 1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]-4-ethynylimidazole. A novel and highly potent anti-inflammatory and cytoprotective agent
Honda, T., Dinkova-Kostova, A. T., David, E., Padegimas, E. M., Sundararajan, C., Visnick, M., Bumeister, R. & Wigley, W. C., 15 Apr 2011, In: Bioorganic & Medicinal Chemistry Letters. 21, 8, p. 2188-2191 4 p.Research output: Contribution to journal › Article › peer-review
18 Citations (Scopus) -
The cytoprotective role of the Keap1-Nrf2 pathway
Baird, L. & Dinkova-Kostova, A. T., Apr 2011, In: Archives of Toxicology. 85, 4, p. 241-272 32 p.Research output: Contribution to journal › Review article › peer-review
603 Citations (Scopus)