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Author

  • Albena Dinkova-Kostova

Whole-exome sequencing validates a preclinical mouse model for the prevention and treatment of cutaneous squamous cell carcinoma

Knatko, E. V., Praslicka, B., Higgins, M., Evans, A., Purdie, K. J., Harwood, C. A., Proby, C. M., Ooi, A. & Dinkova-Kostova, A. T., Jan 2017, In : Cancer Prevention Research. 10, 1, p. 67-75 9 p.

Research output: Contribution to journalArticle

Open Access
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7 Citations (Scopus)
138 Downloads (Pure)

Transcription factors NRF2 and HSF1 have opposing functions in autophagy

Dayalan Naidu, S., Dikovskaya, D., Gaurilcikaite, E., Knatko, E., Healy, Z. R., Mohan, H., Koh, G., Laurell, A., Ball, G., Olagnier, D., de la Vega, L., Ganley, I., Talalay, P. & Dinkova-Kostova, A., 8 Sep 2017, In : Scientific Reports. 7, p. 1-12 12 p., 11023.

Research output: Contribution to journalArticle

Open Access
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23 Citations (Scopus)
198 Downloads (Pure)

Transcription factors Hsf1 and Nrf2 engage in crosstalk for cytoprotection

Dayalan Naidu, S., Kostov, R. V. & Dinkova-Kostova, A. T., Jan 2015, In : Trends in Pharmacological Sciences. 36, 1, p. 6-14 9 p.

Research output: Contribution to journalArticle

57 Citations (Scopus)

The spatiotemporal regulation of the Keap1-Nrf2 pathway and its importance in cellular bioenergetics

Dinkova-Kostova, A. T., Baird, L., Holmström, K. M., Meyer, C. J. & Abramov, A. Y., Aug 2015, In : Biochemical Society Transactions. 43, 4, p. 602-610 9 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)

The role of Nrf2 signaling in counteracting neurodegenerative diseases

Dinkova-Kostova, A. T., Kostov, R. V. & Kazantsev, A. G., 1 Oct 2018, In : FEBS Journal. 285, 19, p. 3576-3590 15 p.

Research output: Contribution to journalReview article

Open Access
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54 Citations (Scopus)
235 Downloads (Pure)

Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases

Cuadrado, A., Rojo, A. I., Wells, G., Hayes, J., Cousin, S. P., Rumsey, W. L., Attucks, O. C., Franklin, S., Levonen, A-L., Kensler, T. W. & Dinkova-Kostova, A., Apr 2019, In : Nature Reviews Drug Discovery. 18, 4, p. 295-317 23 p.

Research output: Contribution to journalReview article

Open Access
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133 Citations (Scopus)
203 Downloads (Pure)
757 Citations (Scopus)

The multifaceted role of sulforaphane in protection against uv radiation-mediated skin damage

Benedict, A. L., Knatko, E. V., Kostov, R. V., Zhang, Y., Higgins, M., Kalra, S., Fahey, J. W., Ibbotson, S. H., Proby, C. M., Talalay, P. & Dinkova-Kostova, A. T., Jan 2016, Broccoli: Cultivation, Nutritional Properties and Effects on Health. Nova Science Publishers, p. 185-208 24 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

The multifaceted role of Nrf2 in mitochondrial function

Holmström, K. M., Kostov, R. V. & Dinkova-Kostova, A. T., Dec 2016, In : Current Opinion in Toxicology. 1, p. 80-91 12 p.

Research output: Contribution to journalReview article

Open Access
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105 Citations (Scopus)
187 Downloads (Pure)

The isothiocyanate sulforaphane inhibits mTOR in an NRF2-independent manner

Zhang, Y., Gilmour, A., Ahn, Y-H., de la Vega, L. & Dinkova-Kostova, A., 5 Aug 2019, In : Phytomedicine. 153062.

Research output: Contribution to journalArticle

Open Access
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1 Citation (Scopus)
97 Downloads (Pure)

The emerging role of Nrf2 in mitochondrial function

Dinkova-Kostova, A. T. & Abramov, A. Y., Nov 2015, In : Free Radical Biology and Medicine. 88, Part B, p. 179-188 10 p.

Research output: Contribution to journalArticle

Open Access
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289 Citations (Scopus)
259 Downloads (Pure)

The cytoprotective role of the Keap1-Nrf2 pathway

Baird, L. & Dinkova-Kostova, A. T., Apr 2011, In : Archives of Toxicology. 85, 4, p. 241-272 32 p.

Research output: Contribution to journalReview article

565 Citations (Scopus)

The chemopreventive power of isothiocyanates

Naidu, S. D., Brodziak-Jarosz, L., Gerhäuser, C. & Dinkova-Kostova, A. T., 2020, Natural Products for Cancer Chemoprevention: Single Compounds and Combinations. Pezzuto, J. M. & Vang, O. (eds.). Switzerland: Springer , p. 271-318 48 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors

Kalin, J. H., Wu, M., Gomez, A. V., Song, Y., Das, J., Hayward, D., Adejola, N., Wu, M., Panova, I., Chung, H. J., Kim, E., Roberts, H. J., Roberts, J. M., Prusevich, P., Jeliazkov, J. R., Burman, S. S. R., Fairall, L., Milano, C., Eroglu, A., Proby, C. & 14 others, Dinkova-Kostova, A., Hancock, W. W., Gray, J. J., Bradner, J. E., Valente, S., Mai, A., Anders, N. M., Rudek, M. A., Hu, Y., Ryu, B., Schwabe, J. W. R., Mattevi, A., Alani, R. M. & Cole, P. A., 4 Jan 2018, In : Nature Communications. 9, 1, p. 1-13 13 p., 53.

Research output: Contribution to journalArticle

Open Access
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61 Citations (Scopus)
166 Downloads (Pure)

Synthesis and NAD(P)H: Quinone oxidoreductase 1 inducer activity of acetamide and pyridine-3-carbonitrile derivatives

Ghorab, M. M., Shahat, A. A., Alsaid, M. S., Higgins, M., Dinkova-Kostova, A. T. & Naser, A. A., 2016, In : Biomedical Research. 27, 4, p. 1045-1048 4 p.

Research output: Contribution to journalArticle

Open Access
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39 Downloads (Pure)
Open Access
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3 Citations (Scopus)
177 Downloads (Pure)

Synthesis and biological evaluation of 1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]-4-ethynylimidazole. A novel and highly potent anti-inflammatory and cytoprotective agent

Honda, T., Dinkova-Kostova, A. T., David, E., Padegimas, E. M., Sundararajan, C., Visnick, M., Bumeister, R. & Wigley, W. C., 15 Apr 2011, In : Bioorganic & Medicinal Chemistry Letters. 21, 8, p. 2188-2191 4 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)
7 Citations (Scopus)

Synthesis, molecular modeling and NAD(P)H: quinone oxidoreductase 1 inducer activity of novel 2-phenylquinazolin-4-amine derivatives

Ghorab, M. M., Alsaid, M. S., Higgins, M., Dinkova-Kostova, A. T., Shahat, A. A., Elghazawy, N. H. & Arafa, R. K., Apr 2016, In : Journal of Enzyme Inhibition and Medicinal Chemistry. 31, 6, p. 1612-1618 7 p.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
138 Downloads (Pure)
93 Citations (Scopus)
243 Downloads (Pure)

Sulphoxythiocarbamates modify cysteine residues in HSP90 causing degradation of client proteins and inhibition of cancer cell proliferation

Zhang, Y., Dayalan Naidu, S., Samarasinghe, K., Van Hecke, G. C., Pheely, A., Boronina, T. N., Cole, R. N., Benjamin, I. J., Cole, P. A., Ahn, Y-H. & Dinkova-Kostova, A. T., 7 Jan 2014, In : British Journal of Cancer. 110, 1, p. 71-82 12 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

SIRT2- and NRF2-Targeting Thiazole-Containing Compound with Therapeutic Activity in Huntington's Disease Models

Quinti, L., Casale, M., Moniot, S., Pais, T. F., Van Kanegan, M. J., Kaltenbach, L. S., Pallos, J., Lim, R. G., Naidu, S. D., Runne, H., Meisel, L., Rauf, N. A., Leyfer, D., Maxwell, M. M., Saiah, E., Landers, J. E., Luthi-Carter, R., Abagyan, R., Dinkova-Kostova, A. T., Steegborn, C. & 4 others, Marsh, J. L., Lo, D. C., Thompson, L. M. & Kazantsev, A. G., 21 Jul 2016, In : Cell Chemical Biology. 23, 7, p. 849-861 13 p.

Research output: Contribution to journalArticle

Open Access
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34 Citations (Scopus)
177 Downloads (Pure)

Semisynthetic flavonoid 7-O-galloylquercetin activates Nrf2 and induces Nrf2-dependent gene expression in RAW264.7 and Hepa1c1c7 cells

Roubalová, L., Biedermann, D., Papoušková, B., Vacek, J., Kuzma, M., Křen, V., Ulrichová, J., Dinkova-Kostova, A. T. & Vrba, J., 25 Dec 2016, In : Chemico-Biological Interactions. 260, p. 58-66 9 p.

Research output: Contribution to journalArticle

Open Access
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5 Citations (Scopus)
149 Downloads (Pure)

Rhodiola rosea L. from golden root to green cell factories

Marchev, A. S., Dinkova-Kostova, A. T., György, Z., Mirmazloum, I., Aneva, I. Y. & Georgiev, M. I., Aug 2016, In : Phytochemistry Reviews. 15, 4, p. 515-536 22 p.

Research output: Contribution to journalArticle

Open Access
File
16 Citations (Scopus)
379 Downloads (Pure)

Regulation of the mammalian heat shock factor 1

Dayalan Naidu, S. & Dinkova-Kostova, A. T., Jun 2017, In : FEBS Journal. 284, 11, p. 1606-1627 22 p.

Research output: Contribution to journalReview article

Open Access
File
50 Citations (Scopus)
234 Downloads (Pure)

Regulation of the CNC-bZIP transcription factor Nrf2 by Keap1 and the axis between GSK-3 and β-TrCP

Hayes, J. D., Ebisine, K., Sharma, R. S., Chowdhry, S., Dinkova-Kostova, A. T. & Sutherland, C., Dec 2016, In : Current Opinion in Toxicology. 1, p. 92-103 12 p.

Research output: Contribution to journalReview article

Open Access
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9 Citations (Scopus)
314 Downloads (Pure)

Radiomodulatory effect of a non-electrophilic NQO1 inducer identified in a screen of new 6, 8-diiodoquinazolin-4(3H)-ones carrying a sulfonamide moiety

Soliman, A. M., Karam, H. M., Mekkawy, M. H., Higgins, M., Dinkova-Kostova, A. & Ghorab, M. M., 18 May 2020, In : European Journal of Medicinal Chemistry. 200, 12 p., 112467.

Research output: Contribution to journalArticle

Open Access
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2 Downloads (Pure)

Potency of extracts from selected Egyptian plants as inducers of the Nrf2-dependent chemopreventive enzyme NQO1

Hamed, A. R., Hegazy, M-E. F., Higgins, M., Mohamed, T. A., Abdel-Azim, N. S., Pare, P. W. & Dinkova-Kostova, A. T., Jul 2016, In : Journal of Natural Medicines. 70, 3, p. 683-688 6 p.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
204 Downloads (Pure)

Phenethyl isothiocyanate, a dual activator of transcription factors NRF2 and HSF1

Dayalan Naidu, S., Suzuki, T., Yamamoto, M., Fahey, J. W. & Dinkova-Kostova, A., 1 Sep 2018, In : Molecular Nutrition & Food Research. 62, 18, p. e1700908 9 p., 1700908.

Research output: Contribution to journalReview article

Open Access
File
9 Citations (Scopus)
153 Downloads (Pure)
Open Access
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9 Citations (Scopus)
141 Downloads (Pure)

Pathogenic p62/SQSTM1 mutations impair energy metabolism through limitation of mitochondrial substrates

Bartolome, F., Esteras, N., Martin-Requero, A., Boutoleau-Bretonniere, C., Vercelletto, M., Gabelle, A., Le Ber, I., Honda, T., Dinkova-Kostova, A. T., Hardy, J., Carro, E. & Abramov, A. Y., 10 May 2017, In : Scientific Reports. 7, p. 1-14 14 p., 1666.

Research output: Contribution to journalArticle

Open Access
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25 Citations (Scopus)
284 Downloads (Pure)

Oxidative stress management in the hair follicle: Could targeting NRF2 counter age-related hair disorders and beyond?

Jadkauskaite, L., Coulombe, P. A., Schäfer, M., Dinkova-Kostova, A. T., Paus, R. & Haslam, I. S., 27 Jul 2017, In : BioEssays. 39, 8, p. 1-9 9 p., 1700029.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Oxidative Stress in Cancer

Hayes, J., Dinkova-Kostova, A. & Tew, K. D., 9 Jul 2020, In : Cancer Cell. 38, 31 p.

Research output: Contribution to journalReview article

Oxidative stress and chronic inflammation in osteoarthritis: can Nrf2 counteract these partners in crime?

Marchev, A. S., Dimitrova, P. A., Burns, A. J., Kostov, R., Dinkova-Kostova, A. & Georgiev, M. I., 11 Sep 2017, In : Annals of the New York Academy of Sciences. 1401, p. 114-135 22 p.

Research output: Contribution to journalReview article

Open Access
File
49 Citations (Scopus)
398 Downloads (Pure)
13 Citations (Scopus)
Open Access
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8 Citations (Scopus)
200 Downloads (Pure)

Obesity and NRF2-mediated cytoprotection: Where is the missing link?

Vasileva, L. V., Savova, M. S., Amirova, K. M., Dinkova-Kostova, A. & Georgiev, M. I., Jun 2020, In : Pharmacological Research. 156, p. 1-9 9 p., 104760.

Research output: Contribution to journalReview article

Open Access
File
5 Citations (Scopus)
57 Downloads (Pure)

Nrf2 regulates ROS production by mitochondria and NADPH oxidase

Kovac, S., Angelova, P. R., Holmström, K. M., Zhang, Y., Dinkova-Kostova, A. T. & Abramov, A. Y., Apr 2015, In : Biochimica et Biophysica Acta: General Subjects. 1850, 4, p. 794-801 8 p.

Research output: Contribution to journalArticle

196 Citations (Scopus)
Open Access
File
15 Citations (Scopus)
137 Downloads (Pure)

NRF2 as an emerging therapeutic target

Copple, I. M., Dinkova-Kostova, A. T., Kensler, T. W., Liby, K. T. & Wigley, W. C., 31 Jan 2017, In : Oxidative Medicine and Cellular Longevity. 2017, p. 1-2 2 p., 8165458.

Research output: Contribution to journalEditorial

Open Access
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19 Citations (Scopus)
176 Downloads (Pure)

Nrf2 affects the efficiency of mitochondrial fatty acid oxidation

Ludtmann, M. H. R., Angelova, P. R., Zhang, Y., Abramov, A. Y. & Dinkova-Kostova, A. T., 1 Feb 2014, In : Biochemical Journal. 457, 3, p. 415-424 10 p.

Research output: Contribution to journalArticle

98 Citations (Scopus)

Nrf2 activation protects against solar-simulated ultraviolet radiation in mice and humans

Knatko, E. V., Ibbotson, S. H., Zhang, Y., Higgins, M., Fahey, J. W., Talalay, P., Dawe, R. S., Ferguson, J., Huang, J. T-J., Clarke, R., Zheng, S., Saito, A., Kalra, S., Benedict, A. L., Honda, T., Proby, C. M. & Dinkova-Kostova, A. T., Jun 2015, In : Cancer Prevention Research. 8, 6, p. 475-486 12 p.

Research output: Contribution to journalArticle

48 Citations (Scopus)

Nrf2 activation in the treatment of neurodegenerative diseases: A focus on its role in mitochondrial bioenergetics and function

Esteras, N., Dinkova-Kostova, A. T. & Abramov, A. Y., May 2016, In : Biological Chemistry. 397, 5, p. 383-400 18 p.

Research output: Contribution to journalArticle

Open Access
File
56 Citations (Scopus)
244 Downloads (Pure)

Novel Thioureido Derivatives Carrying Thione and Sulfonamide Moieties Induce the Cytoprotective Enzyme NAD(P)H:Quione Oxidoreductase 1: Quinone oxidoreductase 1

Ghorab, M. M., Higgins, M., Dinkova-Kostova, A. T., Alsaid, M. S. & Shahat, A. A., 1 Dec 2014, In : Asian Journal of Chemistry. 26, 24, p. 8501-8504 4 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

New monocyclic, bicyclic, and tricyclic ethynylcyanodienones as activators of the Keap1/Nrf2/ARE pathway and inhibitors of inducible nitric oxide synthase

Li, W., Zheng, S., Higgins, M., Morra, R. P., Mendis, A. T., Chien, C-W., Ojima, I., Mierke, D. F., Dinkova-Kostova, A. T. & Honda, T., 11 Jun 2015, In : Journal of Medicinal Chemistry. 58, 11, p. 4738-4748 11 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

NAD(P)H: quinone oxidoreductase 1 inducer activity of some novel anilinoquinazoline derivatives

Ghorab, M. M., Alsaid, M. S., Higgins, M., Dinkova-Kostova, A. T., Shahat, A. A., Elghazawy, N. H. & Arafa, R. K., 8 Aug 2016, In : Drug Design, Development and Therapy. 10, p. 2515-2524 10 p.

Research output: Contribution to journalArticle

Open Access
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3 Citations (Scopus)
154 Downloads (Pure)

NAD(P)H: Quinone oxidoreductase 1 inducer activity of novel 4-aminoquinazoline derivatives

Ghorab, M. M., Alsaid, M. S., El-Gazzar, M. G., Higgins, M., Dinkova-Kostova, A. T. & Shahat, A. A., 2016, In : Journal of Enzyme Inhibition and Medicinal Chemistry. 31, 6, p. 1369-1374 7 p.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
152 Downloads (Pure)

NAD(P)H: Quinone oxidoreductase 1 inducer activity of some enaminone derivatives

Alsaid, M. S., Ghorab, M. M., Higgins, M., Dinkova-Kostova, A. T. & Shahat, A. A., 2015, In : Biomedical Research. 26, 1, p. 7-12 6 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Monitoring Keap1-Nrf2 interactions in single live cells

Baird, L., Swift, S., Llères, D. & Dinkova-Kostova, A. T., 1 Nov 2014, In : Biotechnology Advances. 32, 6, p. 1133-1144 12 p.

Research output: Contribution to journalArticle

Open Access
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77 Citations (Scopus)
346 Downloads (Pure)