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• Design, synthesis, and evaluation of triazole derivatives that induce Nrf2 dependent gene products and inhibit the Keap1-Nrf2 protein-protein interaction

  Bertrand, H. C., Schaap, M., Baird, L., Georgakopoulos, N. D., Fowkes, A., Thiollier, C., Kachi, H., Dinkova-Kostova, A. T. & Wells, G., 24 Sep 2015, In: Journal of Medicinal Chemistry. 58, 18, p. 7186-7194 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Triazoles
  • 1,4-diphenyl-1,2,3-triazole
  • Genes
  • Proteins
  • Metabolic Networks and Pathways
  71 Citations (Scopus)

• Dual regulation of transcription factor Nrf2 by Keap1 and by the combined actions of β-TrCP and GSK-3

  Hayes, J. D., Chowdhry, S., Dinkova-Kostova, A. T. & Sutherland, C., Aug 2015, In: Biochemical Society Transactions. 43, 4, p. 611-620 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Kelch-Like ECH-Associated Protein 1
  • NF-E2 Transcription Factor
  • NF-E2-Related Factor 2
  • Glycogen Synthase Kinase 3
  • Phosphorylation
  66 Citations (Scopus)

• Effects of chemoprotective agent HBB-2 on cell survival in SH-SY5Y neuroblastoma cells

  Scuto, M. C., Cavallaro, M. M., Luca, M., Cornelius, C., Cambria, M. T., Rizza, S., Salinaro, A. T., Dinkova-Kostova, A. & Calabrese, V., 2011, In: FEBS Journal. 278, S1, p. 268 1 p., P14.37.

  Research output: Contribution to journal › Meeting abstract › peer-review

• HSF1-Dependent Upregulation of Hsp70 by Sulfhydryl-Reactive Inducers of the KEAP1/NRF2/ARE Pathway

  Zhang, Y., Ahn, Y-H., Benjamin, I. J., Honda, T., Hicks, R. J., Calabrese, V., Cole, P. A. & Dinkova-Kostova, A. T., 23 Nov 2011, In: Chemistry & Biology. 18, 11, p. 1355-1361 7 p.

  Research output: Contribution to journal › Article › peer-review
  70 Citations (Scopus)

• Induction of the Keapl/Nrf2/ARE pathway by oxidizable diphenols

  Dinkova-Kostova, A. T. & Wang, X. J., 30 Jun 2011, In: Chemico-Biological Interactions. 192, 1-2, p. 101-106 6 p.

  Research output: Contribution to journal › Article › peer-review
  50 Citations (Scopus)

• Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease

  Tebay, L. E., Robertson, H., Durant, S. T., Vitale, S. R., Penning, T. M., Dinkova-Kostova, A. T. & Hayes, J. D., Nov 2015, In: Free Radical Biology and Medicine. 88, Part B, p. 108-146 39 p.

  Research output: Contribution to journal › Article › peer-review

  • Cullin 1
  • SKP Cullin F-Box Protein Ligases
  • Kelch-Like ECH-Associated Protein 1
  • F-Box Proteins
  • Oxidation-Reduction
  353 Citations (Scopus)

• NAD(P)H: Quinone oxidoreductase 1 inducer activity of some enaminone derivatives

  Alsaid, M. S., Ghorab, M. M., Higgins, M., Dinkova-Kostova, A. T. & Shahat, A. A., 2015, In: Biomedical Research. 26, 1, p. 7-12 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Carbon-13 Magnetic Resonance Spectroscopy
  • quinone
  • Nuclear magnetic resonance
  • NAD
  • Oxidoreductases
  5 Citations (Scopus)

• New monocyclic, bicyclic, and tricyclic ethynylcyanodienones as activators of the Keap1/Nrf2/ARE pathway and inhibitors of inducible nitric oxide synthase

  Li, W., Zheng, S., Higgins, M., Morra, R. P., Mendis, A. T., Chien, C-W., Ojima, I., Mierke, D. F., Dinkova-Kostova, A. T. & Honda, T., 11 Jun 2015, In: Journal of Medicinal Chemistry. 58, 11, p. 4738-4748 11 p.

  Research output: Contribution to journal › Article › peer-review

  • 3-ethynyl-3-methyl-6-oxocyclohexa-1,4-dienecarbonitrile
  • Nitric Oxide Synthase Type II
  • Synthetic Drugs
  • Pharmaceutical Preparations
  • Carcinogenesis
  23 Citations (Scopus)

• Nrf2 activation protects against solar-simulated ultraviolet radiation in mice and humans

  Knatko, E. V., Ibbotson, S. H., Zhang, Y., Higgins, M., Fahey, J. W., Talalay, P., Dawe, R. S., Ferguson, J., Huang, J. T-J., Clarke, R., Zheng, S., Saito, A., Kalra, S., Benedict, A. L., Honda, T., Proby, C. M. & Dinkova-Kostova, A. T., Jun 2015, In: Cancer Prevention Research. 8, 6, p. 475-486 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Ultraviolet Rays
  • TBE 31
  • Skin Neoplasms
  • Carcinogens
  • Carcinogenesis
  54 Citations (Scopus)

• Nrf2 regulates ROS production by mitochondria and NADPH oxidase

  Kovac, S., Angelova, P. R., Holmström, K. M., Zhang, Y., Dinkova-Kostova, A. T. & Abramov, A. Y., Apr 2015, In: Biochimica et Biophysica Acta: General Subjects. 1850, 4, p. 794-801 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Kelch-Like ECH-Associated Protein 1
  • Mitochondria
  • NADPH Oxidases
  • Antioxidants
  • Tissue
  232 Citations (Scopus)

• Oral Azathioprine Leads to Higher Incorporation of 6-Thioguanine in DNA of Skin than Liver: The Protective Role of the Keap1/Nrf2/ARE Pathway

  Kalra, S., Zhang, Y., Knatko, E. V., Finlayson, S., Yamamoto, M. & Dinkova-Kostova, A. T., Oct 2011, In: Cancer Prevention Research. 4, 10, p. 1665-1674 10 p.

  Research output: Contribution to journal › Article › peer-review
  13 Citations (Scopus)

• Pharmacokinetics and pharmacodynamics of orally administered acetylenic tricyclic bis(cyanoenone), a highly potent Nrf2 activator with a reversible covalent mode of action

  Kostov, R. V., Knatko, E. V., McLaughlin, L. A., Henderson, C. J., Zheng, S., Huang, J. T. J., Honda, T. & Dinkova-Kostova, A. T., 25 Sep 2015, In: Biochemical and Biophysical Research Communications. 465, 3, p. 402-407 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • TBE 31
  • Pharmacodynamics
  • Pharmacokinetics
  • Kelch-Like ECH-Associated Protein 1
  • Cysteine
  11 Citations (Scopus)

  164 Downloads (Pure)

• Synthesis and biological evaluation of 1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]-4-ethynylimidazole. A novel and highly potent anti-inflammatory and cytoprotective agent

  Honda, T., Dinkova-Kostova, A. T., David, E., Padegimas, E. M., Sundararajan, C., Visnick, M., Bumeister, R. & Wigley, W. C., 15 Apr 2011, In: Bioorganic & Medicinal Chemistry Letters. 21, 8, p. 2188-2191 4 p.

  Research output: Contribution to journal › Article › peer-review
  18 Citations (Scopus)

• The cytoprotective role of the Keap1-Nrf2 pathway

  Baird, L. & Dinkova-Kostova, A. T., Apr 2011, In: Archives of Toxicology. 85, 4, p. 241-272 32 p.

  Research output: Contribution to journal › Review article › peer-review
  609 Citations (Scopus)

• The emerging role of Nrf2 in mitochondrial function

  Dinkova-Kostova, A. T. & Abramov, A. Y., Nov 2015, In: Free Radical Biology and Medicine. 88, Part B, p. 179-188 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Mitochondria
  • Biosynthesis
  • 1,4-diphenyl-1,2,3-triazole
  • 1,5-dihydro-FAD
  • NF-E2 Transcription Factor
  350 Citations (Scopus)

  293 Downloads (Pure)

• The spatiotemporal regulation of the Keap1-Nrf2 pathway and its importance in cellular bioenergetics

  Dinkova-Kostova, A. T., Baird, L., Holmström, K. M., Meyer, C. J. & Abramov, A. Y., Aug 2015, In: Biochemical Society Transactions. 43, 4, p. 602-610 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Kelch-Like ECH-Associated Protein 1
  • NF-E2-Related Factor 2
  • Energy Metabolism
  • Conformations
  • Oxidants
  49 Citations (Scopus)

• Transcription factors Hsf1 and Nrf2 engage in crosstalk for cytoprotection

  Dayalan Naidu, S., Kostov, R. V. & Dinkova-Kostova, A. T., Jan 2015, In: Trends in Pharmacological Sciences. 36, 1, p. 6-14 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Activating Transcription Factor 3
  • Heat Shock Transcription Factors
  • HSP70 Heat-Shock Proteins
  • Cytoprotection
  • Crosstalk
  66 Citations (Scopus)