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• 2017

  Activation of Nrf2 signaling as a common treatment of neurodegenerative diseases

  Dinkova-Kostova, A. T. & Kazantsev, A. G., Apr 2017, In: Neurodegenerative Disease Management. 7, 2, p. 97-100 4 p.

  Research output: Contribution to journal › Editorial

  Open Access

  File
  11 Citations (Scopus)

  198 Downloads (Pure)

• Activation of Nrf2 signaling augments Vesicular Stomatitis Virus Oncolysis via Autophagy-Driven Suppression of Antiviral Immunity

  Olagnier, D., Lababidi, R. R., Bel Hadj, S., Sze, A., Liu, Y., Dayalan Naidu, S., Ferrari, M., Jiang, Y., Chiang, C., Beljanski, V., Goulet, M-L., Knatko, E. V., Dinkova-Kostova, A. T., Hiscott, J. & Lin, R., 2 Aug 2017, In: Molecular Therapy. 25, 8, p. 1900-1916 17 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Vesicular Stomatitis
  • Autophagy
  • Antiviral Agents
  • Immunity
  • Oncolytic Viruses
  35 Citations (Scopus)

  190 Downloads (Pure)

• Crosstalk between NRF2 and HIPK2 shapes cytoprotective responses

  Torrente, L., Sanchez, C., Moreno Dorta, R., Chowdhry, S., Cabello, P., Isono, K., Koseki, H., Honda, T., Hayes, J., Dinkova-Kostova, A. & de la Vega, L., 2 Nov 2017, In: Oncogene. 36, 44, p. 6204-6212 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Homeodomain Proteins
  • Protein Kinases
  • Neoplasms
  • Phosphotransferases
  • Oncogenes
  30 Citations (Scopus)

  237 Downloads (Pure)

• Epigenetic Control of NRF2-Directed Cellular Antioxidant Status in Dictating Life-Death Decisions

  Hayes, J. D. & Dinkova-Kostova, A. T., 5 Oct 2017, In: Molecular Cell. 68, 1, p. 5-7 3 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Epigenomics
  • Antioxidants
  • Tumor Suppressor Proteins
  • Acetylation
  • Oxidation-Reduction
  8 Citations (Scopus)

  310 Downloads (Pure)

• Flavonolignan 2,3-dehydrosilydianin activates Nrf2 and upregulates NAD(P)H: quinone oxidoreductase 1 in Hepa1c1c7 cells

  Roubalová, L., Dinkova-Kostova, A. T., Biedermann, D., Křen, V., Ulrichová, J. & Vrba, J., Jun 2017, In: Fitoterapia. 119, p. 115-120 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Flavonolignans
  • quinone
  • Milk Thistle
  • NAD
  • Oxidoreductases
  16 Citations (Scopus)

  190 Downloads (Pure)

• Keap1, the cysteine-based mammalian intracellular sensor for electrophiles and oxidants

  Dinkova-Kostova, A. T., Kostov, R. V. & Canning, P., 1 Mar 2017, In: Archives of Biochemistry and Biophysics. 617, p. 84-93 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Kelch-Like ECH-Associated Protein 1
  • Oxidants
  • Cysteine
  • NF-E2-Related Factor 2
  • Sensors
  103 Citations (Scopus)

  178 Downloads (Pure)

• KEAP1 and done? Targeting the NRF2 pathway with sulforaphane: Targeting the NRF2 Pathway with Sulforaphane

  Dinkova-Kostova, A. T., Fahey, J. W., Kostov, R. V. & Kensler, T. W., Nov 2017, In: Trends in Food Science and Technology. 69, B, p. 257-269 13 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • sulforaphane
  • sulforafan
  • Brassica
  • broccoli
  • clinical trials
  86 Citations (Scopus)

  420 Downloads (Pure)

• KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients

  Quinti, L., Dayalan Naidu, S., Träge, U., Chen, X., Kegel-Gleason, K., Lleres, D., Connolly, C., Chopra, V., Low, C., Moniot, S., Sapp, E., Tousley, A. R., Vodicka, P., Van Kanegan, M. J., Kaltenbach, L. S., Crawford, L. A., Fuszard, M., Higgins, M., Miller, J. R. C., Farmer, R. E. & 19 others, Potluri, V., Samajdar, S., Meisel, L., Zhang, N., Snyder, A., Stein, R., Hersch, S. M., Ellerby, L. M., Weerapana, E., Schwarzschild, M. A., Steegborn, C., Leavitt, B. R., Degterev, A., Tabrizi, S. J., Lo, D. C., DiFiglia, M., Thompson, L. M., Dinkova-Kostova, A. & Kazantsev, A. G., 6 Jun 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 23, p. e4676-e4685 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Kelch-Like ECH-Associated Protein 1
  • Neural Stem Cells
  • Huntington Disease
  • NF-E2 Transcription Factor
  • Interleukin-6
  41 Citations (Scopus)

  181 Downloads (Pure)

• Metabolic and Homeostatic Changes in Seizures and Acquired Epilepsy-Mitochondria, Calcium Dynamics and Reactive Oxygen Species

  Kovac, S., Dinkova Kostova, A. T., Herrmann, A. M., Melzer, N., Meuth, S. G. & Gorji, A., 8 Sep 2017, In: International Journal of Molecular Sciences. 18, 9, p. 1-19 19 p., 1935.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Mitochondria
  • epilepsy
  • seizures
  • mitochondria
  • Metabolism
  26 Citations (Scopus)

  196 Downloads (Pure)

• NRF2 as an emerging therapeutic target

  Copple, I. M., Dinkova-Kostova, A. T., Kensler, T. W., Liby, K. T. & Wigley, W. C., 31 Jan 2017, In: Oxidative Medicine and Cellular Longevity. 2017, p. 1-2 2 p., 8165458.

  Research output: Contribution to journal › Editorial › peer-review

  Open Access

  File
  20 Citations (Scopus)

  199 Downloads (Pure)

• Oncogene-Stimulated Congestion at the KEAP1 Stress Signaling Hub Allows Bypass of NRF2 and Induction of NRF2-Target Genes that Promote Tumor Survival

  Hayes, J. D. & Dinkova-Kostova, A. T., Nov 2017, In: Cancer Cell. 32, 5, p. 539-541 3 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Oncogenes
  • Oncogene Proteins
  • Ligases
  • Genes
  • Neoplasms
  11 Citations (Scopus)

  243 Downloads (Pure)

• Oxidative stress and chronic inflammation in osteoarthritis: can Nrf2 counteract these partners in crime?

  Marchev, A. S., Dimitrova, P. A., Burns, A. J., Kostov, R., Dinkova-Kostova, A. & Georgiev, M. I., 11 Sep 2017, In: Annals of the New York Academy of Sciences. 1401, p. 114-135 22 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Oxidative stress
  • Osteoarthritis
  • Crime
  • Inflammation
  • Bone
  57 Citations (Scopus)

  427 Downloads (Pure)

• Oxidative stress management in the hair follicle: Could targeting NRF2 counter age-related hair disorders and beyond?

  Jadkauskaite, L., Coulombe, P. A., Schäfer, M., Dinkova-Kostova, A. T., Paus, R. & Haslam, I. S., 27 Jul 2017, In: BioEssays. 39, 8, p. 1-9 9 p., 1700029.

  Research output: Contribution to journal › Article › peer-review

  • Oxidative stress
  • Oxidation-Reduction
  • Hair Follicle
  • Oxidative Stress
  • Chemical activation
  16 Citations (Scopus)

• Pathogenic p62/SQSTM1 mutations impair energy metabolism through limitation of mitochondrial substrates

  Bartolome, F., Esteras, N., Martin-Requero, A., Boutoleau-Bretonniere, C., Vercelletto, M., Gabelle, A., Le Ber, I., Honda, T., Dinkova-Kostova, A. T., Hardy, J., Carro, E. & Abramov, A. Y., 10 May 2017, In: Scientific Reports. 7, p. 1-14 14 p., 1666.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Frontotemporal Dementia With Motor Neuron Disease
  • Mitochondrial Membrane Potential
  • NAD
  • Energy Metabolism
  • Fibroblasts
  32 Citations (Scopus)

  305 Downloads (Pure)

• Regulation of the mammalian heat shock factor 1

  Dayalan Naidu, S. & Dinkova-Kostova, A. T., Jun 2017, In: FEBS Journal. 284, 11, p. 1606-1627 22 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Heat-Shock Response
  • Machinery
  • Acetylation
  • Phosphorylation
  • Heat Shock Transcription Factors
  59 Citations (Scopus)

  252 Downloads (Pure)

• Transcription factors NRF2 and HSF1 have opposing functions in autophagy

  Dayalan Naidu, S., Dikovskaya, D., Gaurilcikaite, E., Knatko, E., Healy, Z. R., Mohan, H., Koh, G., Laurell, A., Ball, G., Olagnier, D., de la Vega, L., Ganley, I., Talalay, P. & Dinkova-Kostova, A., 8 Sep 2017, In: Scientific Reports. 7, p. 1-12 12 p., 11023.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Heat Shock Transcription Factors
  • Autophagy
  • Heat-Shock Response
  • Sequestosome-1 Protein
  • GATA1 Transcription Factor
  25 Citations (Scopus)

  218 Downloads (Pure)

• Whole-exome sequencing validates a preclinical mouse model for the prevention and treatment of cutaneous squamous cell carcinoma

  Knatko, E. V., Praslicka, B., Higgins, M., Evans, A., Purdie, K. J., Harwood, C. A., Proby, C. M., Ooi, A. & Dinkova-Kostova, A. T., Jan 2017, In: Cancer Prevention Research. 10, 1, p. 67-75 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Whole Exome Sequencing
  • Squamous Cell Carcinoma
  • Single Nucleotide Polymorphism
  • Skin
  • Mutation Rate
  9 Citations (Scopus)

  155 Downloads (Pure)
• 2016

  Bioactive polymethoxylated flavonoids from Chiliadenus montanus

  Hamed, A. R., Mohamed, T. A., Tawfik, W. A., Hassan, E. M., Higgins, M., El-Toumy, S. A. & Dinkova-Kostova, A. T., 31 Mar 2016, In: Journal of Chemical and Pharmaceutical Research. 8, 3, p. 788-793 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Flavonoids
  • vitamin B 12 factor III
  • Phytochemicals
  • Biological Assay
  • NAD
  134 Downloads (Pure)

• Chemical constituents and NAD(P)H:Quinone oxidoreductase 1 (NQO1) inducer activity of Teucrium oliverianum Ging. ex Benth

  Shahat, A. A., Alsaid, M. S., Khan, J. A., Higgins, M. & Dinkova-Kostova, A. T., Apr 2016, In: Indian Journal of Traditional Knowledge. 15, 2, p. 232-236 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • eupatorin
  • Teucrium
  • quinone
  • 8-O-acetylharpagide
  • NAD
  3 Citations (Scopus)

  41 Downloads (Pure)

• Electron affinity of tricyclic, bicyclic, and monocyclic compounds containing cyanoenones correlates with their potency as inducers of a cytoprotective enzyme

  Bensasson, R. V., Dinkova-Kostova, A. T., Zheng, S., Saito, A., Li, W., Zoete, V. & Honda, T., 1 Sep 2016, In: Bioorganic & Medicinal Chemistry Letters. 26, 17, p. 4345-4349 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Electron affinity
  • Density Functional Theory
  • Molecular orbitals
  • Density functional theory
  • Electrons
  3 Citations (Scopus)

  165 Downloads (Pure)

• Filaggrin genotype does not determine the skin's threshold to UV-induced erythema

  Forbes, D., Johnston, L., Gardner, J., MacCallum, S. F., Campbell, L. E., Dinkova-Kostova, A. T., McLean, W. H. I., Ibbotson, S. H., Dawe, R. S. & Brown, S. J., Apr 2016, In: Journal of Allergy and Clinical Immunology. 137, 4, p. 1280-1282.e3 6 p.

  Research output: Contribution to journal › Letter › peer-review

  Open Access

  File
  6 Citations (Scopus)

  140 Downloads (Pure)

• Glucosinolates from the Brassica Vegetables and Their Health Effects

  Johnson, T. L., Dinkova-Kostova, A. T. & Fahey, J. W., 2016, Encyclopedia of Food and Health. Caballero, B., Finglas, P. M. & Toldrá, F. (eds.). Elsevier Inc., p. 248-255 8 p. (Reference Module in Food Science).

  Research output: Chapter in Book/Report/Conference proceeding › Entry for encyclopedia/dictionary

  • Glucosinolates
  • Brassica
  • Vegetables
  • Thioglucosides
  • Magnoliopsida
  5 Citations (Scopus)

• Heat Shock Factor 1 is a Substrate for p38 Mitogen-Activated Protein Kinases

  Dayalan Naidu, S., Sutherland, C., Zhang, Y., Risco, A., de la Vega, L., Caunt, C. J., Hastie, C. J., Lamont, D. J., Torrente, L., Chowdhry, S., Benjamin, I. J., Keyse, S. M., Cuenda, A. & Dinkova-Kostova, A. T., 15 Sep 2016, In: Molecular and Cellular Biology. 36, 18, p. 2403-2417 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Heat-Shock Response
  • p38 Mitogen-Activated Protein Kinases
  • Phosphorylation
  • phenethyl isothiocyanate
  • Heat Shock Transcription Factors
  27 Citations (Scopus)

  277 Downloads (Pure)

• Loss of Nrf2 abrogates the protective effect of Keap1 down regulation in a preclinical model of cutaneous squamous cell carcinoma

  Knatko, E. V., Higgins, M., Fahey, J. W. & Dinkova-Kostova, A., 24 May 2016, In: Scientific Reports. 6, 7 p., 25804.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Kelch-Like ECH-Associated Protein 1
  • NF-E2-Related Factor 2
  • Squamous Cell Carcinoma
  • Down-Regulation
  • Skin
  20 Citations (Scopus)

  199 Downloads (Pure)

• NAD(P)H: quinone oxidoreductase 1 inducer activity of some novel anilinoquinazoline derivatives

  Ghorab, M. M., Alsaid, M. S., Higgins, M., Dinkova-Kostova, A. T., Shahat, A. A., Elghazawy, N. H. & Arafa, R. K., 8 Aug 2016, In: Drug Design, Development and Therapy. 10, p. 2515-2524 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • anilinoquinazoline
  • Kelch-Like ECH-Associated Protein 1
  • quinone
  • NAD
  • Oxidoreductases
  3 Citations (Scopus)

  176 Downloads (Pure)

• NAD(P)H: Quinone oxidoreductase 1 inducer activity of novel 4-aminoquinazoline derivatives

  Ghorab, M. M., Alsaid, M. S., El-Gazzar, M. G., Higgins, M., Dinkova-Kostova, A. T. & Shahat, A. A., 2016, In: Journal of Enzyme Inhibition and Medicinal Chemistry. 31, 6, p. 1369-1374 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • 4-aminoquinazoline
  • quinone
  • NAD
  • Oxidoreductases
  • Aptitude
  3 Citations (Scopus)

  197 Downloads (Pure)

• Nrf2 activation in the treatment of neurodegenerative diseases: A focus on its role in mitochondrial bioenergetics and function

  Esteras, N., Dinkova-Kostova, A. T. & Abramov, A. Y., May 2016, In: Biological Chemistry. 397, 5, p. 383-400 18 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Neurodegenerative diseases
  • NF-E2-Related Factor 2
  • Energy Metabolism
  • Chemical activation
  • Neurodegenerative Diseases
  64 Citations (Scopus)

  286 Downloads (Pure)

• Nrf2-mediated neuroprotection response to recurrent hypoglycemia is insufficient to prevent cognitive impairment in a rodent model of type 1 diabetes

  McNeilly, A. D., Gallagher, J. R., Dinkova-Kostova, A. T., Hayes, J. D., Sharkey, J., Ashford, M. L. J. & McCrimmon, R. J., 1 Oct 2016, In: Diabetes. 65, 10, p. 3151-3160 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Neuroprotection
  • Hypoglycemia
  • Type 1 Diabetes Mellitus
  • Cognitive Dysfunction
  • Rodentia
  18 Citations (Scopus)

  156 Downloads (Pure)

• Potency of extracts from selected Egyptian plants as inducers of the Nrf2-dependent chemopreventive enzyme NQO1

  Hamed, A. R., Hegazy, M-E. F., Higgins, M., Mohamed, T. A., Abdel-Azim, N. S., Pare, P. W. & Dinkova-Kostova, A. T., Jul 2016, In: Journal of Natural Medicines. 70, 3, p. 683-688 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Chemoprevention
  • NF-E2-Related Factor 2
  • NF-E2 Transcription Factor
  • quinone
  • Heme Oxygenase-1
  6 Citations (Scopus)

  225 Downloads (Pure)

• Regulation of the CNC-bZIP transcription factor Nrf2 by Keap1 and the axis between GSK-3 and β-TrCP

  Hayes, J. D., Ebisine, K., Sharma, R. S., Chowdhry, S., Dinkova-Kostova, A. T. & Sutherland, C., Dec 2016, In: Current Opinion in Toxicology. 1, p. 92-103 12 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Kelch-Like ECH-Associated Protein 1
  • Basic-Leucine Zipper Transcription Factors
  • NF-E2-Related Factor 2
  • Mouse Keap1 protein
  • Glycogen Synthase Kinase 3
  10 Citations (Scopus)

  355 Downloads (Pure)

• Rhodiola rosea L. from golden root to green cell factories

  Marchev, A. S., Dinkova-Kostova, A. T., György, Z., Mirmazloum, I., Aneva, I. Y. & Georgiev, M. I., Aug 2016, In: Phytochemistry Reviews. 15, 4, p. 515-536 22 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Rhodiola
  • Rhodiola rosea
  • factories
  • secondary metabolites
  • Plant Roots
  17 Citations (Scopus)

  433 Downloads (Pure)

• Semisynthetic flavonoid 7-O-galloylquercetin activates Nrf2 and induces Nrf2-dependent gene expression in RAW264.7 and Hepa1c1c7 cells

  Roubalová, L., Biedermann, D., Papoušková, B., Vacek, J., Kuzma, M., Křen, V., Ulrichová, J., Dinkova-Kostova, A. T. & Vrba, J., 25 Dec 2016, In: Chemico-Biological Interactions. 260, p. 58-66 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Quercetin
  • Gene expression
  • Flavonoids
  • Heme Oxygenase-1
  • Gene Expression
  7 Citations (Scopus)

  169 Downloads (Pure)

• SIRT2- and NRF2-Targeting Thiazole-Containing Compound with Therapeutic Activity in Huntington's Disease Models

  Quinti, L., Casale, M., Moniot, S., Pais, T. F., Van Kanegan, M. J., Kaltenbach, L. S., Pallos, J., Lim, R. G., Naidu, S. D., Runne, H., Meisel, L., Rauf, N. A., Leyfer, D., Maxwell, M. M., Saiah, E., Landers, J. E., Luthi-Carter, R., Abagyan, R., Dinkova-Kostova, A. T., Steegborn, C. & 4 others, Marsh, J. L., Lo, D. C., Thompson, L. M. & Kazantsev, A. G., 21 Jul 2016, In: Cell Chemical Biology. 23, 7, p. 849-861 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Sirtuin 2
  • Thiazoles
  • Huntington Disease
  • Lead compounds
  • Systems Biology
  37 Citations (Scopus)

  199 Downloads (Pure)

• Synthesis, molecular modeling and NAD(P)H: quinone oxidoreductase 1 inducer activity of novel 2-phenylquinazolin-4-amine derivatives

  Ghorab, M. M., Alsaid, M. S., Higgins, M., Dinkova-Kostova, A. T., Shahat, A. A., Elghazawy, N. H. & Arafa, R. K., Apr 2016, In: Journal of Enzyme Inhibition and Medicinal Chemistry. 31, 6, p. 1612-1618 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • quinone
  • Amines
  • NAD
  • Oxidoreductases
  • Reactive Oxygen Species
  3 Citations (Scopus)

  155 Downloads (Pure)

• Synthesis and biological evaluation of novel 2-phenylquinazoline-4-amine derivatives: identification of 6-phenyl-8H-benzo[g]quinazolino[4,3-b]quinazolin-8-one as a highly potent inducer of NAD(P)H quinone oxidoreductase 1

  Ghorab, M. M., Alsaid, M. S., El-Gazzar, M. G., Higgins, M., Dinkova-Kostova, A. T. & Shahat, A. A., 2016, In: Journal of Enzyme Inhibition and Medicinal Chemistry. 31, Suppl. 1, p. 34-49 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • quinone
  • NAD
  • Oxidoreductases
  • Kelch Repeat
  • Quinazolines
  4 Citations (Scopus)

  196 Downloads (Pure)

• Synthesis and NAD(P)H: Quinone oxidoreductase 1 inducer activity of acetamide and pyridine-3-carbonitrile derivatives

  Ghorab, M. M., Shahat, A. A., Alsaid, M. S., Higgins, M., Dinkova-Kostova, A. T. & Naser, A. A., 2016, In: Biomedical Research. 27, 4, p. 1045-1048 4 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • pyridine-3-carbonitrile
  • Pyridones
  • acetamide
  • quinone
  • NAD
  47 Downloads (Pure)

• The multifaceted role of Nrf2 in mitochondrial function

  Holmström, K. M., Kostov, R. V. & Dinkova-Kostova, A. T., Dec 2016, In: Current Opinion in Toxicology. 1, p. 80-91 12 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Stem cells
  • Mitochondria
  • NF-E2 Transcription Factor
  • Antioxidants
  • Stem Cells
  128 Citations (Scopus)

  213 Downloads (Pure)

• The multifaceted role of sulforaphane in protection against uv radiation-mediated skin damage

  Benedict, A. L., Knatko, E. V., Kostov, R. V., Zhang, Y., Higgins, M., Kalra, S., Fahey, J. W., Ibbotson, S. H., Proby, C. M., Talalay, P. & Dinkova-Kostova, A. T., Jan 2016, Broccoli: Cultivation, Nutritional Properties and Effects on Health. Nova Science Publishers, p. 185-208 24 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • sulforafan
  • Ultraviolet Rays
  • Radiation
  • Skin
  • isothiocyanic acid
  1 Citation (Scopus)
• 2015

  Design, synthesis, and evaluation of triazole derivatives that induce Nrf2 dependent gene products and inhibit the Keap1-Nrf2 protein-protein interaction

  Bertrand, H. C., Schaap, M., Baird, L., Georgakopoulos, N. D., Fowkes, A., Thiollier, C., Kachi, H., Dinkova-Kostova, A. T. & Wells, G., 24 Sep 2015, In: Journal of Medicinal Chemistry. 58, 18, p. 7186-7194 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Triazoles
  • 1,4-diphenyl-1,2,3-triazole
  • Genes
  • Proteins
  • Metabolic Networks and Pathways
  69 Citations (Scopus)

• Dual regulation of transcription factor Nrf2 by Keap1 and by the combined actions of β-TrCP and GSK-3

  Hayes, J. D., Chowdhry, S., Dinkova-Kostova, A. T. & Sutherland, C., Aug 2015, In: Biochemical Society Transactions. 43, 4, p. 611-620 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Kelch-Like ECH-Associated Protein 1
  • NF-E2 Transcription Factor
  • NF-E2-Related Factor 2
  • Glycogen Synthase Kinase 3
  • Phosphorylation
  61 Citations (Scopus)

• Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease

  Tebay, L. E., Robertson, H., Durant, S. T., Vitale, S. R., Penning, T. M., Dinkova-Kostova, A. T. & Hayes, J. D., Nov 2015, In: Free Radical Biology and Medicine. 88, Part B, p. 108-146 39 p.

  Research output: Contribution to journal › Article › peer-review

  • Cullin 1
  • SKP Cullin F-Box Protein Ligases
  • Kelch-Like ECH-Associated Protein 1
  • F-Box Proteins
  • Oxidation-Reduction
  346 Citations (Scopus)

• NAD(P)H: Quinone oxidoreductase 1 inducer activity of some enaminone derivatives

  Alsaid, M. S., Ghorab, M. M., Higgins, M., Dinkova-Kostova, A. T. & Shahat, A. A., 2015, In: Biomedical Research. 26, 1, p. 7-12 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Carbon-13 Magnetic Resonance Spectroscopy
  • quinone
  • Nuclear magnetic resonance
  • NAD
  • Oxidoreductases
  5 Citations (Scopus)

• New monocyclic, bicyclic, and tricyclic ethynylcyanodienones as activators of the Keap1/Nrf2/ARE pathway and inhibitors of inducible nitric oxide synthase

  Li, W., Zheng, S., Higgins, M., Morra, R. P., Mendis, A. T., Chien, C-W., Ojima, I., Mierke, D. F., Dinkova-Kostova, A. T. & Honda, T., 11 Jun 2015, In: Journal of Medicinal Chemistry. 58, 11, p. 4738-4748 11 p.

  Research output: Contribution to journal › Article › peer-review

  • 3-ethynyl-3-methyl-6-oxocyclohexa-1,4-dienecarbonitrile
  • Nitric Oxide Synthase Type II
  • Synthetic Drugs
  • Pharmaceutical Preparations
  • Carcinogenesis
  23 Citations (Scopus)

• Nrf2 activation protects against solar-simulated ultraviolet radiation in mice and humans

  Knatko, E. V., Ibbotson, S. H., Zhang, Y., Higgins, M., Fahey, J. W., Talalay, P., Dawe, R. S., Ferguson, J., Huang, J. T-J., Clarke, R., Zheng, S., Saito, A., Kalra, S., Benedict, A. L., Honda, T., Proby, C. M. & Dinkova-Kostova, A. T., Jun 2015, In: Cancer Prevention Research. 8, 6, p. 475-486 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Ultraviolet Rays
  • TBE 31
  • Skin Neoplasms
  • Carcinogens
  • Carcinogenesis
  54 Citations (Scopus)

• Nrf2 regulates ROS production by mitochondria and NADPH oxidase

  Kovac, S., Angelova, P. R., Holmström, K. M., Zhang, Y., Dinkova-Kostova, A. T. & Abramov, A. Y., Apr 2015, In: Biochimica et Biophysica Acta: General Subjects. 1850, 4, p. 794-801 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Kelch-Like ECH-Associated Protein 1
  • Mitochondria
  • NADPH Oxidases
  • Antioxidants
  • Tissue
  227 Citations (Scopus)

• Pharmacokinetics and pharmacodynamics of orally administered acetylenic tricyclic bis(cyanoenone), a highly potent Nrf2 activator with a reversible covalent mode of action

  Kostov, R. V., Knatko, E. V., McLaughlin, L. A., Henderson, C. J., Zheng, S., Huang, J. T. J., Honda, T. & Dinkova-Kostova, A. T., 25 Sep 2015, In: Biochemical and Biophysical Research Communications. 465, 3, p. 402-407 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • TBE 31
  • Pharmacodynamics
  • Pharmacokinetics
  • Kelch-Like ECH-Associated Protein 1
  • Cysteine
  11 Citations (Scopus)

  162 Downloads (Pure)

• The emerging role of Nrf2 in mitochondrial function

  Dinkova-Kostova, A. T. & Abramov, A. Y., Nov 2015, In: Free Radical Biology and Medicine. 88, Part B, p. 179-188 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Mitochondria
  • Biosynthesis
  • 1,4-diphenyl-1,2,3-triazole
  • 1,5-dihydro-FAD
  • NF-E2 Transcription Factor
  344 Citations (Scopus)

  288 Downloads (Pure)

• The spatiotemporal regulation of the Keap1-Nrf2 pathway and its importance in cellular bioenergetics

  Dinkova-Kostova, A. T., Baird, L., Holmström, K. M., Meyer, C. J. & Abramov, A. Y., Aug 2015, In: Biochemical Society Transactions. 43, 4, p. 602-610 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Kelch-Like ECH-Associated Protein 1
  • NF-E2-Related Factor 2
  • Energy Metabolism
  • Conformations
  • Oxidants
  48 Citations (Scopus)

• Transcription factors Hsf1 and Nrf2 engage in crosstalk for cytoprotection

  Dayalan Naidu, S., Kostov, R. V. & Dinkova-Kostova, A. T., Jan 2015, In: Trends in Pharmacological Sciences. 36, 1, p. 6-14 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Activating Transcription Factor 3
  • Heat Shock Transcription Factors
  • HSP70 Heat-Shock Proteins
  • Cytoprotection
  • Crosstalk
  63 Citations (Scopus)
• 2011

  Effects of chemoprotective agent HBB-2 on cell survival in SH-SY5Y neuroblastoma cells

  Scuto, M. C., Cavallaro, M. M., Luca, M., Cornelius, C., Cambria, M. T., Rizza, S., Salinaro, A. T., Dinkova-Kostova, A. & Calabrese, V., 2011, In: FEBS Journal. 278, S1, p. 268 1 p., P14.37.

  Research output: Contribution to journal › Meeting abstract › peer-review