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  • Albena Dinkova-Kostova

Activation of transcription factor Nrf2 to counteract mitochondrial dysfunction in Parkinson’s disease

Bento-Pereira, C. & Dinkova-Kostova, A., 18 Jul 2020, In : Medicinal Research Reviews. 18 p.

Research output: Contribution to journalReview article

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18 Downloads (Pure)

A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia

Baardman, J., Verberk, S. G. S., Prange, K. H. M., van Weeghel, M., van der Velden, S., Ryan, D. G., Wüst, R. C. I., Neele, A. E., Speijer, D., Denis, S. W., Witte, M. E., Houtkooper, R. H., O'neill, L. A., Knatko, E. V., Dinkova-Kostova, A. T., Lutgens, E., de Winther, M. P. J. & Van den Bossche, J., 20 Nov 2018, In : Cell Reports. 25, 8, p. 2044-2052.e5 15 p.

Research output: Contribution to journalArticle

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35 Citations (Scopus)
181 Downloads (Pure)

Author Correction: Pathogenic p62/SQSTM1 mutations impair energy metabolism through limitation of mitochondrial substrates (Scientific Reports DOI: 10.1038/s41598-017-01678-4)

Bartolome, F., Esteras, N., Martin-Requero, A., Boutoleau-Bretonniere, C., Vercelletto, M., Gabelle, A., Ber, I. L., Honda, T., Dinkova-Kostova, A. T., Hardy, J., Carro, E. & Abramov, A. Y., 1 Dec 2018, In : Scientific Reports. 8, p. 1-2 2 p., 4064.

Research output: Contribution to journalComment/debate

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152 Downloads (Pure)

Bioactive polymethoxylated flavonoids from Chiliadenus montanus

Hamed, A. R., Mohamed, T. A., Tawfik, W. A., Hassan, E. M., Higgins, M., El-Toumy, S. A. & Dinkova-Kostova, A. T., 31 Mar 2016, In : Journal of Chemical and Pharmaceutical Research. 8, 3, p. 788-793 6 p.

Research output: Contribution to journalArticle

Open Access
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117 Downloads (Pure)

Biomarker Exploration in Human Peripheral Blood Mononuclear Cells for Monitoring Sulforaphane Treatment Responses in Autism Spectrum Disorder

Liu, H., Zimmerman, A. W., Singh, K., Connors, S. L., Diggins, E., Stephenson, K. K., Dinkova-Kostova, A. & Fahey, J. W., 2 Apr 2020, In : Scientific Reports. 10, 1, p. 1-11 11 p., 5822.

Research output: Contribution to journalArticle

Open Access
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4 Citations (Scopus)
26 Downloads (Pure)

C151 in KEAP1 is the main cysteine sensor for the cyanoenone class of NRF2 activators, irrespective of molecular size or shape

Dayalan Naidu, S., Muramatsu, A., Saito, R., Asami, S., Honda, T., Hosoya, T., Itoh, K., Yamamoto, M., Suzuki, T. & Dinkova-Kostova, A., 23 May 2018, In : Scientific Reports. 8, 1, p. 1-12 12 p., 8037.

Research output: Contribution to journalArticle

Open Access
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13 Citations (Scopus)
135 Downloads (Pure)

Can activation of NRF2 be a strategy against COVID-19?

Cuadrado, A., Pajares, M., Benito, C., Jiménez-Villegas, J., Escoll, M., Fernández-Ginés, R., Garcia Yagüe, A. J., Lastra, D., Manda, G., Rojo, A. I. & Dinkova-Kostova, A. T., Sep 2020, In : Trends in Pharmacological Sciences. 41, 9, p. 598-610 13 p.

Research output: Contribution to journalReview article

Open Access
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4 Citations (Scopus)
103 Downloads (Pure)

Chemical constituents and NAD(P)H:Quinone oxidoreductase 1 (NQO1) inducer activity of Teucrium oliverianum Ging. ex Benth

Shahat, A. A., Alsaid, M. S., Khan, J. A., Higgins, M. & Dinkova-Kostova, A. T., Apr 2016, In : Indian Journal of Traditional Knowledge. 15, 2, p. 232-236 5 p.

Research output: Contribution to journalArticle

Open Access
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3 Citations (Scopus)
37 Downloads (Pure)

Design, synthesis, and evaluation of triazole derivatives that induce Nrf2 dependent gene products and inhibit the Keap1-Nrf2 protein-protein interaction

Bertrand, H. C., Schaap, M., Baird, L., Georgakopoulos, N. D., Fowkes, A., Thiollier, C., Kachi, H., Dinkova-Kostova, A. T. & Wells, G., 24 Sep 2015, In : Journal of Medicinal Chemistry. 58, 18, p. 7186-7194 9 p.

Research output: Contribution to journalArticle

66 Citations (Scopus)

Downregulation of Keap1 confers features of a fasted metabolic state

Knatko, E. V., Tatham, M. H., Zhang, Y., Castro, C., Higgins, M., Dayalan Naidu, S., Leonardi, C., de la Vega, L., Honda, T., Griffin, J. L., Hay, R. T. & Dinkova-Kostova, A. T., 23 Oct 2020, In : iScience. 23, 10, 48 p., 101638.

Research output: Contribution to journalArticle

Open Access
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10 Downloads (Pure)
60 Citations (Scopus)

Effects of chemoprotective agent HBB-2 on cell survival in SH-SY5Y neuroblastoma cells

Scuto, M. C., Cavallaro, M. M., Luca, M., Cornelius, C., Cambria, M. T., Rizza, S., Salinaro, A. T., Dinkova-Kostova, A. & Calabrese, V., 2011, In : FEBS Journal. 278, S1, p. 268 1 p., P14.37.

Research output: Contribution to journalMeeting abstract

Electron affinity of tricyclic, bicyclic, and monocyclic compounds containing cyanoenones correlates with their potency as inducers of a cytoprotective enzyme

Bensasson, R. V., Dinkova-Kostova, A. T., Zheng, S., Saito, A., Li, W., Zoete, V. & Honda, T., 1 Sep 2016, In : Bioorganic & Medicinal Chemistry Letters. 26, 17, p. 4345-4349 5 p.

Research output: Contribution to journalArticle

Open Access
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3 Citations (Scopus)
158 Downloads (Pure)
Open Access
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56 Citations (Scopus)
156 Downloads (Pure)

Filaggrin genotype does not determine the skin's threshold to UV-induced erythema

Forbes, D., Johnston, L., Gardner, J., MacCallum, S. F., Campbell, L. E., Dinkova-Kostova, A. T., McLean, W. H. I., Ibbotson, S. H., Dawe, R. S. & Brown, S. J., Apr 2016, In : Journal of Allergy and Clinical Immunology. 137, 4, p. 1280-1282.e3 6 p.

Research output: Contribution to journalLetter

Open Access
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6 Citations (Scopus)
128 Downloads (Pure)

Glucosinolates from the Brassica Vegetables and Their Health Effects

Johnson, T. L., Dinkova-Kostova, A. T. & Fahey, J. W., 2016, Encyclopedia of Food and Health. Caballero, B., Finglas, P. M. & Toldrá, F. (eds.). Elsevier Inc., p. 248-255 8 p. (Reference Module in Food Science).

Research output: Chapter in Book/Report/Conference proceedingEntry for encyclopedia/dictionary

5 Citations (Scopus)

Heat Shock Factor 1 is a Substrate for p38 Mitogen-Activated Protein Kinases

Dayalan Naidu, S., Sutherland, C., Zhang, Y., Risco, A., de la Vega, L., Caunt, C. J., Hastie, C. J., Lamont, D. J., Torrente, L., Chowdhry, S., Benjamin, I. J., Keyse, S. M., Cuenda, A. & Dinkova-Kostova, A. T., 15 Sep 2016, In : Molecular and Cellular Biology. 36, 18, p. 2403-2417 15 p.

Research output: Contribution to journalArticle

Open Access
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26 Citations (Scopus)
260 Downloads (Pure)

High NRF2 Levels Correlate with Poor Prognosis in Colorectal Cancer Patients and with Sensitivity to the Kinase Inhibitor AT9283 In Vitro

Torrente Fernandez, L., Maan, G., Rezig, A. O., Quinn, J., Jackson, A., Grilli, A., Casares, L., Zhang, Y., Kulesskiy, E., Saarela, J., Bicciato, S., Edwards, J., Dinkova-Kostova, A. & de la Vega, L., Oct 2020, In : Biomolecules. 10, 10, 16 p., 1365.

Research output: Contribution to journalArticle

Open Access
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5 Downloads (Pure)

HSF1-Dependent Upregulation of Hsp70 by Sulfhydryl-Reactive Inducers of the KEAP1/NRF2/ARE Pathway

Zhang, Y., Ahn, Y-H., Benjamin, I. J., Honda, T., Hicks, R. J., Calabrese, V., Cole, P. A. & Dinkova-Kostova, A. T., 23 Nov 2011, In : Chemistry & Biology. 18, 11, p. 1355-1361 7 p.

Research output: Contribution to journalArticle

68 Citations (Scopus)

Induction of the Keapl/Nrf2/ARE pathway by oxidizable diphenols

Dinkova-Kostova, A. T. & Wang, X. J., 30 Jun 2011, In : Chemico-Biological Interactions. 192, 1-2, p. 101-106 6 p.

Research output: Contribution to journalArticle

49 Citations (Scopus)

Isomeric O-methyl cannabidiolquinones with dual BACH1/NRF2 activity

Casares Perez, L., Unciti-Broceta, J. D., Prados, M. E., Caprioglio, D., Mattoteia, D., Higgins, M., Apendino, G., Dinkova-Kostova, A. T., Muñoz, E. & de la Vega, L., Oct 2020, In : Redox Biology. 37, p. 1-10 10 p., 101689.

Research output: Contribution to journalArticle

Open Access
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5 Downloads (Pure)

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

Mills, E. L., Ryan, D. G., Prag, H. A., Dikovskaya, D., Menon, D., Zaslona, Z., Jedrychowski, M. P., Costa, A. S. H., Higgins, M., Hams, E., Szpyt, J., Runtsch, M. C., King, M. S., McGouran, J. F., Fischer, R., Kessler, B. M., McGettrick, A. F., Hughes, M. M., Carroll, R. G., Booty, L. M. & 15 others, Knatko, E. V., Meakin, P. J., Ashford, M. L. J., Modis, L. K., Brunori, G., Sévin, D. C., Fallon, P. G., Caldwell, S. T., Kunji, E. R. S., Chouchani, E. T., Frezza, C., Dinkova-Kostova, A. T., Hartley, R. C., Murphy, M. P. & O'Neill, L. A., 5 Apr 2018, In : Nature. 556, 7699, p. 113-117 5 p.

Research output: Contribution to journalArticle

Open Access
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287 Citations (Scopus)
740 Downloads (Pure)
Open Access
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2 Citations (Scopus)
16 Downloads (Pure)

KEAP1 inhibition is neuroprotective and suppresses the development of epilepsy

Shekh-Ahmad, T., Eckel, R., Dayalan Naidu, S., Higgins, M., Yamamoto, M., Dinkova-Kostova, A., Kovac, S., Abramov, A. Y. & Walker, M. C., May 2018, In : Brain. 141, 5, p. 1390-1403 14 p.

Research output: Contribution to journalArticle

Open Access
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34 Citations (Scopus)
182 Downloads (Pure)
Open Access
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19 Citations (Scopus)
190 Downloads (Pure)
Open Access
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9 Downloads (Pure)

Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease

Tebay, L. E., Robertson, H., Durant, S. T., Vitale, S. R., Penning, T. M., Dinkova-Kostova, A. T. & Hayes, J. D., Nov 2015, In : Free Radical Biology and Medicine. 88, Part B, p. 108-146 39 p.

Research output: Contribution to journalArticle

321 Citations (Scopus)

NAD(P)H: quinone oxidoreductase 1 inducer activity of some novel anilinoquinazoline derivatives

Ghorab, M. M., Alsaid, M. S., Higgins, M., Dinkova-Kostova, A. T., Shahat, A. A., Elghazawy, N. H. & Arafa, R. K., 8 Aug 2016, In : Drug Design, Development and Therapy. 10, p. 2515-2524 10 p.

Research output: Contribution to journalArticle

Open Access
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3 Citations (Scopus)
167 Downloads (Pure)

NAD(P)H: Quinone oxidoreductase 1 inducer activity of novel 4-aminoquinazoline derivatives

Ghorab, M. M., Alsaid, M. S., El-Gazzar, M. G., Higgins, M., Dinkova-Kostova, A. T. & Shahat, A. A., 2016, In : Journal of Enzyme Inhibition and Medicinal Chemistry. 31, 6, p. 1369-1374 7 p.

Research output: Contribution to journalArticle

Open Access
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3 Citations (Scopus)
165 Downloads (Pure)

NAD(P)H: Quinone oxidoreductase 1 inducer activity of some enaminone derivatives

Alsaid, M. S., Ghorab, M. M., Higgins, M., Dinkova-Kostova, A. T. & Shahat, A. A., 2015, In : Biomedical Research. 26, 1, p. 7-12 6 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

New monocyclic, bicyclic, and tricyclic ethynylcyanodienones as activators of the Keap1/Nrf2/ARE pathway and inhibitors of inducible nitric oxide synthase

Li, W., Zheng, S., Higgins, M., Morra, R. P., Mendis, A. T., Chien, C-W., Ojima, I., Mierke, D. F., Dinkova-Kostova, A. T. & Honda, T., 11 Jun 2015, In : Journal of Medicinal Chemistry. 58, 11, p. 4738-4748 11 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Nrf2 activation in the treatment of neurodegenerative diseases: A focus on its role in mitochondrial bioenergetics and function

Esteras, N., Dinkova-Kostova, A. T. & Abramov, A. Y., May 2016, In : Biological Chemistry. 397, 5, p. 383-400 18 p.

Research output: Contribution to journalArticle

Open Access
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58 Citations (Scopus)
268 Downloads (Pure)

Nrf2 activation protects against solar-simulated ultraviolet radiation in mice and humans

Knatko, E. V., Ibbotson, S. H., Zhang, Y., Higgins, M., Fahey, J. W., Talalay, P., Dawe, R. S., Ferguson, J., Huang, J. T-J., Clarke, R., Zheng, S., Saito, A., Kalra, S., Benedict, A. L., Honda, T., Proby, C. M. & Dinkova-Kostova, A. T., Jun 2015, In : Cancer Prevention Research. 8, 6, p. 475-486 12 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)
Open Access
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16 Citations (Scopus)
144 Downloads (Pure)

Nrf2 regulates ROS production by mitochondria and NADPH oxidase

Kovac, S., Angelova, P. R., Holmström, K. M., Zhang, Y., Dinkova-Kostova, A. T. & Abramov, A. Y., Apr 2015, In : Biochimica et Biophysica Acta: General Subjects. 1850, 4, p. 794-801 8 p.

Research output: Contribution to journalArticle

216 Citations (Scopus)

Obesity and NRF2-mediated cytoprotection: Where is the missing link?

Vasileva, L. V., Savova, M. S., Amirova, K. M., Dinkova-Kostova, A. & Georgiev, M. I., Jun 2020, In : Pharmacological Research. 156, p. 1-9 9 p., 104760.

Research output: Contribution to journalReview article

Open Access
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9 Citations (Scopus)
94 Downloads (Pure)
13 Citations (Scopus)

Oxidative Stress in Cancer

Hayes, J., Dinkova-Kostova, A. & Tew, K. D., 10 Aug 2020, In : Cancer Cell. 38, 31 p.

Research output: Contribution to journalReview article

7 Citations (Scopus)
Open Access
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11 Citations (Scopus)
152 Downloads (Pure)

Phenethyl isothiocyanate, a dual activator of transcription factors NRF2 and HSF1

Dayalan Naidu, S., Suzuki, T., Yamamoto, M., Fahey, J. W. & Dinkova-Kostova, A., 1 Sep 2018, In : Molecular Nutrition & Food Research. 62, 18, p. e1700908 9 p., 1700908.

Research output: Contribution to journalReview article

Open Access
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11 Citations (Scopus)
166 Downloads (Pure)

Potency of extracts from selected Egyptian plants as inducers of the Nrf2-dependent chemopreventive enzyme NQO1

Hamed, A. R., Hegazy, M-E. F., Higgins, M., Mohamed, T. A., Abdel-Azim, N. S., Pare, P. W. & Dinkova-Kostova, A. T., Jul 2016, In : Journal of Natural Medicines. 70, 3, p. 683-688 6 p.

Research output: Contribution to journalArticle

Open Access
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6 Citations (Scopus)
212 Downloads (Pure)

Radiomodulatory effect of a non-electrophilic NQO1 inducer identified in a screen of new 6, 8-diiodoquinazolin-4(3H)-ones carrying a sulfonamide moiety

Soliman, A. M., Karam, H. M., Mekkawy, M. H., Higgins, M., Dinkova-Kostova, A. & Ghorab, M. M., 15 Aug 2020, In : European Journal of Medicinal Chemistry. 200, 12 p., 112467.

Research output: Contribution to journalArticle

Open Access
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1 Citation (Scopus)
10 Downloads (Pure)

Regulation of the CNC-bZIP transcription factor Nrf2 by Keap1 and the axis between GSK-3 and β-TrCP

Hayes, J. D., Ebisine, K., Sharma, R. S., Chowdhry, S., Dinkova-Kostova, A. T. & Sutherland, C., Dec 2016, In : Current Opinion in Toxicology. 1, p. 92-103 12 p.

Research output: Contribution to journalReview article

Open Access
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9 Citations (Scopus)
330 Downloads (Pure)

Rhodiola rosea L. from golden root to green cell factories

Marchev, A. S., Dinkova-Kostova, A. T., György, Z., Mirmazloum, I., Aneva, I. Y. & Georgiev, M. I., Aug 2016, In : Phytochemistry Reviews. 15, 4, p. 515-536 22 p.

Research output: Contribution to journalArticle

Open Access
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17 Citations (Scopus)
400 Downloads (Pure)

Semisynthetic flavonoid 7-O-galloylquercetin activates Nrf2 and induces Nrf2-dependent gene expression in RAW264.7 and Hepa1c1c7 cells

Roubalová, L., Biedermann, D., Papoušková, B., Vacek, J., Kuzma, M., Křen, V., Ulrichová, J., Dinkova-Kostova, A. T. & Vrba, J., 25 Dec 2016, In : Chemico-Biological Interactions. 260, p. 58-66 9 p.

Research output: Contribution to journalArticle

Open Access
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6 Citations (Scopus)
159 Downloads (Pure)

SIRT2- and NRF2-Targeting Thiazole-Containing Compound with Therapeutic Activity in Huntington's Disease Models

Quinti, L., Casale, M., Moniot, S., Pais, T. F., Van Kanegan, M. J., Kaltenbach, L. S., Pallos, J., Lim, R. G., Naidu, S. D., Runne, H., Meisel, L., Rauf, N. A., Leyfer, D., Maxwell, M. M., Saiah, E., Landers, J. E., Luthi-Carter, R., Abagyan, R., Dinkova-Kostova, A. T., Steegborn, C. & 4 others, Marsh, J. L., Lo, D. C., Thompson, L. M. & Kazantsev, A. G., 21 Jul 2016, In : Cell Chemical Biology. 23, 7, p. 849-861 13 p.

Research output: Contribution to journalArticle

Open Access
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35 Citations (Scopus)
186 Downloads (Pure)

Sulfoxythiocarbamate S-4 inhibits HSP90 in human cutaneous squamous cell carcinoma cells

Zhang, Y., VanHecke, G. C., Ahn, Y-H., Proby, C. M. & Dinkova-Kostova, A. T., 6 Oct 2020, In : European Journal of Pharmacology. 889, 9 p., 173609.

Research output: Contribution to journalArticle

Synthesis, molecular modeling and NAD(P)H: quinone oxidoreductase 1 inducer activity of novel 2-phenylquinazolin-4-amine derivatives

Ghorab, M. M., Alsaid, M. S., Higgins, M., Dinkova-Kostova, A. T., Shahat, A. A., Elghazawy, N. H. & Arafa, R. K., Apr 2016, In : Journal of Enzyme Inhibition and Medicinal Chemistry. 31, 6, p. 1612-1618 7 p.

Research output: Contribution to journalArticle

Open Access
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3 Citations (Scopus)
147 Downloads (Pure)

Synthesis and biological evaluation of 1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]-4-ethynylimidazole. A novel and highly potent anti-inflammatory and cytoprotective agent

Honda, T., Dinkova-Kostova, A. T., David, E., Padegimas, E. M., Sundararajan, C., Visnick, M., Bumeister, R. & Wigley, W. C., 15 Apr 2011, In : Bioorganic & Medicinal Chemistry Letters. 21, 8, p. 2188-2191 4 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)
Open Access
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4 Citations (Scopus)
185 Downloads (Pure)