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• Activation of transcription factor Nrf2 to counteract mitochondrial dysfunction in Parkinson’s disease

  Bento-Pereira, C. & Dinkova-Kostova, A., 18 Jul 2020, In: Medicinal Research Reviews. 18 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Parkinson Disease
  • Transcription Factors
  • NF-E2 Transcription Factor
  • Names
  • Neurodegenerative Diseases
  26 Downloads (Pure)

• Biomarker Exploration in Human Peripheral Blood Mononuclear Cells for Monitoring Sulforaphane Treatment Responses in Autism Spectrum Disorder

  Liu, H., Zimmerman, A. W., Singh, K., Connors, S. L., Diggins, E., Stephenson, K. K., Dinkova-Kostova, A. & Fahey, J. W., 2 Apr 2020, In: Scientific Reports. 10, 11 p., 5822.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • sulforafan
  • Autism Spectrum Disorder
  • Blood Cells
  • Biomarkers
  • Messenger RNA
  7 Citations (Scopus)

  42 Downloads (Pure)

• Can activation of NRF2 be a strategy against COVID-19?

  Cuadrado, A., Pajares, M., Benito, C., Jiménez-Villegas, J., Escoll, M., Fernández-Ginés, R., Garcia Yagüe, A. J., Lastra, D., Manda, G., Rojo, A. I. & Dinkova-Kostova, A. T., Sep 2020, In: Trends in Pharmacological Sciences. 41, 9, p. 598-610 13 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Alveolar Epithelial Cells
  • Chemical activation
  • methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate
  • Anti-Inflammatory Agents
  • T-cells
  16 Citations (Scopus)

  120 Downloads (Pure)

• Design, synthesis, and evaluation of triazole derivatives that induce Nrf2 dependent gene products and inhibit the Keap1-Nrf2 protein-protein interaction

  Bertrand, H. C., Schaap, M., Baird, L., Georgakopoulos, N. D., Fowkes, A., Thiollier, C., Kachi, H., Dinkova-Kostova, A. T. & Wells, G., 24 Sep 2015, In: Journal of Medicinal Chemistry. 58, 18, p. 7186-7194 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Triazoles
  • 1,4-diphenyl-1,2,3-triazole
  • Genes
  • Proteins
  • Metabolic Networks and Pathways
  70 Citations (Scopus)

• Downregulation of Keap1 confers features of a fasted metabolic state

  Knatko, E. V., Tatham, M. H., Zhang, Y., Castro, C., Higgins, M., Dayalan Naidu, S., Leonardi, C., de la Vega, L., Honda, T., Griffin, J. L., Hay, R. T. & Dinkova-Kostova, A. T., 23 Oct 2020, In: iScience. 23, 10, 48 p., 101638.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Kelch-Like ECH-Associated Protein 1
  • Mouse Keap1 protein
  • Down-Regulation
  • Oxidation-Reduction
  • NF-E2 Transcription Factor
  18 Downloads (Pure)

• Dual regulation of transcription factor Nrf2 by Keap1 and by the combined actions of β-TrCP and GSK-3

  Hayes, J. D., Chowdhry, S., Dinkova-Kostova, A. T. & Sutherland, C., Aug 2015, In: Biochemical Society Transactions. 43, 4, p. 611-620 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Kelch-Like ECH-Associated Protein 1
  • NF-E2 Transcription Factor
  • NF-E2-Related Factor 2
  • Glycogen Synthase Kinase 3
  • Phosphorylation
  65 Citations (Scopus)

• Effects of chemoprotective agent HBB-2 on cell survival in SH-SY5Y neuroblastoma cells

  Scuto, M. C., Cavallaro, M. M., Luca, M., Cornelius, C., Cambria, M. T., Rizza, S., Salinaro, A. T., Dinkova-Kostova, A. & Calabrese, V., 2011, In: FEBS Journal. 278, S1, p. 268 1 p., P14.37.

  Research output: Contribution to journal › Meeting abstract › peer-review

• High NRF2 Levels Correlate with Poor Prognosis in Colorectal Cancer Patients and with Sensitivity to the Kinase Inhibitor AT9283 In Vitro

  Torrente Fernandez, L., Maan, G., Rezig, A. O., Quinn, J., Jackson, A., Grilli, A., Casares, L., Zhang, Y., Kulesskiy, E., Saarela, J., Bicciato, S., Edwards, J., Dinkova-Kostova, A. & de la Vega, L., Oct 2020, In: Biomolecules. 10, 10, 16 p., 1365.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • 1-cyclopropyl-3-(3-(5-morpholin-4-ylmethyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl)urea
  • NF-E2-Related Factor 2
  • Colorectal Neoplasms
  • Phosphotransferases
  • In Vitro Techniques
  1 Citation (Scopus)

  12 Downloads (Pure)

• HSF1-Dependent Upregulation of Hsp70 by Sulfhydryl-Reactive Inducers of the KEAP1/NRF2/ARE Pathway

  Zhang, Y., Ahn, Y-H., Benjamin, I. J., Honda, T., Hicks, R. J., Calabrese, V., Cole, P. A. & Dinkova-Kostova, A. T., 23 Nov 2011, In: Chemistry & Biology. 18, 11, p. 1355-1361 7 p.

  Research output: Contribution to journal › Article › peer-review
  70 Citations (Scopus)

• Induction of the Keapl/Nrf2/ARE pathway by oxidizable diphenols

  Dinkova-Kostova, A. T. & Wang, X. J., 30 Jun 2011, In: Chemico-Biological Interactions. 192, 1-2, p. 101-106 6 p.

  Research output: Contribution to journal › Article › peer-review
  49 Citations (Scopus)

• Isomeric O-methyl cannabidiolquinones with dual BACH1/NRF2 activity

  Casares Perez, L., Unciti-Broceta, J. D., Prados, M. E., Caprioglio, D., Mattoteia, D., Higgins, M., Apendino, G., Dinkova-Kostova, A. T., Muñoz, E. & de la Vega, L., Oct 2020, In: Redox Biology. 37, p. 1-10 10 p., 101689.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cannabidiol
  • Neurodegenerative diseases
  • Neurodegenerative Diseases
  • Oxidative stress
  • Derivatives
  1 Citation (Scopus)

  23 Downloads (Pure)

• KEAP1, a cysteine-based sensor and a drug target for the prevention and treatment of chronic disease: KEAP1, a sensor and a drug target

  Dayalan Naidu, S. & Dinkova-Kostova, A., Jun 2020, In: Open Biology. 10, 6, p. 1-13 13 p., 200105.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Kelch-Like ECH-Associated Protein 1
  • Oxidation-Reduction
  • Cysteine
  • Chronic Disease
  • Sensors
  5 Citations (Scopus)

  20 Downloads (Pure)

• Measuring Changes in Keap1‐Nrf2 Protein Complex Conformation in Individual Cells by FLIM‐FRET

  Dikovskaya, D. & Dinkova-Kostova, A., Sep 2020, In: Current Protocols in Toxicology. 85, 1, p. 1-34 34 p., e96.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Kelch-Like ECH-Associated Protein 1
  • Protein Conformation
  • Conformations
  • Fluorescence
  • Photons
  16 Downloads (Pure)

• Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease

  Tebay, L. E., Robertson, H., Durant, S. T., Vitale, S. R., Penning, T. M., Dinkova-Kostova, A. T. & Hayes, J. D., Nov 2015, In: Free Radical Biology and Medicine. 88, Part B, p. 108-146 39 p.

  Research output: Contribution to journal › Article › peer-review

  • Cullin 1
  • SKP Cullin F-Box Protein Ligases
  • Kelch-Like ECH-Associated Protein 1
  • F-Box Proteins
  • Oxidation-Reduction
  348 Citations (Scopus)

• NAD(P)H: Quinone oxidoreductase 1 inducer activity of some enaminone derivatives

  Alsaid, M. S., Ghorab, M. M., Higgins, M., Dinkova-Kostova, A. T. & Shahat, A. A., 2015, In: Biomedical Research. 26, 1, p. 7-12 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Carbon-13 Magnetic Resonance Spectroscopy
  • quinone
  • Nuclear magnetic resonance
  • NAD
  • Oxidoreductases
  5 Citations (Scopus)

• New monocyclic, bicyclic, and tricyclic ethynylcyanodienones as activators of the Keap1/Nrf2/ARE pathway and inhibitors of inducible nitric oxide synthase

  Li, W., Zheng, S., Higgins, M., Morra, R. P., Mendis, A. T., Chien, C-W., Ojima, I., Mierke, D. F., Dinkova-Kostova, A. T. & Honda, T., 11 Jun 2015, In: Journal of Medicinal Chemistry. 58, 11, p. 4738-4748 11 p.

  Research output: Contribution to journal › Article › peer-review

  • 3-ethynyl-3-methyl-6-oxocyclohexa-1,4-dienecarbonitrile
  • Nitric Oxide Synthase Type II
  • Synthetic Drugs
  • Pharmaceutical Preparations
  • Carcinogenesis
  23 Citations (Scopus)

• Nrf2 activation protects against solar-simulated ultraviolet radiation in mice and humans

  Knatko, E. V., Ibbotson, S. H., Zhang, Y., Higgins, M., Fahey, J. W., Talalay, P., Dawe, R. S., Ferguson, J., Huang, J. T-J., Clarke, R., Zheng, S., Saito, A., Kalra, S., Benedict, A. L., Honda, T., Proby, C. M. & Dinkova-Kostova, A. T., Jun 2015, In: Cancer Prevention Research. 8, 6, p. 475-486 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Ultraviolet Rays
  • TBE 31
  • Skin Neoplasms
  • Carcinogens
  • Carcinogenesis
  54 Citations (Scopus)

• NRF2 and the Ambiguous Consequences of Its Activation during Initiation and the Subsequent Stages of Tumourigenesis

  Robertson, H., Dinkova-Kostova, A. T. & Hayes, J. D., 2 Dec 2020, In: Cancers. 12, 12, 48 p., 3609.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Kelch-Like ECH-Associated Protein 1
  • Cullin Proteins
  • Neoplasms
  • Mutation
  • Sulfhydryl Compounds
  13 Downloads (Pure)

• Nrf2 is activated by disruption of mitochondrial thiol homeostasis but not by enhanced mitochondrial superoxide production

  Cvetko, F., Caldwell, S. T., Higgins, M., Suzuki, T., Yamamoto, M., Prag, H. A., Hartley, R. C., Dinkova-Kostova, A. & Murphy, M. P., 20 Dec 2020, In: Journal of Biological Chemistry. 296, 14 p., 100169.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Sulfhydryl Compounds
  • Hydrogen Peroxide
  • Superoxides
  • Oxidation-Reduction
  • Homeostasis
  26 Downloads (Pure)

• Nrf2 regulates ROS production by mitochondria and NADPH oxidase

  Kovac, S., Angelova, P. R., Holmström, K. M., Zhang, Y., Dinkova-Kostova, A. T. & Abramov, A. Y., Apr 2015, In: Biochimica et Biophysica Acta: General Subjects. 1850, 4, p. 794-801 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Kelch-Like ECH-Associated Protein 1
  • Mitochondria
  • NADPH Oxidases
  • Antioxidants
  • Tissue
  227 Citations (Scopus)

• Obesity and NRF2-mediated cytoprotection: Where is the missing link?

  Vasileva, L. V., Savova, M. S., Amirova, K. M., Dinkova-Kostova, A. & Georgiev, M. I., Jun 2020, In: Pharmacological Research. 156, p. 1-9 9 p., 104760.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Cytoprotection
  • Obesity
  • NF-E2 Transcription Factor
  • Oxidative Stress
  • Reactive Nitrogen Species
  12 Citations (Scopus)

  128 Downloads (Pure)

• Oral Azathioprine Leads to Higher Incorporation of 6-Thioguanine in DNA of Skin than Liver: The Protective Role of the Keap1/Nrf2/ARE Pathway

  Kalra, S., Zhang, Y., Knatko, E. V., Finlayson, S., Yamamoto, M. & Dinkova-Kostova, A. T., Oct 2011, In: Cancer Prevention Research. 4, 10, p. 1665-1674 10 p.

  Research output: Contribution to journal › Article › peer-review
  13 Citations (Scopus)

• Oxidative Stress in Cancer

  Hayes, J., Dinkova-Kostova, A. & Tew, K. D., 10 Aug 2020, In: Cancer Cell. 38, 31 p.

  Research output: Contribution to journal › Review article › peer-review

  • NADP
  • Oxidative Stress
  • Pentose Phosphate Pathway
  • Reactive Oxygen Species
  • Antioxidants
  20 Citations (Scopus)

• Pharmacokinetics and pharmacodynamics of orally administered acetylenic tricyclic bis(cyanoenone), a highly potent Nrf2 activator with a reversible covalent mode of action

  Kostov, R. V., Knatko, E. V., McLaughlin, L. A., Henderson, C. J., Zheng, S., Huang, J. T. J., Honda, T. & Dinkova-Kostova, A. T., 25 Sep 2015, In: Biochemical and Biophysical Research Communications. 465, 3, p. 402-407 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • TBE 31
  • Pharmacodynamics
  • Pharmacokinetics
  • Kelch-Like ECH-Associated Protein 1
  • Cysteine
  11 Citations (Scopus)

  162 Downloads (Pure)

• Radiomodulatory effect of a non-electrophilic NQO1 inducer identified in a screen of new 6, 8-diiodoquinazolin-4(3H)-ones carrying a sulfonamide moiety

  Soliman, A. M., Karam, H. M., Mekkawy, M. H., Higgins, M., Dinkova-Kostova, A. & Ghorab, M. M., 15 Aug 2020, In: European Journal of Medicinal Chemistry. 200, 12 p., 112467.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • acetamide
  • Sulfonamides
  • Quinazolinones
  • benzenesulfonamide
  • compound 18
  3 Citations (Scopus)

  28 Downloads (Pure)

• Sulfoxythiocarbamate S-4 inhibits HSP90 in human cutaneous squamous cell carcinoma cells

  Zhang, Y., VanHecke, G. C., Ahn, Y-H., Proby, C. M. & Dinkova-Kostova, A. T., 15 Dec 2020, In: European Journal of Pharmacology. 889, 9 p., 173609.

  Research output: Contribution to journal › Article › peer-review

  • HSP90 Heat-Shock Proteins
  • Squamous Cell Carcinoma
  • Skin
  • E2F Transcription Factors
  • Cyclin D

• Synthesis and biological evaluation of 1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]-4-ethynylimidazole. A novel and highly potent anti-inflammatory and cytoprotective agent

  Honda, T., Dinkova-Kostova, A. T., David, E., Padegimas, E. M., Sundararajan, C., Visnick, M., Bumeister, R. & Wigley, W. C., 15 Apr 2011, In: Bioorganic & Medicinal Chemistry Letters. 21, 8, p. 2188-2191 4 p.

  Research output: Contribution to journal › Article › peer-review
  18 Citations (Scopus)

• The chemopreventive power of isothiocyanates

  Naidu, S. D., Brodziak-Jarosz, L., Gerhäuser, C. & Dinkova-Kostova, A. T., 2020, Natural Products for Cancer Chemoprevention: Single Compounds and Combinations. Pezzuto, J. M. & Vang, O. (eds.). Switzerland: Springer , p. 271-318 48 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Isothiocyanates
  • benzyl isothiocyanate
  • Glucosinolates
  • phenethyl isothiocyanate
  • sulforafan

• The cytoprotective role of the Keap1-Nrf2 pathway

  Baird, L. & Dinkova-Kostova, A. T., Apr 2011, In: Archives of Toxicology. 85, 4, p. 241-272 32 p.

  Research output: Contribution to journal › Review article › peer-review
  603 Citations (Scopus)

• The emerging role of Nrf2 in mitochondrial function

  Dinkova-Kostova, A. T. & Abramov, A. Y., Nov 2015, In: Free Radical Biology and Medicine. 88, Part B, p. 179-188 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Mitochondria
  • Biosynthesis
  • 1,4-diphenyl-1,2,3-triazole
  • 1,5-dihydro-FAD
  • NF-E2 Transcription Factor
  345 Citations (Scopus)

  289 Downloads (Pure)

• The spatiotemporal regulation of the Keap1-Nrf2 pathway and its importance in cellular bioenergetics

  Dinkova-Kostova, A. T., Baird, L., Holmström, K. M., Meyer, C. J. & Abramov, A. Y., Aug 2015, In: Biochemical Society Transactions. 43, 4, p. 602-610 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Kelch-Like ECH-Associated Protein 1
  • NF-E2-Related Factor 2
  • Energy Metabolism
  • Conformations
  • Oxidants
  49 Citations (Scopus)

• The stress-responsive kinase DYRK2 activates heat shock factor 1 promoting resistance to proteotoxic stress

  Moreno Dorta, R., Banerjee, S., Jackson, A. W., Quinn, J., Baillie, G., Dixon, J. E., Dinkova-Kostova, A., Edwards, J. & de la Vega, L., 2 Dec 2020, In: Cell Death & Differentiation. 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • TYK2 Kinase
  • Heat-Shock Response
  • Triple Negative Breast Neoplasms
  • Phosphotransferases
  • Heat Shock Transcription Factors
  24 Downloads (Pure)

• Transcription factors Hsf1 and Nrf2 engage in crosstalk for cytoprotection

  Dayalan Naidu, S., Kostov, R. V. & Dinkova-Kostova, A. T., Jan 2015, In: Trends in Pharmacological Sciences. 36, 1, p. 6-14 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Activating Transcription Factor 3
  • Heat Shock Transcription Factors
  • HSP70 Heat-Shock Proteins
  • Cytoprotection
  • Crosstalk
  63 Citations (Scopus)