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• Bioactive polymethoxylated flavonoids from Chiliadenus montanus

  Hamed, A. R., Mohamed, T. A., Tawfik, W. A., Hassan, E. M., Higgins, M., El-Toumy, S. A. & Dinkova-Kostova, A. T., 31 Mar 2016, In: Journal of Chemical and Pharmaceutical Research. 8, 3, p. 788-793 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Flavonoids
  • vitamin B 12 factor III
  • Phytochemicals
  • Biological Assay
  • NAD
  134 Downloads (Pure)

• Broccoli or Sulforaphane: Is It the Source or Dose That Matters?

  Yagishita, Y., Fahey, J. W., Dinkova-Kostova, A. T. & Kensler, T. W., Oct 2019, In: Molecules and Cells. 24, 19, p. 1-38 38 p., 3593.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • sulforafan
  • Brassica
  • glucoraphanin
  • thioglucosidase
  • Pharmacodynamics
  31 Citations (Scopus)

  283 Downloads (Pure)

• Chemical constituents and NAD(P)H:Quinone oxidoreductase 1 (NQO1) inducer activity of Teucrium oliverianum Ging. ex Benth

  Shahat, A. A., Alsaid, M. S., Khan, J. A., Higgins, M. & Dinkova-Kostova, A. T., Apr 2016, In: Indian Journal of Traditional Knowledge. 15, 2, p. 232-236 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • eupatorin
  • Teucrium
  • quinone
  • 8-O-acetylharpagide
  • NAD
  3 Citations (Scopus)

  41 Downloads (Pure)

• Effects of chemoprotective agent HBB-2 on cell survival in SH-SY5Y neuroblastoma cells

  Scuto, M. C., Cavallaro, M. M., Luca, M., Cornelius, C., Cambria, M. T., Rizza, S., Salinaro, A. T., Dinkova-Kostova, A. & Calabrese, V., 2011, In: FEBS Journal. 278, S1, p. 268 1 p., P14.37.

  Research output: Contribution to journal › Meeting abstract › peer-review

• Electron affinity of tricyclic, bicyclic, and monocyclic compounds containing cyanoenones correlates with their potency as inducers of a cytoprotective enzyme

  Bensasson, R. V., Dinkova-Kostova, A. T., Zheng, S., Saito, A., Li, W., Zoete, V. & Honda, T., 1 Sep 2016, In: Bioorganic & Medicinal Chemistry Letters. 26, 17, p. 4345-4349 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  • Electron affinity
  • Density Functional Theory
  • Molecular orbitals
  • Density functional theory
  • Electrons
  3 Citations (Scopus)

  165 Downloads (Pure)

• Filaggrin genotype does not determine the skin's threshold to UV-induced erythema

  Forbes, D., Johnston, L., Gardner, J., MacCallum, S. F., Campbell, L. E., Dinkova-Kostova, A. T., McLean, W. H. I., Ibbotson, S. H., Dawe, R. S. & Brown, S. J., Apr 2016, In: Journal of Allergy and Clinical Immunology. 137, 4, p. 1280-1282.e3 6 p.

  Research output: Contribution to journal › Letter › peer-review

  Open Access

  File
  6 Citations (Scopus)

  140 Downloads (Pure)

• Glucosinolates from the Brassica Vegetables and Their Health Effects

  Johnson, T. L., Dinkova-Kostova, A. T. & Fahey, J. W., 2016, Encyclopedia of Food and Health. Caballero, B., Finglas, P. M. & Toldrá, F. (eds.). Elsevier Inc., p. 248-255 8 p. (Reference Module in Food Science).

  Research output: Chapter in Book/Report/Conference proceeding › Entry for encyclopedia/dictionary

  • Glucosinolates
  • Brassica
  • Vegetables
  • Thioglucosides
  • Magnoliopsida
  5 Citations (Scopus)

• Heat Shock Factor 1 is a Substrate for p38 Mitogen-Activated Protein Kinases

  Dayalan Naidu, S., Sutherland, C., Zhang, Y., Risco, A., de la Vega, L., Caunt, C. J., Hastie, C. J., Lamont, D. J., Torrente, L., Chowdhry, S., Benjamin, I. J., Keyse, S. M., Cuenda, A. & Dinkova-Kostova, A. T., 15 Sep 2016, In: Molecular and Cellular Biology. 36, 18, p. 2403-2417 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Heat-Shock Response
  • p38 Mitogen-Activated Protein Kinases
  • Phosphorylation
  • phenethyl isothiocyanate
  • Heat Shock Transcription Factors
  27 Citations (Scopus)

  281 Downloads (Pure)

• HSF1-Dependent Upregulation of Hsp70 by Sulfhydryl-Reactive Inducers of the KEAP1/NRF2/ARE Pathway

  Zhang, Y., Ahn, Y-H., Benjamin, I. J., Honda, T., Hicks, R. J., Calabrese, V., Cole, P. A. & Dinkova-Kostova, A. T., 23 Nov 2011, In: Chemistry & Biology. 18, 11, p. 1355-1361 7 p.

  Research output: Contribution to journal › Article › peer-review
  70 Citations (Scopus)

• Induction of the Keapl/Nrf2/ARE pathway by oxidizable diphenols

  Dinkova-Kostova, A. T. & Wang, X. J., 30 Jun 2011, In: Chemico-Biological Interactions. 192, 1-2, p. 101-106 6 p.

  Research output: Contribution to journal › Article › peer-review
  49 Citations (Scopus)

• Investigation into the use of histone deacetylase inhibitor MS-275 as a topical agent for the prevention and treatment of cutaneous squamous cell carcinoma in an SKH-1 hairless mouse model

  Kalin, J. H., Eroglu, A., Liu, H., Holtzclaw, W. D., Leigh, I., Proby, C. M., Fahey, J. W., Cole, P. A. & Dinkova-Kostova, A. T., 13 Mar 2019, In: PLoS ONE. 14, 3, p. 1-13 13 p., e0213095.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • entinostat
  • Epithelial Cells
  • squamous cell carcinoma
  • histone deacetylase
  • Hairless Mouse
  2 Citations (Scopus)

  135 Downloads (Pure)

• Loss of Nrf2 abrogates the protective effect of Keap1 down regulation in a preclinical model of cutaneous squamous cell carcinoma

  Knatko, E. V., Higgins, M., Fahey, J. W. & Dinkova-Kostova, A., 24 May 2016, In: Scientific Reports. 6, 7 p., 25804.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Kelch-Like ECH-Associated Protein 1
  • NF-E2-Related Factor 2
  • Squamous Cell Carcinoma
  • Down-Regulation
  • Skin
  20 Citations (Scopus)

  200 Downloads (Pure)

• Measuring the Interaction of Transcription Factor Nrf2 with Its Negative Regulator Keap1 in Single Live Cells by an Improved FRET/FLIM Analysis

  Dikovskaya, D., Appleton, P., Bento-Pereira, C. & Dinkova-Kostova, A., 18 Mar 2019, In: Chemical Research in Toxicology. 32, 3, p. 500-512 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Kelch-Like ECH-Associated Protein 1
  • NF-E2 Transcription Factor
  • Forster resonance energy transfer
  • NF-E2-Related Factor 2
  • Transcription Factors
  3 Citations (Scopus)

  157 Downloads (Pure)

• NAD(P)H: Quinone oxidoreductase 1 inducer activity of novel 4-aminoquinazoline derivatives

  Ghorab, M. M., Alsaid, M. S., El-Gazzar, M. G., Higgins, M., Dinkova-Kostova, A. T. & Shahat, A. A., 2016, In: Journal of Enzyme Inhibition and Medicinal Chemistry. 31, 6, p. 1369-1374 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • 4-aminoquinazoline
  • quinone
  • NAD
  • Oxidoreductases
  • Aptitude
  3 Citations (Scopus)

  198 Downloads (Pure)

• NAD(P)H: quinone oxidoreductase 1 inducer activity of some novel anilinoquinazoline derivatives

  Ghorab, M. M., Alsaid, M. S., Higgins, M., Dinkova-Kostova, A. T., Shahat, A. A., Elghazawy, N. H. & Arafa, R. K., 8 Aug 2016, In: Drug Design, Development and Therapy. 10, p. 2515-2524 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • anilinoquinazoline
  • Kelch-Like ECH-Associated Protein 1
  • quinone
  • NAD
  • Oxidoreductases
  3 Citations (Scopus)

  176 Downloads (Pure)

• Nrf2 activation in the treatment of neurodegenerative diseases: A focus on its role in mitochondrial bioenergetics and function

  Esteras, N., Dinkova-Kostova, A. T. & Abramov, A. Y., May 2016, In: Biological Chemistry. 397, 5, p. 383-400 18 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Neurodegenerative diseases
  • NF-E2-Related Factor 2
  • Energy Metabolism
  • Chemical activation
  • Neurodegenerative Diseases
  64 Citations (Scopus)

  288 Downloads (Pure)

• Nrf2-mediated neuroprotection response to recurrent hypoglycemia is insufficient to prevent cognitive impairment in a rodent model of type 1 diabetes

  McNeilly, A. D., Gallagher, J. R., Dinkova-Kostova, A. T., Hayes, J. D., Sharkey, J., Ashford, M. L. J. & McCrimmon, R. J., 1 Oct 2016, In: Diabetes. 65, 10, p. 3151-3160 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Neuroprotection
  • Hypoglycemia
  • Type 1 Diabetes Mellitus
  • Cognitive Dysfunction
  • Rodentia
  18 Citations (Scopus)

  157 Downloads (Pure)

• Oral Azathioprine Leads to Higher Incorporation of 6-Thioguanine in DNA of Skin than Liver: The Protective Role of the Keap1/Nrf2/ARE Pathway

  Kalra, S., Zhang, Y., Knatko, E. V., Finlayson, S., Yamamoto, M. & Dinkova-Kostova, A. T., Oct 2011, In: Cancer Prevention Research. 4, 10, p. 1665-1674 10 p.

  Research output: Contribution to journal › Article › peer-review
  13 Citations (Scopus)

• Potency of extracts from selected Egyptian plants as inducers of the Nrf2-dependent chemopreventive enzyme NQO1

  Hamed, A. R., Hegazy, M-E. F., Higgins, M., Mohamed, T. A., Abdel-Azim, N. S., Pare, P. W. & Dinkova-Kostova, A. T., Jul 2016, In: Journal of Natural Medicines. 70, 3, p. 683-688 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Chemoprevention
  • NF-E2-Related Factor 2
  • NF-E2 Transcription Factor
  • quinone
  • Heme Oxygenase-1
  6 Citations (Scopus)

  226 Downloads (Pure)

• Regulation of the CNC-bZIP transcription factor Nrf2 by Keap1 and the axis between GSK-3 and β-TrCP

  Hayes, J. D., Ebisine, K., Sharma, R. S., Chowdhry, S., Dinkova-Kostova, A. T. & Sutherland, C., Dec 2016, In: Current Opinion in Toxicology. 1, p. 92-103 12 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Kelch-Like ECH-Associated Protein 1
  • Basic-Leucine Zipper Transcription Factors
  • NF-E2-Related Factor 2
  • Mouse Keap1 protein
  • Glycogen Synthase Kinase 3
  10 Citations (Scopus)

  356 Downloads (Pure)

• Rhodiola rosea L. from golden root to green cell factories

  Marchev, A. S., Dinkova-Kostova, A. T., György, Z., Mirmazloum, I., Aneva, I. Y. & Georgiev, M. I., Aug 2016, In: Phytochemistry Reviews. 15, 4, p. 515-536 22 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Rhodiola
  • Rhodiola rosea
  • factories
  • secondary metabolites
  • Plant Roots
  18 Citations (Scopus)

  436 Downloads (Pure)

• Semisynthetic flavonoid 7-O-galloylquercetin activates Nrf2 and induces Nrf2-dependent gene expression in RAW264.7 and Hepa1c1c7 cells

  Roubalová, L., Biedermann, D., Papoušková, B., Vacek, J., Kuzma, M., Křen, V., Ulrichová, J., Dinkova-Kostova, A. T. & Vrba, J., 25 Dec 2016, In: Chemico-Biological Interactions. 260, p. 58-66 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Quercetin
  • Gene expression
  • Flavonoids
  • Heme Oxygenase-1
  • Gene Expression
  7 Citations (Scopus)

  171 Downloads (Pure)

• SIRT2- and NRF2-Targeting Thiazole-Containing Compound with Therapeutic Activity in Huntington's Disease Models

  Quinti, L., Casale, M., Moniot, S., Pais, T. F., Van Kanegan, M. J., Kaltenbach, L. S., Pallos, J., Lim, R. G., Naidu, S. D., Runne, H., Meisel, L., Rauf, N. A., Leyfer, D., Maxwell, M. M., Saiah, E., Landers, J. E., Luthi-Carter, R., Abagyan, R., Dinkova-Kostova, A. T., Steegborn, C. & 4 others, Marsh, J. L., Lo, D. C., Thompson, L. M. & Kazantsev, A. G., 21 Jul 2016, In: Cell Chemical Biology. 23, 7, p. 849-861 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Sirtuin 2
  • Thiazoles
  • Huntington Disease
  • Lead compounds
  • Systems Biology
  37 Citations (Scopus)

  199 Downloads (Pure)

• Synthesis, molecular modeling and NAD(P)H: quinone oxidoreductase 1 inducer activity of novel 2-phenylquinazolin-4-amine derivatives

  Ghorab, M. M., Alsaid, M. S., Higgins, M., Dinkova-Kostova, A. T., Shahat, A. A., Elghazawy, N. H. & Arafa, R. K., Apr 2016, In: Journal of Enzyme Inhibition and Medicinal Chemistry. 31, 6, p. 1612-1618 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • quinone
  • Amines
  • NAD
  • Oxidoreductases
  • Reactive Oxygen Species
  3 Citations (Scopus)

  155 Downloads (Pure)

• Synthesis and biological evaluation of 1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]-4-ethynylimidazole. A novel and highly potent anti-inflammatory and cytoprotective agent

  Honda, T., Dinkova-Kostova, A. T., David, E., Padegimas, E. M., Sundararajan, C., Visnick, M., Bumeister, R. & Wigley, W. C., 15 Apr 2011, In: Bioorganic & Medicinal Chemistry Letters. 21, 8, p. 2188-2191 4 p.

  Research output: Contribution to journal › Article › peer-review
  18 Citations (Scopus)

• Synthesis and biological evaluation of novel 2-phenylquinazoline-4-amine derivatives: identification of 6-phenyl-8H-benzo[g]quinazolino[4,3-b]quinazolin-8-one as a highly potent inducer of NAD(P)H quinone oxidoreductase 1

  Ghorab, M. M., Alsaid, M. S., El-Gazzar, M. G., Higgins, M., Dinkova-Kostova, A. T. & Shahat, A. A., 2016, In: Journal of Enzyme Inhibition and Medicinal Chemistry. 31, Suppl. 1, p. 34-49 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • quinone
  • NAD
  • Oxidoreductases
  • Kelch Repeat
  • Quinazolines
  4 Citations (Scopus)

  196 Downloads (Pure)

• Synthesis and NAD(P)H: Quinone oxidoreductase 1 inducer activity of acetamide and pyridine-3-carbonitrile derivatives

  Ghorab, M. M., Shahat, A. A., Alsaid, M. S., Higgins, M., Dinkova-Kostova, A. T. & Naser, A. A., 2016, In: Biomedical Research. 27, 4, p. 1045-1048 4 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • pyridine-3-carbonitrile
  • Pyridones
  • acetamide
  • quinone
  • NAD
  47 Downloads (Pure)

• The cytoprotective role of the Keap1-Nrf2 pathway

  Baird, L. & Dinkova-Kostova, A. T., Apr 2011, In: Archives of Toxicology. 85, 4, p. 241-272 32 p.

  Research output: Contribution to journal › Review article › peer-review
  603 Citations (Scopus)

• The isothiocyanate sulforaphane inhibits mTOR in an NRF2-independent manner

  Zhang, Y., Gilmour, A., Ahn, Y-H., de la Vega, L. & Dinkova-Kostova, A., 5 Aug 2019, In: Phytomedicine. 153062.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • sulforafan
  • isothiocyanic acid
  • Sirolimus
  • Histone Deacetylase 6
  • Inhibition (Psychology)
  3 Citations (Scopus)

  117 Downloads (Pure)

• The multifaceted role of Nrf2 in mitochondrial function

  Holmström, K. M., Kostov, R. V. & Dinkova-Kostova, A. T., Dec 2016, In: Current Opinion in Toxicology. 1, p. 80-91 12 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Stem cells
  • Mitochondria
  • NF-E2 Transcription Factor
  • Antioxidants
  • Stem Cells
  128 Citations (Scopus)

  215 Downloads (Pure)

• The multifaceted role of sulforaphane in protection against uv radiation-mediated skin damage

  Benedict, A. L., Knatko, E. V., Kostov, R. V., Zhang, Y., Higgins, M., Kalra, S., Fahey, J. W., Ibbotson, S. H., Proby, C. M., Talalay, P. & Dinkova-Kostova, A. T., Jan 2016, Broccoli: Cultivation, Nutritional Properties and Effects on Health. Nova Science Publishers, p. 185-208 24 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • sulforafan
  • Ultraviolet Rays
  • Radiation
  • Skin
  • isothiocyanic acid
  1 Citation (Scopus)

• Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases

  Cuadrado, A., Rojo, A. I., Wells, G., Hayes, J., Cousin, S. P., Rumsey, W. L., Attucks, O. C., Franklin, S., Levonen, A-L., Kensler, T. W. & Dinkova-Kostova, A., Apr 2019, In: Nature Reviews Drug Discovery. 18, 4, p. 295-317 23 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Kelch-Like ECH-Associated Protein 1
  • Chronic Disease
  • NF-E2-Related Factor 2
  • Proteostasis
  • Cytoprotection
  215 Citations (Scopus)

  252 Downloads (Pure)