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• Review article

  Broccoli or Sulforaphane: Is It the Source or Dose That Matters?

  Yagishita, Y., Fahey, J. W., Dinkova-Kostova, A. T. & Kensler, T. W., Oct 2019, In: Molecules and Cells. 24, 19, p. 1-38 38 p., 3593.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

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  • sulforafan
  • Brassica
  • glucoraphanin
  • thioglucosidase
  • Pharmacodynamics
  40 Citations (Scopus)

  313 Downloads (Pure)

• KEAP1 and done? Targeting the NRF2 pathway with sulforaphane: Targeting the NRF2 Pathway with Sulforaphane

  Dinkova-Kostova, A. T., Fahey, J. W., Kostov, R. V. & Kensler, T. W., Nov 2017, In: Trends in Food Science and Technology. 69, B, p. 257-269 13 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

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  • sulforaphane
  • sulforafan
  • Brassica
  • broccoli
  • clinical trials
  92 Citations (Scopus)

  444 Downloads (Pure)

• Metabolic and Homeostatic Changes in Seizures and Acquired Epilepsy-Mitochondria, Calcium Dynamics and Reactive Oxygen Species

  Kovac, S., Dinkova Kostova, A. T., Herrmann, A. M., Melzer, N., Meuth, S. G. & Gorji, A., 8 Sep 2017, In: International Journal of Molecular Sciences. 18, 9, p. 1-19 19 p., 1935.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

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  • Mitochondria
  • epilepsy
  • seizures
  • mitochondria
  • Metabolism
  27 Citations (Scopus)

  212 Downloads (Pure)

• Oxidative stress and chronic inflammation in osteoarthritis: can Nrf2 counteract these partners in crime?

  Marchev, A. S., Dimitrova, P. A., Burns, A. J., Kostov, R., Dinkova-Kostova, A. & Georgiev, M. I., 11 Sep 2017, In: Annals of the New York Academy of Sciences. 1401, p. 114-135 22 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

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  • Oxidative stress
  • Osteoarthritis
  • Crime
  • Inflammation
  • Bone
  61 Citations (Scopus)

  454 Downloads (Pure)

• Regulation of the mammalian heat shock factor 1

  Dayalan Naidu, S. & Dinkova-Kostova, A. T., Jun 2017, In: FEBS Journal. 284, 11, p. 1606-1627 22 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Heat-Shock Response
  • Machinery
  • Acetylation
  • Phosphorylation
  • Heat Shock Transcription Factors
  63 Citations (Scopus)

  274 Downloads (Pure)

• The cytoprotective role of the Keap1-Nrf2 pathway

  Baird, L. & Dinkova-Kostova, A. T., Apr 2011, In: Archives of Toxicology. 85, 4, p. 241-272 32 p.

  Research output: Contribution to journal › Review article › peer-review
  627 Citations (Scopus)

• Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases

  Cuadrado, A., Rojo, A. I., Wells, G., Hayes, J., Cousin, S. P., Rumsey, W. L., Attucks, O. C., Franklin, S., Levonen, A-L., Kensler, T. W. & Dinkova-Kostova, A., Apr 2019, In: Nature Reviews Drug Discovery. 18, 4, p. 295-317 23 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Kelch-Like ECH-Associated Protein 1
  • Chronic Disease
  • NF-E2-Related Factor 2
  • Proteostasis
  • Cytoprotection
  258 Citations (Scopus)

  276 Downloads (Pure)
• Meeting abstract

  Effects of chemoprotective agent HBB-2 on cell survival in SH-SY5Y neuroblastoma cells

  Scuto, M. C., Cavallaro, M. M., Luca, M., Cornelius, C., Cambria, M. T., Rizza, S., Salinaro, A. T., Dinkova-Kostova, A. & Calabrese, V., 2011, In: FEBS Journal. 278, S1, p. 268 1 p., P14.37.

  Research output: Contribution to journal › Meeting abstract › peer-review
• Editorial

  Activation of Nrf2 signaling as a common treatment of neurodegenerative diseases

  Dinkova-Kostova, A. T. & Kazantsev, A. G., Apr 2017, In: Neurodegenerative Disease Management. 7, 2, p. 97-100 4 p.

  Research output: Contribution to journal › Editorial

  Open Access

  File
  11 Citations (Scopus)

  207 Downloads (Pure)

• NRF2 as an emerging therapeutic target

  Copple, I. M., Dinkova-Kostova, A. T., Kensler, T. W., Liby, K. T. & Wigley, W. C., 31 Jan 2017, In: Oxidative Medicine and Cellular Longevity. 2017, p. 1-2 2 p., 8165458.

  Research output: Contribution to journal › Editorial › peer-review

  Open Access

  File
  23 Citations (Scopus)

  205 Downloads (Pure)
• Article

  Activation of Nrf2 signaling augments Vesicular Stomatitis Virus Oncolysis via Autophagy-Driven Suppression of Antiviral Immunity

  Olagnier, D., Lababidi, R. R., Bel Hadj, S., Sze, A., Liu, Y., Dayalan Naidu, S., Ferrari, M., Jiang, Y., Chiang, C., Beljanski, V., Goulet, M-L., Knatko, E. V., Dinkova-Kostova, A. T., Hiscott, J. & Lin, R., 2 Aug 2017, In: Molecular Therapy. 25, 8, p. 1900-1916 17 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Vesicular Stomatitis
  • Autophagy
  • Antiviral Agents
  • Immunity
  • Oncolytic Viruses
  37 Citations (Scopus)

  204 Downloads (Pure)

• Crosstalk between NRF2 and HIPK2 shapes cytoprotective responses

  Torrente, L., Sanchez, C., Moreno Dorta, R., Chowdhry, S., Cabello, P., Isono, K., Koseki, H., Honda, T., Hayes, J., Dinkova-Kostova, A. & de la Vega, L., 2 Nov 2017, In: Oncogene. 36, 44, p. 6204-6212 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Homeodomain Proteins
  • Protein Kinases
  • Neoplasms
  • Phosphotransferases
  • Oncogenes
  33 Citations (Scopus)

  246 Downloads (Pure)

• Epigenetic Control of NRF2-Directed Cellular Antioxidant Status in Dictating Life-Death Decisions

  Hayes, J. D. & Dinkova-Kostova, A. T., 5 Oct 2017, In: Molecular Cell. 68, 1, p. 5-7 3 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Epigenomics
  • Antioxidants
  • Tumor Suppressor Proteins
  • Acetylation
  • Oxidation-Reduction
  9 Citations (Scopus)

  327 Downloads (Pure)

• Flavonolignan 2,3-dehydrosilydianin activates Nrf2 and upregulates NAD(P)H: quinone oxidoreductase 1 in Hepa1c1c7 cells

  Roubalová, L., Dinkova-Kostova, A. T., Biedermann, D., Křen, V., Ulrichová, J. & Vrba, J., Jun 2017, In: Fitoterapia. 119, p. 115-120 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Flavonolignans
  • quinone
  • Milk Thistle
  • NAD
  • Oxidoreductases
  18 Citations (Scopus)

  199 Downloads (Pure)

• HSF1-Dependent Upregulation of Hsp70 by Sulfhydryl-Reactive Inducers of the KEAP1/NRF2/ARE Pathway

  Zhang, Y., Ahn, Y-H., Benjamin, I. J., Honda, T., Hicks, R. J., Calabrese, V., Cole, P. A. & Dinkova-Kostova, A. T., 23 Nov 2011, In: Chemistry & Biology. 18, 11, p. 1355-1361 7 p.

  Research output: Contribution to journal › Article › peer-review
  70 Citations (Scopus)

• Induction of the Keapl/Nrf2/ARE pathway by oxidizable diphenols

  Dinkova-Kostova, A. T. & Wang, X. J., 30 Jun 2011, In: Chemico-Biological Interactions. 192, 1-2, p. 101-106 6 p.

  Research output: Contribution to journal › Article › peer-review
  51 Citations (Scopus)

• Investigation into the use of histone deacetylase inhibitor MS-275 as a topical agent for the prevention and treatment of cutaneous squamous cell carcinoma in an SKH-1 hairless mouse model

  Kalin, J. H., Eroglu, A., Liu, H., Holtzclaw, W. D., Leigh, I., Proby, C. M., Fahey, J. W., Cole, P. A. & Dinkova-Kostova, A. T., 13 Mar 2019, In: PLoS ONE. 14, 3, p. 1-13 13 p., e0213095.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • entinostat
  • Epithelial Cells
  • squamous cell carcinoma
  • histone deacetylase
  • Hairless Mouse
  2 Citations (Scopus)

  142 Downloads (Pure)

• Keap1, the cysteine-based mammalian intracellular sensor for electrophiles and oxidants

  Dinkova-Kostova, A. T., Kostov, R. V. & Canning, P., 1 Mar 2017, In: Archives of Biochemistry and Biophysics. 617, p. 84-93 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Kelch-Like ECH-Associated Protein 1
  • Oxidants
  • Cysteine
  • NF-E2-Related Factor 2
  • Sensors
  111 Citations (Scopus)

  193 Downloads (Pure)

• KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients

  Quinti, L., Dayalan Naidu, S., Träge, U., Chen, X., Kegel-Gleason, K., Lleres, D., Connolly, C., Chopra, V., Low, C., Moniot, S., Sapp, E., Tousley, A. R., Vodicka, P., Van Kanegan, M. J., Kaltenbach, L. S., Crawford, L. A., Fuszard, M., Higgins, M., Miller, J. R. C., Farmer, R. E. & 19 others, Potluri, V., Samajdar, S., Meisel, L., Zhang, N., Snyder, A., Stein, R., Hersch, S. M., Ellerby, L. M., Weerapana, E., Schwarzschild, M. A., Steegborn, C., Leavitt, B. R., Degterev, A., Tabrizi, S. J., Lo, D. C., DiFiglia, M., Thompson, L. M., Dinkova-Kostova, A. & Kazantsev, A. G., 6 Jun 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 23, p. e4676-e4685 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Kelch-Like ECH-Associated Protein 1
  • Neural Stem Cells
  • Huntington Disease
  • NF-E2 Transcription Factor
  • Interleukin-6
  41 Citations (Scopus)

  193 Downloads (Pure)

• Measuring the Interaction of Transcription Factor Nrf2 with Its Negative Regulator Keap1 in Single Live Cells by an Improved FRET/FLIM Analysis

  Dikovskaya, D., Appleton, P., Bento-Pereira, C. & Dinkova-Kostova, A., 18 Mar 2019, In: Chemical Research in Toxicology. 32, 3, p. 500-512 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Kelch-Like ECH-Associated Protein 1
  • NF-E2 Transcription Factor
  • Forster resonance energy transfer
  • NF-E2-Related Factor 2
  • Transcription Factors
  4 Citations (Scopus)

  169 Downloads (Pure)

• Oncogene-Stimulated Congestion at the KEAP1 Stress Signaling Hub Allows Bypass of NRF2 and Induction of NRF2-Target Genes that Promote Tumor Survival

  Hayes, J. D. & Dinkova-Kostova, A. T., Nov 2017, In: Cancer Cell. 32, 5, p. 539-541 3 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Oncogenes
  • Oncogene Proteins
  • Ligases
  • Ubiquitin
  • Genes
  11 Citations (Scopus)

  256 Downloads (Pure)

• Oral Azathioprine Leads to Higher Incorporation of 6-Thioguanine in DNA of Skin than Liver: The Protective Role of the Keap1/Nrf2/ARE Pathway

  Kalra, S., Zhang, Y., Knatko, E. V., Finlayson, S., Yamamoto, M. & Dinkova-Kostova, A. T., Oct 2011, In: Cancer Prevention Research. 4, 10, p. 1665-1674 10 p.

  Research output: Contribution to journal › Article › peer-review
  14 Citations (Scopus)

• Oxidative stress management in the hair follicle: Could targeting NRF2 counter age-related hair disorders and beyond?

  Jadkauskaite, L., Coulombe, P. A., Schäfer, M., Dinkova-Kostova, A. T., Paus, R. & Haslam, I. S., 27 Jul 2017, In: BioEssays. 39, 8, p. 1-9 9 p., 1700029.

  Research output: Contribution to journal › Article › peer-review

  • Oxidative stress
  • Oxidation-Reduction
  • Hair Follicle
  • Oxidative Stress
  • Chemical activation
  16 Citations (Scopus)

• Pathogenic p62/SQSTM1 mutations impair energy metabolism through limitation of mitochondrial substrates

  Bartolome, F., Esteras, N., Martin-Requero, A., Boutoleau-Bretonniere, C., Vercelletto, M., Gabelle, A., Le Ber, I., Honda, T., Dinkova-Kostova, A. T., Hardy, J., Carro, E. & Abramov, A. Y., 10 May 2017, In: Scientific Reports. 7, p. 1-14 14 p., 1666.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Frontotemporal Dementia With Motor Neuron Disease
  • Mitochondrial Membrane Potential
  • NAD
  • Energy Metabolism
  • Fibroblasts
  33 Citations (Scopus)

  312 Downloads (Pure)

• Synthesis and biological evaluation of 1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]-4-ethynylimidazole. A novel and highly potent anti-inflammatory and cytoprotective agent

  Honda, T., Dinkova-Kostova, A. T., David, E., Padegimas, E. M., Sundararajan, C., Visnick, M., Bumeister, R. & Wigley, W. C., 15 Apr 2011, In: Bioorganic & Medicinal Chemistry Letters. 21, 8, p. 2188-2191 4 p.

  Research output: Contribution to journal › Article › peer-review
  18 Citations (Scopus)

• The isothiocyanate sulforaphane inhibits mTOR in an NRF2-independent manner

  Zhang, Y., Gilmour, A., Ahn, Y-H., de la Vega, L. & Dinkova-Kostova, A., 5 Aug 2019, In: Phytomedicine. 153062.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • sulforafan
  • isothiocyanic acid
  • Sirolimus
  • Histone Deacetylase 6
  • Inhibition (Psychology)
  4 Citations (Scopus)

  125 Downloads (Pure)

• Transcription factors NRF2 and HSF1 have opposing functions in autophagy

  Dayalan Naidu, S., Dikovskaya, D., Gaurilcikaite, E., Knatko, E., Healy, Z. R., Mohan, H., Koh, G., Laurell, A., Ball, G., Olagnier, D., de la Vega, L., Ganley, I., Talalay, P. & Dinkova-Kostova, A., 8 Sep 2017, In: Scientific Reports. 7, p. 1-12 12 p., 11023.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Heat Shock Transcription Factors
  • Autophagy
  • Heat-Shock Response
  • Sequestosome-1 Protein
  • GATA1 Transcription Factor
  25 Citations (Scopus)

  226 Downloads (Pure)

• Whole-exome sequencing validates a preclinical mouse model for the prevention and treatment of cutaneous squamous cell carcinoma

  Knatko, E. V., Praslicka, B., Higgins, M., Evans, A., Purdie, K. J., Harwood, C. A., Proby, C. M., Ooi, A. & Dinkova-Kostova, A. T., Jan 2017, In: Cancer Prevention Research. 10, 1, p. 67-75 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Whole Exome Sequencing
  • Squamous Cell Carcinoma
  • Single Nucleotide Polymorphism
  • Skin
  • Mutation Rate
  9 Citations (Scopus)

  168 Downloads (Pure)