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2019
Broccoli or Sulforaphane: Is It the Source or Dose That Matters?
Yagishita, Y., Fahey, J. W., Dinkova-Kostova, A. T. & Kensler, T. W., Oct 2019, In: Molecules and Cells. 24, 19, p. 1-38 38 p., 3593.Research output: Contribution to journal › Review article › peer-review
Open AccessFile29 Citations (Scopus)281 Downloads (Pure) -
Investigation into the use of histone deacetylase inhibitor MS-275 as a topical agent for the prevention and treatment of cutaneous squamous cell carcinoma in an SKH-1 hairless mouse model
Kalin, J. H., Eroglu, A., Liu, H., Holtzclaw, W. D., Leigh, I., Proby, C. M., Fahey, J. W., Cole, P. A. & Dinkova-Kostova, A. T., 13 Mar 2019, In: PLoS ONE. 14, 3, p. 1-13 13 p., e0213095.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)134 Downloads (Pure) -
Measuring the Interaction of Transcription Factor Nrf2 with Its Negative Regulator Keap1 in Single Live Cells by an Improved FRET/FLIM Analysis
Dikovskaya, D., Appleton, P., Bento-Pereira, C. & Dinkova-Kostova, A., 18 Mar 2019, In: Chemical Research in Toxicology. 32, 3, p. 500-512 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)157 Downloads (Pure) -
The isothiocyanate sulforaphane inhibits mTOR in an NRF2-independent manner
Zhang, Y., Gilmour, A., Ahn, Y-H., de la Vega, L. & Dinkova-Kostova, A., 5 Aug 2019, In: Phytomedicine. 153062.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)117 Downloads (Pure) -
Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases
Cuadrado, A., Rojo, A. I., Wells, G., Hayes, J., Cousin, S. P., Rumsey, W. L., Attucks, O. C., Franklin, S., Levonen, A-L., Kensler, T. W. & Dinkova-Kostova, A., Apr 2019, In: Nature Reviews Drug Discovery. 18, 4, p. 295-317 23 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile210 Citations (Scopus)251 Downloads (Pure) -
2016
Bioactive polymethoxylated flavonoids from Chiliadenus montanus
Hamed, A. R., Mohamed, T. A., Tawfik, W. A., Hassan, E. M., Higgins, M., El-Toumy, S. A. & Dinkova-Kostova, A. T., 31 Mar 2016, In: Journal of Chemical and Pharmaceutical Research. 8, 3, p. 788-793 6 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile134 Downloads (Pure) -
Chemical constituents and NAD(P)H:Quinone oxidoreductase 1 (NQO1) inducer activity of Teucrium oliverianum Ging. ex Benth
Shahat, A. A., Alsaid, M. S., Khan, J. A., Higgins, M. & Dinkova-Kostova, A. T., Apr 2016, In: Indian Journal of Traditional Knowledge. 15, 2, p. 232-236 5 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)41 Downloads (Pure) -
Electron affinity of tricyclic, bicyclic, and monocyclic compounds containing cyanoenones correlates with their potency as inducers of a cytoprotective enzyme
Bensasson, R. V., Dinkova-Kostova, A. T., Zheng, S., Saito, A., Li, W., Zoete, V. & Honda, T., 1 Sep 2016, In: Bioorganic & Medicinal Chemistry Letters. 26, 17, p. 4345-4349 5 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)165 Downloads (Pure) -
Filaggrin genotype does not determine the skin's threshold to UV-induced erythema
Forbes, D., Johnston, L., Gardner, J., MacCallum, S. F., Campbell, L. E., Dinkova-Kostova, A. T., McLean, W. H. I., Ibbotson, S. H., Dawe, R. S. & Brown, S. J., Apr 2016, In: Journal of Allergy and Clinical Immunology. 137, 4, p. 1280-1282.e3 6 p.Research output: Contribution to journal › Letter › peer-review
Open AccessFile6 Citations (Scopus)140 Downloads (Pure) -
Glucosinolates from the Brassica Vegetables and Their Health Effects
Johnson, T. L., Dinkova-Kostova, A. T. & Fahey, J. W., 2016, Encyclopedia of Food and Health. Caballero, B., Finglas, P. M. & Toldrá, F. (eds.). Elsevier Inc., p. 248-255 8 p. (Reference Module in Food Science).Research output: Chapter in Book/Report/Conference proceeding › Entry for encyclopedia/dictionary
5 Citations (Scopus) -
Heat Shock Factor 1 is a Substrate for p38 Mitogen-Activated Protein Kinases
Dayalan Naidu, S., Sutherland, C., Zhang, Y., Risco, A., de la Vega, L., Caunt, C. J., Hastie, C. J., Lamont, D. J., Torrente, L., Chowdhry, S., Benjamin, I. J., Keyse, S. M., Cuenda, A. & Dinkova-Kostova, A. T., 15 Sep 2016, In: Molecular and Cellular Biology. 36, 18, p. 2403-2417 15 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile27 Citations (Scopus)278 Downloads (Pure) -
Loss of Nrf2 abrogates the protective effect of Keap1 down regulation in a preclinical model of cutaneous squamous cell carcinoma
Knatko, E. V., Higgins, M., Fahey, J. W. & Dinkova-Kostova, A., 24 May 2016, In: Scientific Reports. 6, 7 p., 25804.Research output: Contribution to journal › Article › peer-review
Open AccessFile20 Citations (Scopus)199 Downloads (Pure) -
NAD(P)H: Quinone oxidoreductase 1 inducer activity of novel 4-aminoquinazoline derivatives
Ghorab, M. M., Alsaid, M. S., El-Gazzar, M. G., Higgins, M., Dinkova-Kostova, A. T. & Shahat, A. A., 2016, In: Journal of Enzyme Inhibition and Medicinal Chemistry. 31, 6, p. 1369-1374 7 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)198 Downloads (Pure) -
NAD(P)H: quinone oxidoreductase 1 inducer activity of some novel anilinoquinazoline derivatives
Ghorab, M. M., Alsaid, M. S., Higgins, M., Dinkova-Kostova, A. T., Shahat, A. A., Elghazawy, N. H. & Arafa, R. K., 8 Aug 2016, In: Drug Design, Development and Therapy. 10, p. 2515-2524 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)176 Downloads (Pure) -
Nrf2 activation in the treatment of neurodegenerative diseases: A focus on its role in mitochondrial bioenergetics and function
Esteras, N., Dinkova-Kostova, A. T. & Abramov, A. Y., May 2016, In: Biological Chemistry. 397, 5, p. 383-400 18 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile64 Citations (Scopus)288 Downloads (Pure) -
Nrf2-mediated neuroprotection response to recurrent hypoglycemia is insufficient to prevent cognitive impairment in a rodent model of type 1 diabetes
McNeilly, A. D., Gallagher, J. R., Dinkova-Kostova, A. T., Hayes, J. D., Sharkey, J., Ashford, M. L. J. & McCrimmon, R. J., 1 Oct 2016, In: Diabetes. 65, 10, p. 3151-3160 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile18 Citations (Scopus)157 Downloads (Pure) -
Potency of extracts from selected Egyptian plants as inducers of the Nrf2-dependent chemopreventive enzyme NQO1
Hamed, A. R., Hegazy, M-E. F., Higgins, M., Mohamed, T. A., Abdel-Azim, N. S., Pare, P. W. & Dinkova-Kostova, A. T., Jul 2016, In: Journal of Natural Medicines. 70, 3, p. 683-688 6 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)226 Downloads (Pure) -
Regulation of the CNC-bZIP transcription factor Nrf2 by Keap1 and the axis between GSK-3 and β-TrCP
Hayes, J. D., Ebisine, K., Sharma, R. S., Chowdhry, S., Dinkova-Kostova, A. T. & Sutherland, C., Dec 2016, In: Current Opinion in Toxicology. 1, p. 92-103 12 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile10 Citations (Scopus)355 Downloads (Pure) -
Rhodiola rosea L. from golden root to green cell factories
Marchev, A. S., Dinkova-Kostova, A. T., György, Z., Mirmazloum, I., Aneva, I. Y. & Georgiev, M. I., Aug 2016, In: Phytochemistry Reviews. 15, 4, p. 515-536 22 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile17 Citations (Scopus)434 Downloads (Pure) -
Semisynthetic flavonoid 7-O-galloylquercetin activates Nrf2 and induces Nrf2-dependent gene expression in RAW264.7 and Hepa1c1c7 cells
Roubalová, L., Biedermann, D., Papoušková, B., Vacek, J., Kuzma, M., Křen, V., Ulrichová, J., Dinkova-Kostova, A. T. & Vrba, J., 25 Dec 2016, In: Chemico-Biological Interactions. 260, p. 58-66 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)171 Downloads (Pure) -
SIRT2- and NRF2-Targeting Thiazole-Containing Compound with Therapeutic Activity in Huntington's Disease Models
Quinti, L., Casale, M., Moniot, S., Pais, T. F., Van Kanegan, M. J., Kaltenbach, L. S., Pallos, J., Lim, R. G., Naidu, S. D., Runne, H., Meisel, L., Rauf, N. A., Leyfer, D., Maxwell, M. M., Saiah, E., Landers, J. E., Luthi-Carter, R., Abagyan, R., Dinkova-Kostova, A. T., Steegborn, C. & 4 others, , 21 Jul 2016, In: Cell Chemical Biology. 23, 7, p. 849-861 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile37 Citations (Scopus)199 Downloads (Pure) -
Synthesis, molecular modeling and NAD(P)H: quinone oxidoreductase 1 inducer activity of novel 2-phenylquinazolin-4-amine derivatives
Ghorab, M. M., Alsaid, M. S., Higgins, M., Dinkova-Kostova, A. T., Shahat, A. A., Elghazawy, N. H. & Arafa, R. K., Apr 2016, In: Journal of Enzyme Inhibition and Medicinal Chemistry. 31, 6, p. 1612-1618 7 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)155 Downloads (Pure) -
Synthesis and biological evaluation of novel 2-phenylquinazoline-4-amine derivatives: identification of 6-phenyl-8H-benzo[g]quinazolino[4,3-b]quinazolin-8-one as a highly potent inducer of NAD(P)H quinone oxidoreductase 1
Ghorab, M. M., Alsaid, M. S., El-Gazzar, M. G., Higgins, M., Dinkova-Kostova, A. T. & Shahat, A. A., 2016, In: Journal of Enzyme Inhibition and Medicinal Chemistry. 31, Suppl. 1, p. 34-49 6 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)196 Downloads (Pure) -
Synthesis and NAD(P)H: Quinone oxidoreductase 1 inducer activity of acetamide and pyridine-3-carbonitrile derivatives
Ghorab, M. M., Shahat, A. A., Alsaid, M. S., Higgins, M., Dinkova-Kostova, A. T. & Naser, A. A., 2016, In: Biomedical Research. 27, 4, p. 1045-1048 4 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile47 Downloads (Pure) -
The multifaceted role of Nrf2 in mitochondrial function
Holmström, K. M., Kostov, R. V. & Dinkova-Kostova, A. T., Dec 2016, In: Current Opinion in Toxicology. 1, p. 80-91 12 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile128 Citations (Scopus)215 Downloads (Pure) -
The multifaceted role of sulforaphane in protection against uv radiation-mediated skin damage
Benedict, A. L., Knatko, E. V., Kostov, R. V., Zhang, Y., Higgins, M., Kalra, S., Fahey, J. W., Ibbotson, S. H., Proby, C. M., Talalay, P. & Dinkova-Kostova, A. T., Jan 2016, Broccoli: Cultivation, Nutritional Properties and Effects on Health. Nova Science Publishers, p. 185-208 24 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter
1 Citation (Scopus) -
2013
Chemoprotection Against Cancer by Isothiocyanates: A Focus on the Animal Models and the Protective Mechanisms
Dinkova-Kostova, A. T., 2013, Natural Products in Cancer Prevention and Therapy. Pezzuto, J. M. & Suh, N. (eds.). Berlin: Springer , p. 179-201 23 p. (Topics in Current Chemistry; vol. 329).Research output: Chapter in Book/Report/Conference proceeding › Chapter
32 Citations (Scopus) -
Diffusion dynamics of the Keap1-Cullin3 interaction in single live cells
Baird, L. & Dinkova-Kostova, A. T., 2013, In: Biochemical and Biophysical Research Communications. 433, 1, p. 58-65 8 p.Research output: Contribution to journal › Article › peer-review
34 Citations (Scopus) -
NAD(P)H: Quinone oxidoreductase 1 inducer activity of some Saudi Arabian medicinal plants
Shahat, A. A., Alsaid, M. S., Alyahya, M. A., Higgins, M. & Dinkova-Kostova, A. T., Apr 2013, In: Planta Medica. 79, 6, p. 459-464 6 p.Research output: Contribution to journal › Article › peer-review
11 Citations (Scopus) -
Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration
Holmström, K. M., Baird, L., Zhang, Y., Hargreaves, I., Chalasani, A., Land, J. M., Stanyer, L., Yamamoto, M., Dinkova-Kostova, A. T. & Abramov, A. Y., 15 Aug 2013, In: Open Biology. 2, 8, p. 761-770 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile205 Citations (Scopus)215 Downloads (Pure) -
Regulatory flexibility in the Nrf2-mediated stress response is conferred by conformational cycling of the Keap1-Nrf2 protein complex
Baird, L., Llères, D., Swift, S. & Dinkova-Kostova, A. T., 17 Sep 2013, In: Proceedings of the National Academy of Sciences of the United States of America. 110, 38, p. 15259-15264 6 p.Research output: Contribution to journal › Article › peer-review
171 Citations (Scopus) -
Synthesis and biological evaluation of biotin conjugates of (±)-(4bS,8aR,10aS)-10a-ethynyl-4b,8,8-trimethyl-3,7-dioxo-3,4b,7,8,8a,9,10,10a-octahydro-phenanthrene-2,6-dicarbonitrile, an activator of the Keap1/Nrf2/ARE pathway, for the isolation of its protein targets
Saito, A., Higgins, M., Zheng, S., Li, W., Ojima, I., Dinkova-Kostova, A. T. & Honda, T., 15 Oct 2013, In: Bioorganic & Medicinal Chemistry Letters. 23, 20, p. 5540-5543 4 p.Research output: Contribution to journal › Article › peer-review
4 Citations (Scopus) -
2012
Arthur Neish Young Investigator Award Lecture a Novel Role for Sulfhydryl-Reactive Activators of Transcription Factor NRF2: HSF1-Dependent Upregulation of Hsp70
Zhang, Y., Ahn, Y-H., Calabrese, V., Cole, P. A. & Dinkova-Kostova, A. T., May 2012, In: Pharmaceutical Biology. 50, 5, p. 625-625 1 p.Research output: Contribution to journal › Special issue › peer-review
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Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity
Calabrese, V., Cornelius, C., Dinkova-Kostova, A. T., Iavicoli, I., Di Paola, R., Koverech, A., Cuzzocrea, S., Rizzarelli, E. & Calabrese, E. J., May 2012, In: Biochimica et Biophysica Acta. Molecular Basis of Disease. 1822, 5, p. 753-783 31 p.Research output: Contribution to journal › Review article › peer-review
265 Citations (Scopus) -
Glucosinolates and isothiocyanates in health and disease
Dinkova-Kostova, A. T. & Kostov, R. V., 2012, In: Trends in Molecular Medicine. 18, 6, p. 337-347 11 p.Research output: Contribution to journal › Article › peer-review
326 Citations (Scopus) -
Glutathione S-transferase genotype is associated with sensitivity to psoralen-ultraviolet A photochemotherapy
Ibbotson, S. H., Dawe, R. S., Dinkova-Kostova, A. T., Weidlich, S., Farr, P. M., Ferguson, J., Wolf, C. R. & Smith, G., Feb 2012, In: British Journal of Dermatology. 166, 2, p. 380-388 9 p.Research output: Contribution to journal › Article › peer-review
17 Citations (Scopus) -
Highly potent activation of Nrf2 by topical tricyclic bis(cyano enone): Implications for protection against UV radiation during thiopurine therapy
Kalra, S., Knatko, E. V., Zhang, Y., Honda, T., Yamamoto, M. & Dinkova-Kostova, A. T., 2012, In: Cancer Prevention Research. 5, 7, p. 973-981 9 p.Research output: Contribution to journal › Article › peer-review
30 Citations (Scopus) -
Neuroprotective effects of sulforaphane after contusive spinal cord injury
Benedict, A. L., Mountney, A., Hurtado, A., Bryan, K. E., Schnaar, R. L., Dinkova-Kostova, A. T. & Talalay, P., 2012, In: Journal of Neurotrauma. 29, 16, p. 2576-2586 11 p.Research output: Contribution to journal › Article › peer-review
46 Citations (Scopus) -
Synthesis, chemical reactivity as Michael acceptors, and biological potency of monocyclic cyanoenones, novel and highly potent anti-inflammatory and cytoprotective agents
Zheng, S., Laxmi, Y. R. S., David, E., Dinkova-Kostova, A. T., Shiavoni, K. H., Ren, Y., Zheng, Y., Trevino, I., Bumeister, R., Ojima, I., Wigley, W. C., Bliska, J. B., Mierke, D. F. & Honda, T., 24 May 2012, In: Journal of Medicinal Chemistry. 55, 10, p. 4837-4846 10 p.Research output: Contribution to journal › Article › peer-review
42 Citations (Scopus) -
The indirect antioxidant sulforaphane protects against thiopurine-mediated photooxidative stress
Benedict, A. L., Knatko, E. V. & Dinkova-Kostova, A. T., Dec 2012, In: Carcinogenesis. 33, 12, p. 2457-2466 10 p.Research output: Contribution to journal › Article › peer-review
32 Citations (Scopus)