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• Article

  New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries

  Understanding Society Scientific Group, Shrine, N., Guyatt, A. L., Erzurumluoglu, A. M., Jackson, V. E., Hobbs, B. D., Melbourne, C. A., Batini, C., Fawcett, K. A., Song, K., Sakornsakolpat, P., Li, X., Boxall, R., Reeve, N. F., Obeidat, M., Zhao, J. H., Wielscher, M., Weiss, S., Kentistou, K. A., Cook, J. P. & 33 others, Sun, B. B., Zhou, J., Hui, J., Karrasch, S., Imboden, M., Harris, S. E., Marten, J., Enroth, S., Kerr, S. M., Surakka, I., Vitart, V., Lehtimäki, T., Allen, R. J., Bakke, P. S., Beaty, T. H., Bleecker, E. R., Bossé, Y., Brandsma, C-A., Chen, Z., Crapo, J. D., Danesh, J., DeMeo, D. L., Dudbridge, F., Ewert, R., Gieger, C., Gulsvik, A., Hansell, A. L., Hao, K., Hoffman, J. D., Hokanson, J. E., Smith, B. H., Tobin, M. D. & Wain, L. V., Mar 2019, In: Nature Genetics. 51, 3, p. 481-493 13 p.

  Research output: Contribution to journal › Article › peer-review

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  • Chronic Obstructive Pulmonary Disease
  • Lung
  • Smokers
  • Genome-Wide Association Study
  • Mortality
  52 Citations (Scopus)

  406 Downloads (Pure)

• Physical activity and exercise for chronic pain in adults: An overview of Cochrane reviews

  Geneen, L., Smith, B., Clarke, C., Martin, D., Colvin, L. A. & Moore, R. A., 25 Aug 2014, In: Cochrane Database of Systematic Reviews. 2014, 8, p. 1-9 9 p., CD011279.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  • Chronic Pain
  • Exercise
  • Quality of Health Care
  • Systematic Reviews
  • Quality of Life
  248 Citations (Scopus)

  105 Downloads (Pure)

• Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution

  T2D-Genes Consortium, The MAGIC Investigators, CHD Exome+ Consortium, EPIC-CVD Consortium, ExomeBP Consortium, Global Lipids Genetic Consortium, GoT2D Genes Consortium, ReproGen Consortium, Justice, A. E., Karaderi, T., Highland, H. M., Young, K. L., Graff, M., Lu, Y., Turcot, V., Auer, P. L., Fine, R. S., Guo, X., Schurmann, C., Lempradl, A. & 40 others, Marouli, E., Mahajan, A., Winkler, T. W., Locke, A. E., Medina-Gomez, C., Esko, T., Vedantam, S., Giri, A., Lo, K. S., Alfred, T., Mudgal, P., Ng, M. C. Y., Heard-Costa, N. L., Feitosa, M. F., Manning, A. K., Willems, S. M., Sivapalaratnam, S., Abecasis, G., Alam, D. S., Allison, M., Amouyel, P., Arzumanyan, Z., Balkau, B., Bastarache, L., Bergmann, S., Bielak, L. F., Blüher, M., Boehnke, M., Boeing, H., Boerwinkle, E., Böger, C. A., Bork-Jensen, J., Evangelou, E., Li, J., Morris, A. P., Smith, B. H., Smith, J. A., Wood, A. R., North, K. E. & Lindgren, C. M., Mar 2019, In: Nature Genetics. 51, 3, p. 452-469 18 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  • Body Fat Distribution
  • Homeostasis
  • Lipids
  • Fats
  • White Adipose Tissue
  21 Citations (Scopus)

  266 Downloads (Pure)

• Regional variation in health is predominantly driven by lifestyle rather than genetics

  Amador, C., Xia, C., Nagy, R., Campbell, A., Porteous, D. J., Smith, B. H., Hastie, N., Vitart, V., Hayward, C., Navarro, P. & Haley, C. S., 6 Oct 2017, In: Nature Communications. 8, p. 1-7 7 p., 801.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  • Genetics
  • health
  • obesity
  • Life Style
  • Health
  5 Citations (Scopus)

  176 Downloads (Pure)

• Stratification by Smoking Status Reveals an Association of CHRNA5-A3-B4 Genotype with Body Mass Index in Never Smokers

  Taylor, A. E., Morris, R. W., Fluharty, M. E., Bjorngaard, J. H., Asvold, B. O., Gabrielsen, M. E., Campbell, A., Marioni, R., Kumari, M., Hällfors, J., Männistö, S., Marques-Vidal, P., Kaakinen, M., Cavadino, A., Postmus, I., Husemoen, L. L. N., Skaaby, T., Ahluwalia, T. S., Treur, J. L., Willemsen, G. & 44 others, Dale, C., Wannamethee, S. G., Lahti, J., Palotie, A., Räikkönen, K., Kisialiou, A., McConnachie, A., Padmanabhan, S., Wong, A., Dalgård, C., Paternoster, L., Ben-Shlomo, Y., Tyrrell, J., Horwood, J., Fergusson, D. M., Kennedy, M. A., Frayling, T., Nohr, E. A., Christiansen, L., Kyvik, K. O., Kuh, D., Watt, G., Eriksson, J., Whincup, P. H., Vink, J. M., Boomsma, D. I., Davey Smith, G., Lawlor, D., Linneberg, A., Ford, I., Jukema, J. W., Power, C., Hyppönen, E., Jarvelin, M-R., Preisig, M., Borodulin, K., Kaprio, J., Kivimaki, M., Smith, B. H., Hayward, C., Romundstad, P. R., Sørensen, T. I. A., Munafò, M. R. & Sattar, N., 4 Dec 2014, In: PLoS Genetics. 10, 12, 6 p., e1004799.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  • body mass index
  • body mass
  • smoking
  • genotype
  • Smokers
  35 Citations (Scopus)

  143 Downloads (Pure)

• Substance misuse of gabapentin

  Smith, B. H., Higgins, C., Baldacchino, A., Kidd, B. & Bannister, J., Aug 2012, In: British Journal of General Practice. 62, 601, p. 406-7 2 p.

  Research output: Contribution to journal › Article › peer-review
  40 Citations (Scopus)

• Systematically searching for and assessing the literature for self-management of chronic pain: a lay users' perspective

  Schofield, P., Smith, B. H., Martin, D., Jones, D., Clarke, A., McNamee, P., Marsh, R., Morrison, M., Morrison, R., Fowler, S., Anthony, G. & Stewart, C., 27 Jul 2014, In: BMC Geriatrics. 14, 1, 8 p., 86.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  • Self-Management
  • Chronic Pain
  • Pain
  • Pain Management
  • Internet
  4 Citations (Scopus)

  139 Downloads (Pure)

• Targeted genetic testing for familial hypercholesterolaemia using next generation sequencing: a population-based study

  Norsworthy, P. J., Vandrovcova, J., Thomas, E. R. A., Campbell, A., Kerr, S. M., Biggs, J., Game, L., Soutar, A. K., Smith, B. H., Dominiczak, A. F., Porteous, D. J., Morris, A. D., Generation Scotland & Aitman, T. J., 23 Jun 2014, In: BMC Medical Genetics. 15, 7 p., 70.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  • Hyperlipoproteinemia Type II
  • Genetic Testing
  • Cholesterol
  • Population
  • Mutation
  42 Citations (Scopus)

  153 Downloads (Pure)

• Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels

  Tin, A., Marten, J., Halperin Kuhns, V. L., Li, Y., Wuttke, M., Kirsten, H., Sieber, K. B., Qiu, C., Gorski, M., Yu, Z., Giri, A., Sveinbjornsson, G., Li, M., Chu, A. Y., Hoppmann, A., O'Connor, L. J., Prins, B., Nutile, T., Noce, D., Akiyama, M. & 31 others, Cocca, M., Ghasemi, S., van der Most, P. J., Horn, K., Xu, Y., Fuchsberger, C., Sedaghat, S., Afaq, S., Amin, N., Ärnlöv, J., Bakker, S. J. L., Bansal, N., Baptista, D., Bergmann, S., Biggs, M. L., Biino, G., Boerwinkle, E., Bottinger, E. P., Boutin, T. S., Brumat, M., Burkhardt, R., Campana, E., Campbell, A., Campbell, H., Carroll, R. J., Catamo, E., Chambers, J. C., Ciullo, M., Concas, M. P., Smith, B. H. & Köttgen, A., Oct 2019, In: Nature Genetics. 51, 10, p. 1459–1474 22 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Uric Acid
  • Gout
  • Serum
  • Genes
  • urate transporter
  30 Citations (Scopus)

  41 Downloads (Pure)

• The National Pain Audit for specialist pain services in England and Wales 2010–2014

  Price, C., de C Williams, A. C., Smith, B. H. & Bottle, A., 1 Aug 2019, In: British Journal of Pain. 13, 3, p. 185-193 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Wales
  • England
  • Pain Clinics
  • Pain
  • Quality Improvement
  3 Citations (Scopus)

  185 Downloads (Pure)

• The Scottish model for chronic pain management services

  Gilbert, S., Holdsworth, L. & Smith, B., 2014, In: British Journal of Healthcare Management. 20, 12, p. 568-577 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Pain Management
  • Chronic Pain
  • Scotland
  • Direction compound

• Towards a definition of refractory neuropathic pain for epidemiological research: an international Delphi survey of experts

  Smith, B. H., Torrance, N., Ferguson, J. A., Bennett, M. I., Serpell, M. G. & Dunn, K. M., 28 May 2012, In: BMC Neurology. 12, 29.

  Research output: Contribution to journal › Article › peer-review

  • Intractable Pain
  • Neuralgia
  • Consensus
  • Pain
  • Self-Examination
  26 Citations (Scopus)
• Editorial

  Editorial IV. Managing chronic pain: a clinical challenge: new SIGN guidelines provide a practical evidence-based approach and identify research gaps

  Colvin, L. A., Stein, A. & Smith, B. H., 2014, In: BRITISH JOURNAL OF ANAESTHESIA. 112, 1, p. 9-12 4 p.

  Research output: Contribution to journal › Editorial › peer-review
  2 Citations (Scopus)

• Opioid prescribing is rising in many countries

  Smith, B. H., Fletcher, E. H. & Colvin, L. A., 17 Oct 2019, In: BMJ. 367, p. 1-2 2 p., l5823.

  Research output: Contribution to journal › Editorial › peer-review

  • Chronic Pain
  • Opioid Analgesics
  4 Citations (Scopus)
• Letter

  Exome-wide association study of plasma lipids in >300,000 individuals

  Liu, D. J., Peloso, G. M., Yu, H., Butterworth, A. S., Wang, X-Y., Mahajan, A., Saleheen, D., Emdin, C., Alam, D. S., Alves, A. C., Amouyel, P., Di Angelantonio, E., Arveiler, D., Assimes, T. L., Auer, P. L., Baber, U., Ballantyne, C. M., Bang, L. E., Benn, M., Bis, J. C. & 33 others, Boehnke, M., Boerwinkle, E., Bork-Jensen, J., Bottinger, E. P., Brandslund, I., Brown, M. J., Busonero, F., Caulfield, M. J., Chambers, J. C., Chasman, D. I., Chen, Y. E., Chen, Y-D. I., Chowdhury, R., Christensen, C., Chu, A. Y., Connell, J. M., Cucca, F., Cupples, L. A., Damrauer, S. M., Davies, G., Deary, I. J., Dedoussis, G., Denny, J. C., Dominiczak, A. F., Dubé, M. P., Ebeling, T., Eiriksdottir, G., Esko, T., Palmer, C. N. A., Smith, B. H., Charge Diabetes Working Group, The EPIC-InterAct Consortium, EPIC-CVD Consortium, GOLD Consortium, VA Million Veteran Program, Kathiresan, S. & Willer, C. J., 30 Oct 2017, In: Nature Genetics. 49, 12, p. 1758-1766 9 p.

  Research output: Contribution to journal › Letter › peer-review

  Open Access

  File

  • Exome
  • Lipids
  • Coronary Artery Disease
  • Triglycerides
  • Type 2 Diabetes Mellitus
  181 Citations (Scopus)

  218 Downloads (Pure)

• Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation

  Christophersen, I. E., Rienstra, M., Roselli, C., Yin, X., Geelhoed, B., Barnard, J., Lin, H., Arking, D. E., Smith, A. V., Albert, C. M., Chaffin, M., Tucker, N. R., Li, M., Klarin, D., Bihlmeyer, N. A., Low, S-K., Weeke, P. E., Mueller-Nurasyid, M., Smith, J. G., Brody, J. A. & 142 others, Niemeijer, M. N., Doerr, M., Trompet, S., Huffman, J. E., Gustafsson, S., Schurmann, C., Kleber, M. E., Lyytikainen, L-P., Seppala, I., Malik, R., Horimoto, A. R. V. R., Perez, M., Sinisalo, J., Aeschbacher, S., Theriault, S., Yao, J., Radmanesh, F., Weiss, S., Teumer, A., Choi, S. H., Weng, L-C., Clauss, S., Deo, R., Rader, D. J., Shah, S. H., Sun, A., Hopewell, J. C., Debette, S., Chauhan, G., Yang, Q., Worrall, B. B., Pare, G., Kamatani, Y., Hagemeijer, Y. P., Verweij, N., Siland, J. E., Kubo, M., Smith, J. D., Van Wagoner, D. R., Bis, J. C., Perz, S., Psaty, B. M., Ridker, P. M., Magnani, J. W., Harris, T. B., Launer, L. J., Shoemaker, M. B., Padmanabhan, S., Haessler, J., Bartz, T. M., Waldenberger, M., Lichtner, P., Arendt, M., Krieger, J. E., Kahonen, M., Risch, L., Mansur, A. J., Peters, A., Smith, B. H., Lind, L., Scott, S. A., Lu, Y., Bottinger, E. B., Hernesniemi, J., Lindgren, C. M., Wong, J. A., Huang, J., Eskola, M., Morris, A. P., Ford, I., Reiner, A. P., Delgado, G., Chen, L. Y., Chen, Y-D. I., Sandhu, R. K., Li, M., Boerwinkle, E., Eisele, L., Lannfelt, L., Rost, N., Anderson, C. D., Taylor, K. D., Campbell, A., Magnusson, P. K. E., Porteous, D. J., Hocking, L. J., Vlachopoulou, E., Pedersen, N. L., Nikus, K., Orho-Melander, M., Hamsten, A., Heeringa, J., Denny, J. C., Kriebel, J., Darbar, D., Newton-Cheh, C., Shaffer, C. M., Macfarlane, P. W., Heilmann-Heimbach, S., Almgren, P., Huang, P. L., Sotoodehnia, N., Soliman, E. Z., Uitterlinden, A. G., Hofman, A., Franco, O. H., Voelker, U., Joeckel, K-H., Sinner, M. F., Lin, H. J., Guo, X., Dichgans, M., Ingelsson, E., Kooperberg, C., Melander, O., Loos, R. J. F., Laurikka, J., Conen, D., Rosand, J., van der Harst, P., Lokki, M-L., Kathiresan, S., Pereira, A., Jukema, J. W., Hayward, C., Rotter, J. I., Maerz, W., Lehtimaki, T., Stricker, B. H. C., Chung, M. K., Felix, S. B., Gudnason, V., Alonso, A., Roden, D. M., Kaeaeb, S., Chasman, D. I., Heckbert, S. R., Benjamin, E. J., Tanaka, T., Lunetta, K. L., Lubitz, S. A. & Ellinor, P. T., Jun 2017, In: Nature Genetics. 49, 6, p. 946-952 7 p.

  Research output: Contribution to journal › Letter › peer-review

  Open Access

  File
  123 Citations (Scopus)

  350 Downloads (Pure)

• Reply to Henningsen et al.

  Rief, W., Korwisi, B., Nicholas, M., Vlaeyen, J. W. S., Smith, B. H., First, M. B., Kosek, E., Barke, A. & Treede, R-D., Jul 2019, In: Pain. 160, 7, p. 1683-1685 3 p.

  Research output: Contribution to journal › Letter › peer-review
• Meeting abstract

  The impact of chronic musculoskeletal pain on physical activity in older adults: implications for self-management

  Martin, D. J., Anthony, G. B., Clarke, A., Jones, D., McNamee, P., Schofield, P. A. & Smith, B. H., 2012, In: Journal of Aging and Physical Activity. 20, Supplement, p. S294-S295 2 p.

  Research output: Contribution to journal › Meeting abstract › peer-review
• Review article

  Chronic pain as a symptom or a disease: the IASP Classification of Chronic Pain for the International Classification of Diseases (ICD-11)

  Treede, R-D., Rief, W., Barke, A., Aziz, Q., Bennett, M. I., Benoliel, R., Cohen, M., Evers, S., Finnerup, N. B., First, M. B., Giamberardino, M. A., Kaasa, S., Korwisi, B., Kosek, E., Lavandʼhomme, P., Nicholas, M., Perrot, S., Scholz, J., Schug, S., Smith, B. H. & 3 others, Svensson, P., Vlaeyen, J. W. S. & Wang, S-J., 1 Jan 2019, In: Pain. 160, 1, p. 19-27 9 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • International Classification of Diseases
  • Chronic Pain
  • Pain
  • Visceral Pain
  • Musculoskeletal Pain
  186 Citations (Scopus)

  825 Downloads (Pure)

• Investigating shared aetiology between type 2 diabetes and major depressive disorder in a population based cohort

  Clarke, T-K., Obsteter, J., Hall, L. S., Hayward, C., Thomson, P. A., Smith, B. H., Padmanabhan, S., Hocking, L. J., Deary, I. J., Porteous, D. J. & McIntosh, A. M., Apr 2017, In: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 174, 3, p. 227-234 8 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Major Depressive Disorder
  • Type 2 Diabetes Mellitus
  • Population
  • Single Nucleotide Polymorphism
  • Medical Genetics
  13 Citations (Scopus)

  165 Downloads (Pure)

• Physical activity and exercise for chronic pain in adults: an overview of Cochrane Reviews

  Geneen, L. J., Moore, R. A., Clarke, C., Martin, D., Colvin, L. A. & Smith, B. H., 14 Jan 2017, In: Cochrane Database of Systematic Reviews. 2017, 4, p. 1-75 75 p., CD011279.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Chronic Pain
  • Exercise
  • Pain
  • Quality of Life
  • Psychology
  5 Citations (Scopus)

  253 Downloads (Pure)

• Physical activity and exercise for chronic pain in adults: an overview of Cochrane Reviews

  Geneen, L. J., Moore, R. A., Clarke, C., Martin, D., Colvin, L. A. & Smith, B. H., 24 Apr 2017, In: Cochrane Database of Systematic Reviews. 2017, 4, p. 1-75 75 p., CD011279.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Chronic Pain
  • Exercise
  • Pain
  • Quality of Life
  • Psychology
  17 Citations (Scopus)

  205 Downloads (Pure)

• Risk factors for neuropathic pain in diabetes mellitus

  Hébert, H. L., Veluchamy, A., Torrance, N. & Smith, B. H., 1 Apr 2017, In: Pain. 158, 4, p. 560-568 9 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File
  29 Citations (Scopus)

  215 Downloads (Pure)

• The genetics of neuropathic pain from model organisms to clinical application

  Calvo, M., Davies, A. J., Hebert, H., Weir, G., Chesler, E. J., Finnerup, N. B., Smith, B. H., Neely, G., Costigan, M. & Bennett, D. L., 20 Nov 2019, In: Neuron. 104, 4, p. 637-653 17 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Neuralgia
  • Genetic Techniques
  • Pain Clinics
  • Nervous System Trauma
  • Clustered Regularly Interspaced Short Palindromic Repeats
  9 Citations (Scopus)

  125 Downloads (Pure)

• The IASP classification of chronic pain for ICD-11: Chronic neuropathic pain

  Scholz, J., Finnerup, N. B., Attal, N., Aziz, Q., Baron, R., Bennett, M. I., Benoliel, R., Cohen, M., Cruccu, G., Davis, K. D., Evers, S., First, M. B., Giamberardino, M. A., Hansson, P. T., Kaasa, S., Korwisi, B., Kosek, E., Lavandʼhomme, P., Nicholas, M., Nurmikko, T. J. & 13 others, Perrot, S., Raja, S. N., Rice, A. S. C., Rowbotham, M. C., Schug, S., Smipson, D. M., Smith, B., Svensson, P., Vlaeyen, J. W. S., Wang, S-J., Barke, A., Rief, W. & Treede, R-D., 1 Jan 2019, In: Pain. 160, 1, p. 53-59 7 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Neuralgia
  • International Classification of Diseases
  • Chronic Pain
  • Pain
  • Postherpetic Neuralgia
  78 Citations (Scopus)

  26 Downloads (Pure)

• The IASP classification of chronic pain for ICD-11: Applicability in Primary Care

  Smith, B., Fors, E. A., Korwisi, B., Barke, A., Cameron, P., Colvin, L., Richardson, C., Rief, W. & Treede, R-D., 1 Jan 2019, In: Pain. 160, 1, p. 83-87 5 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • International Classification of Diseases
  • Chronic Pain
  • Primary Health Care
  • Forensic Anthropology
  • Delivery of Health Care
  18 Citations (Scopus)

  24 Downloads (Pure)