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  Genome-wide regional heritability mapping identifies a locus within the TOX2 gene associated with Major Depressive Disorder

  Yanni, Z., Navarro, P., Shirali, M., Howard, D. M., Adams, M. J., Hall, L. S., Clarke, T-K., Thomson, P. A., Smith, B. H., Murray, A., Padmanabhan, S., Hayward, C., Boutin, T., MacIntyre, D. J., Lewis, C. M., Wray, N. R., Mehta, D., Penninx, B. W. J. H., Milaneschi, Y., Baune, B. T. & 20 others, Air, T., Hottenga, J-J., Mbarek, H., Castelao, E., Pistis, G., Schulze, T. G., Streit, F., Forstner, A. J., Byrne, E. M., Martin, N. G., Breen, G., Müller-Myhsok, B., Lucae, S., Kloiber, S., Domenici, E., Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Deary, I. J., Porteous, D. J., Haley, C. S. & McIntosh, A. M., 1 Sep 2017, In: Biological Psychiatry. 82, 5, p. 312-321 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  • Major Depressive Disorder
  • Haplotypes
  • Genome
  • Single Nucleotide Polymorphism
  • Genes
  128 Downloads (Pure)

• Haplotype-based association analysis of general cognitive ability in Generation Scotland, the English Longitudinal Study of Ageing, and UK Biobank

  Howard, D. M., Adams, M. J., Clarke, T-K., Wigmore, E. M., Zeng, Y., Hagenaars, S. P., Lyall, D. M., Thomson, P. A., Evans, K. L., Porteous, D. J., Nagy, R., Hayward, C., Haley, C. S., Smith, B. H., Murray, A. D., Batty, G. D., Deary, I. J. & McIntosh, A. M., 10 Aug 2017, In: Wellcome Open Research. 2, p. 1-13 13 p., 61.

  Research output: Contribution to journal › Article › peer-review

  File

  • Scotland
  • Haplotypes
  • Genes
  • Longitudinal Studies
  • Aging of materials
  3 Citations (Scopus)

  151 Downloads (Pure)

• Heritability of chronic pain in 2195 extended families

  Hocking, L. J., Morris, A. D., Dominiczak, A. F., Porteous, D. J., Smith, B. H. & Generation Scotland, Aug 2012, In: European Journal of Pain. 16, 7, p. 1053-1063 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Chronic Pain
  • Scotland
  • Family Health
  • Occupations
  • Social Adjustment
  45 Citations (Scopus)

• "I feel so stupid because I can't give a proper answer..." How older adults describe chronic pain: a qualitative study

  Clarke, A., Anthony, G., Gray, D., Jones, D., McNamee, P., Schofield, P., Smith, B. H. & Martin, D., 2012, In: BMC Geriatrics. 12, 1, 78.

  Research output: Contribution to journal › Article › peer-review

  • Chronic Pain
  • Pain
  • Metaphor
  • Interviews
  • Scotland
  16 Citations (Scopus)

• Implementation of Patient-Reported Outcomes (PROMs) from specialist pain clinics in England and Wales: experience from a nationwide study

  Price, C. M., C. de C. Williams, A., Smith, B. H. & Bottle, A., 1 Aug 2019, In: European Journal of Pain. 23, 7, p. 1368-1377 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Pain Clinics
  • Wales
  • Patient Reported Outcome Measures
  • England
  • Quality of Life
  1 Citation (Scopus)

  29 Downloads (Pure)

• Insulin resistance: Genetic associations with depression and cognition in population based cohorts

  Frangou, S., Shirali, M., Adams, M. J., Howard, D. M., Gibson, J., Hall, L. S., Smith, B. H., Padmanabhan, S., Murray, A. D., Porteous, D. J., Haley, C. S., Deary, I. J., Clarke, T-K. & McIntosh, A. M., Jun 2019, In: Experimental Neurology. 316, p. 20-26 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  • Insulin Resistance
  • Cognition
  • Depression
  • Population
  • Intelligence
  1 Citation (Scopus)

  125 Downloads (Pure)

• "I try and smile, I try and be cheery, I try not to be pushy. I try to say 'I'm here for help' but I leave feeling… worried": a qualitative study of perceptions of interactions with health professionals by community-based older adults with chronic pain

  Clarke, A., Martin, D., Jones, D., Schofield, P., Anthony, G., McNamee, P., Gray, D. & Smith, B. H., Sep 2014, In: PLoS ONE. 9, 9, 7 p., e105450.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • health care workers
  • pain
  • Chronic Pain
  • Emotions
  • Health
  15 Citations (Scopus)

  208 Downloads (Pure)

• Low-frequency variation in TP53 has large effects on head circumference and intracranial volume

  UK10K Consortium, 21 Jan 2019, In: Nature Communications. 10, 1, 357.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • circumferences
  • Head
  • Genetic Variation
  • Genetic Models
  • Human Development
  9 Citations (Scopus)

  113 Downloads (Pure)

• Managing chronic pain in the non-specialist setting: a new SIGN guideline

  Smith, B. H., Hardman, J. D., Stein, A., Colvin, L. & SIGN Chronic Pain Guideline Development Group, 1 Jul 2014, In: British Journal of General Practice. 64, 624, p. e462-e464 3 p.

  Research output: Contribution to journal › Article › peer-review
  5 Citations (Scopus)

• Molecular genetic contributions to socioeconomic status and intelligence

  Marioni, R. E., Davies, G., Hayward, C., Liewald, D., Kerr, S. M., Campbell, A., Luciano, M., Smith, B. H., Padmanabhan, S., Hocking, L. J., Hastie, N. D., Wright, A. F., Porteous, D. J., Visscher, P. M. & Deary, I. J., 2014, In: Intelligence. 44, May-June, p. 26-32 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Molecular Genetics
  • Socioeconomic Status
  • Intelligence
  • Social Class
  • Molecular Biology
  80 Citations (Scopus)

  161 Downloads (Pure)

• Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions

  InterAct Consortium, LifeLines Cohort Study, de Vries, P. S., Brown, M. R., Bentley, A. R., Sung, Y. J., Winkler, T. W., Ntalla, I., Schwander, K., Kraja, A. T., Guo, X., Franceschini, N., Cheng, C-Y., Sim, X., Vojinovic, D., Huffman, J. E., Musani, S. K., Li, C., Feitosa, M. F., Richard, M. A. & 34 others, Noordam, R., Aschard, H., Bartz, T. M., Bielak, L. F., Deng, X., Dorajoo, R., Lohman, K. K., Manning, A. K., Rankinen, T., Smith, A. V., Tajuddin, S. M., Evangelou, E., Graff, M., Alver, M., Boissel, M., Chai, J. F., Chen, X., Divers, J., Gandin, I., Gao, C., Goel, A., Hagemeijer, Y., Harris, S. E., Hartwig, F. P., He, M., Horimoto, A. R. V. R., Hsu, F-C., Jackson, A. U., Kasturiratne, A., Komulainen, P., Connell, J. M., Smith, B. H., Rao, D. C. & Morrison, A. C., 1 Jun 2019, In: American Journal of Epidemiology. 188, 6, p. 1033-1054 22 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Genome-Wide Association Study
  • Alcohols
  • Lipids
  • APOBEC-1 Deaminase
  • Vascular Endothelial Growth Factor B
  18 Citations (Scopus)

  198 Downloads (Pure)

• NeuPSIG: investing in solutions to the growing global challenge of neuropathic pain

  Smith, B. & Raja, S. N., 1 Oct 2017, In: British Journal of Anaesthesia. 119, 4, p. 705-708 4 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  3 Citations (Scopus)

  105 Downloads (Pure)

• Neuropathic pain in the general population: a systematic review of epidemiological studies

  van Hecke, O., Austin, S. K., Khan, R. A., Smith, B. H. & Torrance, N., Apr 2014, In: Pain. 155, 4, p. 654-662 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Neuralgia
  • Epidemiologic Studies
  • Systematic Reviews
  • Population
  • Glossopharyngeal Nerve Diseases
  527 Citations (Scopus)

• New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries

  Understanding Society Scientific Group, Shrine, N., Guyatt, A. L., Erzurumluoglu, A. M., Jackson, V. E., Hobbs, B. D., Melbourne, C. A., Batini, C., Fawcett, K. A., Song, K., Sakornsakolpat, P., Li, X., Boxall, R., Reeve, N. F., Obeidat, M., Zhao, J. H., Wielscher, M., Weiss, S., Kentistou, K. A., Cook, J. P. & 33 others, Sun, B. B., Zhou, J., Hui, J., Karrasch, S., Imboden, M., Harris, S. E., Marten, J., Enroth, S., Kerr, S. M., Surakka, I., Vitart, V., Lehtimäki, T., Allen, R. J., Bakke, P. S., Beaty, T. H., Bleecker, E. R., Bossé, Y., Brandsma, C-A., Chen, Z., Crapo, J. D., Danesh, J., DeMeo, D. L., Dudbridge, F., Ewert, R., Gieger, C., Gulsvik, A., Hansell, A. L., Hao, K., Hoffman, J. D., Hokanson, J. E., Smith, B. H., Tobin, M. D. & Wain, L. V., Mar 2019, In: Nature Genetics. 51, 3, p. 481-493 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Chronic Obstructive Pulmonary Disease
  • Lung
  • Smokers
  • Genome-Wide Association Study
  • Mortality
  54 Citations (Scopus)

  430 Downloads (Pure)

• Physical activity and exercise for chronic pain in adults: An overview of Cochrane reviews

  Geneen, L., Smith, B., Clarke, C., Martin, D., Colvin, L. A. & Moore, R. A., 25 Aug 2014, In: Cochrane Database of Systematic Reviews. 2014, 8, p. 1-9 9 p., CD011279.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Chronic Pain
  • Exercise
  • Quality of Health Care
  • Systematic Reviews
  • Quality of Life
  258 Citations (Scopus)

  111 Downloads (Pure)

• Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution

  T2D-Genes Consortium, The MAGIC Investigators, CHD Exome+ Consortium, EPIC-CVD Consortium, ExomeBP Consortium, Global Lipids Genetic Consortium, GoT2D Genes Consortium, ReproGen Consortium, Justice, A. E., Karaderi, T., Highland, H. M., Young, K. L., Graff, M., Lu, Y., Turcot, V., Auer, P. L., Fine, R. S., Guo, X., Schurmann, C., Lempradl, A. & 40 others, Marouli, E., Mahajan, A., Winkler, T. W., Locke, A. E., Medina-Gomez, C., Esko, T., Vedantam, S., Giri, A., Lo, K. S., Alfred, T., Mudgal, P., Ng, M. C. Y., Heard-Costa, N. L., Feitosa, M. F., Manning, A. K., Willems, S. M., Sivapalaratnam, S., Abecasis, G., Alam, D. S., Allison, M., Amouyel, P., Arzumanyan, Z., Balkau, B., Bastarache, L., Bergmann, S., Bielak, L. F., Blüher, M., Boehnke, M., Boeing, H., Boerwinkle, E., Böger, C. A., Bork-Jensen, J., Evangelou, E., Li, J., Morris, A. P., Smith, B. H., Smith, J. A., Wood, A. R., North, K. E. & Lindgren, C. M., Mar 2019, In: Nature Genetics. 51, 3, p. 452-469 18 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Body Fat Distribution
  • Homeostasis
  • Lipids
  • Fats
  • White Adipose Tissue
  22 Citations (Scopus)

  279 Downloads (Pure)

• Regional variation in health is predominantly driven by lifestyle rather than genetics

  Amador, C., Xia, C., Nagy, R., Campbell, A., Porteous, D. J., Smith, B. H., Hastie, N., Vitart, V., Hayward, C., Navarro, P. & Haley, C. S., 6 Oct 2017, In: Nature Communications. 8, p. 1-7 7 p., 801.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Genetics
  • health
  • obesity
  • Life Style
  • Health
  5 Citations (Scopus)

  182 Downloads (Pure)

• Stratification by Smoking Status Reveals an Association of CHRNA5-A3-B4 Genotype with Body Mass Index in Never Smokers

  Taylor, A. E., Morris, R. W., Fluharty, M. E., Bjorngaard, J. H., Asvold, B. O., Gabrielsen, M. E., Campbell, A., Marioni, R., Kumari, M., Hällfors, J., Männistö, S., Marques-Vidal, P., Kaakinen, M., Cavadino, A., Postmus, I., Husemoen, L. L. N., Skaaby, T., Ahluwalia, T. S., Treur, J. L., Willemsen, G. & 44 others, Dale, C., Wannamethee, S. G., Lahti, J., Palotie, A., Räikkönen, K., Kisialiou, A., McConnachie, A., Padmanabhan, S., Wong, A., Dalgård, C., Paternoster, L., Ben-Shlomo, Y., Tyrrell, J., Horwood, J., Fergusson, D. M., Kennedy, M. A., Frayling, T., Nohr, E. A., Christiansen, L., Kyvik, K. O., Kuh, D., Watt, G., Eriksson, J., Whincup, P. H., Vink, J. M., Boomsma, D. I., Davey Smith, G., Lawlor, D., Linneberg, A., Ford, I., Jukema, J. W., Power, C., Hyppönen, E., Jarvelin, M-R., Preisig, M., Borodulin, K., Kaprio, J., Kivimaki, M., Smith, B. H., Hayward, C., Romundstad, P. R., Sørensen, T. I. A., Munafò, M. R. & Sattar, N., 4 Dec 2014, In: PLoS Genetics. 10, 12, 6 p., e1004799.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • body mass index
  • body mass
  • smoking
  • genotype
  • Smokers
  35 Citations (Scopus)

  144 Downloads (Pure)

• Substance misuse of gabapentin

  Smith, B. H., Higgins, C., Baldacchino, A., Kidd, B. & Bannister, J., Aug 2012, In: British Journal of General Practice. 62, 601, p. 406-7 2 p.

  Research output: Contribution to journal › Article › peer-review
  40 Citations (Scopus)

• Systematically searching for and assessing the literature for self-management of chronic pain: a lay users' perspective

  Schofield, P., Smith, B. H., Martin, D., Jones, D., Clarke, A., McNamee, P., Marsh, R., Morrison, M., Morrison, R., Fowler, S., Anthony, G. & Stewart, C., 27 Jul 2014, In: BMC Geriatrics. 14, 1, 8 p., 86.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Self-Management
  • Chronic Pain
  • Pain
  • Pain Management
  • Internet
  4 Citations (Scopus)

  142 Downloads (Pure)

• Targeted genetic testing for familial hypercholesterolaemia using next generation sequencing: a population-based study

  Norsworthy, P. J., Vandrovcova, J., Thomas, E. R. A., Campbell, A., Kerr, S. M., Biggs, J., Game, L., Soutar, A. K., Smith, B. H., Dominiczak, A. F., Porteous, D. J., Morris, A. D., Generation Scotland & Aitman, T. J., 23 Jun 2014, In: BMC Medical Genetics. 15, 7 p., 70.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Hyperlipoproteinemia Type II
  • Genetic Testing
  • Cholesterol
  • Population
  • Mutation
  42 Citations (Scopus)

  156 Downloads (Pure)

• Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels

  Tin, A., Marten, J., Halperin Kuhns, V. L., Li, Y., Wuttke, M., Kirsten, H., Sieber, K. B., Qiu, C., Gorski, M., Yu, Z., Giri, A., Sveinbjornsson, G., Li, M., Chu, A. Y., Hoppmann, A., O'Connor, L. J., Prins, B., Nutile, T., Noce, D., Akiyama, M. & 31 others, Cocca, M., Ghasemi, S., van der Most, P. J., Horn, K., Xu, Y., Fuchsberger, C., Sedaghat, S., Afaq, S., Amin, N., Ärnlöv, J., Bakker, S. J. L., Bansal, N., Baptista, D., Bergmann, S., Biggs, M. L., Biino, G., Boerwinkle, E., Bottinger, E. P., Boutin, T. S., Brumat, M., Burkhardt, R., Campana, E., Campbell, A., Campbell, H., Carroll, R. J., Catamo, E., Chambers, J. C., Ciullo, M., Concas, M. P., Smith, B. H. & Köttgen, A., Oct 2019, In: Nature Genetics. 51, 10, p. 1459–1474 22 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Uric Acid
  • Gout
  • Serum
  • Genes
  • urate transporter
  32 Citations (Scopus)

  48 Downloads (Pure)

• The National Pain Audit for specialist pain services in England and Wales 2010–2014

  Price, C., de C Williams, A. C., Smith, B. H. & Bottle, A., 1 Aug 2019, In: British Journal of Pain. 13, 3, p. 185-193 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Wales
  • England
  • Pain Clinics
  • Pain
  • Quality Improvement
  3 Citations (Scopus)

  189 Downloads (Pure)

• The Scottish model for chronic pain management services

  Gilbert, S., Holdsworth, L. & Smith, B., 2014, In: British Journal of Healthcare Management. 20, 12, p. 568-577 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Pain Management
  • Chronic Pain
  • Scotland
  • Direction compound

• Towards a definition of refractory neuropathic pain for epidemiological research: an international Delphi survey of experts

  Smith, B. H., Torrance, N., Ferguson, J. A., Bennett, M. I., Serpell, M. G. & Dunn, K. M., 28 May 2012, In: BMC Neurology. 12, 29.

  Research output: Contribution to journal › Article › peer-review

  • Intractable Pain
  • Neuralgia
  • Consensus
  • Pain
  • Self-Examination
  26 Citations (Scopus)