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  • 2019
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Author

  • Albena Dinkova-Kostova
2013

Chemoprotection Against Cancer by Isothiocyanates: A Focus on the Animal Models and the Protective Mechanisms

Dinkova-Kostova, A. T., 2013, Natural Products in Cancer Prevention and Therapy. Pezzuto, J. M. & Suh, N. (eds.). Berlin: Springer , p. 179-201 23 p. (Topics in Current Chemistry; vol. 329).

Research output: Chapter in Book/Report/Conference proceedingChapter

30 Citations (Scopus)

Diffusion dynamics of the Keap1-Cullin3 interaction in single live cells

Baird, L. & Dinkova-Kostova, A. T., 2013, In : Biochemical and Biophysical Research Communications. 433, 1, p. 58-65 8 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

NAD(P)H: Quinone oxidoreductase 1 inducer activity of some Saudi Arabian medicinal plants

Shahat, A. A., Alsaid, M. S., Alyahya, M. A., Higgins, M. & Dinkova-Kostova, A. T., Apr 2013, In : Planta Medica. 79, 6, p. 459-464 6 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration

Holmström, K. M., Baird, L., Zhang, Y., Hargreaves, I., Chalasani, A., Land, J. M., Stanyer, L., Yamamoto, M., Dinkova-Kostova, A. T. & Abramov, A. Y., 15 Aug 2013, In : Open Biology. 2, 8, p. 761-770 10 p.

Research output: Contribution to journalArticle

Open Access
File
181 Citations (Scopus)
198 Downloads (Pure)
159 Citations (Scopus)
4 Citations (Scopus)
2014

Chemical tuning enhances both potency toward Nrf2 and in vitro therapeutic index of triterpenoids

Copple, I. M., Shelton, L. M., Walsh, J., Kratschmar, D. V., Lister, A., Odermatt, A., Goldring, C. E., Dinkova-Kostova, A. T., Honda, T. & Park, B. K., Aug 2014, In : Toxicological Sciences. 140, 2, p. 462-469 8 p.

Research output: Contribution to journalArticle

Open Access
File
12 Citations (Scopus)
561 Downloads (Pure)

Monitoring Keap1-Nrf2 interactions in single live cells

Baird, L., Swift, S., Llères, D. & Dinkova-Kostova, A. T., 1 Nov 2014, In : Biotechnology Advances. 32, 6, p. 1133-1144 12 p.

Research output: Contribution to journalArticle

Open Access
File
79 Citations (Scopus)
350 Downloads (Pure)

Novel Thioureido Derivatives Carrying Thione and Sulfonamide Moieties Induce the Cytoprotective Enzyme NAD(P)H:Quione Oxidoreductase 1: Quinone oxidoreductase 1

Ghorab, M. M., Higgins, M., Dinkova-Kostova, A. T., Alsaid, M. S. & Shahat, A. A., 1 Dec 2014, In : Asian Journal of Chemistry. 26, 24, p. 8501-8504 4 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Nrf2 affects the efficiency of mitochondrial fatty acid oxidation

Ludtmann, M. H. R., Angelova, P. R., Zhang, Y., Abramov, A. Y. & Dinkova-Kostova, A. T., 1 Feb 2014, In : Biochemical Journal. 457, 3, p. 415-424 10 p.

Research output: Contribution to journalArticle

100 Citations (Scopus)

Sulphoxythiocarbamates modify cysteine residues in HSP90 causing degradation of client proteins and inhibition of cancer cell proliferation

Zhang, Y., Dayalan Naidu, S., Samarasinghe, K., Van Hecke, G. C., Pheely, A., Boronina, T. N., Cole, R. N., Benjamin, I. J., Cole, P. A., Ahn, Y-H. & Dinkova-Kostova, A. T., 7 Jan 2014, In : British Journal of Cancer. 110, 1, p. 71-82 12 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)
96 Citations (Scopus)
267 Downloads (Pure)
7 Citations (Scopus)
785 Citations (Scopus)
2015

Design, synthesis, and evaluation of triazole derivatives that induce Nrf2 dependent gene products and inhibit the Keap1-Nrf2 protein-protein interaction

Bertrand, H. C., Schaap, M., Baird, L., Georgakopoulos, N. D., Fowkes, A., Thiollier, C., Kachi, H., Dinkova-Kostova, A. T. & Wells, G., 24 Sep 2015, In : Journal of Medicinal Chemistry. 58, 18, p. 7186-7194 9 p.

Research output: Contribution to journalArticle

64 Citations (Scopus)
56 Citations (Scopus)

Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease

Tebay, L. E., Robertson, H., Durant, S. T., Vitale, S. R., Penning, T. M., Dinkova-Kostova, A. T. & Hayes, J. D., Nov 2015, In : Free Radical Biology and Medicine. 88, Part B, p. 108-146 39 p.

Research output: Contribution to journalArticle

311 Citations (Scopus)

NAD(P)H: Quinone oxidoreductase 1 inducer activity of some enaminone derivatives

Alsaid, M. S., Ghorab, M. M., Higgins, M., Dinkova-Kostova, A. T. & Shahat, A. A., 2015, In : Biomedical Research. 26, 1, p. 7-12 6 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

New monocyclic, bicyclic, and tricyclic ethynylcyanodienones as activators of the Keap1/Nrf2/ARE pathway and inhibitors of inducible nitric oxide synthase

Li, W., Zheng, S., Higgins, M., Morra, R. P., Mendis, A. T., Chien, C-W., Ojima, I., Mierke, D. F., Dinkova-Kostova, A. T. & Honda, T., 11 Jun 2015, In : Journal of Medicinal Chemistry. 58, 11, p. 4738-4748 11 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Nrf2 activation protects against solar-simulated ultraviolet radiation in mice and humans

Knatko, E. V., Ibbotson, S. H., Zhang, Y., Higgins, M., Fahey, J. W., Talalay, P., Dawe, R. S., Ferguson, J., Huang, J. T-J., Clarke, R., Zheng, S., Saito, A., Kalra, S., Benedict, A. L., Honda, T., Proby, C. M. & Dinkova-Kostova, A. T., Jun 2015, In : Cancer Prevention Research. 8, 6, p. 475-486 12 p.

Research output: Contribution to journalArticle

49 Citations (Scopus)

Nrf2 regulates ROS production by mitochondria and NADPH oxidase

Kovac, S., Angelova, P. R., Holmström, K. M., Zhang, Y., Dinkova-Kostova, A. T. & Abramov, A. Y., Apr 2015, In : Biochimica et Biophysica Acta: General Subjects. 1850, 4, p. 794-801 8 p.

Research output: Contribution to journalArticle

205 Citations (Scopus)
Open Access
File
10 Citations (Scopus)
147 Downloads (Pure)

The emerging role of Nrf2 in mitochondrial function

Dinkova-Kostova, A. T. & Abramov, A. Y., Nov 2015, In : Free Radical Biology and Medicine. 88, Part B, p. 179-188 10 p.

Research output: Contribution to journalArticle

Open Access
File
303 Citations (Scopus)
264 Downloads (Pure)

The spatiotemporal regulation of the Keap1-Nrf2 pathway and its importance in cellular bioenergetics

Dinkova-Kostova, A. T., Baird, L., Holmström, K. M., Meyer, C. J. & Abramov, A. Y., Aug 2015, In : Biochemical Society Transactions. 43, 4, p. 602-610 9 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)

Transcription factors Hsf1 and Nrf2 engage in crosstalk for cytoprotection

Dayalan Naidu, S., Kostov, R. V. & Dinkova-Kostova, A. T., Jan 2015, In : Trends in Pharmacological Sciences. 36, 1, p. 6-14 9 p.

Research output: Contribution to journalArticle

59 Citations (Scopus)
2017

Activation of Nrf2 signaling as a common treatment of neurodegenerative diseases

Dinkova-Kostova, A. T. & Kazantsev, A. G., Apr 2017, In : Neurodegenerative Disease Management. 7, 2, p. 97-100 4 p.

Research output: Contribution to journalEditorial

Open Access
File
10 Citations (Scopus)
182 Downloads (Pure)

Activation of Nrf2 signaling augments Vesicular Stomatitis Virus Oncolysis via Autophagy-Driven Suppression of Antiviral Immunity

Olagnier, D., Lababidi, R. R., Bel Hadj, S., Sze, A., Liu, Y., Dayalan Naidu, S., Ferrari, M., Jiang, Y., Chiang, C., Beljanski, V., Goulet, M-L., Knatko, E. V., Dinkova-Kostova, A. T., Hiscott, J. & Lin, R., 2 Aug 2017, In : Molecular Therapy. 25, 8, p. 1900-1916 17 p.

Research output: Contribution to journalArticle

Open Access
File
31 Citations (Scopus)
174 Downloads (Pure)

Crosstalk between NRF2 and HIPK2 shapes cytoprotective responses

Torrente, L., Sanchez, C., Moreno Dorta, R., Chowdhry, S., Cabello, P., Isono, K., Koseki, H., Honda, T., Hayes, J., Dinkova-Kostova, A. & de la Vega, L., 2 Nov 2017, In : Oncogene. 36, 44, p. 6204-6212 9 p.

Research output: Contribution to journalArticle

Open Access
File
25 Citations (Scopus)
222 Downloads (Pure)
Open Access
File
6 Citations (Scopus)
285 Downloads (Pure)

Flavonolignan 2,3-dehydrosilydianin activates Nrf2 and upregulates NAD(P)H: quinone oxidoreductase 1 in Hepa1c1c7 cells

Roubalová, L., Dinkova-Kostova, A. T., Biedermann, D., Křen, V., Ulrichová, J. & Vrba, J., Jun 2017, In : Fitoterapia. 119, p. 115-120 6 p.

Research output: Contribution to journalArticle

Open Access
File
13 Citations (Scopus)
177 Downloads (Pure)

Keap1, the cysteine-based mammalian intracellular sensor for electrophiles and oxidants

Dinkova-Kostova, A. T., Kostov, R. V. & Canning, P., 1 Mar 2017, In : Archives of Biochemistry and Biophysics. 617, p. 84-93 10 p.

Research output: Contribution to journalArticle

Open Access
File
86 Citations (Scopus)
164 Downloads (Pure)

KEAP1 and done? Targeting the NRF2 pathway with sulforaphane: Targeting the NRF2 Pathway with Sulforaphane

Dinkova-Kostova, A. T., Fahey, J. W., Kostov, R. V. & Kensler, T. W., Nov 2017, In : Trends in Food Science and Technology. 69, B, p. 257-269 13 p.

Research output: Contribution to journalReview article

Open Access
File
74 Citations (Scopus)
382 Downloads (Pure)

KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients

Quinti, L., Dayalan Naidu, S., Träge, U., Chen, X., Kegel-Gleason, K., Lleres, D., Connolly, C., Chopra, V., Low, C., Moniot, S., Sapp, E., Tousley, A. R., Vodicka, P., Van Kanegan, M. J., Kaltenbach, L. S., Crawford, L. A., Fuszard, M., Higgins, M., Miller, J. R. C., Farmer, R. E. & 19 others, Potluri, V., Samajdar, S., Meisel, L., Zhang, N., Snyder, A., Stein, R., Hersch, S. M., Ellerby, L. M., Weerapana, E., Schwarzschild, M. A., Steegborn, C., Leavitt, B. R., Degterev, A., Tabrizi, S. J., Lo, D. C., DiFiglia, M., Thompson, L. M., Dinkova-Kostova, A. & Kazantsev, A. G., 6 Jun 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 23, p. e4676-e4685 10 p.

Research output: Contribution to journalArticle

Open Access
File
32 Citations (Scopus)
164 Downloads (Pure)

Metabolic and Homeostatic Changes in Seizures and Acquired Epilepsy-Mitochondria, Calcium Dynamics and Reactive Oxygen Species

Kovac, S., Dinkova Kostova, A. T., Herrmann, A. M., Melzer, N., Meuth, S. G. & Gorji, A., 8 Sep 2017, In : International Journal of Molecular Sciences. 18, 9, p. 1-19 19 p., 1935.

Research output: Contribution to journalReview article

Open Access
File
24 Citations (Scopus)
172 Downloads (Pure)

NRF2 as an emerging therapeutic target

Copple, I. M., Dinkova-Kostova, A. T., Kensler, T. W., Liby, K. T. & Wigley, W. C., 31 Jan 2017, In : Oxidative Medicine and Cellular Longevity. 2017, p. 1-2 2 p., 8165458.

Research output: Contribution to journalEditorial

Open Access
File
19 Citations (Scopus)
182 Downloads (Pure)
Open Access
File
8 Citations (Scopus)
213 Downloads (Pure)

Oxidative stress and chronic inflammation in osteoarthritis: can Nrf2 counteract these partners in crime?

Marchev, A. S., Dimitrova, P. A., Burns, A. J., Kostov, R., Dinkova-Kostova, A. & Georgiev, M. I., 11 Sep 2017, In : Annals of the New York Academy of Sciences. 1401, p. 114-135 22 p.

Research output: Contribution to journalReview article

Open Access
File
51 Citations (Scopus)
403 Downloads (Pure)

Oxidative stress management in the hair follicle: Could targeting NRF2 counter age-related hair disorders and beyond?

Jadkauskaite, L., Coulombe, P. A., Schäfer, M., Dinkova-Kostova, A. T., Paus, R. & Haslam, I. S., 27 Jul 2017, In : BioEssays. 39, 8, p. 1-9 9 p., 1700029.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Pathogenic p62/SQSTM1 mutations impair energy metabolism through limitation of mitochondrial substrates

Bartolome, F., Esteras, N., Martin-Requero, A., Boutoleau-Bretonniere, C., Vercelletto, M., Gabelle, A., Le Ber, I., Honda, T., Dinkova-Kostova, A. T., Hardy, J., Carro, E. & Abramov, A. Y., 10 May 2017, In : Scientific Reports. 7, p. 1-14 14 p., 1666.

Research output: Contribution to journalArticle

Open Access
File
26 Citations (Scopus)
292 Downloads (Pure)

Regulation of the mammalian heat shock factor 1

Dayalan Naidu, S. & Dinkova-Kostova, A. T., Jun 2017, In : FEBS Journal. 284, 11, p. 1606-1627 22 p.

Research output: Contribution to journalReview article

Open Access
File
50 Citations (Scopus)
241 Downloads (Pure)

Transcription factors NRF2 and HSF1 have opposing functions in autophagy

Dayalan Naidu, S., Dikovskaya, D., Gaurilcikaite, E., Knatko, E., Healy, Z. R., Mohan, H., Koh, G., Laurell, A., Ball, G., Olagnier, D., de la Vega, L., Ganley, I., Talalay, P. & Dinkova-Kostova, A., 8 Sep 2017, In : Scientific Reports. 7, p. 1-12 12 p., 11023.

Research output: Contribution to journalArticle

Open Access
File
25 Citations (Scopus)
202 Downloads (Pure)

Whole-exome sequencing validates a preclinical mouse model for the prevention and treatment of cutaneous squamous cell carcinoma

Knatko, E. V., Praslicka, B., Higgins, M., Evans, A., Purdie, K. J., Harwood, C. A., Proby, C. M., Ooi, A. & Dinkova-Kostova, A. T., Jan 2017, In : Cancer Prevention Research. 10, 1, p. 67-75 9 p.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
143 Downloads (Pure)
2018

A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia

Baardman, J., Verberk, S. G. S., Prange, K. H. M., van Weeghel, M., van der Velden, S., Ryan, D. G., Wüst, R. C. I., Neele, A. E., Speijer, D., Denis, S. W., Witte, M. E., Houtkooper, R. H., O'neill, L. A., Knatko, E. V., Dinkova-Kostova, A. T., Lutgens, E., de Winther, M. P. J. & Van den Bossche, J., 20 Nov 2018, In : Cell Reports. 25, 8, p. 2044-2052.e5 15 p.

Research output: Contribution to journalArticle

Open Access
File
31 Citations (Scopus)
176 Downloads (Pure)

Author Correction: Pathogenic p62/SQSTM1 mutations impair energy metabolism through limitation of mitochondrial substrates (Scientific Reports DOI: 10.1038/s41598-017-01678-4)

Bartolome, F., Esteras, N., Martin-Requero, A., Boutoleau-Bretonniere, C., Vercelletto, M., Gabelle, A., Ber, I. L., Honda, T., Dinkova-Kostova, A. T., Hardy, J., Carro, E. & Abramov, A. Y., 1 Dec 2018, In : Scientific Reports. 8, p. 1-2 2 p., 4064.

Research output: Contribution to journalComment/debate

Open Access
File
149 Downloads (Pure)

C151 in KEAP1 is the main cysteine sensor for the cyanoenone class of NRF2 activators, irrespective of molecular size or shape

Dayalan Naidu, S., Muramatsu, A., Saito, R., Asami, S., Honda, T., Hosoya, T., Itoh, K., Yamamoto, M., Suzuki, T. & Dinkova-Kostova, A., 23 May 2018, In : Scientific Reports. 8, 1, p. 1-12 12 p., 8037.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
134 Downloads (Pure)
Open Access
File
45 Citations (Scopus)
152 Downloads (Pure)

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

Mills, E. L., Ryan, D. G., Prag, H. A., Dikovskaya, D., Menon, D., Zaslona, Z., Jedrychowski, M. P., Costa, A. S. H., Higgins, M., Hams, E., Szpyt, J., Runtsch, M. C., King, M. S., McGouran, J. F., Fischer, R., Kessler, B. M., McGettrick, A. F., Hughes, M. M., Carroll, R. G., Booty, L. M. & 15 others, Knatko, E. V., Meakin, P. J., Ashford, M. L. J., Modis, L. K., Brunori, G., Sévin, D. C., Fallon, P. G., Caldwell, S. T., Kunji, E. R. S., Chouchani, E. T., Frezza, C., Dinkova-Kostova, A. T., Hartley, R. C., Murphy, M. P. & O'Neill, L. A., 5 Apr 2018, In : Nature. 556, 7699, p. 113-117 5 p.

Research output: Contribution to journalArticle

Open Access
File
263 Citations (Scopus)
699 Downloads (Pure)

KEAP1 inhibition is neuroprotective and suppresses the development of epilepsy

Shekh-Ahmad, T., Eckel, R., Dayalan Naidu, S., Higgins, M., Yamamoto, M., Dinkova-Kostova, A., Kovac, S., Abramov, A. Y. & Walker, M. C., May 2018, In : Brain. 141, 5, p. 1390-1403 14 p.

Research output: Contribution to journalArticle

Open Access
File
33 Citations (Scopus)
177 Downloads (Pure)

Phenethyl isothiocyanate, a dual activator of transcription factors NRF2 and HSF1

Dayalan Naidu, S., Suzuki, T., Yamamoto, M., Fahey, J. W. & Dinkova-Kostova, A., 1 Sep 2018, In : Molecular Nutrition & Food Research. 62, 18, p. e1700908 9 p., 1700908.

Research output: Contribution to journalReview article

Open Access
File
10 Citations (Scopus)
161 Downloads (Pure)