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  A catalog of genetic loci associated with kidney function from analyses of a million individuals

  LifeLines Cohort Study, Million Veteran Program, Wuttke, M., Li, Y., Li, M., Sieber, K. B., Feitosa, M. F., Gorski, M., Tin, A., Wang, L., Chu, A. Y., Hoppmann, A., Kirsten, H., Giri, A., Chai, J-F., Sveinbjornsson, G., Tayo, B. O., Nutile, T., Fuchsberger, C., Marten, J. & 34 others, Cocca, M., Ghasemi, S., Xu, Y., Horn, K., Noce, D., van der Most, P. J., Sedaghat, S., Yu, Z., Akiyama, M., Afaq, S., Ahluwalia, T. S., Almgren, P., Amin, N., Ärnlöv, J., Bakker, S. J. L., Bansal, N., Baptista, D., Bergmann, S., Biggs, M. L., Biino, G., Boehnke, M., Boerwinkle, E., Boissel, M., Bottinger, E. P., Boutin, T. S., Brenner, H., Brumat, M., Burkhardt, R., Butterworth, A. S., Campana, E., Campbell, A., Smith, B. H., Köttgen, A. & Pattaro, C., Jun 2019, In: Nature Genetics. 51, 6, p. 957-972 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Catalogs
  • Genetic Loci
  • Kidney
  • Glomerular Filtration Rate
  • Chronic Renal Insufficiency
  65 Citations (Scopus)

  193 Downloads (Pure)

• A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure

  LifeLines Cohort Study, Sung, Y. J., de Las Fuentes, L., Winkler, T. W., Chasman, D. I., Bentley, A. R., Kraja, A. T., Ntalla, I., Warren, H. R., Guo, X., Schwander, K., Manning, A. K., Brown, M. R., Aschard, H., Feitosa, M. F., Franceschini, N., Lu, Y., Cheng, C-Y., Sim, X., Vojinovic, D. & 40 others, Marten, J., Musani, S. K., Kilpeläinen, T. O., Richard, M. A., Aslibekyan, S., Bartz, T. M., Dorajoo, R., Li, C., Liu, Y., Rankinen, T., Smith, A. V., Tajuddin, S. M., Tayo, B. O., Zhao, W., Zhou, Y., Matoba, N., Sofer, T., Alver, M., Amini, M., Boissel, M., Chai, J. F., Chen, X., Divers, J., Gandin, I., Gao, C., Giulianini, F., Goel, A., Harris, S. E., Hartwig, F. P., Connell, J. M., Smith, B. H., Rotter, J. I., Franks, P. W., Rice, K., Elliott, P., Caulfield, M. J., Gauderman, W. J., Munroe, P. B., Rao, D. C. & Morrison, A. C., 1 Aug 2019, In: Human Molecular Genetics. 28, 15, p. 2615-2633 19 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  • Arterial Pressure
  • Smoking
  • Genome
  • Blood Pressure
  • Genes
  4 Citations (Scopus)

  60 Downloads (Pure)

• Ask the experts: neuropathic pain from a primary care perspective

  Smith, B. H., May 2013, In: Pain Management. 3, 3, p. 173-6 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Scotland
  • Neuralgia
  • Primary Health Care
  • General Practitioners
  • Chronic Pain

• Associations of autozygosity with a broad range of human phenotypes

  Clark, D. W., Okada, Y., Moore, K. H. S., Mason, D., Pirastu, N., Gandin, I., Mattsson, H., Barnes, C. L. K., Lin, K., Zhao, J. H., Deelen, P., Rohde, R., Schurmann, C., Guo, X., Giulianini, F., Zhang, W., Medina-Gomez, C., Karlsson, R., Bao, Y., Bartz, T. M. & 416 others, Baumbach, C., Biino, G., Bixley, M. J., Brumat, M., Chai, J-F., Corre, T., Cousminer, D. L., Dekker, A. M., Eccles, D. A., van Eijk, K. R., Fuchsberger, C., Gao, H., Germain, M., Gordon, S. D., de Haan, H. G., Harris, S. E., Hofer, E., Huerta-Chagoya, A., Igartua, C., Jansen, I. E., Jia, Y., Kacprowski, T., Karlsson, T., Kleber, M. E., Li, S. A., Li-Gao, R., Mahajan, A., Matsuda, K., Meidtner, K., Meng, W., Montasser, M. E., van der Most, P. J., Munz, M., Nutile, T., Palviainen, T., Prasad, G., Prasad, R. B., Priyanka, T. D. S., Rizzi, F., Salvi, E., Sapkota, B. R., Shriner, D., Skotte, L., Smart, M. C., Smith, A. V., van der Spek, A., Spracklen, C. N., Strawbridge, R. J., Tajuddin, S. M., Trompet, S., Turman, C., Verweij, N., Viberti, C., Wang, L., Warren, H. R., Wootton, R. E., Yanek, L. R., Yao, J., Yousri, N. A., Zhao, W., Adeyemo, A. A., Afaq, S., Aguilar-Salinas, C. A., Akiyama, M., Albert, M. L., Allison, M. A., Alver, M., Aung, T., Azizi, F., Bentley, A. R., Boeing, H., Boerwinkle, E., Borja, J. B., de Borst, G. J., Bottinger, E. P., Broer, L., Campbell, H., Chanock, S., Chee, M-L., Chen, G., Chen, Y-D. I., Chen, Z., Chiu, Y-F., Cocca, M., Collins, F. S., Concas, M. P., Corley, J., Cugliari, G., van Dam, R. M., Damulina, A., Daneshpour, M. S., Day, F. R., Delgado, G. E., Dhana, K., Doney, A. S. F., Dörr, M., Doumatey, A. P., Dzimiri, N., Ebenesersdóttir, S. S., Elliott, J., Elliott, P., Ewert, R., Felix, J. F., Fischer, K., Freedman, B. I., Girotto, G., Goel, A., Gögele, M., Goodarzi, M. O., Graff, M., Granot-Hershkovitz, E., Grodstein, F., Guarrera, S., Gudbjartsson, D. F., Guity, K., Gunnarsson, B., Guo, Y., Hagenaars, S. P., Haiman, C. A., Halevy, A., Harris, T. B., Hedayati, M., van Heel, D. A., Hirata, M., Höfer, I., Hsiung, C. A., Huang, J., Hung, Y-J., Ikram, M. A., Jagadeesan, A., Jousilahti, P., Kamatani, Y., Kanai, M., Kerrison, N. D., Kessler, T., Khaw, K-T., Khor, C. C., de Kleijn, D. P. V., Koh, W-P., Kolcic, I., Kraft, P., Krämer, B. K., Kutalik, Z., Kuusisto, J., Langenberg, C., Launer, L. J., Lawlor, D. A., Lee, I-T., Lee, W-J., Lerch, M. M., Li, L., Liu, J., Loh, M., London, S. J., Loomis, S., Lu, Y., Luan, J., Mägi, R., Manichaikul, A. W., Manunta, P., Másson, G., Matoba, N., Mei, X. W., Meisinger, C., Meitinger, T., Mezzavilla, M., Milani, L., Millwood, I. Y., Momozawa, Y., Moore, A., Morange, P-E., Moreno-Macías, H., Mori, T. A., Morrison, A. C., Muka, T., Murakami, Y., Murray, A. D., de Mutsert, R., Mychaleckyj, J. C., Nalls, M. A., Nauck, M., Neville, M. J., Nolte, I. M., Ong, K. K., Orozco, L., Padmanabhan, S., Pálsson, G., Pankow, J. S., Pattaro, C., Pattie, A., Polasek, O., Poulter, N., Pramstaller, P. P., Quintana-Murci, L., Räikkönen, K., Ralhan, S., Rao, D. C., van Rheenen, W., Rich, S. S., Ridker, P. M., Rietveld, C. A., Robino, A., van Rooij, F. J. A., Ruggiero, D., Saba, Y., Sabanayagam, C., Sabater-Lleal, M., Sala, C. F., Salomaa, V., Sandow, K., Schmidt, H., Scott, L. J., Scott, W. R., Sedaghati-Khayat, B., Sennblad, B., van Setten, J., Sever, P. J., Sheu, W. H-H., Shi, Y., Shrestha, S., Shukla, S. R., Sigurdsson, J. K., Sikka, T. T., Singh, J. R., Smith, B. H., Stančáková, A., Stanton, A., Starr, J. M., Stefansdottir, L., Straker, L., Sulem, P., Sveinbjornsson, G., Swertz, M. A., Taylor, A. M., Taylor, K. D., Terzikhan, N., Tham, Y-C., Thorleifsson, G., Thorsteinsdottir, U., Tillander, A., Tracy, R. P., Tusié-Luna, T., Tzoulaki, I., Vaccargiu, S., Vangipurapu, J., Veldink, J. H., Vitart, V., Völker, U., Vuoksimaa, E., Wakil, S. M., Waldenberger, M., Wander, G. S., Wang, Y. X., Wareham, N. J., Wild, S., Yajnik, C. S., Yuan, J-M., Zeng, L., Zhang, L., Zhou, J., Amin, N., Asselbergs, F. W., Bakker, S. J. L., Becker, D. M., Lehne, B., Bennett, D. A., van den Berg, L. H., Berndt, S. I., Bharadwaj, D., Bielak, L. F., Bochud, M., Boehnke, M., Bouchard, C., Bradfield, J. P., Brody, J. A., Campbell, A., Carmi, S., Caulfield, M. J., Cesarini, D., Chambers, J. C., Chandak, G. R., Cheng, C-Y., Ciullo, M., Cornelis, M., Cusi, D., Smith, G. D., Deary, I. J., Dorajoo, R., van Duijn, C. M., Ellinghaus, D., Erdmann, J., Eriksson, J. G., Evangelou, E., Evans, M. K., Faul, J. D., Feenstra, B., Feitosa, M., Foisy, S., Franke, A., Friedlander, Y., Gasparini, P., Gieger, C., Gonzalez, C., Goyette, P., Grant, S. F. A., Griffiths, L. R., Groop, L., Gudnason, V., Gyllensten, U., Hakonarson, H., Hamsten, A., van der Harst, P., Heng, C-K., Hicks, A. A., Hochner, H., Huikuri, H., Hunt, S. C., Jaddoe, V. W. V., De Jager, P. L., Johannesson, M., Johansson, Å., Jonas, J. B., Jukema, J. W., Junttila, J., Kaprio, J., Kardia, S. L. R., Karpe, F., Kumari, M., Laakso, M., van der Laan, S. W., Lahti, J., Laudes, M., Lea, R. A., Lieb, W., Lumley, T., Martin, N. G., März, W., Matullo, G., McCarthy, M. I., Medland, S. E., Merriman, T. R., Metspalu, A., Meyer, B. F., Mohlke, K. L., Montgomery, G. W., Mook-Kanamori, D., Munroe, P. B., North, K. E., Nyholt, D. R., O'connell, J. R., Ober, C., Oldehinkel, A. J., Palmas, W., Palmer, C., Pasterkamp, G. G., Patin, E., Pennell, C. E., Perusse, L., Peyser, P. A., Pirastu, M., Polderman, T. J. C., Porteous, D. J., Posthuma, D., Psaty, B. M., Rioux, J. D., Rivadeneira, F., Rotimi, C., Rotter, J. I., Rudan, I., Den Ruijter, H. M., Sanghera, D. K., Sattar, N., Schmidt, R., Schulze, M. B., Schunkert, H., Scott, R. A., Shuldiner, A. R., Sim, X., Small, N., Smith, J. A., Sotoodehnia, N., Tai, E-S., Teumer, A., Timpson, N. J., Toniolo, D., Tregouet, D-A., Tuomi, T., Vollenweider, P., Wang, C. A., Weir, D. R., Whitfield, J. B., Wijmenga, C., Wong, T-Y., Wright, J., Yang, J., Yu, L., Zemel, B. S., Zonderman, A. B., Perola, M., Magnusson, P. K. E., Uitterlinden, A. G., Kooner, J. S., Chasman, D. I., Loos, R. J. F., Franceschini, N., Franke, L., Haley, C. S., Hayward, C., Walters, R. G., Perry, J. R. B., Esko, T., Helgason, A., Stefansson, K., Joshi, P. K., Kubo, M. & Wilson, J. F., 31 Oct 2019, In: Nature Communications. 10, 1, p. 1-17 17 p., 4957.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Inbreeding Depression
  • phenotype
  • Inbreeding
  • social factors
  • Phenotype
  6 Citations (Scopus)

  79 Downloads (Pure)

• A study of National Health Service management of chronic osteoarthritis and low back pain

  Hart, O. R., Uden, R. M., McMullan, J. E., Ritchie, M. S., Williams, T. D. & Smith, B. H., 2014, In: Primary Health Care Research and Development. 16, 2, p. 157-166 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • National Health Programs
  • Low Back Pain
  • Osteoarthritis
  • Chronic Pain
  • Primary Health Care
  4 Citations (Scopus)

  180 Downloads (Pure)

• Author Correction: New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries

  Understanding Society Scientific Group, Shrine, N., Guyatt, A. L., Erzurumluoglu, A. M., Jackson, V. E., Hobbs, B. D., Melbourne, C. A., Batini, C., Fawcett, K. A., Song, K., Sakornsakolpat, P., Li, X., Boxall, R., Reeve, N. F., Obeidat, M., Zhao, J. H., Wielscher, M., Weiss, S., Kentistou, K. A., Cook, J. P. & 33 others, Sun, B. B., Zhou, J., Hui, J., Karrasch, S., Imboden, M., Harris, S. E., Marten, J., Enroth, S., Kerr, S. M., Surakka, I., Vitart, V., Lehtimäki, T., Allen, R. J., Bakke, P. S., Beaty, T. H., Bleecker, E. R., Bossé, Y., Brandsma, C-A., Chen, Z., Crapo, J. D., Danesh, J., DeMeo, D. L., Dudbridge, F., Ewert, R., Gieger, C., Gulsvik, A., Hansell, A. L., Hao, K., Hoffman, J. D., Hokanson, J. E., Smith, B. H., Tobin, M. D. & Wain, L. V., Jun 2019, In: Nature Genetics. 51, 6, p. 1067 1 p.

  Research output: Contribution to journal › Article › peer-review

  • Chronic Obstructive Pulmonary Disease
  • Lung

• Can pragmatic trials help us better understand chronic pain and improve treatment?

  Rowbotham, M. C., Gilron, I., Glazer, C., Rice, A. S. C., Smith, B. H., Stewart, W. F. & Wasan, A. D., May 2013, In: Pain. 154, 5, p. 643-646 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Pragmatic Clinical Trials
  • Chronic Pain
  • Population Health
  • Global Health
  • Comorbidity
  27 Citations (Scopus)

• Cardiovascular risk factors associated with the metabolic syndrome are more prevalent in people reporting chronic pain: results from a cross-sectional general population study

  Goodson, N. J., Smith, B. H., Hocking, L. J., McGilchrist, M. M., Dominiczak, A. F., Morris, A., Porteous, D. J. & Goebel, A., Sep 2013, In: Pain. 154, 9, p. 1595-1602 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Metabolic Syndrome
  • Chronic Pain
  • Population
  • Coronary Disease
  • Pain
  39 Citations (Scopus)

• Chronic pain: a review of its epidemiology and associated factors in population-based studies

  Mills, S. E. E., Nicolson, K. P. & Smith, B. H., 1 Aug 2019, In: British Journal of Anaesthesia. 123, 2, p. e273-e283 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Chronic Pain
  • Epidemiology
  • Life Style
  • Population
  • Psychology
  55 Citations (Scopus)

  16 Downloads (Pure)

• Chronic pain epidemiology and its clinical relevance

  van Hecke, O., Torrance, N. & Smith, B. H., 2013, In: British Journal of Anaesthesia. 111, 1, p. 13-18 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Chronic Pain
  • Epidemiology
  • Biological Factors
  • Epidemiologic Studies
  • Population
  236 Citations (Scopus)

• Cohort profile: Generation Scotland: Scottish Family Health Study (GS:SFHS). The study, its participants and their potential for genetic research on health and illness

  Smith, B. H., Campbell, A., Linksted, P., Fitzpatrick, B., Jackson, C., Kerr, S. M., Deary, I. J., Macintyre, D. J., Campbell, H., McGilchrist, M., Hocking, L. J., Wisely, L., Ford, I., Lindsay, R. S., Morton, R., Palmer, C. N. A., Dominiczak, A. F., Porteous, D. J. & Morris, A. D., Jun 2013, In: International Journal of Epidemiology. 42, 3, p. 689-700 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Genetic Research
  • Family Health
  • Scotland
  • Health
  • Comprehensive Health Care
  133 Citations (Scopus)

• Common genetic variants associated with cognitive performance identified using the proxy-phenotype method

  Rietveld, C. A., Esko, T., Davies, G., Pers, T. H., Turley, P., Benyamin, B., Chabris, C. F., Emilsson, V., Johnson, A. D., Lee, J. J., Leeuw, C. D., Marioni, R. E., Medland, S. E., Miller, M. B., Rostapshova, O., van der Lee, S. J., Vinkhuyzen, A. A. E., Amin, N., Conley, D., Derringer, J. & 39 others, van Duijn, C. M., Fehrmann, R., Franke, L., Glaeser, E. L., Hansell, N. K., Hayward, C., Iacono, W. G., Ibrahim-Verbaas, C., Jaddoe, V., Karjalainen, J., Laibson, D., Lichtenstein, P., Liewald, D. C., Magnusson, P. K. E., Martin, N. G., McGue, M., McMahon, G., Pedersen, N. L., Pinker, S., Porteous, D. J., Posthuma, D., Rivadeneira, F., Smith, B. H., Starr, J. M., Tiemeier, H., Timpson, N. J., Trzaskowski, M., Uitterlinden, A. G., Verhulst, F. C., Ward, M. E., Wright, M. J., Davey Smith, G., Deary, I. J., Johannesson, M., Plomin, R., Visscher, P. M., Benjamin, D. J., Cesarini, D. & Koellinger, P. D., 23 Sep 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 38, p. 13790-13794 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Proxy
  • Single Nucleotide Polymorphism
  • Phenotype
  • Education
  • Memory
  133 Citations (Scopus)

• Comparison of psychiatric comorbidity in treatment‐seeking, opioid‐dependent patients with versus without chronic pain

  Higgins, C., Smith, B. H. & Matthews, K., 6 Aug 2019, In: Addiction. 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Chronic Pain
  • Comorbidity
  • Psychiatry
  • Scotland
  • Opioid Analgesics
  4 Citations (Scopus)

  32 Downloads (Pure)

• Corrigendum to "Neuropathic pain in the general population:a systematic review of epidemiological studies": [PAIN® 155(4) pp. 654-662 (2014)] (DOI:10.1016/j.pain.2013.11.013)

  van Hecke, O., Austin, S. K., Khan, R. A., Smith, B. H. & Torrance, N., Sep 2014, In: Pain. 155, 9, p. 1907 1 p.

  Research output: Contribution to journal › Article › peer-review
  3 Citations (Scopus)

• Cost-effectiveness of self-management methods for the treatment of chronic pain in an aging adult population: a systematic review of the literature

  Boyers, D., McNamee, P., Clarke, A., Jones, D., Martin, D., Schofield, P. & Smith, B. H., Apr 2013, In: Clinical Journal of Pain. 29, 4, p. 366-375 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Self-Management
  • Chronic Pain
  • Cost-Benefit Analysis
  • Systematic Reviews
  • Quality-Adjusted Life Years
  25 Citations (Scopus)

• Does a history of depression actually mediate smoking-related pain? findings from a cross-sectional general population-based study

  van Hecke, O., Torrance, N., Cochrane, L., Cavanagh, J., Donnan, P. T., Padmanabhan, S., Porteous, D. J., Hocking, L. & Smith, B. H., Oct 2014, In: European Journal of Pain. 18, 9, p. 1223-1230 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Smoking
  • Depression
  • Pain
  • Population
  • Smokers
  5 Citations (Scopus)

• Erratum: Neuropathic pain: a pathway for care developed by the British Pain Society

  Smith, B. H., Lee, J., Price, C. & Baranowski, A. P., Sep 2013, In: BRITISH JOURNAL OF ANAESTHESIA. 111, 3, p. 522 1 p.

  Research output: Contribution to journal › Article › peer-review

• Estimating the burden of disease in chronic pain with and without neuropathic characteristics: does the choice between the EQ-5D and SF-6D matter?

  Torrance, N., Lawson, K. D., Afolabi, E., Bennett, M. I., Serpell, M. G., Dunn, K. M. & Smith, B. H., Oct 2014, In: Pain. 155, 10, p. 1996-2004 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Chronic Pain
  • Health
  • Pain
  • Quality of Life
  • Mental Health
  35 Citations (Scopus)

  264 Downloads (Pure)

• Evidence of opioid-induced hyperalgesia in clinical populations after chronic opioid exposure: a systematic review and meta-analysis

  Higgins, C., Smith, B. & Matthews, K., Jun 2019, In: British Journal of Anaesthesia. 122, 6, p. e114-e126 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Hyperalgesia
  • Opioid Analgesics
  • Meta-Analysis
  • Systematic Reviews
  • Population
  6 Citations (Scopus)

  230 Downloads (Pure)

• Factors affecting use of unscheduled care for people with advanced cancer: a retrospective cohort study in Scotland

  Mills, S., Buchanan, D., Guthrie, B., Donnan, P. & Smith, B., Dec 2019, In: British Journal of General Practice. 69, 689, p. e860-e868 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Scotland
  • Cohort Studies
  • Retrospective Studies
  • Neoplasms
  • Public Health
  1 Citation (Scopus)

  72 Downloads (Pure)

• Genetic and shared couple environmental contributions to smoking and alcohol use in the UK population

  Clarke, T-K., Adams, M. J., Howard, D. M., Xia, C., Davies, G., Hayward, C., Campbell, A., Padmanabhan, S., Smith, B., Murray, A., Porteous, D., Deary, I. J. & McIntosh, A. M., 25 Nov 2019, In: Molecular Psychiatry. 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Alcohols
  • Smoking
  • Population
  • Single Nucleotide Polymorphism
  • Mating Factor
  1 Citation (Scopus)

  64 Downloads (Pure)

• Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations

  Understanding Society Scientific Group, Sakornsakolpat, P., Prokopenko, D., Lamontagne, M., Reeve, N. F., Guyatt, A. L., Jackson, V. E., Shrine, N., Qiao, D., Bartz, T. M., Kim, D. K., Lee, M. K., Latourelle, J. C., Li, X., Morrow, J. D., Obeidat, M., Wyss, A. B., Bakke, P., Barr, R. G., Beaty, T. H. & 35 others, Belinsky, S. A., Brusselle, G. G., Crapo, J. D., de Jong, K., DeMeo, D. L., Fingerlin, T. E., Gharib, S. A., Gulsvik, A., Hall, I. P., Hokanson, J. E., Kim, W. J., Lomas, D. A., London, S. J., Meyers, D. A., O’Connor, G. T., Rennard, S. I., Schwartz, D. A., Sliwinski, P., Sparrow, D., Strachan, D. P., Tal-Singer, R., Tesfaigzi, Y., Vestbo, J., Vonk, J. M., Yim, J. J., Zhou, X., Bossé, Y., Manichaikul, A., Lahousse, L., Silverman, E. K., Boezen, H. M., Wain, L. V., Tobin, M. D., Hobbs, B. D. & Cho, M. H., 1 Mar 2019, In: Nature Genetics. 51, 3, p. 494-505 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Chronic Obstructive Pulmonary Disease
  • Phenotype
  • Genetic Loci
  • Lung
  • Genetic Heterogeneity
  46 Citations (Scopus)

• Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

  23andMe Research Team, Karlsson Linnér, R., Biroli, P., Kong, E., Meddens, S. F. W., Wedow, R., Fontana, M. A., Lebreton, M., Tino, S. P., Abdellaoui, A., Hammerschlag, A. R., Nivard, M. G., Okbay, A., Rietveld, C. A., Timshel, P. N., Trzaskowski, M., Vlaming, R. D., Zünd, C. L., Bao, Y., Buzdugan, L. & 22 others, Caplin, A. H., Chen, C. Y., Eibich, P., Fontanillas, P., Gonzalez, J. R., Joshi, P. K., Karhunen, V., Kleinman, A., Levin, R. Z., Lill, C. M., Meddens, G. A., Muntané, G., Sanchez-Roige, S., Rooij, F. J. V., Taskesen, E., Wu, Y., Zhang, F., Auton, A., Boardman, J. D., Clark, D. W., Conlin, A. & Beauchamp, J. P., 2019, In: Nature Genetics. 51, 2, p. 245-257 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Genetic Loci
  • Genome-Wide Association Study
  • Single Nucleotide Polymorphism
  • Driving Under the Influence
  • Computational Biology
  74 Citations (Scopus)

• Genome-wide association analysis identifies six new loci associated with forced vital capacity

  Loth, D. W., Artigas, M. S., Gharib, S. A., Wain, L. V., Franceschini, N., Koch, B., Pottinger, T. D., Smith, A. V., Duan, Q., Oldmeadow, C., Lee, M. K., Strachan, D. P., James, A. L., Huffman, J. E., Vitart, V., Ramasamy, A., Wareham, N. J., Kaprio, J., Wang, X-Q., Trochet, H. & 33 others, Kähönen, M., Flexeder, C., Albrecht, E., Lopez, L. M., de Jong, K., Thyagarajan, B., Alves, A. C., Enroth, S., Omenaas, E., Joshi, P. K., Fall, T., Viñuela, A., Launer, L. J., Loehr, L. R., Fornage, M., Li, G., Wilk, J. B., Tang, W., Manichaikul, A., Lahousse, L., Harris, T. B., North, K. E., Rudnicka, A. R., Hui, J., Gu, X., Lumley, T., Wright, A. F., Hastie, N. D., Campbell, S., Generation Scotland, Smith, B. H., Tobin, M. D. & London, S. J., Jul 2014, In: Nature Genetics. 46, 7, p. 669-677 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Vital Capacity
  • Genome-Wide Association Study
  • Lung
  • Lung Diseases
  • Hispanic Americans
  88 Citations (Scopus)

• Genome-wide association study meta-analysis of chronic widespread pain: evidence for involvement of the 5p15.2 region

  Peters, M. J., Broer, L., Willemen, H. L. D. M., Eiriksdottir, G., Hocking, L. J., Holliday, K. L., Horan, M. A., Meulenbelt, I., Neogi, T., Popham, M., Schmidt, C. O., Soni, A., Valdes, A. M., Amin, N., Dennison, E. M., Eijkelkamp, N., Harris, T. B., Hart, D. J., Hofman, A., Huygen, F. J. P. M. & 32 others, Jameson, K. A., Jones, G. T., Launer, L. J., Kerkhof, H. J. M., De Kruijf, M., McBeth, J., Kloppenburg, M., Ollier, W. E., Oostra, B., Payton, A., Rivadeneira, F., Smith, B. H., Smith, A. V., Stolk, L., Teumer, A., Thomson, W., Uitterlinden, A. G., Wang, K., Van Wingerden, S. H., Arden, N. K., Cooper, C., Felson, D., Gudnason, V., Macfarlane, G. J., Pendleton, N., Slagboom, P. E., Spector, T. D., Völzke, H., Kavelaars, A., Van Duijn, C. M., Williams, F. M. K. & Van Meurs, J. B. J., Mar 2013, In: Annals of the Rheumatic Diseases. 72, 3, p. 427-436 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Genome-Wide Association Study
  • Chronic Pain
  • Genes
  • Meta-Analysis
  • Chaperonins
  68 Citations (Scopus)

• Genome-wide association study of knee pain identifies associations with GDF5 and COL27A1 in UK Biobank

  Meng, W., Adams, M. J., Palmer, C. N. A., 23andMe Research Team, Shi, J., Auton, A., Ryan, K. A., Jordan, J. M., Mitchell, B. D., Jackson, R. D., Yau, M. S., McIntosh, A. M. & Smith, B. H., 28 Aug 2019, In: Communications Biology. 2, p. 1-8 8 p., 321.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • knees
  • genome-wide association study
  • osteoarthritis
  • Genome-Wide Association Study
  • pain
  7 Citations (Scopus)

  120 Downloads (Pure)

• Implementation of Patient-Reported Outcomes (PROMs) from specialist pain clinics in England and Wales: experience from a nationwide study

  Price, C. M., C. de C. Williams, A., Smith, B. H. & Bottle, A., 1 Aug 2019, In: European Journal of Pain. 23, 7, p. 1368-1377 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Pain Clinics
  • Wales
  • Patient Reported Outcome Measures
  • England
  • Quality of Life
  1 Citation (Scopus)

  25 Downloads (Pure)

• Insulin resistance: Genetic associations with depression and cognition in population based cohorts

  Frangou, S., Shirali, M., Adams, M. J., Howard, D. M., Gibson, J., Hall, L. S., Smith, B. H., Padmanabhan, S., Murray, A. D., Porteous, D. J., Haley, C. S., Deary, I. J., Clarke, T-K. & McIntosh, A. M., Jun 2019, In: Experimental Neurology. 316, p. 20-26 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Insulin Resistance
  • Cognition
  • Depression
  • Population
  • Intelligence
  1 Citation (Scopus)

  123 Downloads (Pure)

• "I try and smile, I try and be cheery, I try not to be pushy. I try to say 'I'm here for help' but I leave feeling… worried": a qualitative study of perceptions of interactions with health professionals by community-based older adults with chronic pain

  Clarke, A., Martin, D., Jones, D., Schofield, P., Anthony, G., McNamee, P., Gray, D. & Smith, B. H., Sep 2014, In: PLoS ONE. 9, 9, 7 p., e105450.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • health care workers
  • pain
  • Chronic Pain
  • Emotions
  • Health
  15 Citations (Scopus)

  201 Downloads (Pure)

• Low-frequency variation in TP53 has large effects on head circumference and intracranial volume

  UK10K Consortium, 21 Jan 2019, In: Nature Communications. 10, 1, 357.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • circumferences
  • Head
  • Genetic Variation
  • Genetic Models
  • Human Development
  8 Citations (Scopus)

  112 Downloads (Pure)

• Managing chronic pain in the non-specialist setting: a new SIGN guideline

  Smith, B. H., Hardman, J. D., Stein, A., Colvin, L. & SIGN Chronic Pain Guideline Development Group, 1 Jul 2014, In: British Journal of General Practice. 64, 624, p. e462-e464 3 p.

  Research output: Contribution to journal › Article › peer-review
  5 Citations (Scopus)

• Molecular genetic contributions to socioeconomic status and intelligence

  Marioni, R. E., Davies, G., Hayward, C., Liewald, D., Kerr, S. M., Campbell, A., Luciano, M., Smith, B. H., Padmanabhan, S., Hocking, L. J., Hastie, N. D., Wright, A. F., Porteous, D. J., Visscher, P. M. & Deary, I. J., 2014, In: Intelligence. 44, May-June, p. 26-32 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Molecular Genetics
  • Socioeconomic Status
  • Intelligence
  • Social Class
  • Molecular Biology
  79 Citations (Scopus)

  157 Downloads (Pure)

• Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions

  InterAct Consortium, LifeLines Cohort Study, de Vries, P. S., Brown, M. R., Bentley, A. R., Sung, Y. J., Winkler, T. W., Ntalla, I., Schwander, K., Kraja, A. T., Guo, X., Franceschini, N., Cheng, C-Y., Sim, X., Vojinovic, D., Huffman, J. E., Musani, S. K., Li, C., Feitosa, M. F., Richard, M. A. & 34 others, Noordam, R., Aschard, H., Bartz, T. M., Bielak, L. F., Deng, X., Dorajoo, R., Lohman, K. K., Manning, A. K., Rankinen, T., Smith, A. V., Tajuddin, S. M., Evangelou, E., Graff, M., Alver, M., Boissel, M., Chai, J. F., Chen, X., Divers, J., Gandin, I., Gao, C., Goel, A., Hagemeijer, Y., Harris, S. E., Hartwig, F. P., He, M., Horimoto, A. R. V. R., Hsu, F-C., Jackson, A. U., Kasturiratne, A., Komulainen, P., Connell, J. M., Smith, B. H., Rao, D. C. & Morrison, A. C., 1 Jun 2019, In: American Journal of Epidemiology. 188, 6, p. 1033-1054 22 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Genome-Wide Association Study
  • Alcohols
  • Lipids
  • APOBEC-1 Deaminase
  • Vascular Endothelial Growth Factor B
  16 Citations (Scopus)

  129 Downloads (Pure)

• Neuropathic pain: a pathway for care developed by the British Pain Society

  Smith, B. H., Lee, J., Price, C. & Baranowski, A. P., Jul 2013, In: British Journal of Anaesthesia. 111, 1, p. 73-79 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Neuralgia
  • Pain
  • Secondary Care
  • Tertiary Healthcare
  • Consensus
  25 Citations (Scopus)

• Neuropathic pain in the community: more under-treated than refractory?

  Torrance, N., Ferguson, J. A., Afolabi, E., Bennett, M. I., Serpell, M. G., Dunn, K. M. & Smith, B. H., May 2013, In: Pain. 154, 5, p. 690–699 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Neuralgia
  • Chronic Pain
  • Pain
  • Self Efficacy
  • Signs and Symptoms
  94 Citations (Scopus)

• Neuropathic pain in the general population: a systematic review of epidemiological studies

  van Hecke, O., Austin, S. K., Khan, R. A., Smith, B. H. & Torrance, N., Apr 2014, In: Pain. 155, 4, p. 654-662 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Neuralgia
  • Epidemiologic Studies
  • Systematic Reviews
  • Population
  • Glossopharyngeal Nerve Diseases
  511 Citations (Scopus)

• New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries

  Understanding Society Scientific Group, Shrine, N., Guyatt, A. L., Erzurumluoglu, A. M., Jackson, V. E., Hobbs, B. D., Melbourne, C. A., Batini, C., Fawcett, K. A., Song, K., Sakornsakolpat, P., Li, X., Boxall, R., Reeve, N. F., Obeidat, M., Zhao, J. H., Wielscher, M., Weiss, S., Kentistou, K. A., Cook, J. P. & 33 others, Sun, B. B., Zhou, J., Hui, J., Karrasch, S., Imboden, M., Harris, S. E., Marten, J., Enroth, S., Kerr, S. M., Surakka, I., Vitart, V., Lehtimäki, T., Allen, R. J., Bakke, P. S., Beaty, T. H., Bleecker, E. R., Bossé, Y., Brandsma, C-A., Chen, Z., Crapo, J. D., Danesh, J., DeMeo, D. L., Dudbridge, F., Ewert, R., Gieger, C., Gulsvik, A., Hansell, A. L., Hao, K., Hoffman, J. D., Hokanson, J. E., Smith, B. H., Tobin, M. D. & Wain, L. V., Mar 2019, In: Nature Genetics. 51, 3, p. 481-493 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Chronic Obstructive Pulmonary Disease
  • Lung
  • Smokers
  • Genome-Wide Association Study
  • Mortality
  50 Citations (Scopus)

  381 Downloads (Pure)

• Pedigree and genotyping quality analyses of over 10,000 DNA samples from the Generation Scotland: Scottish Family Health Study

  Kerr, S. M., Campbell, A., Murphy, L., Hayward, C., Jackson, C., Wain, L. V., Tobin, M. D., Dominiczak, A., Morris, A., Smith, B. H. & Porteous, D. J., 22 Mar 2013, In: BMC Medical Genetics. 14, 38.

  Research output: Contribution to journal › Article › peer-review

  • Family Health
  • Scotland
  • Pedigree
  • Single Nucleotide Polymorphism
  • DNA
  31 Citations (Scopus)

• Pharmacist-led management of chronic pain in primary care: results from a randomised controlled exploratory trial

  Bruhn, H., Bond, C. M., Elliott, A. M., Hannaford, P. C., Lee, A. J., McNamee, P., Smith, B. H., Watson, M. C., Holland, R. & Wright, D., 2013, In: BMJ Open. 3, 4, e002361.

  Research output: Contribution to journal › Article › peer-review

  • Pharmacists
  • Chronic Pain
  • Primary Health Care
  • Randomized Controlled Trials
  • Anxiety
  52 Citations (Scopus)

• Physical activity and exercise for chronic pain in adults: An overview of Cochrane reviews

  Geneen, L., Smith, B., Clarke, C., Martin, D., Colvin, L. A. & Moore, R. A., 25 Aug 2014, In: Cochrane Database of Systematic Reviews. 2014, 8, p. 1-9 9 p., CD011279.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Chronic Pain
  • Exercise
  • Quality of Health Care
  • Systematic Reviews
  • Quality of Life
  248 Citations (Scopus)

  105 Downloads (Pure)

• Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution

  T2D-Genes Consortium, The MAGIC Investigators, CHD Exome+ Consortium, EPIC-CVD Consortium, ExomeBP Consortium, Global Lipids Genetic Consortium, GoT2D Genes Consortium, ReproGen Consortium, Justice, A. E., Karaderi, T., Highland, H. M., Young, K. L., Graff, M., Lu, Y., Turcot, V., Auer, P. L., Fine, R. S., Guo, X., Schurmann, C., Lempradl, A. & 40 others, Marouli, E., Mahajan, A., Winkler, T. W., Locke, A. E., Medina-Gomez, C., Esko, T., Vedantam, S., Giri, A., Lo, K. S., Alfred, T., Mudgal, P., Ng, M. C. Y., Heard-Costa, N. L., Feitosa, M. F., Manning, A. K., Willems, S. M., Sivapalaratnam, S., Abecasis, G., Alam, D. S., Allison, M., Amouyel, P., Arzumanyan, Z., Balkau, B., Bastarache, L., Bergmann, S., Bielak, L. F., Blüher, M., Boehnke, M., Boeing, H., Boerwinkle, E., Böger, C. A., Bork-Jensen, J., Evangelou, E., Li, J., Morris, A. P., Smith, B. H., Smith, J. A., Wood, A. R., North, K. E. & Lindgren, C. M., Mar 2019, In: Nature Genetics. 51, 3, p. 452-469 18 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Body Fat Distribution
  • Homeostasis
  • Lipids
  • Fats
  • White Adipose Tissue
  21 Citations (Scopus)

  266 Downloads (Pure)

• Stratification by Smoking Status Reveals an Association of CHRNA5-A3-B4 Genotype with Body Mass Index in Never Smokers

  Taylor, A. E., Morris, R. W., Fluharty, M. E., Bjorngaard, J. H., Asvold, B. O., Gabrielsen, M. E., Campbell, A., Marioni, R., Kumari, M., Hällfors, J., Männistö, S., Marques-Vidal, P., Kaakinen, M., Cavadino, A., Postmus, I., Husemoen, L. L. N., Skaaby, T., Ahluwalia, T. S., Treur, J. L., Willemsen, G. & 44 others, Dale, C., Wannamethee, S. G., Lahti, J., Palotie, A., Räikkönen, K., Kisialiou, A., McConnachie, A., Padmanabhan, S., Wong, A., Dalgård, C., Paternoster, L., Ben-Shlomo, Y., Tyrrell, J., Horwood, J., Fergusson, D. M., Kennedy, M. A., Frayling, T., Nohr, E. A., Christiansen, L., Kyvik, K. O., Kuh, D., Watt, G., Eriksson, J., Whincup, P. H., Vink, J. M., Boomsma, D. I., Davey Smith, G., Lawlor, D., Linneberg, A., Ford, I., Jukema, J. W., Power, C., Hyppönen, E., Jarvelin, M-R., Preisig, M., Borodulin, K., Kaprio, J., Kivimaki, M., Smith, B. H., Hayward, C., Romundstad, P. R., Sørensen, T. I. A., Munafò, M. R. & Sattar, N., 4 Dec 2014, In: PLoS Genetics. 10, 12, 6 p., e1004799.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • body mass index
  • body mass
  • smoking
  • genotype
  • Smokers
  35 Citations (Scopus)

  143 Downloads (Pure)

• Systematically searching for and assessing the literature for self-management of chronic pain: a lay users' perspective

  Schofield, P., Smith, B. H., Martin, D., Jones, D., Clarke, A., McNamee, P., Marsh, R., Morrison, M., Morrison, R., Fowler, S., Anthony, G. & Stewart, C., 27 Jul 2014, In: BMC Geriatrics. 14, 1, 8 p., 86.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Self-Management
  • Chronic Pain
  • Pain
  • Pain Management
  • Internet
  4 Citations (Scopus)

  139 Downloads (Pure)

• Targeted genetic testing for familial hypercholesterolaemia using next generation sequencing: a population-based study

  Norsworthy, P. J., Vandrovcova, J., Thomas, E. R. A., Campbell, A., Kerr, S. M., Biggs, J., Game, L., Soutar, A. K., Smith, B. H., Dominiczak, A. F., Porteous, D. J., Morris, A. D., Generation Scotland & Aitman, T. J., 23 Jun 2014, In: BMC Medical Genetics. 15, 7 p., 70.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Hyperlipoproteinemia Type II
  • Genetic Testing
  • Cholesterol
  • Population
  • Mutation
  42 Citations (Scopus)

  153 Downloads (Pure)

• Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels

  Tin, A., Marten, J., Halperin Kuhns, V. L., Li, Y., Wuttke, M., Kirsten, H., Sieber, K. B., Qiu, C., Gorski, M., Yu, Z., Giri, A., Sveinbjornsson, G., Li, M., Chu, A. Y., Hoppmann, A., O'Connor, L. J., Prins, B., Nutile, T., Noce, D., Akiyama, M. & 31 others, Cocca, M., Ghasemi, S., van der Most, P. J., Horn, K., Xu, Y., Fuchsberger, C., Sedaghat, S., Afaq, S., Amin, N., Ärnlöv, J., Bakker, S. J. L., Bansal, N., Baptista, D., Bergmann, S., Biggs, M. L., Biino, G., Boerwinkle, E., Bottinger, E. P., Boutin, T. S., Brumat, M., Burkhardt, R., Campana, E., Campbell, A., Campbell, H., Carroll, R. J., Catamo, E., Chambers, J. C., Ciullo, M., Concas, M. P., Smith, B. H. & Köttgen, A., Oct 2019, In: Nature Genetics. 51, 10, p. 1459–1474 22 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Uric Acid
  • Gout
  • Serum
  • Genes
  • urate transporter
  30 Citations (Scopus)

  41 Downloads (Pure)

• The National Pain Audit for specialist pain services in England and Wales 2010–2014

  Price, C., de C Williams, A. C., Smith, B. H. & Bottle, A., 1 Aug 2019, In: British Journal of Pain. 13, 3, p. 185-193 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Wales
  • England
  • Pain Clinics
  • Pain
  • Quality Improvement
  3 Citations (Scopus)

  185 Downloads (Pure)

• The Scottish model for chronic pain management services

  Gilbert, S., Holdsworth, L. & Smith, B., 2014, In: British Journal of Healthcare Management. 20, 12, p. 568-577 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Pain Management
  • Chronic Pain
  • Scotland
  • Direction compound
• Chapter

  The effect of Stanford-type self-management programmes on pain and function in older people with persistent pain

  Martin, D., Schofield, P., Jones, D., McNamee, P., Clarke, A., Anthony, G. & Smith, B., 1 Jan 2013, Pain: International Research in Pain Management. Nova Science Publishers, p. 165-172 8 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • pain
  • management
  • lack
  • evidence
• Comment/debate

  Lessons from Mackenzie that still resonate

  Van Hecke, O., Smith, B. H. & Sullivan, F. M., Mar 2013, In: British Journal of General Practice. 63, 608, p. 158-159 2 p.

  Research output: Contribution to journal › Comment/debate › peer-review

  • General Practitioners
  • Primary Health Care
  • Epidemiology
  • Medicine
  • Research Personnel
• Editorial

  Editorial IV. Managing chronic pain: a clinical challenge: new SIGN guidelines provide a practical evidence-based approach and identify research gaps

  Colvin, L. A., Stein, A. & Smith, B. H., 2014, In: BRITISH JOURNAL OF ANAESTHESIA. 112, 1, p. 9-12 4 p.

  Research output: Contribution to journal › Editorial › peer-review
  2 Citations (Scopus)