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A mechanism-inspired UDP-N-acetylglucosamine pyrophosphorylase inhibitor
Raimi, O., Hurtado-Guerrero, R., Borodkin, V., Ferenbach, A., Urbaniak, M., Ferguson, M. & van Aalten, D., 1 Apr 2020, In: RSC Chemical Biology. 1, p. 13-25 13 p.Research output: Contribution to journal › Article › peer-review
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A mechanistic target of rapamycin complex 1/2 (mTORC1)/V-Akt murine thymoma viral oncogene homolog 1 (AKT1)/cathepsin H axis controls filaggrin expression and processing in skin, a novel mechanism for skin barrier disruption in patients with atopic dermatitis
Naeem, A. S., Tommasi, C., Cole, C., Brown, S. J., Zhu, Y., Way, B., Willis Owen, S. A. G., Moffatt, M., Cookson, W. O., Harper, J. I., Di, W. L., Brown, S. J., Reinheckel, T. & O'Shaughnessy, R. F. L., Apr 2017, In: Journal of Allergy and Clinical Immunology. 139, 4, p. 1228-1241 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile12 Citations (Scopus)217 Downloads (Pure) -
A membrane-depolarizing toxin substrate of the Staphylococcus aureus type VII secretion system mediates intraspecies competition
Ulhuq, F. R., Gomes, M. C., Duggan, G. M., Guo, M., Mendonca, C., Buchanan, G., Chalmers, J. D., Cao, Z., Kneuper, H., Murdoch, S., Thomson, S., Strahl, H., Trost, M., Mostowy, S. & Palmer, T., 25 Aug 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 34, p. 20836-20847 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)19 Downloads (Pure) -
A Mendelian Randomization Study Provides Evidence That Adiposity and Dyslipidemia Lead to Lower Urinary Albumin-to-Creatinine Ratio, a Marker of Microvascular Function
Casanova, F., Wood, A. R., Yaghootkar, H., Beaumont, R. N., Jones, S. E., Gooding, K. M., Aizawa, K., Strain, W. D., Hattersley, A. T., Khan, F., Shore, A. C., Frayling, T. M. & Tyrrell, J., May 2020, In: Diabetes. 69, 5, p. 1072-1082 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)158 Downloads (Pure) -
America First and the Human Rights Regime
Mills, K. & Payne, R. A., 2020, In: Journal of Human Rights. 19, 4, p. 399-424 26 p.Research output: Contribution to journal › Article › peer-review
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A method for automatic segmentation and splitting of hyperspectral images of raspberry plants collected in field conditions
Williams, D., Britten, A., McCallum, S., Jones, H., Aitkenhead, M., Karley, A., Loades, K., Prashar, A. & Graham, J., 1 Nov 2017, In: Plant Methods. 13, p. 1-12 12 p., 74.Research output: Contribution to journal › Article › peer-review
Open AccessFile9 Citations (Scopus)175 Downloads (Pure) -
A Method to Evaluate Trainee Progression During Simulation Training at the Urology Simulation Boot Camp (USBC) Course
Kailavasan, M., Hanchanale, V., Rajpal, S., Morley, R., Mcllhenny, C., Somani, B., Nabi, G., Gowda, R., Jain, S., Biyani, C. S. & Myatt, A., Jan 2019, In: Journal of Surgical Education. 76, 1, p. 215-222 8 p.Research output: Contribution to journal › Article › peer-review
6 Citations (Scopus) -
A Method to Exploit the Structure of Genetic Ancestry Space to Enhance Case-Control Studies
Bodea, C. A., Neale, B. M., Ripke, S., International IBD Genetics Consortium, Daly, M. J., Devlin, B. & Roeder, K., 5 May 2016, In: American Journal of Human Genetics. 98, 5, p. 857-868 12 p.Research output: Contribution to journal › Article › peer-review
6 Citations (Scopus) -
A minimally invasive tool to study immune response and skin barrier in children with atopic dermatitis
Hulshof, L., Hack, D. P., Hasnoe, Q. C. J., Dontje, B., Jakasa, I., Riethmüller, C., McLean, W. H. I., van Aalderen, W. M. C., Van't Land, B., Kezic, S., Sprikkelman, A. B. & Middelkamp-Hup, M. A., Mar 2019, In: British Journal of Dermatology. 180, 3, p. 621-630 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile19 Citations (Scopus)150 Downloads (Pure) -
A mink-free GB: perspectives on eradicating American mink Neovison vison from Great Britain and its islands
Martin, A. R. & Lea, V. J., 1 Apr 2020, In: Mammal Review. 50, 2, p. 170-179 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)77 Downloads (Pure) -
Amino acid neurotoxins in feathers of the Lesser Flamingo, Phoeniconaias minor
Metcalf, J. S., Banack, S. A., Kotut, K., Krienitz, L. & Codd, G. A., Jan 2013, In: Chemosphere. 90, 2, p. 835-839 5 p.Research output: Contribution to journal › Article › peer-review
24 Citations (Scopus) -
Amino acid secretion influences the size and composition of copper carbonate nanoparticles synthesized by ureolytic fungi
Liu, F., Csetenyi, L. & Gadd, G., Sep 2019, In: Applied Microbiology and Biotechnology. 103, 17, p. 7217-7230 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile11 Citations (Scopus)111 Downloads (Pure) -
Amino acid substitutions in the human homomeric β3 GABAA receptor that enable activation by GABA
Gottschald Chiodi, C., Baptista-Hon, D., Hunter, W. & Hales, T., 15 Feb 2019, In: Journal of Biological Chemistry. 294, 7, p. 2375-2385 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)121 Downloads (Pure) -
A missense mutation in a patient with developmental delay affects the activity and structure of the hexosamine biosynthetic pathway enzyme AGX1
Chen, X., Raimi, O., Ferenbach, A. & van Aalten, D., 24 Oct 2020, In: FEBS Letters. 13 p.Research output: Contribution to journal › Article › peer-review
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A missense mutation in the catalytic domain of O-GlcNAc transferase links perturbations in protein O-GlcNAcylation to X-linked intellectual disability
Pravata, V. M., Gundogdu, M., Bartual, S. G., Ferenbach, A. T., Stavridis, M., Õunap, K., Pajusalu, S., Žordania, R., Wojcik, M. H. & van Aalten, D. M. F., 7 Nov 2019, In: FEBS Letters. 594, 4, p. 717-727 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Citations (Scopus)14 Downloads (Pure) -
A Mixed Analytical/Numerical Method for Velocity and Heat Transfer of Laminar Power-Law Fluids
Li, B., Zheng, L., Lin, P., Wang, Z. & Liao, M., 3 Aug 2016, In: Numerical Mathematics: Theory, Methods and Applications. 9, 3, p. 315-336 22 p.Research output: Contribution to journal › Article › peer-review
6 Citations (Scopus) -
A mixed methods approach to understanding funder trust and due diligence processes in online crowdfunding investment
Jones, H. S. & Moncur, W., Feb 2020, In: ACM Transactions on Social Computing. 3, 1, p. 1-29 29 p., 3.Research output: Contribution to journal › Article › peer-review
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A model based criterion for gene expression calls using RNA-seq data
Wagner, G. P., Kin, K. & Lynch, V. J., Sep 2013, In: Theory in Biosciences. 132, 3, p. 159-164 6 p.Research output: Contribution to journal › Article › peer-review
78 Citations (Scopus) -
A Model for (Quasi-)Periodic Multiwavelength Photometric Variability in Young Stellar Objects
Kesseli, A. Y., Petkova, M. A., Wood, K., Whitney, B. A., Hillenbrand, L. A., Gregory, S. G., Stauffer, J. R., Morales-Calderon, M., Rebull, L. & Alencar, S. H. P., Sep 2016, In: Astrophysical Journal. 828, 1, p. 1-15 15 p., 42.Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Citations (Scopus)84 Downloads (Pure) -
A model for dynamic reconfiguration in service-oriented architectures
Fiadeiro, J. L. & Lopes, A., 1 May 2013, In: Software and Systems Modeling. 12, 2, p. 349-367 19 p.Research output: Contribution to journal › Article › peer-review
26 Citations (Scopus) -
A model of consultation in prostate cancer care: evidence from a systematic review
Paterson, C. & Nabi, G., 2017, In: Cancer Nursing. 40, 4, p. 276-288 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile13 Citations (Scopus)406 Downloads (Pure) -
A model of the transformative journey into reflexivity: an exploration into students' experiences of critical reflection
Shaw, R., 15 Feb 2013, In: Reflective Practice. 14, 3, p. 319-335 17 p.Research output: Contribution to journal › Article › peer-review
9 Citations (Scopus) -
A Modified AUGIS Delphi Process to Establish Future Research Priorities in Benign Upper Gastrointestinal Surgery
Wilson, M. S. J., Vaughan-Shaw, P., Boyle, C., Yong, G. L., Oglesby, S., Skipworth, R., Lamb, P., Griffiths, E. A. T. & Attwood, S. E. A., Apr 2020, In: World Journal of Surgery. 44, p. 1216-1222 7 p.Research output: Contribution to journal › Article › peer-review
2 Citations (Scopus) -
A modified Delphi process to establish future research priorities in malignant oesophagogastric surgery
Wilson, M. S. J., Blencowe, N. S., Boyle, C., Knight, S. R., Petty, R., Vohra, R. S. & Underwood, T. J., 16 Dec 2019, In: Surgeon: Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland. 6 p.Research output: Contribution to journal › Article › peer-review
2 Citations (Scopus) -
A molecular explanation for the recessive nature of parkin-linked Parkinson's disease
Spratt, D. E., Julio Martinez-Torres, R., Noh, Y. J., Mercier, P., Manczyk, N., Barber, K. R., Aguirre, J. D., Burchell, L., Purkiss, A., Walden, H. & Shaw, G. S., 1 Jan 2013, In: Nature Communications. 4, 12 p., 1983.Research output: Contribution to journal › Article › peer-review
88 Citations (Scopus) -
A More Scientific Approach to Applied Economics: Reconstructing Statistical, Analytical Significance, and Correlation Analysis
Altman, M., 28 Feb 2019, In: SSRN Working Paper Series. 23 p.Research output: Contribution to journal › Article
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A Morphological identification cell cytotoxicity assay using cytoplasm-localized fluorescent probe (CLFP) to distinguish living and dead cells
Lai, F., Shen, Z., Wen, H., Chen, J., Zhang, X., Lin, P., Yin, D., Cui, H. & Chen, X., 8 Jan 2017, In: Biochemical and Biophysical Research Communications. 482, 2, p. 257-263 7 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile10 Citations (Scopus)412 Downloads (Pure) -
A mouse model for functional dissection of TAB1 O-GlcNAcylation
Authier, F., Muha, V. & van Aalten, D. M. F., 27 Aug 2019, In: Wellcome Open Research. 4, 16 p., 128.Research output: Contribution to journal › Article › peer-review
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A moving interface finite element formulation for layered structures
Funari, M. F., Greco, F. & Lonetti, P., 1 Jul 2016, In: Composites Part B: Engineering. 96, p. 325-337 13 p.Research output: Contribution to journal › Article › peer-review
34 Citations (Scopus) -
A moving interface finite element formulation to predict dynamic edge debonding in FRP-strengthened concrete beams in service conditions
Funari, M. F., Spadea, S., Fabbrocino, F. & Luciano, R., Jun 2020, In: Fibers. 8, 6, p. 1-9 9 p., 42.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)213 Downloads (Pure) -
AMP-activated protein kinase: a cellular energy sensor that comes in twelve flavours
Ross, F. A., MacKintosh, C. & Hardie, D. G., 24 Mar 2016, In: FEBS Journal. 283, 16, p. 2987-3001 15 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile138 Citations (Scopus)114 Downloads (Pure) -
AMP-activated protein kinase (AMPK)α2 plays a role in determining the cellular fate of glucose in insulin-resistant mouse skeletal muscle
Lee-Young, R. S., Bonner, J. S., Mayes, W. H., Iwueke, I., Barrick, B. A., Hasenour, C. M., Kang, L. & Wasserman, D. H., Mar 2013, In: Diabetologia. 56, 3, p. 608-617 10 p.Research output: Contribution to journal › Article › peer-review
18 Citations (Scopus) -
AMP-activated protein kinase activator A-769662 increases intracellular calcium and ATP release from astrocytes in an AMPK-independent manner
Vlachaki Walker, J. M., Robb, J. L., Cruz, A. M., Malhi, A., Weightman Potter, P. G., Ashford, M. L. J., McCrimmon, R. J., Ellacott, K. L. J. & Beall, C., 21 Apr 2017, In: Diabetes, Obesity & Metabolism. 19, 7, p. 997-1005 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile14 Citations (Scopus)296 Downloads (Pure) -
AMP-activated protein kinase inhibits Kv1.5 channel currents of pulmonary arterial myocytes in response to hypoxia and inhibition of mitochondrial oxidative phosphorylation
Moral-Sanz, J., Mahmoud, A. D., Ross, F. A., Eldstrom, J., Fedida, D., Hardie, D. G. & Evans, A. M., 1 Sep 2016, In: Journal of Physiology. 594, 17, p. 4901-4915 15 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile16 Citations (Scopus)162 Downloads (Pure) -
Amphiphilic oxygenated amorphous carbon-graphite buckypapers with gas sensitivity to polar and non-polar VOCs
Homaeigohar, S., Sep 2019, In: Nanomaterials. 9, 9, p. 1-14 14 p., 1343.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)22 Downloads (Pure) -
AMP Is a True Physiological Regulator of AMP-Activated Protein Kinase by Both Allosteric Activation and Enhancing Net Phosphorylation
Gowans, G. J., Hawley, S. A., Ross, F. A. & Hardie, D. G., 1 Oct 2013, In: Cell Metabolism. 18, 4, p. 556-566 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile275 Citations (Scopus)167 Downloads (Pure) -
AMPK: a target for drugs and natural products with effects on both diabetes and cancer
Hardie, D. G., Jul 2013, In: Diabetes. 62, 7, p. 2164-2172 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile264 Citations (Scopus)143 Downloads (Pure) -
AMPK: opposing the metabolic changes in both tumour cells and inflammatory cells?
Dandapani, M. & Hardie, D. G., Apr 2013, In: Biochemical Society Transactions. 41, 2, p. 687-693 7 p.Research output: Contribution to journal › Article › peer-review
34 Citations (Scopus) -
AMPK activation induces mitophagy and promotes mitochondrial fission while activating TBK1 in a PINK1-Parkin independent manner
Seabright, A. P., Fine, N. H. F., Barlow, J. P., Lord, S. O., Musa, I., Gray, A., Bryant, J. A., Banzhaf, M., Lavery, G. G., Hardie, D. G., Hodson, D. J., Philp, A. & Lai, Y-C., 4 May 2020, In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 34, 5, p. 6284-6301 18 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)81 Downloads (Pure) -
AMPK antagonizes hepatic glucagon-stimulated cyclic AMP signalling via phosphorylation-induced activation of cyclic nucleotide phosphodiesterase 4B
Johanns, M., Lai, Y. C., Hsu, M. F., Jacobs, R., Vertommen, D., Van Sande, J., Dumont, J. E., Woods, A., Carling, D., Hue, L., Viollet, B., Foretz, M. & Rider, M. H., 8 Mar 2016, In: Nature Communications. 7, 10856.Research output: Contribution to journal › Article › peer-review
Open Access58 Citations (Scopus) -
AMPK Causes Cell Cycle Arrest in LKB1-deficient Cells via Activation of CAMKK2
Fogarty, S., Ross, F. A., Vara Ciruelos, D., Gray, A., Gowans, G. J. & Hardie, D. G., 1 Aug 2016, In: Molecular Cancer Research. 14, 8, p. 683-695 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile34 Citations (Scopus)320 Downloads (Pure) -
AMPK modulates glucose-sensing in insulin-secreting cells by altered phosphotransfer to KATP channels
Beall, C., Watterson, K. R., McCrimmon, R. J. & Ashford, M. L. J., Jun 2013, In: Journal of Bioenergetics and Biomembranes. 45, 3, p. 229-241 13 p.Research output: Contribution to journal › Article › peer-review
14 Citations (Scopus) -
AMPKα1: a glucose sensor that controls CD8 T-cell memory
Rolf, J., Zarrouk, M., Finlay, D. K., Foretz, M., Viollet, B. & Cantrell, D. A., Apr 2013, In: European Journal of Immunology. 43, 4, p. 889-896 8 p.Research output: Contribution to journal › Article › peer-review
138 Citations (Scopus) -
A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure
LifeLines Cohort Study, Sung, Y. J., de Las Fuentes, L., Winkler, T. W., Chasman, D. I., Bentley, A. R., Kraja, A. T., Ntalla, I., Warren, H. R., Guo, X., Schwander, K., Manning, A. K., Brown, M. R., Aschard, H., Feitosa, M. F., Franceschini, N., Lu, Y., Cheng, C-Y., Sim, X., Vojinovic, D. & 40 others, , 1 Aug 2019, In: Human Molecular Genetics. 28, 15, p. 2615-2633 19 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)69 Downloads (Pure) -
A Multicenter, Randomized, Placebo-Controlled Trial of Atorvastatin for the Primary Prevention of Cardiovascular Events in Patients With Rheumatoid Arthritis: A multicenter, randomized, placebo controlled trial
Kitas, G. D., Nightingale, P., Armitage, J., Sattar, N., Belch, J. J. F. & Symmons, D. P. M., Sep 2019, In: Arthritis and Rheumatology. 71, 9, p. 1437-1449 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile31 Citations (Scopus)44 Downloads (Pure) -
A multi-centre, prospective epidemiological surveillance study considering ophthalmic complications of functional endoscopic sinus surgery
Burgess, S., Foulds, J., White, P., Foot, B. & Macewen, C., Mar 2020, In: Journal of Laryngology and Otology. 134, 3, p. 228-232 5 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)47 Downloads (Pure) -
A multicentre parallel-group randomised trial assessing multiparametric MRI characterisation and image-guided biopsy of prostate in men suspected of having prostate cancer: MULTIPROS study protocol
Szewczyk-Bieda, M., Wei, C., Coll, K., Gandy, S., Donnan, P., Ragupathy, S. K. A., Singh, P., Wilson, J. & Nabi, G., 21 Nov 2019, In: Trials. 20, p. 1-8 8 p., 638.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)77 Downloads (Pure) -
A Multi-disciplinary Approach to the Archaeological Investigation of a Bedrock-Dominated Shallow-Marine Landscape: An example from the Bay of Firth, Orkney, UK
Bates, M. R., Nayling, N., Bates, R., Dawson, S., Huws, D. & Wickham-Jones, C., Mar 2013, In: International Journal of Nautical Archaeology. 42, 1, p. 24-43 20 p.Research output: Contribution to journal › Article › peer-review
22 Citations (Scopus) -
A multi-ethnic genome-wide association study identifies novel loci for non-syndromic cleft lip with or without cleft palate on 2p24.2, 17q23 and 19q13
Leslie, E. J., Carlson, J. C., Shaffer, J. R., Feingold, E., Wehby, G., Laurie, C. A., Jain, D., Laurie, C. C., Doheny, K. F., McHenry, T., Resick, J., Sanchez, C., Jacobs, J., Emanuele, B., Vieira, A. R., Neiswanger, K., Lidral, A. C., Valencia-Ramirez, L. C., Lopez-Palacio, A. M., Valencia, D. R. & 35 others, , 1 Jul 2016, In: Human Molecular Genetics. 25, 13, p. 2862-2872 11 p.Research output: Contribution to journal › Article › peer-review
86 Citations (Scopus) -
A multimodal approach to cardiovascular risk stratification in patients with type 2 diabetes incorporating retinal, genomic and clinical features
Fetit, A., Doney, A., Hogg, S., Wang, R., MacGillivray, T., Wardlaw, J. M., Doubal, F. N., McKay, G. J., McKenna, S. & Trucco, E., 5 Mar 2019, In: Scientific Reports. 9, 10 p., 3591.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)139 Downloads (Pure)