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2019

CD44 contributes to hyaluronan-mediated insulin resistance in skeletal muscle of high fat-fed C57BL/6 mice

Hasib, A., Hennayake, C., Bracy, D. P., Bugler-Lamb, A-R., Lantier, L., Khan, F., Ashford, M., McCrimmon, R., Wasserman, D. H. & Kang, L., 1 Dec 2019, In : American Journal of Physiology, Endocrinology and Metabolism. 317, 6, p. E973-E983 11 p.

Research output: Contribution to journalArticle

Hyaluronic Acid
Inbred C57BL Mouse
Insulin Resistance
Skeletal Muscle
Fats

Corrigendum to "The BACE1 product sAPPβ induces ER stress and inflammation and impairs insulin signaling" [Metab Clin Exp 85 (2018) 59-75]

Botteri, G., Salvadó, L., Gumà, A., Hamilton, D. L., Meakin, P. J., Montagut, G., Ashford, M. L. J., Ceperuelo-Mallafré, V., Fernández-Veledo, S., Vendrell, J., Calderón-Dominguez, M., Serra, D., Herrero, L., Pizarro, J., Barroso, E., Palomer, X. & Vázquez-Carrera, M., Jul 2019, In : Metabolism: Clinical and Experimental. 96, p. 101-102 2 p.

Research output: Contribution to journalArticle

Insulin
Inflammation
corrigendum
2018
8 Citations (Scopus)
146 Downloads (Pure)

Bace1-dependent amyloid processing regulates hypothalamic leptin sensitivity in obese mice

Meakin, P. J., Jalicy, S. M., Montagut, G., Allsop, D. J. P., Cavellini, D. L., Irvine, S. W., McGinley, C., Liddell, M. K., McNeilly, A. D., Parmionova, K., Liu, Y-R., Bailey, C. S. L., Dale, J. K., Heisler, L. K., McCrimmon, R. J. & Ashford, M. L. J., 8 Jan 2018, In : Scientific Reports. 8, 1, p. 55 16 p., 55.

Research output: Contribution to journalArticle

Open Access
File
Obese Mice
Leptin
Amyloid
Obesity
Homeostasis
2 Citations (Scopus)
93 Downloads (Pure)

Calcium Channel CaV2.3 Subunits Regulate Hepatic Glucose Production by Modulating Leptin-Induced Excitation of Arcuate Pro-opiomelanocortin Neurons

Smith, M. A., Katsouri, L., Virtue, S., Choudhury, A. I., Vidal-Puig, A., Ashford, M. L. J. & Withers, D. J., 9 Oct 2018, In : Cell Reports. 25, 2, p. 278-287.e4 15 p.

Research output: Contribution to journalArticle

Open Access
File
Pro-Opiomelanocortin
Calcium Channels
Leptin
Neurons
Glucose
28 Citations (Scopus)
121 Downloads (Pure)
Open Access
File
NF-E2-Related Factor 2
Fructose
Liver Cirrhosis
Fats
Endoplasmic Reticulum Stress
164 Citations (Scopus)
524 Downloads (Pure)

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

Mills, E. L., Ryan, D. G., Prag, H. A., Dikovskaya, D., Menon, D., Zaslona, Z., Jedrychowski, M. P., Costa, A. S. H., Higgins, M., Hams, E., Szpyt, J., Runtsch, M. C., King, M. S., McGouran, J. F., Fischer, R., Kessler, B. M., McGettrick, A. F., Hughes, M. M., Carroll, R. G., Booty, L. M. & 15 others, Knatko, E. V., Meakin, P. J., Ashford, M. L. J., Modis, L. K., Brunori, G., Sévin, D. C., Fallon, P. G., Caldwell, S. T., Kunji, E. R. S., Chouchani, E. T., Frezza, C., Dinkova-Kostova, A. T., Hartley, R. C., Murphy, M. P. & O'Neill, L. A., 5 Apr 2018, In : Nature. 556, 7699, p. 113-117 5 p.

Research output: Contribution to journalArticle

Open Access
File
Alkylation
Anti-Inflammatory Agents
Interferon Type I
Cysteine
Lipopolysaccharides
14 Citations (Scopus)
73 Downloads (Pure)

Small vessels, dementia and chronic diseases: molecular mechanisms and pathophysiology

Horsburgh, K., Wardlaw, J. M., van Agtmael, T., Allan, S. M., Ashford, M. L. J., Bath, P. M., Brown, R., Berwick, J., Cader, M. Z., Carare, R. O., Davis, J. B., Duncombe, J., Farr, T. D., Fowler, J. H., Goense, J., Granata, A., Hall, C. N., Hainsworth, A. H., Harvey, A., Hawkes, C. A. & 26 others, Joutel, A., Kalaria, R. N., Kehoe, P. G., Lawrence, C. B., Lockhart, A., Love, S., Macleod, M. R., Macrae, I. M., Markus, H. S., McCabe, C., McColl, B. W., Meakin, P. J., Miller, A., Nedergaard, M., O'Sullivan, M., Quinn, T. J., Rajani, R., Saksida, L. M., Smith, C., Smith, K. J., Touyz, R. M., Trueman, R. C., Wang, T., Williams, A., Williams, S. C. R. & Work, L. M., 30 Apr 2018, In : Clinical Science. 132, 8, p. 851-868 18 p.

Research output: Contribution to journalArticle

Open Access
File
Dementia
Chronic Disease
Cerebral Small Vessel Diseases
Education
Cerebrovascular Disorders
6 Citations (Scopus)
84 Downloads (Pure)

The BACE1 product sAPPβ induces ER stress and inflammation and impairs insulin signaling

Botteri, G., Salvadó, L., Gumà, A., Hamilton, D. L., Meakin, P. J., Montagut, G., Ashford, M. L. J., Ceperuelo-Mallafré, V., Fernández-Veledo, S., Vendrell, J., Calderón-Dominguez, M., Serra, D., Herrero, L., Pizarro, J., Barroso, E., Palomer, X. & Vázquez-Carrera, M., Aug 2018, In : Metabolism. 85, p. 59-75 17 p.

Research output: Contribution to journalArticle

Open Access
File
Endoplasmic Reticulum Stress
Insulin Resistance
Insulin
Palmitates
Inflammation
8 Citations (Scopus)
100 Downloads (Pure)

The beta secretase BACE1 regulates the expression of the insulin receptor in the liver

Meakin, P., Mezzapesa, A., Benabou, E., Haas, M., Bonardo, B., Grino, M., Brunel, J-M., Biddinger, S. B., Desbois-Mouthon, C., Govers, R., Ashford, M. L. J. & Peiretti, F., 3 Apr 2018, In : Nature Communications. 9, p. 1-14 14 p., 1306.

Research output: Contribution to journalArticle

Open Access
File
Amyloid Precursor Protein Secretases
insulin
Insulin Receptor
liver
Liver
2017
8 Citations (Scopus)
196 Downloads (Pure)

AMP-activated protein kinase activator A-769662 increases intracellular calcium and ATP release from astrocytes in an AMPK-independent manner

Vlachaki Walker, J. M., Robb, J. L., Cruz, A. M., Malhi, A., Weightman Potter, P. G., Ashford, M. L. J., McCrimmon, R. J., Ellacott, K. L. J. & Beall, C., 21 Apr 2017, In : Diabetes, Obesity & Metabolism. 19, 7, p. 997-1005 9 p.

Research output: Contribution to journalArticle

Open Access
File
A 769662
AMP-Activated Protein Kinases
Astrocytes
Adenosine Triphosphate
Calcium
6 Citations (Scopus)
227 Downloads (Pure)
Open Access
File
Hypoglycemia
Hypoglycemic Agents
Rodentia
Type 1 Diabetes Mellitus
Brain-Derived Neurotrophic Factor
4 Citations (Scopus)
85 Downloads (Pure)

Oleate induces KATP channel-dependent hyperpolarisation in mouse hypothalamic glucose-excited neurones without altering cellular energy charge

Dadak, S., Beall, C., Vlachaki Walker, J. M., Soutar, M. P. M., McCrimmon, R. J. & Ashford, M. L. J., 27 Mar 2017, In : Neuroscience. 346, p. 29-42 14 p.

Research output: Contribution to journalArticle

Open Access
File
KATP Channels
Oleic Acid
Neurons
Glucose
Arcuate Nucleus of Hypothalamus
2016
2 Citations (Scopus)
141 Downloads (Pure)

Chronic exposure to KATP channel openers results in attenuated glucose sensing in hypothalamic GT1-7 neurons

Hathorne, E., Hamilton, D. L., Findlay, J. A., Beall, C., McCrimmon, R. J. & Ashford, M. L. J., Dec 2016, In : Neuropharmacology. 111, p. 212-222 11 p.

Research output: Contribution to journalArticle

Open Access
File
KATP Channels
Neurons
Glucose
Hypoglycemia
Hypoglycemic Agents
31 Citations (Scopus)
211 Downloads (Pure)

Dimethyl fumarate blocks pro-inflammatory cytokine production via inhibition of TLR induced M1 and K63 ubiquitin chain formation

McGuire, V. A., Ruiz-Zorrilla Diez, T., Emmerich, C. H., Strickson, S., Ritorto, M. S., Sutavani, R. V., Weiβ, A., Houslay, K. F., Knebel, A., Meakin, P. J., Phair, I. R., Ashford, M. L. J., Trost, M. & Arthur, J. S. C., 8 Aug 2016, In : Scientific Reports. 6, p. 1-17 17 p., 31159.

Research output: Contribution to journalArticle

Open Access
File
Ubiquitin
Cytokines
Oxidants
Polyubiquitin
Autoimmunity
13 Citations (Scopus)
111 Downloads (Pure)
Open Access
File
Type 1 Diabetes Mellitus
Hypoglycemia
Rodentia
Oxidative Stress
Inflammation