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  • James Chalmers
Article

Is bronchiectasis really a disease?

Shteinberg, M., Flume, P. A. & Chalmers, J. D., 31 Mar 2020, In : European Respiratory Review. 29, 155, p. 1-10 10 p., 190051.

Research output: Contribution to journalArticle

Open Access
File
36 Downloads (Pure)

Long-term macrolide antibiotics for the treatment of bronchiectasis in adults: an individual participant data meta-analysis

Chalmers, J. D., Boersma, W., Lonergan, M., Jayaram, L., Crichton, M. L., Karalus, N., Taylor, S. L., Martin, M. L., Burr, L. D., Wong, C. & Altenburg, J., Oct 2019, In : The Lancet Respiratory Medicine. 7, 10, p. 845-854 10 p.

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
70 Downloads (Pure)

Macrolide therapy is associated with lower mortality in community-acquired bacteraemic pneumonia

Jul 2018, In : Respiratory Medicine. 140, p. 115-121 7 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Management of chronic airway diseases: What can we learn from real-life data?

Chalmers, J. D., 17 Mar 2017, In : COPD. 14, Suppl. 1, p. S1-S2 2 p.

Research output: Contribution to journalArticle

Open Access
File
187 Downloads (Pure)

Managing and preventing exacerbation of bronchiectasis

Abo-Leyah, H. & Chalmers, J. D., Apr 2020, In : Current Opinion in Infectious Diseases. 33, 2, p. 189-196 8 p.

Research output: Contribution to journalArticle

Microbiological changes observed over 48 weeks of treatment with inhaled liposomal ciprofloxacin in individuals with non-cystic fibrosis bronchiectasis and chronic Pseudomonas aeruginosa lung infection

VanDevanter, D. R., Gonda, I., Dahms, J., Cipolla, D., Davis, A. M., Chalmers, J. D. & Froehlich, J., Dec 2019, In : Clinical Microbiology and Infection. 25, 12, p. 1532-1538 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Multidimensional severity assessment in bronchiectasis: An analysis of 7 European cohorts.

McDonnell, M. J., Alberti, S., Goeminne, P. C., Dimakou, K., Davidson, J., Ward, C., LAffey, JG., Finch, S., Pesci, A., Dupont, LJ., Fardon, T. C., Skrbic, D., Obradovic, D., Cowman, S., Loebinger, M. R., Rutherford, RM., De Soyza, A. & Chalmers, J. D., Dec 2016, In : Thorax. 71, 12, p. 1110-1118 9 p.

Research output: Contribution to journalArticle

Open Access
File
69 Citations (Scopus)
143 Downloads (Pure)

Neutrophil elastase activity is associated with exacerbations and lung function decline in Bronchiectasis

Chalmers, J. D., Moffitt, K. L., Suarez-Cuartin, G., Sibila, O., Finch, S., Furrie, E., Dicker, A., Wrobel, K., Elborn, J. S., Walker, B., Martin, S. L., Marshall, S. E., Huang, J. T-J. & Fardon, T. C., 15 May 2017, In : American Journal of Respiratory and Critical Care Medicine. 195, 10, p. 1384-1393 10 p.

Research output: Contribution to journalArticle

Open Access
File
80 Citations (Scopus)
137 Downloads (Pure)

Neutrophil extracellular traps are associated with disease severity and microbiota diversity in patients with chronic obstructive pulmonary disease

Dicker, A. J., Crichton, M. L., Pumphrey, E. G., Cassidy, A. J., Suarez-Cuartin, G., Sibila, O., Furrie, E., Fong, C. J., Ibrahim, W., Brady, G., Einarsson, G. G., Elborn, J. S., Schembri, S., Marshall, S. E., Palmer, C. N. A. & Chalmers, J. D., Jan 2018, In : Journal of Allergy and Clinical Immunology. 141, 1, p. 117-127 11 p.

Research output: Contribution to journalArticle

Open Access
File
61 Citations (Scopus)
127 Downloads (Pure)

Oral versus intravenous clarithromycin in moderate to severe community-acquired pneumonia: an observational study

Rae, N., Singanayagam, A., Schembri, S. & Chalmers, J. D., 5 Feb 2017, In : Pneumonia . 9, p. 1-5 5 p., 2.

Research output: Contribution to journalArticle

Open Access
File
155 Downloads (Pure)

Personalised anti-inflammatory therapy for bronchiectasis and cystic fibrosis: selecting patients for controlled trials of neutrophil elastase inhibition

Keir, H. R., Fong, C. J., Crichton, M. L., Barth, P., Chevalier, E., Brady, G., Kennedy, G., Zimmermann, J., Bruijnzeel, P. L. B., Dicker, A. J. & Chalmers, J. D., 1 Feb 2019, In : ERJ Open Research. 5, 1, p. 1-9 9 p., 00252-2018.

Research output: Contribution to journalArticle

Open Access
File
103 Downloads (Pure)

Plasma desmosine, an elastin degradation product, predicts outcomes in at risk populations

Iskandar, Z., Mordi, I., Huang, J. T. J., Newby, D., Chalmers, J., Bown, M., Lang, C. & Choy, A. M., 12 Mar 2019, In : Journal of the American College of Cardiology. 73, 9, Supplement 1, p. 1805 1 p.

Research output: Contribution to journalArticle

Pregnancy Zone Protein is Associated with Airway Infection, Neutrophil Extracellular Trap Formation and Disease Severity in Bronchiectasis

Finch, S., Shoemark, A., Dicker, A. J., Keir, H. R., Smith, A., Ong, S., Tan, B., Choi, J., Fardon, T. C., Cassidy, D., Huang, J. T. J. & Chalmers, J. D., 15 Oct 2019, In : American Journal of Respiratory and Critical Care Medicine. 200, 8, p. 992-1001 10 p.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
128 Downloads (Pure)
4 Citations (Scopus)

Pseudomonas aeruginosa resistance patterns and clinical outcomes in hospitalized exacerbations of COPD

Rodrigo-Troyano, A., Suarez-Cuartin, G., Peiró, M., Barril, S., Castillo, D., Sanchez-Reus, F., Plaza, V., Restrepo, M. I., Chalmers, J. D. & Sibila, O., Oct 2016, In : Respirology . 21, 7, p. 1235-1242 8 p.

Research output: Contribution to journalArticle

Open Access
File
20 Citations (Scopus)
154 Downloads (Pure)

Pulmonary exacerbation in adults with bronchiectasis: a consensus definition for clinical research

Hill, A. T., Haworth, C. S., Aliberti, S., Barker, A., Blasi, F., Boersma, W., Chalmers, J. D., De Soyza, A., Dimakou, K., Elborn, J. S., Feldman, C., Flume, P., Goeminne, P. C., Loebinger, M. R., Menendez, R., Morgan, L., Murris-Espin, M., Polverino, E., Quittner, A., Ringshausen, F. C. & 9 others, Tino, G., Torres, A., Vendrell, M., Welte, T., Wilson, R., Wong, C., O'Donnell, A., Aksamit, T. & for the EMBARC/BRR definitions working group, 1 Jun 2017, In : European Respiratory Journal. 49, 6, 8 p., 1700051.

Research output: Contribution to journalArticle

Open Access
80 Citations (Scopus)

Pulmonary Rehabilitation after exacerbation of bronchiectasis: a pilot randomized controlled trial

Chalmers, J. D., Crichton, M. L., Brady, G., Finch, S., Lonergan, M. & Fardon, T., 6 May 2019, In : BMC Pulmonary Medicine. 19, p. 1-9 9 p., 85.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
104 Downloads (Pure)

Quality control for multiple breath washout tests in multicentre bronchiectasis studies: Experiences from the BRONCH-UK clinimetrics study

O'Neill, K., Lakshmipathy, G. R., Ferguson, K., Cosgrove, D., Hill, A. T., Loebinger, M., Carroll, M., Chalmers, J., Gatheral, T., Johnson, C., DeSoyza, A., Hurst, J. R., Bradbury, I., Elborn, J. S. & Bradley, J. M., Dec 2018, In : Respiratory Medicine. 145, p. 206-211 6 p.

Research output: Contribution to journalArticle

Open Access
File
57 Downloads (Pure)

Quality standards for the management of bronchiectasis in Italy: a national audit

SIP Bronchiectasis Audit Working Group, Aliberti, S., Hill, A. T., Mantero, M., Battaglia, S., Centanni, S., Lo Cicero, S., Lacedonia, D., Saetta, M., Chalmers, J. D. & Blasi, F., 30 Jun 2016, In : European Respiratory Journal. 48, 1, p. 244-248 5 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Recommendations for travelling with bronchiectasis: a joint ELF/EMBARC/ERN-Lung collaboration

Shteinberg, M., Crossley, B., Lavie, T., Nadler, S., Boyd, J., Ringshausen, F. C., Aksamit, T., Chalmers, J. D. & Goeminne, P., Oct 2019, In : ERJ Open Research. 5, 4, p. 1-22 22 p., 00113-2019.

Research output: Contribution to journalArticle

Open Access
File
56 Downloads (Pure)

Research priorities in bronchiectasis: a consensus statement from the EMBARC Clinical Research Collaboration

Aliberti, S., Masefield, S., Polverino, E., De Soyza, A., Loebinger, M. R., Menendez, R., Ringshausen, F. C., Vendrell, M., Powell, P., Chalmers, J. D. &  on behalf of the EMBARC Study Group, 1 Sep 2016, In : European Respiratory Journal. 48, 3, p. 632-647 16 p.

Research output: Contribution to journalArticle

Open Access
File
83 Citations (Scopus)
204 Downloads (Pure)

Review of the British Thoracic Society Winter Meeting 2015, 2-4 December, London, UK

José, R. J., Chalmers, J. D., Greening, N. J. & Janes, S. M., Jun 2016, In : Thorax. 71, 6, p. 555-559 5 p.

Research output: Contribution to journalArticle

Open Access
File
204 Downloads (Pure)

Risk factors for Clostridium difficile infection in hospitalized patients with community-acquired pneumonia

Chalmers, J. D., Akram, A. R., Singanayagam, A., Wilcox, M. H. & Hill, A. T., Jul 2016, In : Journal of Infection. 73, 1, p. 45-53 9 p.

Research output: Contribution to journalArticle

Open Access
File
27 Citations (Scopus)
224 Downloads (Pure)

Role of cephalosporins in the era of Clostridium difficile infection

Wilcox, M. H., Chalmers, J. D., Nord, C. E., Freeman, J. & Bouza, E., Jan 2017, In : Journal of Antimicrobial Chemotherapy. 72, 1, p. 1-18 18 p.

Research output: Contribution to journalArticle

Open Access
File
23 Citations (Scopus)
125 Downloads (Pure)

Severe Paediatric Asthma Collaborative in Europe (SPACE): protocol for a European registry

Liu, N. M., van Aalderen, W., Carlsen, K. C. L., Coleman, C., Chalmers, J. D., Cunningham, S., Fernandes, R. M., Fleming, L. J., Gappa, M., Karadag, B., Midulla, F., Pijnenburg, M. W. H., Rutjes, N. W., Rusconi, F. & Grigg, J., 1 Jun 2018, In : Breathe. 14, 2, p. 93-98 6 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
129 Downloads (Pure)

Severe Pneumococcal Pneumonia Causes Acute Cardiac Toxicity and Subsequent Cardiac Remodeling

Reyes, L. F., Restrepo, M. I., Hinojosa, C. A., Soni, N. J., Anzueto, A., Babu, B. L., Gonzalez-Juarbe, N., Rodriguez, A. H., Jimenez, A., Chalmers, J. D., Aliberti, S., Sibila, O., Winter, V. T., Coalson, J. J., Giavedoni, L. D., Dela Cruz, C. S., Waterer, G. W., Witzenrath, M., Suttorp, N., Dube, P. H. & 1 others, Orihuela, C. J., 1 Sep 2017, In : American Journal of Respiratory and Critical Care Medicine. 196, 5, p. 609-620 12 p.

Research output: Contribution to journalArticle

Open Access
File
36 Citations (Scopus)
288 Downloads (Pure)

The BRICS (Bronchiectasis Radiologically Indexed CT Score)- a multi-center study score for use in idiopathic and post infective bronchiectasis

Bedi, P., Chalmers, J. D., Goeminne, P. C., Mai, C., Saravanamuthu, P., Velu, P. P., Cartlidge, M. K., Loebinger, M. R., Jacob, J., Kamal, F., Schembri, N., Aliberti, S., Hill, U., Harrison, M., Johnson, C., Screaton, N., Haworth, C., Polverino, E., Rosales, E., Torres, A. & 4 others, Benegas, M. N., Rossi, A. G., Patel, D. & Hill, A. T., May 2018, In : Chest. 153, 5, p. 1177-1186 10 p.

Research output: Contribution to journalArticle

Open Access
File
11 Citations (Scopus)
173 Downloads (Pure)

The economic burden of bronchiectasis - known and unknown: a systematic review

Goeminne, P. C., Hernandez, F., Diel, R., Filonenko, A., Hughes, R., Juelich, F., Solomon, G. M., Upton, A., Wichmann, K., Xu, W. & Chalmers, J. D., 28 Feb 2019, In : BMC Pulmonary Medicine. 19, 1, p. 1-11 11 p., 54.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
119 Downloads (Pure)

The effect of changes to GOLD severity stage on long term morbidity and mortality in COPD

Flynn, R. W. V., MacDonald, T. M., Chalmers, J. D. & Schembri, S., 12 Dec 2018, In : Respiratory Research. 19, p. 1-10 10 p., 249.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
120 Downloads (Pure)
Open Access
File
6 Citations (Scopus)
25 Downloads (Pure)

The EMBARC European Bronchiectasis Registry: protocol for an international observational study

Chalmers, J. D., Aliberti, S., Polverino, E., Vendrell, M., Crichton, M., Loebinger, M., Dimakou, K., Clifton, I., van der Eerden, M., Rohde, G., Murris-Espin, M., Masefield, S., Gerada, E., Shteinberg, M., Ringshausen, F., Haworth, C., Boersma, W., Rademacher, J., Hill, A. T., Aksamit, T. & 17 others, O'Donnell, A., Morgan, L., Milenkovic, B., Tramma, L., Neves, J., Menendez, R., Paggiaro, P., Botnaru, V., Skrgat, S., Wilson, R., Goeminne, P., De Soyza, A., Welte, T., Torres, A., Elborn, J. S., Blasi, F. & on behalf of EMBARC, Jan 2016, In : ERJ Open Research. 2, 1, p. 1-9 9 p., 00081-2015.

Research output: Contribution to journalArticle

Open Access
File
78 Citations (Scopus)
155 Downloads (Pure)

The generalizability of bronchiectasis randomized controlled trials: a multicentre cohort study

Chalmers, J. D., McDonnell, M. J., Rutherford, R., Davidson, J., Finch, S., Crichton, M., Dupont, L., Hill, A. T., Fardon, T. C., De Soyza, A., Aliberti, S. & Goeminne, P., Mar 2016, In : Respiratory Medicine. 112, p. 51-58 8 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

The heterogeneity of systemic inflammation in bronchiectasis

Saleh, A. D., Chalmers, J. D., De Soyza, A., Fardon, T. C., Koustas, S. O., Scott, J., Simpson, A. J., Brown, J. S. & Hurst, J. R., Jun 2017, In : Respiratory Medicine. 127, p. 33-39 7 p.

Research output: Contribution to journalArticle

Open Access
File
15 Citations (Scopus)
183 Downloads (Pure)

The impact of acute air pollution fluctuations on bronchiectasis pulmonary exacerbation: A case-crossover analysis

Goeminne, P. C., Cox, B., Finch, S., Loebinger, M., Bedi, P., Hill, A. T., Fardon, T., de Hoogh, K., Nawrot, T. S. & Chalmers, J., 27 Jul 2018, In : European Respiratory Journal. 52, 1, 1702557.

Research output: Contribution to journalArticle

Open Access
File
14 Citations (Scopus)
48 Downloads (Pure)

The independent contribution of Pseudomonas aeruginosa infection to long-term clinical outcomes in bronchiectasis

Araújo, D., Shteinberg, M., Aliberti, S., Goeminne, P. C., Hill, A. T., Fardon, T. C., Obradovic, D., Stone, G., Trautmann, M., Davis, A., Dimakou, K., Polverino, E., De Soyza, A., McDonnell, M. J. & Chalmers, J. D., 1 Feb 2018, In : European Respiratory Journal. 51, 2, 1701953.

Research output: Contribution to journalArticle

Open Access
File
52 Citations (Scopus)
162 Downloads (Pure)

The Italian registry of pulmonary non-tuberculous mycobacteria - IRENE: The study protocol

IRENE Network, Aliberti, S., Codecasa, L. R., Gori, A., Sotgiu, G., Spotti, M., Di Biagio, A., Calcagno, A., Nardini, S., Assael, B. M., Tortoli, E., Besozzi, G., Ferrarese, M., Matteelli, A., Girardi, E., De Lorenzo, S., Seia, M., Gramegna, A., Del Prato, B., Terranova, L. & 11 others, Oriano, M., Sverzellati, N., Mirsaeidi, M., Chalmers, J. D., Haworth, C. S., Loebinger, M. R., Aksamit, T., Winthrop, K., Ringshausen, F. C., Previdi, G. & Blasi, F., 9 Aug 2018, In : Multidisciplinary Respiratory Medicine. 13, Suppl. 1, 6 p., 33.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
124 Downloads (Pure)

The microbiome in bronchiectasis

Richardson, H., Dicker, A. J., Barclay, H. & Chalmers, J. D., 30 Sep 2019, In : European Respiratory Review. 28, 153, p. 1-10 10 p., 190048.

Research output: Contribution to journalArticle

Open Access
File
76 Downloads (Pure)

"The missing ingredient": The patient perspective of health related quality of life in bronchiectasis: a qualitative study

Dudgeon, E. K., Crichton, M. & Chalmers, J., 22 May 2018, In : BMC Pulmonary Medicine. 18, 1, p. 1-10 10 p., 81.

Research output: Contribution to journalArticle

Open Access
File
12 Citations (Scopus)
133 Downloads (Pure)

The Relationship Between Symptoms, Exacerbations and Treatment Response in Bronchiectasis

Gao, Y-H., Abo Leyah, H., Finch, S., Lonergan, M., Aliberti, S., De Soyza, A., Fardon, T. C., Tino, G. & Chalmers, J. D., 25 Feb 2020, In : American Journal of Respiratory and Critical Care Medicine.

Research output: Contribution to journalArticle

The Sputum Microbiome, Airway Inflammation and Mortality in Chronic Obstructive Pulmonary Disease

Dicker, A. J., Huang, J. T. J., Lonergan, M., Keir, H. R., Fong, C. J., Tan, B., Cassidy, A. J., Finch, S., Mullerova, H., Miller, B. E., Tal-Singer, R. & Chalmers, J. D., 28 Apr 2020, In : Journal of Allergy and Clinical Immunology.

Research output: Contribution to journalArticle

The type VII secretion system of Staphylococcus aureus secretes a nuclease toxin that targets competitor bacteria

Cao, Z., Kneuper, H., Casabona, M. G., Chalmers, J. D. & Palmer, T., 10 Oct 2016, In : Nature Microbiology. 2, p. 1-11 11 p., 16183.

Research output: Contribution to journalArticle

Open Access
File
68 Citations (Scopus)
280 Downloads (Pure)

Using Cluster Analysis of Cytokines to Identify Patterns of Inflammation in Hospitalized Patients with Community-acquired Pneumonia: A Pilot Study

Wiemken, T. L., Kelley, R., Fernandez-Botran, R., Mattingly, W. A., Arnold, F. W., Furmanek, S. P., Restrepo, M. I., Chalmers, J. D., Peyrani, P., Cavallazzi, R., Bordon, J., Aliberti, S. & Ramirez, J. A., 30 Jan 2017, In : University of Louisville Journal of Respiratory Infections. 1, 1, p. 3-11 9 p., 1.

Research output: Contribution to journalArticle

Open Access
File
172 Downloads (Pure)

Utility of routine screening for alpha-1 antitrypsin deficiency in patients with bronchiectasis

Carreto, L., Morrison, M., Donovan, J., Finch, S., Tan, G. L., Fardon, T., Wilson, R., Furrie, E., Loebinger, M. & Chalmers, J. D., 17 Apr 2020, In : Thorax. 2 p., 2019-214195.

Research output: Contribution to journalArticle

Open Access
File
9 Downloads (Pure)

Validation of the COPD Assessment Test (CAT) as an outcome measure in bronchiectasis

Finch, S., Laska, I. F., Abo-Leyah, H., Fardon, T. C. & Chalmers, J. D., 12 Nov 2019, In : Chest. 9 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Withdrawal of Inhaled Corticosteroids in Chronic Obstructive Pulmonary Disease: A European Respiratory Society Guideline

Chalmers, J. D., Laska, I. F., Franssen, F. M. E., Janssens, W., Pavord, I., Rigau, D., McDonnell, M. J., Roche, N., Sin, D. D., Stolz, D., Suissa, S., Wedzicha, J. & Miravitlles, M., 4 May 2020, In : European Respiratory Journal. 53 p.

Research output: Contribution to journalArticle

Chapter (peer-reviewed)

Non-cystic fibrosis bronchiectasis

Finch, S., Dicker, A. & Chalmers, J., 1 Sep 2017, Acute Exacerbations of Pulmonary Diseases. Burgel, P-R., Contoli, M. & López-Campos, J. L. (eds.). European Respiratory Society, p. 38-57 20 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Comment/debate

Community-acquired pneumonia in the United Kingdom: a call to action

Chalmers, J., Campling, J., Ellsbury, G., Hawkey, P. M., Madhava, H. & Slack, M., 5 Oct 2017, In : Pneumonia . 9, 6 p., 15.

Research output: Contribution to journalComment/debate

Open Access
File
165 Downloads (Pure)

Cystic fibrosis lung disease and bronchiectasis

Chalmers, J. D., Jan 2020, In : The Lancet Respiratory Medicine. 8, 1, p. 12-14 3 p.

Research output: Contribution to journalComment/debate

Open Access
File
14 Downloads (Pure)
Editorial

10 years since TORCH: shining a new light on the risks of inhaled corticosteroids in COPD

Chalmers, J. D. & Keir, H. R., 1 Sep 2017, In : European Respiratory Journal. 50, 3, 5 p., 1701582.

Research output: Contribution to journalEditorial

3 Citations (Scopus)