Find Research Outputs

Search in all content

Filters for Research Outputs

Search concepts
Selected filters

Publication Year

  • 2020
  • 2019
  • 2018
  • 2017
  • 2016

Author

  • Angus Lamond
2020

Cardelino: computational integration of somatic clonal substructure and single-cell transcriptomes

McCarthy, D. J., Rostom, R., Huang, Y., Kunz, D. J., Danecek, P., Bonder, M. J., Hagai, T., Lyu, R., Wang, W., Gaffney, D. J., Simons, B. D., Stegle, O. & Teichmann, S. A., 16 Mar 2020, In : Nature Methods. 17, 4, p. 414-421 8 p.

Research output: Contribution to journalArticle

Cyclin A triggers Mitosis either via the Greatwall kinase pathway or Cyclin B

Hegarat, N., Crncec, A., Suarez Peredoa Rodriguez, M. F., Iturra, F. E., Gu, Y., Busby, O., Lang, P. F., Barr, A. R., Bakal, C., Kanemaki, M. T., Lamond, A. I., Novak, B., Ly, T. & Hochegger, H., 2 Jun 2020, In : EMBO Journal. 39, 11, p. 1-23 23 p., e104419.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
28 Downloads (Pure)

Phosphoproteomics identifies a bimodal EPHA2 receptor switch that promotes embryonic stem cell differentiation

Fernandez-Alonso, R., Bustos, F., Budzyk, M., Kumar, P., Helbig, A. O., Hukelmann, J., Lamond, A. I., Lanner, F., Zhou, H., Petsalaki, E. & Findlay, G. M., 13 Mar 2020, In : Nature Communications. 11, 1, p. 1-13 13 p., 1357.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
19 Downloads (Pure)

Publisher Correction: Single-cell RNA-sequencing of differentiating iPS cells reveals dynamic genetic effects on gene expression

Cuomo, A. S. E., Seaton, D. D., McCarthy, D. J., Martinez, I., Vallier, L., Marioni, J. C., Chhatriwala, M. & Stegle, O., 23 Mar 2020, In : Nature Communications. 11, 1 p., 1572.

Research output: Contribution to journalComment/debate

Open Access
File
9 Downloads (Pure)

Quantitative profiling of the human substantia nigra proteome from laser-capture microdissected FFPE tissue

Griesser, E., Wyatt, H., Ten Have, S., Stierstorfer, B., Lenter, M. & Lamond, A. I., 1 May 2020, In : Molecular & Cellular Proteomics. 19, 5, p. 839-851 13 p.

Research output: Contribution to journalArticle

Open Access
File
21 Downloads (Pure)
2019

Antigen receptor control of methionine metabolism in T cells

Sinclair, L. V., Howden, A., Brenes Murillo, A., Spinelli, L., Hukelmann, J., Macintyre, A. N., Liu, X., Thomson, S., Taylor, P., Rathmell, J. C., Locasale, J. W., Lamond, A. & Cantrell, D. A., 27 Mar 2019, In : eLife. 8, p. 1-29 29 p., e44210.

Research output: Contribution to journalArticle

Open Access
File
14 Citations (Scopus)
107 Downloads (Pure)

Composition of the Survival Motor Neuron (SMN) complex in Drosophila melanogaster

Matera, A. G., Raimer, A. C., Schmidt, C. A., Kelly, J. A., Droby, G. N., Baillat, D., Ten Have, S., Lamond, A. I., Wagner, E. J. & Gray, K. M., 1 Feb 2019, In : G3 : Genes, Genomes, Genetics. 9, 2, p. 491-503 13 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
124 Downloads (Pure)

EMSY expression affects multiple components of the skin barrier with relevance to atopic dermatitis

Elias, M. S., Wright, S. C., Remenyi, J., Abbott, J. C., Bray, S. E., Cole, C., Edwards, S., Gierlinski, M., Glok, M., McGrath, J. A., Nicholson, W. V., Paternoster, L., Prescott, A. R., Have, S. T., Whitfield, P. D., Lamond, A. I. & Brown, S. J., Aug 2019, In : Journal of Allergy and Clinical Immunology. 144, 2, p. 470-481 12 p.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
4 Downloads (Pure)
Open Access
File
51 Downloads (Pure)

Multi-batch TMT reveals false positives, batch effects and missing values

Brenes Murillo, A., Hukelmann, J., Bensaddek, D. & Lamond, A., 1 Oct 2019, In : Molecular and Cellular Proteomics. 18, 10, p. 1967-1980 14 p.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
6 Downloads (Pure)
Open Access
File
1 Citation (Scopus)
64 Downloads (Pure)
Open Access
File
1 Citation (Scopus)
65 Downloads (Pure)
Open Access
File
8 Citations (Scopus)
12 Downloads (Pure)

Signal enhanced proteomics: a biological perspective on dissecting the functional organisation of cell proteomes

Bensaddek, D., Nicolas, A. & Lamond, A. I., Feb 2019, In : Current Opinion in Chemical Biology. 48, p. 114-122 9 p.

Research output: Contribution to journalReview article

1 Citation (Scopus)

The Encyclopedia of Proteome Dynamics: The KinoViewer

Brenes Murillo, A. & Lamond, A., 15 Apr 2019, In : Bioinformatics. 35, 8, p. 1441-1442 2 p., bty823.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
91 Downloads (Pure)
2018

Amino acid-dependent cMyc expression is essential for NK cell metabolic and functional responses in mice

Loftus, R. M., Assmann, N., Kedia-Mehta, N., O'Brien, K. L., Garcia, A., Gillespie, C., Hukelmann, J. L., Oefner, P. J., Lamond, A. I., Gardiner, C. M., Dettmer, K., Cantrell, D. A., Sinclair, L. V. & Finlay, D. K., 14 Jun 2018, In : Nature Communications. 9, 1, p. 1-15 15 p., 2341.

Research output: Contribution to journalArticle

Open Access
File
36 Citations (Scopus)
141 Downloads (Pure)

An evolutionarily conserved ribosome-rescue pathway maintains epidermal homeostasis

Liakath-Ali, K., Mills, E. W., Sequeira, I., Lichtenberger, B. M., Pisco, A. O., Sipilä, K. H., Mishra, A., Yoshikawa, H., Wu, C. C-C., Ly, T., Lamond, A. I., Adham, I. M., Green, R. & Watt, F. M., 11 Apr 2018, In : Nature. 556, p. 376-380 5 p.

Research output: Contribution to journalLetter

Open Access
File
14 Citations (Scopus)
249 Downloads (Pure)

Efficient Analysis of Mammalian Polysomes in cells and tissues using Ribo Mega-SEC

Yoshikawa, H., Larance, M., Harney, D. J., Sundaramoorthy, R., Ly, T., Owen-Hughes, T. & Lamond, A. I., 10 Aug 2018, In : eLife. 7, 7, p. 1-26 26 p., e36530.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
129 Downloads (Pure)

PIP30/FAM192A is a novel regulator of the nuclear proteasome activator PA28γ

Jonik-Nowak, B., Menneteau, T., Fesquet, D., Baldin, V., Bonne-Andrea, C., Méchali, F., Fabre, B., Boisguerin, P., de Rossi, S., Henriquet, C., Pugnière, M., Ducoux-Petit, M., Burlet-Schiltz, O., Lamond, A., Fort, P., Boulon, S., Bousquet, M-P. & Coux, O., 10 Jul 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 28, p. E6477-E6486 10 p., 201722299.

Research output: Contribution to journalArticle

Open Access
File
9 Citations (Scopus)
183 Downloads (Pure)
File
2 Citations (Scopus)
126 Downloads (Pure)

Proteomic analysis of the cell cycle of procylic form Trypanosoma brucei

Crozier, T. W. M., Tinti, M., Wheeler, R. J., Ly, T., Ferguson, M. A. J. & Lamond, A. I., 1 Jun 2018, In : Molecular & Cellular Proteomics. 17, 6, p. 1184-1195 12 p.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
131 Downloads (Pure)

Self-oligomerization regulates stability of survival motor neuron protein isoforms by sequestering an SCFSlmb degron

Gray, K. M., Kaifer, K. A., Baillat, D., Wen, Y., Bonacci, T. R., Ebert, A. D., Raimer, A. C., Spring, A. M., Have, S. T., Glascock, J. J., Gupta, K., Van Duyne, G. D., Emanuele, M. J., Lamond, A. I., Wagner, E. J., Lorson, C. L. & Matera, A. G., 15 Jan 2018, In : Molecular Biology of the Cell. 29, 2, p. 96-110 15 p.

Research output: Contribution to journalArticle

Open Access
File
12 Citations (Scopus)
105 Downloads (Pure)

The Encyclopedia of Proteome Dynamics – A big data ecosystem for (prote)omics

Brenes Murillo, A., Afzal, V., Kent, R. & Lamond, A., 4 Jan 2018, In : Nucleic Acids Research. 46, D1, p. D1202-D1209 8 p.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
143 Downloads (Pure)
2017

A protein phosphatase network controls the temporal and spatial dynamics of differentiation commitment in human epidermis

Mishra, A., Oulès, B., Pisco, A. O., Ly, T., Liakath-Ali, K., Walko, G., Viswanathan, P., Tihy, M., Nijjhar, J., Dunn, S-J., Lamond, A. I. & Watt, F. M., 18 Oct 2017, In : eLife. 6, p. 1-20 20 p., e27356.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
215 Downloads (Pure)
Open Access
File
6 Citations (Scopus)
172 Downloads (Pure)

Characterisation of the biflavonoid hinokiflavone as a premRNA splicing modulator that inhibits SENP

Pawellek, A., Ryder, U., Tammsalu, T., King, L. J., Kreinin, H., Ly, T., Hay, R. T., Hartley, R. & Lamond, A., 8 Sep 2017, In : eLife. 6, e27402.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
147 Downloads (Pure)

Common genetic variation drives molecular heterogeneity in human iPSCs

Kilpinen, H., Goncalves, A., Leha, A., Afzal, V., Alasoo, K., Ashford, S., Bala, S., Bensaddek, D., Casale, F. P., Culley, O. J., Danecek, P., Faulconbridge, A., Harrison, P. W., Kathuria, A., McCarthy, D. J., McCarthy, S. A., Meleckyte, R., Memari, Y., Moens, N., Soares, F. & 23 others, Mann, A., Streeter, I., Agu, C. A., Alderton, A., Nelson, R., Harper, S., Patel, M., White, A., Patel, S. R., Clarke, L., Halai, R., Kirton, C. M., Kolb-Kokocinski, A., Beales, P. L., Birney, E., Danovi, D., Lamond, A. I., Ouwehand, W. H., Vallier, L., Watt, F. M., Durbin, R., Stegle, O. & Gaffney, D. J., 15 Jun 2017, In : Nature. 546, 7658, p. 370-375 6 p.

Research output: Contribution to journalArticle

Open Access
File
134 Citations (Scopus)
147 Downloads (Pure)
Open Access
File
4 Citations (Scopus)
166 Downloads (Pure)

Corrigendum: Common genetic variation drives molecular heterogeneity in human iPSCs (Nature (2017) 546 (370-375) DOI: 10.1038/nature22403)

Kilpinen, H., Goncalves, A., Leha, A., Afzal, V., Alasoo, K., Ashford, S., Bala, S., Bensaddek, D., Casale, F. P., Culley, O. J., Danecek, P., Faulconbridge, A., Harrison, P. W., Kathuria, A., McCarthy, D. J., McCarthy, S. A., Meleckyte, R., Memari, Y., Moens, N., Soares, F. & 23 others, Mann, A., Streeter, I., Agu, C. A., Alderton, A., Nelson, R., Harper, S., Patel, M., White, A., Patel, S. R., Clarke, L., Halai, R., Kirton, C. M., Kolb-Kokocinski, A., Beales, P. L., Birney, E., Danovi, D., Lamond, A., Ouwehand, W. H., Vallier, L., Watt, F. M., Durbin, R., Stegle, O. & Gaffney, D. J., 29 Jun 2017, In : Nature. 546, 7660, p. 686 1 p.

Research output: Contribution to journalComment/debate

5 Citations (Scopus)

Human RIF1 and protein phosphatase 1 stimulate DNA replication origin licensing but suppress origin activation

Hiraga, S., Ly, T., Garzón, J., Hořejší, Z., Ohkubo, Y., Endo, A., Obuse, C., Boulton, S. J., Lamond, A. & Donaldson, A. D., 1 Mar 2017, In : EMBO Reports. 18, 3, p. 403-419 17 p.

Research output: Contribution to journalArticle

Open Access
File
43 Citations (Scopus)
125 Downloads (Pure)

Multi-omics Analyses of Starvation Responses Reveal a Central Role for Lipoprotein Metabolism in Acute Starvation Survival in C. elegans

Harvald, E. B., Sprenger, R. R., Dall, K. B., Ejsing, C. S., Nielsen, R., Mandrup, S., Brenes Murillo, A., Larance, M., Gartner, A., Lamond, A. & Færgeman, N. J., 26 Jul 2017, In : Cell Systems. 5, 1, p. 38-52.e4 13 p.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
204 Downloads (Pure)

New Apex in Proteome Analysis

Ly, T. & Lamond, A. I., 28 Jun 2017, In : Cell Systems. 4, 6, p. 581-582 2 p.

Research output: Contribution to journalArticle

Open Access
File
159 Downloads (Pure)

Prediction of protein complexes in Trypanosoma brucei by protein correlation profiling mass spectrometry and machine learning

Crozier, T. W. M., Tinti, M., Larance, M., Lamond, A. I. & Ferguson, M. A. J., 1 Dec 2017, In : Molecular & Cellular Proteomics. 16, 12, p. 2254-2267 14 p.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
166 Downloads (Pure)

Proteomic analysis of cell cycle progression in asynchronous cultures, including mitotic subphases, using PRIMMUS

Ly, T., Whigham, A., Clarke, R., Brenes-Murillo, A. J., Estes, B., Madhessian, D., Lundberg, E., Wadsworth, P. & Lamond, A. I., 20 Oct 2017, In : eLife. 6, p. 1-35 35 p., e27574.

Research output: Contribution to journalArticle

Open Access
File
18 Citations (Scopus)
201 Downloads (Pure)

The chromatin assembly factor complex 1 (CAF1) and 5-Azacytidine (5-AzaC) affect cell motility in Src-transformed human epithelial cells

Endo, A., Ly, T., Pippa, R., Bensaddek, D., Nicolas, A. & Lamond, A. I., 6 Jan 2017, In : Journal of Biological Chemistry. 292, 1, p. 172-184 13 p.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
189 Downloads (Pure)

The Helicase Aquarius/EMB-4 Is Required to Overcome Intronic Barriers to Allow Nuclear RNAi Pathways to Heritably Silence Transcription

Akay, A., Di Domenico, T., Suen, K. M., Nabih, A., Parada, G. E., Larance, M., Medhi, R., Berkyurek, A. C., Zhang, X., Wedeles, C. J., Rudolph, K. L. M., Engelhardt, J., Hemberg, M., Ma, P., Lamond, A. I., Claycomb, J. M. & Miska, E. A., 7 Aug 2017, In : Developmental Cell. 42, 3, p. 241-255.e6 21 p.

Research output: Contribution to journalArticle

Open Access
File
16 Citations (Scopus)
166 Downloads (Pure)
2016

Analysis of mass spectrometry data for nucleolar proteomics experiments

Nicolas, A., Bensaddek, D. & Lamond, A. I., 2016, The nucleolus: methods and protocols. Németh, A. (ed.). New York: Springer , p. 263-276 14 p. (Methods in molecular biology; vol. 1455).

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

CDK-dependent phosphorylation of PHD1 on serine 130 alters its substrate preference in cells

Ortmann, B., Bensaddek, D., Carvalhal, S., Moser, S. C., Mudie, S., Griffis, E. R., Swedlow, J. R., Lamond, A. I. & Rocha, S., Jan 2016, In : Journal of Cell Science. 129, 1, p. 191-205 15 p.

Research output: Contribution to journalArticle

Open Access
File
11 Citations (Scopus)
195 Downloads (Pure)

Deep Proteome Analysis Identifies Age-Related Processes in C. elegans

Narayan, V., Ly, T., Pourkarimi, E., Brenes Murillo, A., Gartner, A., Lamond, A. & Kenyon, C., 24 Aug 2016, In : Cell Systems. 3, 2, p. 144-159 15 p.

Research output: Contribution to journalArticle

Open Access
File
34 Citations (Scopus)
281 Downloads (Pure)

Enhanced snoMEN Vectors Facilitate Establishment of GFP–HIF-1α Protein Replacement Human Cell Lines

Ono, M., Ono, K., Bensaddek, D., Afzal, V., Biddlestone, J., Ortmann, B., Mudie, S., Boivin, V., S. Scott, M., Rocha, S. & Lamond, A. I., 29 Apr 2016, In : PLoS ONE. 11, 4, 28 p., e0154759.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
173 Downloads (Pure)

Global membrane protein interactome analysis using in vivo crosslinking and MS-based protein correlation profiling

Larance, M., Kirkwood, K. J., Tinti, M., Brenes Murillo, A., Ferguson, M. & Lamond, A., 1 Jul 2016, In : Molecular & Cellular Proteomics. 15, 7, p. 2476-2490 15 p.

Research output: Contribution to journalArticle

Open Access
File
27 Citations (Scopus)
120 Downloads (Pure)

Micro-proteomics with iterative data analysis: proteome analysis in C.elegans at the single worm level

Bensaddek, D., Narayan, V., Nicolas, A., Brenes Murillo, A., Gartner, A., Kenyon, C. & Lamond, A., 10 Feb 2016, In : Proteomics. 16, 3, p. 381-392

Research output: Contribution to journalArticle

Open Access
File
13 Citations (Scopus)
128 Downloads (Pure)

Quantitative proteomic analysis of the human nucleolus

Bensaddek, D., Nicolas, A. & Lamond, A. I., 2016, The nucleolus: methods and protocols. Németh, A. (ed.). New York: Springer , p. 249-262 14 p. (Methods in molecular biology; vol. 1455).

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

4 Citations (Scopus)

The cytotoxic T cell proteome and its shaping by the kinase mTOR

Hukelmann, J. L., Anderson, K. E., Sinclair, L. V., Grzes, K. M., Brenes Murillo, A., Hawkins, P. T., Stephens, L. R., Lamond, A. I. & Cantrell, D. A., Jan 2016, In : Nature Immunology. 17, 1, p. 104-112 9 p.

Research output: Contribution to journalArticle

Open Access
File
83 Citations (Scopus)
212 Downloads (Pure)

The histone chaperone Vps75 forms multiple oligomeric assemblies capable of mediating exchange between histone H3–H4 tetramers and Asf1–H3–H4 complexes

Hammond, C. M., Sundaramoorthy, R., Larance, M., Lamond, A., Stevens, M. A., El-Mkami, H., Norman, D. & Owen-Hughes, T., 27 Jul 2016, In : Nucleic Acids Research. 44, 13, p. 6157-6172 16 p.

Research output: Contribution to journalArticle

Open Access
File
18 Citations (Scopus)
244 Downloads (Pure)

The NEDD8 inhibitor MLN4924 increases the size of the nucleolus and activates p53 through the ribosomal-Mdm2 pathway

Bailly, A., Perrin, A., Bou Malhab, L. J., Pion, E., Larance, M., Nagala, M., Smith, P., O'Donohue, M-F., Gleizes, P-E., Zomerdijk, J., Lamond, A. I. & Xirodimas, D. P., 28 Jan 2016, In : Oncogene. 35, 4, p. 415-426 12 p.

Research output: Contribution to journalArticle

Open Access
File
21 Citations (Scopus)
298 Downloads (Pure)

The Nucleolus

Lamond, A. I., Ly, T., Hutten, S. & Nicolas, A., 1 Jan 2016, Functional Cell Biology. Elsevier Inc., Vol. 3. p. 254-269 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Unlocking the chromatin code by deciphering protein–DNA interactions

Bensaddek, D. & Lamond, A., Nov 2016, In : Molecular Systems Biology. 12, 11, p. 1-3 3 p., 887.

Research output: Contribution to journalArticle

Open Access
File
178 Downloads (Pure)