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2020
7 Downloads (Pure)

Impact of EMA regulatory label changes on systemic diclofenac initiation, discontinuation, and switching to other pain medicines in Scotland, England, Denmark, and The Netherlands

Morales, D. R., Morant, S. V., MacDonald, T. M., Mackenzie, I. S., Doney, A. S. F., Mitchell, L., Bennie, M., Robertson, C., Hallas, J., Pottegard, A., Ernst, M. T., Wei, L., Nicholson, L., Morris, C., Herings, R. M. C., Overbeek, J. A., Smits, E. & Flynn, R. W. V., 3 Jan 2020, In : Pharmacoepidemiology and Drug Safety. 10 p.

Research output: Contribution to journalArticle

Open Access
File
Diclofenac
Scotland
Denmark
England
Netherlands

Reply

Gingles, C. R., Symon, R., Gandy, S. J., Struthers, A. D., Houston, G., MacDonald, T. M., Lang, C. C., Donnan, P. T. & George, J., 1 Jan 2020, In : Journal of Hypertension. 38, 1, p. 177-178 2 p.

Research output: Contribution to journalLetter

2019
2 Citations (Scopus)
99 Downloads (Pure)

Allopurinol treatment adversely impacts left ventricular mass regression in patients with well-controlled hypertension

Gingles, C., Symon, R., Gandy, S., Struthers, A., Houston, G., MacDonald, T., Lang, C., Donnan, P. & George, J., Dec 2019, In : Journal of Hypertension. 37, 12, p. 2481-2489 9 p.

Research output: Contribution to journalArticle

Open Access
File
Allopurinol
Hypertension
Placebos
Oxidative Stress
Left Ventricular Hypertrophy
1 Citation (Scopus)
40 Downloads (Pure)

Cardiovascular Safety of Prucalopride in Patients with Chronic Constipation: A Multinational Population-Based Cohort Study

Gilsenan, A., Fortuny, J., Cainzos-Achirica, M., Cantero, O. F., Flynn, R. W. V., Garcia-Rodriguez, L., Harding, A., Kollhorst, B., Karlsson, P., Linnér, L., MacDonald, T. M., Odsbu, I., Plana, E., Ruigómez, A., Schink, T., Ziemiecki, R. & Andrews, E. B., Oct 2019, In : Drug Safety. 42, 10, p. 1179-1190 12 p.

Research output: Contribution to journalArticle

Open Access
File
prucalopride
Constipation
Cohort Studies
Safety
Incidence
76 Downloads (Pure)
Open Access
File
Allopurinol
Clinical Trials
Random Allocation
Gout
Registries
1 Citation (Scopus)
90 Downloads (Pure)
Open Access
File
3 Citations (Scopus)
79 Downloads (Pure)

Incidence of type 2 diabetes mellitus in men receiving steroid 5α-reductase inhibitors: population based cohort study

Wei, L., Lai, E. C-C., Kao-Yang, Y-H., Walker, B. R., MacDonald, T. M. & Andrew, R., 10 Apr 2019, In : BMJ (Clinical research ed.). 365, p. 1-11 11 p., l1204.

Research output: Contribution to journalArticle

Open Access
File
tamsulosin
Finasteride
Type 2 Diabetes Mellitus
Oxidoreductases
Cohort Studies

Lowering Uric Acid in Normouricaemic Hypertensive Patients Has an Adverse Effect on Left Ventricular Hypertrophy Regression: Mechanistic Proof of the Urate Paradox

Gingles, C., Symon, R., Gandy, S. J., Struthers, A. D., Houston, G., Macdonald, T. M., Lang, C. C., Donnan, P. T. & George, J., 1 Jul 2019, In : Journal of Hypertension. 37, p. e57

Research output: Contribution to journalMeeting abstract

Left Ventricular Hypertrophy
Uric Acid
Allopurinol
Placebos
Oxidative Stress
1 Citation (Scopus)
70 Downloads (Pure)

Study Design and Cohort Comparability in a Study of Major Cardiovascular Events in New Users of Prucalopride Versus Polyethylene Glycol 3350

Fortuny, J., Gilsenan, A., Cainzos-Achirica, M., Cantero, O. F., Flynn, R. W. V., Garcia-Rodriguez, L., Kollhorst, B., Karlsson, P., Linnér, L., MacDonald, T. M., Plana, E., Ruigómez, A., Schink, T., Ziemiecki, R. & Andrews, E. B., Oct 2019, In : Drug Safety. 42, 10, p. 1167-1177 11 p.

Research output: Contribution to journalArticle

Open Access
File
prucalopride
Cohort Studies
Sweden
Databases
Germany
1 Citation (Scopus)
30 Downloads (Pure)
Open Access
File
Bendroflumethiazide
Indapamide
Odds Ratio
Hypertension
Confidence Intervals
2018

AB1029 Allopurinol and cardiovascular outcomes in patients with ischaemic heart disease (ALL-HEART) study: baseline characteristics of the randomised patient population

Mackenzie, I., Ford, I., Hawkey, C., Begg, A., Taggar, J., Struthers, A., Wei, L., Avery, A., Walker, A., Duce, S., Barr, R., Dumbleton, J. & Macdonald, T., 12 Jun 2018, In : Annals of the Rheumatic Diseases. 77, suppl. 2, p. 1631.1-1631 1 p.

Research output: Contribution to journalConference article

Allopurinol
Myocardial Ischemia
History
Population
Blood Pressure
38 Citations (Scopus)
71 Downloads (Pure)

Endocrine and haemodynamic changes in resistant hypertension, and blood pressure responses to spironolactone or amiloride: the PATHWAY-2 mechanisms substudies

Williams, B., MacDonald, T. M., Morant, S. V., Webb, D. J., Sever, P., McInnes, G. T., Ford, I., Cruickshank, J. K., Caulfield, M. J., Padmanabhan, S., Mackenzie, I. S., Salsbury, J. & Brown, M. J., 1 Jun 2018, In : The Lancet Diabetes and Endocrinology. 6, 6, p. 464-475 12 p.

Research output: Contribution to journalArticle

Open Access
File
Spironolactone
Amiloride
Hemodynamics
Blood Pressure
Hypertension
2 Citations (Scopus)
103 Downloads (Pure)

Evaluation of pregnancy outcomes in patients with multiple sclerosis after fingolimod exposure

Geissbühler, Y., Vile, J., Koren, G., Guennec, M., Butzkueven, H., Tilson, H., MacDonald, T. M. & Hellwig, K., 2018, In : Therapeutic Advances in Neurological Disorders. 11, p. 1-9 9 p.

Research output: Contribution to journalArticle

Open Access
File
Pregnancy Outcome
Multiple Sclerosis
Population
Live Birth
Spontaneous Abortion
119 Downloads (Pure)

Ibuprofen and Paracetamol: Acceptably Safe for All?

Pigazzani, F., Mackenzie, I. & MacDonald, T. M., Nov 2018, In : Drug Safety. 41, 11, p. 999-1001 3 p.

Research output: Contribution to journalComment/debate

Open Access
File

In response to: 'Thyroid hormone replacement - a counterblast to guidelines'

Leese, G. P., Flynn, R. V., MacDonald, T. M., Schofield, C. & Mackie, A. D., Mar 2018, In : Journal of the Royal College of Physicians of Edinburgh. 48, 1, p. 93 1 p.

Research output: Contribution to journalLetter

Open Access
4 Citations (Scopus)
125 Downloads (Pure)

Investigating Real-World Clopidogrel Pharmacogenetics in Stroke Using a Bioresource Linked to Electronic Medical Records

Tornio, A., Flynn, R., Morant, S., Velten, E., Palmer, C. N. A., MacDonald, T. M. & Doney, A. S. F., 1 Feb 2018, In : Clinical Pharmacology & Therapeutics. 103, 2, p. 281-286 6 p.

Research output: Contribution to journalArticle

Open Access
File
clopidogrel
Electronic Health Records
Pharmacogenetics
Stroke
Confidence Intervals
16 Downloads (Pure)
Open Access
File
Sleep
Randomized Controlled Trials
Antihypertensive Agents
Therapeutics
Stroke
91 Downloads (Pure)
Open Access
File
1 Citation (Scopus)
93 Downloads (Pure)

The effect of changes to GOLD severity stage on long term morbidity and mortality in COPD

Flynn, R. W. V., MacDonald, T. M., Chalmers, J. D. & Schembri, S., 12 Dec 2018, In : Respiratory Research. 19, p. 1-10 10 p., 249.

Research output: Contribution to journalArticle

Open Access
File
Chronic Obstructive Pulmonary Disease
Morbidity
Mortality
Hospitalization
Spirometry
2017
11 Citations (Scopus)
144 Downloads (Pure)

Acid-suppression medications and bacterial gastroenteritis: a population-based cohort study

Wei, L., Ratnayake, L., Phillips, G., McGuigan, C. C., Morant, S. V., Flynn, R. W., Mackenzie, I. S. & MacDonald, T. M., Jun 2017, In : British Journal of Clinical Pharmacology. 83, 6, p. 1298-1308 11 p.

Research output: Contribution to journalArticle

Open Access
File
Gastroenteritis
Cohort Studies
Campylobacter
Confidence Intervals
Acids
12 Citations (Scopus)
113 Downloads (Pure)

Combination Therapy Is Superior to Sequential Monotherapy for the Initial Treatment of Hypertension: A Double-Blind Randomized Controlled Trial

MacDonald, T. M., Williams, B., Webb, D. J., Morant, S., Caulfield, M., Cruickshank, J. K., Ford, I., Sever, P., Mackenzie, I. S., Padmanabhan, S., McCann, G. P., Salsbury, J., McInnes, G., Brown, M. J. & for The British Hypertension Society Programme of Prevention And Treatment of Hypertension With Algorithm‐based Therapy (PATHWAY), Nov 2017, In : Journal of the American Heart Association. 6, 11, p. 1-28 28 p., e006986.

Research output: Contribution to journalArticle

Open Access
File
Randomized Controlled Trials
Blood Pressure
Hypertension
Hydrochlorothiazide
Losartan
7 Citations (Scopus)
262 Downloads (Pure)
Open Access
File
Pharmacoepidemiology
Clinical Trials
Technology
PubMed
Libraries
10 Citations (Scopus)

Erratum: The British Society for Rheumatology Guideline for the Management of Gout

Hui, M., Carr, A., Cameron, S., Davenport, G., Doherty, M., Forrester, H., Jenkins, W., Jordan, K. M., Mallen, C. D., MacDonald, T., Nuki, G., Pywell, A., Zhang, W. & Roddy, E., 1 Jul 2017, In : Rheumatology. 56, 7, p. 1246 1 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)
102 Downloads (Pure)

Randomised trial of switching from prescribed non-selective non-steroidal anti-inflammatory drugs to prescribed celecoxib: The Standard care versus Celecoxib Outcome Trial (SCOT)

MacDonald, T., Hawkey, C. J., Ford, I., McMurray, J. J. V., Scheiman, J. M., Hallas, J., Findlay, E., Grobbee, D. E., Hobbs, FD. R., Ralston, S. H., Reid, D. M., Walters, M., Webster, J., Ruschitzka, F., Ritchie, L. D., Perez-Gutthann, S., Connolly, E., Greenlaw, N., Wilson, A., Wei, L. & 1 others, Mackenzie, I., 14 Jun 2017, In : European Heart Journal. 38, 23, p. 1843-1850 9 p.

Research output: Contribution to journalArticle

Open Access
File
Celecoxib
Anti-Inflammatory Agents
Pharmaceutical Preparations
Cardiovascular Diseases
Myocardial Infarction
11 Citations (Scopus)
131 Downloads (Pure)

Spironolactone use and risk of incident cancers: a retrospective, matched cohort study

Mackenzie, I. S., Morant, S. V., Wei, L., Thompson, A. M. & MacDonald, T. M., 14 Feb 2017, In : British Journal of Clinical Pharmacology. 83, 3, p. 653-663 11 p.

Research output: Contribution to journalArticle

Open Access
File
Spironolactone
Cohort Studies
Neoplasms
Incidence
Prostatic Neoplasms
4 Citations (Scopus)
81 Downloads (Pure)

Study protocol for statin web-based investigation of side effects (StatinWISE): a series of randomised controlled N-of-1 trials comparing atorvastatin and placebo in UK primary care

Herrett, E., Williamson, E., Beaumont, D., Prowse, D., Youssouf, N., Brack, K., Armitage, J., Goldacre, B., MacDonald, T., Staa, T. V., Roberts, I., Shakur-Still, H. & Smeeth, L., 1 Dec 2017, In : BMJ Open. 7, 12, p. 1-8 8 p., e016604.

Research output: Contribution to journalArticle

Open Access
File
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Primary Health Care
Placebos
Muscles
Visual Analog Scale
521 Downloads (Pure)

Successful recruitment to a large online randomised trial: the TIME study

Rogers, A., Mackenzie, I., Rorie, D. & MacDonald, T., 2 May 2017, Trials: Meeting abstracts from the 4th International Clinical Trials Methodology Conference (ICTMC) and the 38th Annual Meeting of the Society for Clinical Trials. Supplement 1 ed. United Kingdom: BioMed Central, Vol. 18. p. 222-223 2 p. 089. (Trials; vol. 18, no. Suppl. 1).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Open Access
File
26 Citations (Scopus)
108 Downloads (Pure)

The British Society for Rheumatology Guideline for the Management of Gout

Hui, M., Carr, A., Cameron, S., Davenport, G., Doherty, M., Forrester, H., Jenkins, W., Jordan, K. M., Mallen, C. D., MacDonald, T., Nuki, G., Pywell, A., Zhang, W. & Roddy, E., Jul 2017, In : Rheumatology. 56, 7, p. 1056-1059 4 p.

Research output: Contribution to journalArticle

Open Access
File
31 Citations (Scopus)
93 Downloads (Pure)

The British Society For Rheumatology guideline for the management of gout

Hui, M., Carr, A., Cameron, S., Davenport, G., Doherty, M., Forrester, H., Jenkins, W., Jordan, K. M., Mallen, C. D., MacDonald, T., Nuki, G., Pywell, A., Zhang, W. & Roddy, E., Jul 2017, In : Rheumatology. 56, 7, p. e1-e20

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
119 Downloads (Pure)
Open Access
File
Technology
Demography
Clinical Trials
Costs and Cost Analysis
Research
2016
1 Citation (Scopus)
148 Downloads (Pure)
Open Access
File
Allopurinol
Randomized Controlled Trials
Pharmaceutical Preparations
Clinical Trials
Software
35 Citations (Scopus)
106 Downloads (Pure)

Effect of amiloride, or amiloride plus hydrochlorothiazide, versus hydrochlorothiazide on glucose tolerance and blood pressure (PATHWAY-3): a parallel-group, double-blind randomised phase 4 trial

Brown, M. J., Williams, B., Morant, S. V., Webb, D. J., Caulfield, M. J., Cruickshank, J. K., Ford, I., McInnes, G., Sever, P., Salsbury, J., Mackenzie, I. S., Padmanabhan, S., MacDonald, T. M. & for the British Hypertension Society's Prevention, Treatment of Hypertension with Algorithm-based Therapy (PATHWAY) Studies Group, Feb 2016, In : The Lancet: Diabetes and Endocrinology. 4, 2, p. 136-147 12 p.

Research output: Contribution to journalArticle

Open Access
File
Hydrochlorothiazide
Amiloride
Blood Pressure
Glucose
Glucose Intolerance
11 Citations (Scopus)
108 Downloads (Pure)

Methods of a large prospective, randomised, open-label, blinded end-point study comparing morning versus evening dosing in hypertensive patients: the Treatment In Morning versus Evening (TIME) study

Rorie, D. A., Rogers, A., Mackenzie, I. S., Ford, I., Webb, D. J., Willams, B., Brown, M., Poulter, N., Findlay, E., Saywood, W. & MacDonald, T. M., 9 Feb 2016, In : BMJ Open. 6, 2, e010313.

Research output: Contribution to journalArticle

Open Access
File
Hospitalization
Antihypertensive Agents
Stroke
Blood Pressure
Therapeutics
22 Citations (Scopus)
174 Downloads (Pure)

Multicentre, prospective, randomised, open-label, blinded end point trial of the efficacy of allopurinol therapy in improving cardiovascular outcomes in patients with ischaemic heart disease: protocol of the ALL-HEART study

Mackenzie, I. S., Ford, I., Walker, A., Hawkey, C., Begg, A., Avery, A., Taggar, J., Wei, L., Struthers, A. D., MacDonald, T. M. & ALL-HEART study group, 8 Sep 2016, In : BMJ Open. 6, 9, p. 1-9 9 p., e013774.

Research output: Contribution to journalArticle

Open Access
File
Allopurinol
Myocardial Ischemia
Myocardial Infarction
Research Ethics
Therapeutics
1 Citation (Scopus)

PATHWAY-2: Spironolactone for resistant hypertension - Authors' reply

Williams, B., MacDonald, T. M., Morant, S. V. & Brown, M. J., 2 Apr 2016, In : Lancet. 387, 10026, p. 1373-1374 2 p.

Research output: Contribution to journalLetter

4 Citations (Scopus)
103 Downloads (Pure)
Open Access
File
Appendectomy
Tonsillectomy
Pregnancy Rate
Cohort Studies
Time-to-Pregnancy
78 Downloads (Pure)

Treatment in the Morning versus Evening (TIME) Study: Feasibility of an Online Study

Rorie, D. A., Rogers, A., Mackenzie, I. S., Findlay, E., MacDonald, T. M., Ford, I., Webb, D. J., Williams, B., Brown, M. & Poulter, N. R., 21 Sep 2016, In : Journal of Clinical Trials. 6, 5, p. 1-7 7 p., 1000281.

Research output: Contribution to journalArticle

Open Access
File
Feasibility Studies
Antihypertensive Agents
Therapeutics
Primary Health Care
Secondary Care