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2020
8 Downloads (Pure)

Salt-inducible kinases (SIKs) regulate TGFβ-mediated transcriptional and apoptotic responses

Hutchinson, L. D., Darling, N. J., Nicolaou, S., Gori, L., Squair, D. R., Cohen, P., Hill, C. S. & Sapkota, G. P., 22 Jan 2020, In : Cell Death and Disease. 11, p. 1-17 17 p., 49.

Research output: Contribution to journalArticle

Open Access
File
Transforming Growth Factors
Phosphotransferases
Salts
Plasminogen Activator Inhibitor 1
Pharmacology
2019

Distinct signals and immune cells drive liver pathology and glomerulonephritis in ABIN1[D485N] mice

Nanda, S. K., Petrova, T., Marchesi, F., Gierlinski, M., Razsolkov, M., Lee, K. L., Wright, S. W., Rao, V. R., Cohen, P. & Arthur, J. S. C., 1 Dec 2019, In : Life Science Alliance. 2, 6, p. 1-19 19 p., e201900533.

Research output: Contribution to journalArticle

Open Access
File
glomerulonephritis
Pathology
pathology
Glomerulonephritis
Liver
4 Citations (Scopus)
137 Downloads (Pure)

Genetic variations in A20 DUB domain provide a genetic link to citrullination and neutrophil extracellular traps in systemic lupus erythematosus

Odqvist, L., Jevnikar, Z., Riise, R., Öberg, L., Rhedin, M., Leonard, D., Yrlid, L., Jackson, S., Mattsson, J., Nanda, S., Cohen, P., Knebel, A., Arthur, S., Thörn, K., Svenungsson, E., Jönsen, A., Gunnarsson, I., Tandre, K., Alexsson, A., Kastbom, A. & 10 others, Rantapää-Dahlqvist, S., Eloranta, M-L., Syvänen, A-C., Bengtsson, A., Johansson, P., Sandling, J. K., Sjöwall, C., Rönnblom, L., Collins, B. & Vaarala, O., 12 Jul 2019, In : Annals of the Rheumatic Diseases. 8 p.

Research output: Contribution to journalArticle

Open Access
File
Systemic Lupus Erythematosus
Polymorphism
Clustered Regularly Interspaced Short Palindromic Repeats
Genes
RNA Sequence Analysis
Open Access
Ubiquitin-Protein Ligases
Ubiquitin
Esters
Viral Structures
Toll-Like Receptors
2 Citations (Scopus)
60 Downloads (Pure)
Open Access
File
Ubiquitin-Protein Ligases
Ubiquitin
Esters
Ubiquitin C
Macrophages
2018
3 Citations (Scopus)

ABIN2 Function Is Required To Suppress DSS-Induced Colitis by a Tpl2-Independent Mechanism

Nanda, S. K., Nagamori, T., Windheim, M., Amu, S., Aviello, G., Patterson-Kane, J., Arthur, J. S. C., Ley, S. C., Fallon, P. & Cohen, P., 1 Dec 2018, In : Journal of Immunology. 201, 11, p. 3373-3382 10 p.

Research output: Contribution to journalArticle

Colitis
Neoplasms
Myofibroblasts
Cyclooxygenase 2
Ubiquitin
1 Citation (Scopus)
71 Downloads (Pure)

The NEDD8 E3 ligase DCNL5 is phosphorylated by IKK alpha during Toll-like receptor activation

Thomas, Y., Scott, D. C., Kristariyanto, Y. A., Rinehart, J., Clark, K., Cohen, P. & Kurz, T., 29 Jun 2018, In : PLoS ONE. 13, 6, p. 1-19 19 p., e0199197.

Research output: Contribution to journalArticle

Open Access
File
IKappaB kinase
I-kappa B Kinase
Cullin Proteins
Ubiquitin-Protein Ligases
Toll-Like Receptors
1 Citation (Scopus)

Ubiquitin chains as second messengers

Cohen, P., Apr 2018, In : Nature Reviews Molecular Cell Biology. 19, 4, 1 p., 212.

Research output: Contribution to journalComment/debate

2017
16 Citations (Scopus)
230 Downloads (Pure)

Identification of TBK1 complexes required for the phosphorylation of IRF3 and the production of interferon β

Bakshi, S., Taylor, J., Strickson, S., Macartney, T. & Cohen, P., 15 Mar 2017, In : Biochemical Journal. 474, 7, p. 1163-1174 12 p.

Research output: Contribution to journalArticle

Open Access
File
Interferon Regulatory Factor-3
Phosphorylation
Interferons
Phosphotransferases
Macrophages
7 Citations (Scopus)
112 Downloads (Pure)

Interleukin-1 and TRAF6-dependent activation of TAK1 in the absence of TAB2 and TAB3

Zhang, J., Macartney, T., Peggie, M. & Cohen, P., 26 Jul 2017, In : Biochemical Journal. 474, 13, p. 2235-2248 16 p.

Research output: Contribution to journalArticle

Open Access
File
TNF Receptor-Associated Factor 6
Interleukin-1
Chemical activation
p38 Mitogen-Activated Protein Kinases
Ubiquitin
27 Citations (Scopus)
121 Downloads (Pure)

Roles of the TRAF6 and Pellino E3 ligases in MyD88 and RANKL signaling

Strickson, S., Emmerich, C. H., Goh, E. T. H., Zhang, J., Kelsall, I. R., Macartney, T., Hastie, C. J., Knebel, A., Peggie, M., Marchesi, F., Arthur, J. S. C. & Cohen, P., 25 Apr 2017, In : Proceedings of the National Academy of Sciences. 114, 7, p. E3481-E3489 9 p.

Research output: Contribution to journalArticle

Open Access
File
TNF Receptor-Associated Factor 6
Ubiquitin-Protein Ligases
Interleukin-1
Macrophages
Ubiquitination
20 Citations (Scopus)
106 Downloads (Pure)

The mechanism of activation of IRAK1 and IRAK4 by interleukin-1 and TollLike receptor agonists

Vollmer, S., Strickson, S., Zhang, T., Gray, N., Lee, K., Rao, V. & Cohen, P., 6 Jun 2017, In : Biochemical Journal. 474, 12, p. 2027-2038 12 p.

Research output: Contribution to journalArticle

Open Access
File
Interleukin-1 Receptor-Associated Kinases
Interleukin-1 Receptors
Interleukin-1
Chemical activation
Protein Kinases
19 Citations (Scopus)
125 Downloads (Pure)

The role of hybrid ubiquitin chains in the MyD88 and other innate immune signalling pathways

Cohen, P. & Strickson, S., May 2017, In : Cell Death & Differentiation. 24, p. 1153-1159 7 p.

Research output: Contribution to journalReview article

Open Access
File
Ubiquitin
Ubiquitin-Protein Ligases
TNF Receptor-Associated Factor 6
Phosphotransferases
Mitogen-Activated Protein Kinases
2016
36 Citations (Scopus)
108 Downloads (Pure)

HCK is a survival determinant transactivated by mutated MYD88, and a direct target of ibrutinib

Yang, G., Buhrlage, S., Tan, L., Liu, X., Chen, J., Xu, L., Tsakmaklis, N., Chen, J. G., Patterson, C. J., Brown, J. R., Castillo, J. J., Zhang, W., Zhang, X., Liu, S., Cohen, P., Hunter, Z. R., Gray, N. S. & Treon, S. P., 23 Jun 2016, In : Blood. 127, 25, p. 3237-3252 16 p.

Research output: Contribution to journalArticle

Open Access
File
Waldenstrom Macroglobulinemia
Survival
Chemical activation
Transcription
Interleukin-6
31 Citations (Scopus)
149 Downloads (Pure)

Lys63/Met1-hybrid ubiquitin chains are commonly formed during the activation of innate immune signalling.

Emmerich, C., Bakshi, S., Kelsall, I., Ortiz-Guerrero, J., Shpiro, N. & Cohen, P., 3 Jun 2016, In : Biochemical and Biophysical Research Communications. 474, 3, p. 452-461 10 p.

Research output: Contribution to journalArticle

Open Access
File
Ubiquitin
Chemical activation
Receptor-Interacting Protein Serine-Threonine Kinases
Interleukin-1 Receptor-Associated Kinases
Tumor Necrosis Factor Receptors
18 Citations (Scopus)
133 Downloads (Pure)
Open Access
File
Lupus Nephritis
Ubiquitin
Splenomegaly
Inflammation
Autoimmunity