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  • Ewan Pearson
2020

Circulating tissue factor-positive procoagulant microparticles in patients with type 1 diabetes

Zhang, C., Ou, Q., Gu, Y., Cheng, G., Du, R., Yuan, L., Cordiner, R., Kang, D., Zhang, J., Huang, Q., Yu, C., Kang, L., Wang, X., Sun, X., Mo, X., Tian, H., Pearson, E., Meng, W. & Li, S., 3 Jan 2020, In : Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 12, p. 2819-2828 10 p.

Research output: Contribution to journalArticle

Open Access
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32 Downloads (Pure)

Dapagliflozin Versus Placebo on Left Ventricular Remodeling in Patients With Diabetes and Heart Failure: The REFORM Trial

Singh, J. S. S., Mordi, I. R., Vickneson, K., Fathi, A., Donnan, P. T., Mohan, M., Choy, A. M. J., Gandy, S., George, J., Khan, F., Pearson, E. R., Houston, J. G., Struthers, A. D. & Lang, C. C., 1 Jun 2020, In : Diabetes Care. 43, 6, p. 1356-1359 4 p.

Research output: Contribution to journalArticle

Open Access
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Precision medicine in diabetes: a Consensus Report from the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)

Chung, W. K., Erion, K., Florez, J. C., Hattersley, A. T., Hivert, M-F., Lee, C. G., McCarthy, M. I., Nolan, J. J., Norris, J. M., Pearson, E. R., Philipson, L., McElvaine, A. T., Cefalu, W. T., Rich, S. S. & Franks, P. W., Jul 2020, In : Diabetes Care. 43, 7, p. 1617-1635 19 p.

Research output: Contribution to journalArticle

Open Access
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5 Downloads (Pure)

Precision medicine in diabetes: a Consensus Report from the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)

Chung, W. K., Erion, K., Florez, J. C., Hattersley, A. T., Hivert, M-F., Lee, C. G., McCarthy, M. I., Nolan, J. J., Norris, J. M., Pearson, E. R., Philipson, L., McElvaine, A. T., Cefalu, W. T., Rich, S. S. & Franks, P. W., 19 Jun 2020, In : Diabetologia. 23 p.

Research output: Contribution to journalArticle

Predicting and elucidating the etiology of fatty liver disease: A machine learning modeling and validation study in the IMI DIRECT cohorts

Atabaki-Pasdar, N., Ohlsson, M., Viñuela, A., Frau, F., Pomares-Millan, H., Haid, M., Jones, A. G., Thomas, E. L., Koivula, R. W., Kurbasic, A., Mutie, P. M., Fitipaldi, H., Fernandez, J., Dawed, A. Y., Giordano, G. N., Forgie, I. M., McDonald, T. J., Rutters, F., Cederberg, H., Chabanova, E. & 43 others, Dale, M., Masi, F. D., Thomas, C. E., Allin, K. H., Hansen, T. H., Heggie, A., Hong, M-G., Elders, P. J. M., Kennedy, G., Kokkola, T., Pedersen, H. K., Mahajan, A., McEvoy, D., Pattou, F., Raverdy, V., Häussler, R. S., Sharma, S., Thomsen, H. S., Vangipurapu, J., Vestergaard, H., 't Hart, L. M., Adamski, J., Musholt, P. B., Brage, S., Brunak, S., Dermitzakis, E., Frost, G., Hansen, T., Laakso, M., Pedersen, O., Ridderstråle, M., Ruetten, H., Hattersley, A. T., Walker, M., Beulens, J. W. J., Mari, A., Schwenk, J. M., Gupta, R., McCarthy, M. I., Pearson, E. R., Bell, J. D., Pavo, I. & Franks, P. W., 19 Jun 2020, In : PLoS Medicine. 17, 6, p. 1-27 27 p., e1003149.

Research output: Contribution to journalArticle

Open Access
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3 Downloads (Pure)

Risk factors for genital infections in people initiating SGLT2 inhibitors and their impact on discontinuation

McGovern, A. P., Hogg, M., Shields, B. M., Sattar, N. A., Holman, R. R., Pearson, E. R., Hattersley, A. T., Jones, A. G., Dennis, J. M. & MASTERMIND consortium, 24 May 2020, In : BMJ Open Diabetes Research and Care. 8, 1, p. 1-8 8 p., e001238.

Research output: Contribution to journalArticle

Open Access
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8 Downloads (Pure)

Strategies to identify individuals with monogenic diabetes: results of an economic evaluation

Peters, J. L., Anderson, R., Shields, B., King, S., Hudson, M., Shepherd, M., McDonald, T. J., Pearson, E., Hattersley, A. & Hyde, C., 18 Mar 2020, In : BMJ Open. 10, 3, p. 1-10 10 p., e034716.

Research output: Contribution to journalArticle

Open Access
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17 Downloads (Pure)

The impact of phenotype, ethnicity and genotype on progression of Type 2 diabetes mellitus

Thakarakkattil Narayanan Nair, A., Donnelly, L. A., Dawed, A. Y., Gan, S., Anjana, R. M., Mohan, V., Palmer, C. & Pearson, E., 20 Apr 2020, In : Endocrinology, Diabetes & Metabolism. 3, 2, p. 1-11 11 p., e00108.

Research output: Contribution to journalReview article

Open Access
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42 Downloads (Pure)

The role of physical activity in metabolic homeostasis before and after the onset of type 2 diabetes: an IMI DIRECT study

Koivula, R. W., Atabaki-Pasdar, N., Giordano, G. N., White, T., Adamski, J., Bell, J. D., Beulens, J., Brage, S., Brunak, S., De Masi, F., Dermitzakis, E. T., Forgie, I. M., Frost, G., Hansen, T., Hansen, T. H., Hattersley, A., Kokkola, T., Kurbasic, A., Laakso, M., Mari, A. & 14 others, McDonald, T. J., Pedersen, O., Rutters, F., Schwenk, J. M., Teare, H. J. A., Thomas, E. L., Vinuela, A., Mahajan, A., McCarthy, M. I., Ruetten, H., Walker, M., Pearson, E., Pavo, I. & Franks, P. W., Apr 2020, In : Diabetologia. 63, 4, p. 744-756 13 p.

Research output: Contribution to journalArticle

Open Access
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24 Downloads (Pure)
Open Access
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139 Downloads (Pure)
2019

4th ESPT Conference: pharmacogenomics and personalized medicine - research progress and clinical implementation

Sipeky, C., Llerena, A., Manolopoulos, V. G., Pearson, E., Mlakar, V., Gozzo, L., Simmaco, M., Marchetti, P., Re, M. D., Stankovic, S., Meyer, U., Cascorbi, I., Ingelman-Sundberg, M., Suarez-Kurtz, G., Marc, J., Katsila, T., Paulmichl, M., Nofziger, C., Ansari, M., Drago, F. & 1 others, van Schaik, R. H., Oct 2019, In : Pharmacogenomics. 20, 15, p. 1063-1069 7 p.

Research output: Contribution to journalArticle

A Type 1 Diabetes Genetic Risk Score Can Identify Patients With GAD65 Autoantibody-Positive Type 2 Diabetes Who Rapidly Progress to Insulin Therapy

Grubb, A. L., McDonald, T. J., Rutters, F., Donnelly, L., Hattersley, A. T., Oram, R. A., Palmer, C., van der Heijden, A. A., Carr, F., Elders, P. J. M., Weedon, M., Slieker, R. C., 't Hart, L. M., Pearson, E., Shields, B. M. & Jones, A. G., 1 Feb 2019, In : Diabetes Care. 42, 2, p. 208-214 7 p.

Research output: Contribution to journalArticle

Open Access
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9 Citations (Scopus)
354 Downloads (Pure)

Development and validation of multivariable clinical diagnostic models to identify type 1 diabetes requiring rapid insulin therapy in adults aged 18-50 years

Lynam, A., McDonald, T., Hill, A., Dennis, J., Oram, R., Pearson, E., Weedon, M., Hattersley, A., Owen, K., Shields, B. & Jones, A., 26 Sep 2019, In : BMJ Open. 9, 9, p. 1-10 10 p., e031586.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
66 Downloads (Pure)

Diabetes: Is there a future for Pharmacogenomics guided treatment?

Pearson, E., 12 Jul 2019, In : Clinical Pharmacology & Therapeutics. 106, 2, p. 329-337 9 p.

Research output: Contribution to journalArticle

Open Access
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2 Citations (Scopus)
79 Downloads (Pure)

Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: descriptive characteristics of the epidemiological studies within the IMI DIRECT Consortium

Koivula, R. W., Forgie, I. M., Kurbasic, A., Viñuela, A., Heggie, A., Giordano, G. N., Hansen, T. H., Hudson, M., Koopman, A. D. M., Rutters, F., Siloaho, M., Allin, K. H., Brage, S., Brorsson, C. A., Dawed, A. Y., De Masi, F., Groves, C. J., Kokkola, T., Mahajan, A., Perry, M. H. & 30 others, Rauh, S. P., Ridderstråle, M., Teare, H. J. A., Thomas, E. L., Tura, A., Vestergaard, H., White, T., Adamski, J., Bell, J. D., Beulens, J. W., Brunak, S., Dermitzakis, E. T., Froguel, P., Frost, G., Gupta, R., Hansen, T., Hattersley, A., Jablonka, B., Kaye, J., Laakso, M., McDonald, T. J., Pedersen, O., Schwenk, J. M., Pavo, I., Mari, A., McCarthy, M. I., Ruetten, H., Walker, M., Pearson, E. & Franks, P. W., 1 Sep 2019, In : Diabetologia. 62, 9, p. 1601-1615 15 p.

Research output: Contribution to journalArticle

Open Access
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3 Citations (Scopus)
9 Downloads (Pure)

Drug-drug-gene interactions and adverse drug reactions

Malki, M. A. & Pearson, E. R., 3 Dec 2019, In : Pharmacogenomics Journal. 12 p.

Research output: Contribution to journalReview article

Open Access
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1 Citation (Scopus)
44 Downloads (Pure)

Genetic studies of abdominal MRI data identify genes regulating hepcidin as major determinants of liver iron concentration

Wilman, H. R., Parisinos, C. A., Atabaki-Pasdar, N., Kelly, M., Thomas, E. L., Neubauer, S., Mahajan, A., Hingorani, A. D., Patel, R. S., Hemingway, H., Franks, P. W., Bell, J. D., Banerjee, R. & Yaghootkar, H., Sep 2019, In : Journal of Hepatology. 71, 3, p. 594-602 9 p.

Research output: Contribution to journalArticle

Open Access
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3 Citations (Scopus)
69 Downloads (Pure)

Genome-Wide and Abdominal MRI-Imaging Data Provides Evidence that a Genetically Determined Favourable Adiposity Phenotype is Characterized by Lower Ectopic Liver Fat and Lower Risk of Type 2 Diabetes, Heart Disease and Hypertension

Ji, Y., Yiorkas, A. M., Frau, F., Mook-Kanamori, D., Staiger, H., Thomas, E. L., Atabaki-Pasdar, N., Campbell, A., Tyrrell, J., Jones, S. E., Beaumont, R. N., Wood, A. R., Tuke, M. A., Ruth, K. S., Mahajan, A., Murray, A., Freathy, R. M., Weedon, M. N., Hattersley, A. T., Hayward, C. & 11 others, Machann, J., Häring, H-U., Franks, P., de Mutsert, R., Pearson, E., Stefan, N., Frayling, T. M., Allebrandt, K. V., Bell, J. D., Blakemore, A. I. & Yaghootkar, H., 1 Jan 2019, In : Diabetes. 68, 1, p. 207-219 13 p.

Research output: Contribution to journalArticle

Open Access
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20 Citations (Scopus)
280 Downloads (Pure)

Metformin increases fasting glucose clearance and endogenous glucose production in non-diabetic individuals

McCreight, L., Mari, A., Coppin, L., Jackson, N., Umpleby, A. M. & Pearson, E., 22 Nov 2019, In : Diabetologia. 4 p.

Research output: Contribution to journalArticle

Open Access
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2 Citations (Scopus)
71 Downloads (Pure)

Motivations for data sharing-views of research participants from four European countries: A DIRECT study

Shah, N., Coathup, V., Teare, H., Forgie, I., Giordano, G. N., Hansen, T. H., Groeneveld, L., Hudson, M., Pearson, E., Ruetten, H. & Kaye, J., 30 Jan 2019, In : European Journal of Human Genetics. 27, 5, p. 721-729 9 p.

Research output: Contribution to journalArticle

Open Access
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5 Citations (Scopus)
98 Downloads (Pure)

Novel Genetic Locus Influencing Retinal Venular Tortuosity Is Also Associated With Risk of Coronary Artery Disease

Veluchamy, A., Ballerini, L., Vitart, V., Schraut, K. E., Kirin, M., Campbell, H., Joshi, P. K., Relan, D., Harris, S., Vaidya, S. S. ., Dhillon, B., Zhou, K., Pearson, E., Hayward, C., Polašek, O., Deary, I. J., MacGillivray, T. J., Wilson, J. F., Trucco, M., Palmer, C. & 1 others, Doney, A., Dec 2019, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 39, 12, p. 2542-2552 11 p.

Research output: Contribution to journalArticle

Open Access
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Sharing data for future research-engaging participants' views about data governance beyond the original project: a DIRECT Study

Shah, N., Coathup, V., Teare, H., Forgie, I., Giordano, G. N., Hansen, T. H., Groeneveld, L., Hudson, M., Pearson, E., Ruetten, H. & Kaye, J., May 2019, In : Genetics in Medicine. 21, p. 1131-1138 8 p.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
348 Downloads (Pure)

The effect of dapagliflozin on glycaemic control and other cardiovascular disease risk factors in type 2 diabetes mellitus: a real-world observational study

Scottish Diabetes Research Network Epidemiology Group, McGurnaghan, S. J., Brierley, L., Caparrotta, T. M., McKeigue, P. M., Blackbourn, L. A. K., Wild, S. H., Leese, G., McCrimmon, R., McKnight, J. A., Pearson, E., Petrie, J. R., Sattar, N. & Colhoun, H. M., Apr 2019, In : Diabetologia. 62, 4, p. 621-632 12 p.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
112 Downloads (Pure)
Open Access
File
9 Citations (Scopus)
99 Downloads (Pure)

Type 2 diabetes: a multifaceted disease

Pearson, E., Jul 2019, In : Diabetologia. 62, 7, p. 1107-1112 6 p.

Research output: Contribution to journalReview article

Open Access
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10 Citations (Scopus)
234 Downloads (Pure)

Variation in the plasma membrane monoamine transporter (PMAT) (encoded by SLC29A4) and organic cation transporter 1 (OCT1) (encoded by SLC22A1) and gastrointestinal intolerance to metformin in type 2 diabetes: An IMI direct study

Dawed, A., Zhou, K., van Leeuwen, N., Mahajan, A., Robertson, N. R., Koivula, R. W., Elders, P. J. M., Rauh, S. P., Jones, A. G., Holl, R. W. ., Stingl, J. C., Franks, P. W., McCarthy, M. I., 't Hart, L. M. & Pearson, E. R., Jun 2019, In : Diabetes Care. 42, 6, p. 1027-1033 7 p.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
152 Downloads (Pure)

What to do with diabetes therapies when HbA1c lowering is inadequate: add, switch, or continue? A MASTERMIND study

MASTERMIND consortium, McGovern, A. P., Dennis, J. M., Shields, B. M., Hattersley, A. T., Pearson, E. R. & Jones, A. G., 12 Apr 2019, In : BMC Medicine. 17, 1, p. 1-17 17 p., 79.

Research output: Contribution to journalArticle

Open Access
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4 Citations (Scopus)
110 Downloads (Pure)

Zinc Transporter 8 Autoantibodies (ZnT8A) and a Type 1 Diabetes Genetic Risk Score Can Exclude Individuals With Type 1 Diabetes From Inappropriate Genetic Testing for Monogenic Diabetes

Patel, K. A., Weedon, M. N., Shields, B. M., Pearson, E. R., Hattersley, A. T. & McDonald, T. J., Feb 2019, In : Diabetes Care. 42, 2, p. e1-e2 2 p.

Research output: Contribution to journalLetter

9 Citations (Scopus)
2018

A UK nationwide prospective study of treatment change in MODY: genetic subtype and clinical characteristics predict optimal glycaemic control after discontinuing insulin and metformin

Shepherd, M. H., Shields, B. M., Hudson, M., Pearson, E. R., Hyde, C., Ellard, S., Hattersley, A. T. & Patel, K. A., Dec 2018, In : Diabetologia. 61, 12, p. 2520-2527 8 p.

Research output: Contribution to journalArticle

Open Access
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15 Citations (Scopus)
89 Downloads (Pure)

Characteristics of people with high visit-to-visit glycaemic variability in Type 2 diabetes

Noyes, J. D., Soto-Pedre, E., Donnelly, L. A. & Pearson, E., 14 Jan 2018, In : Diabetic Medicine. 35, 2, p. 262-267 6 p.

Research output: Contribution to journalArticle

Open Access
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9 Citations (Scopus)
142 Downloads (Pure)

Cohort Profile: Genetics of Diabetes Audit and Research in Tayside Scotland (GoDARTS)

Hébert, H. L., Shepherd, B., Milburn, K., Veluchamy, A., Meng, W., Carr, F., Donnelly, L. A., Tavendale, R., Leese, G., Colhoun, H. M., Dow, E., Morris, A. D., Doney, A. S., Lang, C. C., Pearson, E. R., Smith, B. H. & Palmer, C. N. A., 1 Apr 2018, In : International Journal of Epidemiology. 47, 2, p. 380-381j 12 p.

Research output: Contribution to journalArticle

Open Access
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12 Citations (Scopus)
207 Downloads (Pure)

C-peptide decline in type 1 diabetes has two phases: An initial exponential fall and a subsequent stable phase

Shields, B. M., McDonald, T. J., Oram, R., Hill, A., Hudson, M., Leete, P., Pearson, E. R., Richardson, S. J., Morgan, N. G. & Hattersley, A. T., 1 Jul 2018, In : Diabetes Care. 41, 7, p. 1486-1492 7 p.

Research output: Contribution to journalArticle

Open Access
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23 Citations (Scopus)
258 Downloads (Pure)

Effectiveness and safety of long-term treatment with sulfonylureas in patients with neonatal diabetes due to KCNJ11 mutations: an international cohort study

Neonatal Diabetes International Collaborative Group, Bowman, P., Sulen, Å., Barbetti, F., Beltrand, J., Svalastoga, P., Codner, E., Tessmann, E. H., Juliusson, P. B., Skrivarhaug, T., Pearson, E. R., Flanagan, S. E., Babiker, T., Thomas, N. J., Shepherd, M. H., Ellard, S., Klimes, I., Szopa, M., Polak, M., Iafusco, D. & 2 others, Hattersley, A. T. & Njølstad, P. R., 1 Aug 2018, In : The Lancet Diabetes and Endocrinology. 6, 8, p. 637-646 10 p.

Research output: Contribution to journalArticle

Open Access
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32 Citations (Scopus)
192 Downloads (Pure)

Evaluating associations between the benefits and risks of drug therapy in type 2 diabetes: A joint modelling approach

MASTERMIND consortium, Dennis, J. M., Shields, B. M., Jones, A. G., Pearson, E., Hattersley, A. T. & Henley, W. E., 14 Dec 2018, In : Clinical Epidemiology. 10, p. 1869-1877 9 p.

Research output: Contribution to journalArticle

Open Access
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3 Citations (Scopus)
69 Downloads (Pure)

First Genome Wide Association Study of Latent Autoimmune Diabetes in Adults Reveals Novel Insights Linking Immune and Metabolic Diabetes

Cousminer, D. L., Ahlqvist, E., Mishra, R., Andersen, M. K., Chesi, A., Hawa, M. I., Davis, A., Hodge, K. M., Bradfield, J. P., Zhou, K., Guy, V. C., Åkerlund, M., Wod, M., Fritsche, L. G., Vestergaard, H., Snyder, J., Højlund, K., Linneberg, A., Käräjämäki, A., Brandslund, I. & 33 others, Kim, C. E., Witte, D. R., Sørgjerd, E. P., Brillon, D. J., Pedersen, O., Beck-Nielsen, H., Grarup, N., Pratley, R. E., Rickels, M. R., Vella, A., Ovalle, F., Melander, O., Harris, R. I., Varvel, S., Grill, V. E. R., Hakonarson, H. H., Froguel, P., Lonsdale, J. T., Mauricio, D., Schloot, N. C., Khunti, K., Greenbaum, C. J., Asvold, B. O., Yderstræde, K. B., Pearson, E., Schwartz, S., Voight, B. F., Hansen, T., Tuomi, T., Boehm, B. O., Groop, L. C., Leslie, R. D. & Grant, S. F. A., 1 Nov 2018, In : Diabetes Care. p. 2396-2403 7 p.

Research output: Contribution to journalArticle

Open Access
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26 Citations (Scopus)
152 Downloads (Pure)

Formalising recall by genotype as an efficient approach to detailed phenotyping and causal inference

Corbin, L. J., Tan, V. Y., Hughes, D. A., Wade, K., Paul, D. S., Tansey, K. E., Butcher, F., Dudbridge, F., Howson, J. M. M., Jallow, M. W., John, C., Kingston, N., Lindgren, C. M., O’Donavan, M., O'Rahilly, S., Owen, M. J., Palmer, C., Pearson, E., Scott, R. A., van Heel, D. & 11 others, Whittaker, J., Frayling, T., Tobin, M. D., Wain, L. V., Smith, G. D., Evans, D. M., Karpe, F., McCarthy, M. I., Danesh, J., Franks, P. W. & Timpson, N. J., 19 Feb 2018, In : Nature Communications. 9, 1, p. 1-11 11 p., 711.

Research output: Contribution to journalArticle

Open Access
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15 Citations (Scopus)
150 Downloads (Pure)

Genetic Variants in CPA6 and PRPF31 are Associated with Variation in Response to Metformin in Individuals with Type 2 Diabetes

Rotroff, D. M., Yee, S. W., Zhou, K., Marvel, S. W., Shah, H. S., Jack, J. R., Havener, T. M., Hedderson, M. M., Kubo, M., Herman, M. A., Gao, H., Mychaleckyi, J. C., McLeod, H. L., Doria, A., Giacomini, K. M., Pearson, E. R., Wagner, M. J., Buse, J. B., Motsinger-Reif, A. A. & MetGen Investigators and the ACCORD/ACCORDion Investigators, Jul 2018, In : Diabetes. 67, 7, p. 1428-1440 13 p.

Research output: Contribution to journalArticle

Open Access
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3 Citations (Scopus)
85 Downloads (Pure)

Integrative network analysis highlights biological processes underlying GLP-1 stimulated insulin secretion: A DIRECT study

Gudmundsdottir, V., Pedersen, H. K., Allebrandt, K. V., Brorsson, C., van Leeuwen, N., Banasik, K., Mahajan, A., Groves, C. J., van de Bunt, M., Dawed, A. Y., Fritsche, A., Staiger, H., Simonis-Bik, A. M. C., Deelen, J., Kramer, M. H. H., Dietrich, A., Hübschle, T., Willemsen, G., Häring, H-U., de Geus, E. J. C. & 8 others, Boomsma, D. I., Eekhoff, E. M. W., Ferrer, J., McCarthy, M. I., Pearson, E. R., Gupta, R., Brunak, S. & 't Hart, L. M., 2 Jan 2018, In : PLoS ONE. 13, 1, p. 1-19 19 p., e0189886.

Research output: Contribution to journalArticle

Open Access
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3 Citations (Scopus)
147 Downloads (Pure)

Lp-PLA2 activity is associated with increased risk of diabetic retinopathy: a longitudinal disease progression study

Siddiqui, M. K., Kennedy, G., Carr, F., Doney, A., Pearson, E., Morris, A., Johnson, T., McLaughlin, M. M., Williams, R. E. & Palmer, C., Jun 2018, In : Diabetologia. 61, 6, p. 1344-1353 10 p.

Research output: Contribution to journalArticle

Open Access
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6 Citations (Scopus)
175 Downloads (Pure)

Metabolite ratios as potential biomarkers for type 2 diabetes: a DIRECT study

Molnos, S., Wahl, S., Haid, M., Eekhoff, E. M. W., Pool, R., Floegel, A., Deelen, J., Much, D., Prehn, C., Breier, M., Draisma, H. H. M., van Leeuwen, N., Simonis-Bik, A. M. C., Jonsson, A., Willemsen, G., Bernigau, W., Wang-Sattler, R., Suhre, K., Peters, A., Thorand, B. & 24 others, Herder, C., Rathmann, W., Roden, M., Gieger, C., Kramer, M. H. H., van Heemst, D., Pedersen, H. K., Gudmundsdottir, V., Schulze, M. B., Pischon, T., de Geus, E. J. C., Boeing, H., Boomsma, D. I., Ziegler, A. G., Slagboom, P. E., Hummel, S., Beekman, M., Grallert, H., Brunak, S., McCarthy, M. I., Gupta, R., Pearson, E. R., Adamski, J. & 't Hart, L. M., Jan 2018, In : Diabetologia. 61, 1, p. 117-129 13 p.

Research output: Contribution to journalArticle

Open Access
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11 Citations (Scopus)
141 Downloads (Pure)

Pancreatic β-cell tRNA hypomethylation and fragmentation link TRMT10A deficiency with diabetes

Cosentino, C., Toivonen, S., Diaz Villamil, E., Atta, M., Ravanat, J-L., Demine, S., Schiavo, A. A., Pachera, N., Deglasse, J-P., Jonas, J-C., Balboa, D., Otonkoski, T., Pearson, E. R., Marchetti, P., Eizirik, D. L., Cnop, M. & Igoillo-Esteve, M., 2 Nov 2018, In : Nucleic Acids Research. 46, 19, p. 10302-10318 17 p.

Research output: Contribution to journalArticle

Open Access
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13 Citations (Scopus)
100 Downloads (Pure)

Performance of Cardiovascular Disease Risk Scores in People Diagnosed With Type 2 Diabetes: External Validation Using Data From the National Scottish Diabetes Register

Scottish Diabetes Research Network Epidemiology Group, Read, S. H., van Diepen, M., Colhoun, H. M., Halbesma, N., Lindsay, R. S., McKnight, J. A., McAllister, D. A., Pearson, E. R., Petrie, J. R., Philip, S., Sattar, N., Woodward, M. & Wild, S. H., 1 Sep 2018, In : Diabetes Care. 41, 9, p. 2010-2018 9 p.

Research output: Contribution to journalArticle

Open Access
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6 Citations (Scopus)
170 Downloads (Pure)

Pharmacogenetics and target identification in diabetes

Pearson, E. R., 1 Jun 2018, In : Current Opinion in Genetics & Development. 50, p. 68-73 6 p.

Research output: Contribution to journalReview article

Open Access
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5 Citations (Scopus)
181 Downloads (Pure)

Pharmacokinetics of metformin in patients with gastrointestinal intolerance

McCreight, L., Stage, T. B., Connelly, P., Lonergan, M., Nielsen, F., Prehn, C., Adamski, J., Brosen, K. & Pearson, E. R., 1 Jul 2018, In : Diabetes, Obesity & Metabolism. 20, 7, p. 1593-1601 9 p.

Research output: Contribution to journalArticle

Open Access
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6 Citations (Scopus)
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Precision Medicine in Type 2 Diabetes: Clinical Markers of Insulin Resistance Are Associated With Altered Short- and Long-Term Glycemic Response to DPP-4 Inhibitor Therapy

Dennis, J. M., Shields, B. M., Hill, A. V., Knight, B. A., McDonald, T. J., Rodgers, L. R., Weedon, M. N., Henley, W. E., Sattar, N., Holman, R. R., Pearson, E. R., Hattersley, A. T., Jones, A. G. & MASTERMIND consortium, Apr 2018, In : Diabetes Care. 41, 4, p. 705-712 8 p.

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23 Citations (Scopus)
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Quantitative MRI evaluation of whole abdomen adipose tissue volumes in healthy volunteers-validation of technique and implications for clinical studies

Marzetti, M., Brunton, T., McCreight, L., Pearson, E., Docherty, S. & Gandy, S. J., 17 May 2018, In : British Journal of Radiology. 91, 1087, 7 p., 20180025.

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2 Citations (Scopus)
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Sex and BMI alter the benefits and risks of sulfonylureas and thiazolidinediones in type 2 diabetes: A framework for evaluating stratification using routine clinical and individual trial data

Dennis, J. M., Henley, W. E., Weedon, M. N., Lonergan, M., Rodgers, L. R., Jones, A. G., Hamilton, W. T., Sattar, N., Janmohamed, S., Holman, R. R., Pearson, E. R., Shields, B. M. & Hattersley, A. T., 1 Sep 2018, In : Diabetes Care. 41, 9, p. 1844-1853 10 p.

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