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2019
1 Citation (Scopus)
87 Downloads (Pure)
Open Access
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Lysosphingolipid Receptors
Drug Discovery
Modulators
Skin
Pharmaceutical Preparations
1 Citation (Scopus)

Dog ownership at three months of age is associated with protection against food allergy

EAT Study Team, Marrs, T., Logan, K., Craven, J., Radulovic, S., McLean, W. H. I., Lack, G., Flohr, C. & Perkin, M. R., 8 Jul 2019, In : Allergy. 8 p.

Research output: Contribution to journalArticle

Food Hypersensitivity
Ownership
Dogs
Atopic Dermatitis
Environmental Exposure
2 Citations (Scopus)

Filaggrin gene loss-of-function mutations constitute a factor in patients with multiple contact allergies

Elhaji, Y., Sasseville, D., Pratt, M., Asai, Y., Matheson, K., McLean, W. H. I. & Hull, P., Jun 2019, In : Contact Dermatitis. 80, 6, p. 354-358 5 p.

Research output: Contribution to journalArticle

Hypersensitivity
Mutation
Genes
Patch Tests
Dermatitis
1 Citation (Scopus)

Longitudinal analysis of the effect of water hardness on atopic eczema: evidence for gene-environment interaction

Jabbar-Lopez, Z. K., Craven, J., Logan, K., Greenblatt, D., Marrs, T., Radulovic, S., McLean, W. H. I., Lack, G., Strachan, D. P., Perkin, M. R., Peacock, J. L. & Flohr, C., 10 Oct 2019, In : British Journal of Dermatology. 9 p.

Research output: Contribution to journalArticle

Gene-Environment Interaction
Hardness
Atopic Dermatitis
Water
Confidence Intervals

Male genital lichen sclerosus and filaggrin

Shim, T. N., Brown, S. J., Francis, N. D., Dinneen, M., Hawkins, D., Muneer, A., Minhas, S., McLean, W. H. I. & Bunker, C. B., 17 Jun 2019, In : Clinical and Experimental Dermatology. 2 p.

Research output: Contribution to journalLetter

Lichen Sclerosus et Atrophicus
Genitalia
Autoimmunity
Skin Diseases
Epidermis
2018
6 Citations (Scopus)
55 Downloads (Pure)

A minimally invasive tool to study immune response and skin barrier in children with atopic dermatitis

Hulshof, L., Hack, D. P., Hasnoe, Q. C. J., Dontje, B., Jakasa, I., Riethmüller, C., McLean, W. H. I., van Aalderen, W. M. C., Van't Land, B., Kezic, S., Sprikkelman, A. B. & Middelkamp-Hup, M. A., 10 Jul 2018, In : British Journal of Dermatology. 10 p.

Research output: Contribution to journalArticle

Open Access
File
Atopic Dermatitis
Skin
Biomarkers
Interleukins
Chemokine CCL8
5 Citations (Scopus)

A randomized controlled trial protocol assessing the effectiveness, safety and cost-effectiveness of methotrexate vs. ciclosporin in the treatment of severe atopic eczema in children: the TREatment of severe Atopic eczema Trial (TREAT)

Guy's and St Thomas' NHS Foundation Trust, Irvine, A. D., Jones, A. P., Beattie, P., Baron, S., Browne, F., Ashoor, F., O'Neill, L., Rosala-Hallas, A., Sach, T., Spowart, C., Taams, L., Walker, C., Wan, M., Webb, N., Williamson, P. & Flohr, C., Dec 2018, In : British Journal of Dermatology. 179, 6, p. 1297-1306 10 p.

Research output: Contribution to journalArticle

Atopic Dermatitis
Clinical Protocols
Methotrexate
Cyclosporine
Cost-Benefit Analysis
10 Citations (Scopus)
201 Downloads (Pure)

Array-based sequencing of filaggrin gene for comprehensive detection of disease-associated variants

Wong, X. F. C. C., Denil, S. L. I. J., Foo, J. N., Chen, H., Ling Tay, A. S., Haines, R. L., Tang, M. B. Y., McLean, W. H. I., Sandilands, A., Smith, F. J. D., Lane, E. B., Liu, J. & Common, J. E. A., Feb 2018, In : Journal of Allergy and Clinical Immunology. 141, 2, p. 814-816 3 p.

Research output: Contribution to journalLetter

Open Access
File
Atopic Dermatitis
Genes
Costs and Cost Analysis
Polymerase Chain Reaction
filaggrin
2 Citations (Scopus)
96 Downloads (Pure)

Clinical features and molecular genetic analysis in a Turkish family with oral white sponge nevus

Kürklü, E., Öztürk, Ş., Cassidy, A. J., Ak, G., Koray, M., Çefle, K., Palandüz, Ş., Güllüoğlu, M. G., Tanyeri, H. & McLean, W. H. I., 1 Mar 2018, In : Medicina Oral Patologia Oral y Cirugia Bucal. 23, 2, p. e144-e150 7 p., 21437.

Research output: Contribution to journalArticle

Open Access
File
Keratin-4
Nevus
Porifera
Molecular Biology
Mutation
3 Citations (Scopus)
153 Downloads (Pure)
Open Access
File
Lysosphingolipid Receptors
Modulators
Esters
Plasma (human)
Butyrylcholinesterase
9 Citations (Scopus)
69 Downloads (Pure)

Early-life regional and temporal variation in filaggrin-derived natural moisturizing factor, filaggrin-processing enzyme activity, corneocyte phenotypes and plasmin activity: Implications for atopic dermatitis

McAleer, M. A., Jaska, I., Raj, N., O'Donnell, C. P. F., Lane, M. E., Rawlings, A. V., Voegeli, R., McLean, W., Kezic, S. & Irvine, A. D., Aug 2018, In : British Journal of Dermatology. 179, 2, p. 431-441 11 p.

Research output: Contribution to journalArticle

Open Access
File
Cheek
Fibrinolysin
Atopic Dermatitis
Phenotype
Cornea
7 Citations (Scopus)
58 Downloads (Pure)

Exome Sequencing and Rare Variant Analysis Reveals Multiple Filaggrin Mutations in Bangladeshi Families with Atopic Eczema and Additional Risk Genes

Pigors, M., Common, J. E. A., Wong, X. F. C. C., Malik, S., Scott, C. A., Tabarra, N., Liany, H., Liu, J., Limviphuvadh, V., Maurer-Stroh, S., Tang, M. B., Lench, N., Margolis, D. J., van Heel, D. A., Mein, C. A., Novak, N., Baurecht, H., Weidinger, S., McLean, W. H. I., Irvine, A. D. & 3 others, O'Toole, E. A., Simpson, M. A. & Kelsell, D. P., Dec 2018, In : Journal of Investigative Dermatology. 138, 12, p. 2674-2677 4 p.

Research output: Contribution to journalLetter

Open Access
File
2 Citations (Scopus)
121 Downloads (Pure)

Filaggrin gene mutations may influence the persistence of food allergies in Japanese primary school children

Kono, M., Akiyama, M., Inoue, Y., Nomura, T., Hata, A., Okamoto, Y., Takeichi, T., Muro, Y., McLean, W. H. I., Shimizu, H., Sugiura, K., Suzuki, Y. & Shimojo, N., 19 Jul 2018, In : British Journal of Dermatology. 179, 1, p. 190-191 2 p.

Research output: Contribution to journalLetter

Open Access
File
Food Hypersensitivity
Mutation
Genes
Ichthyosis Vulgaris
Atopic Dermatitis
6 Citations (Scopus)
127 Downloads (Pure)

Gentamicin-induced readthrough and nonsense-mediated mRNA decay of SERPINB7 nonsense mutant transcripts

Ohguchi, Y., Nomura, T., Suzuki, S., Takeda, M., Miyauchi, T., Mizuno, O., Shinkuma, S., Fujita, Y., Nemoto, O., Ono, K., McLean, W. H. I. & Shimizu, H., 1 Apr 2018, In : Journal of Investigative Dermatology. 138, 4, p. 836-843 8 p.

Research output: Contribution to journalArticle

Open Access
File
Nonsense Mediated mRNA Decay
Palmoplantar Keratoderma
Gentamicins
Messenger RNA
Compassionate Use Trials
5 Citations (Scopus)
92 Downloads (Pure)

Lysosomal protease deficiency or substrate overload induces an oxidative-stress mediated STAT3-dependent pathway of lysosomal homeostasis

Martinez-Fabregas, J., Prescott, A., van Kasteren, S., Leslie Pedrioli, D., McLean, W., Moles, A., Reinheckel, T., Poli, V. & Watts, C., 17 Dec 2018, In : Nature Communications. 9, 1, p. 1-16 16 p., 5343.

Research output: Contribution to journalArticle

Open Access
File
homeostasis
protease
Oxidative stress
Endopeptidases
Oxidative Stress
13 Citations (Scopus)
120 Downloads (Pure)

Mutations involving the SRY-related gene SOX8 are associated with a spectrum of human reproductive anomalies.

Portnoi, M-F., Dumargne, M-C., Rojo, S., Witchel, S. F., Duncan, A. J., Eozenou, C., Bignon-Topalovic, J., Yatsenko, S. A., Rajkovic, A., Reyes-Mugica, M., Almstrup, K., Fusee, L., Srivastava, Y., Chantot-Bastaraud, S., Hyon, C., Louis-Sylvestre, C., Validire, P., de Malleray Pichard, C., Ravel, C., Christin-Maitre, S. & 18 others, Brauner, R., Rossetti, R., Persani, L., Charreau, E. H., Dain, L., Chiauzzi, V. A., Mazen, I., Rouba, H., Schluth-Bolard, C., MacGowan, S., McLean, W. H. I., Patin, E., Rajpert-De Meyts, E., Jauch, R., Achermann, J. C., Siffroi, J-P., McElreavey, K. & Bashamboo, A., 1 Apr 2018, In : Human Molecular Genetics. 27, 7, p. 1228-1240 13 p.

Research output: Contribution to journalArticle

Open Access
File
Sexual Development
Mutation
Genes
Primary Ovarian Insufficiency
Male Infertility
1 Citation (Scopus)
114 Downloads (Pure)

Patients with atopic dermatitis with filaggrin loss-of-function mutations show good but lower responses to immunosuppressive treatment

Roekevisch, E., Leeflang, M. M. G., Schram, M. E., Campbell, L. E., Irwin McLean, W. H., Kezic, S., Bos, J. D., Spuls, P. I. & Middelkamp-Hup, M. A., 8 Jan 2018, In : British Journal of Dermatology. 177, 6, p. 1745-1746 2 p.

Research output: Contribution to journalLetter

Open Access
File
Atopic Dermatitis
Immunosuppressive Agents
Mutation
Randomized Controlled Trials
Therapeutics
9 Citations (Scopus)
110 Downloads (Pure)

Systemic and stratum corneum biomarkers of severity in infant atopic dermatitis include markers of innate and T helper cell-related immunity and angiogenesis

McAleer, M. A., Jakasa, I., Hurault, G., Sarvari, P., McLean, W., Tanaka, R. J., Kezic, S. & Irvine, A. D., 22 Aug 2018, In : British Journal of Dermatology. 11 p.

Research output: Contribution to journalArticle

Open Access
File
Atopic Dermatitis
Helper-Inducer T-Lymphocytes
Cornea
Immunity
Biomarkers
2017
17 Citations (Scopus)
144 Downloads (Pure)

Biallelic mutations in KDSR disrupt ceramide synthesis and result in a spectrum of keratinization disorders associated with thrombocytopenia

Takeichi, T., Torrelo, A., Lee, J. Y. W., Ohno, Y., Lozano, M. L., Kihara, A., Liu, L., Yasuda, Y., Ishikawa, J., Murase, T., Rodrigo, A. B., Fernández-Crehuet, P., Toi, Y., Mellerio, J. E., Rivera, J., Vicente, V., Kelsell, D. P., Nishimura, Y., Okuno, Y., Kojima, D. & 6 others, Ogawa, Y., Sugiura, K., Simpson, M. A., McLean, W. H. I., Akiyama, M. & McGrath, J. A., Nov 2017, In : Journal of Investigative Dermatology. 137, 11, p. 2344-2353 10 p.

Research output: Contribution to journalArticle

Open Access
File
Ceramides
Thrombocytopenia
Skin
Mutation
Biosynthesis
5 Citations (Scopus)
124 Downloads (Pure)

Calpain 12 function revealed through the study of an atypical case of autosomal recessive congenital ichthyosis

Bochner, R., Samuelov, L., Sarig, O., Li, Q., Adase, C. A., Isakov, O., Malchin, N., Vodo, D., Shayevitch, R., Peled, A., Yu, B. D., Fainberg, G., Warshauer, E., Adir, N., Erez, N., Gat, A., Gottlieb, Y., Rogers, T., Pavlovsky, M., Goldberg, I. & 9 others, Shomron, N., Sandilands, A., Campbell, L. E., MacCallum, S., McLean, W. H. I., Ast, G., Gallo, R. L., Uitto, J. & Sprecher, E., Feb 2017, In : Journal of Investigative Dermatology. 137, 2, p. 385-393 9 p.

Research output: Contribution to journalArticle

Open Access
File
Ichthyosis
Calpain
Skin
Hair Follicle
Exfoliative Dermatitis
29 Citations (Scopus)
107 Downloads (Pure)

Clumping factor B promotes adherence of Staphylococcus aureus to corneocytes in atopic dermatitis

Fleury, O. M., McAleer, M. A., Feuillie, C., Formosa-Dague, C., Sansevere, E., Bennett, D. E., Towell, A. M., McLean, W. H. I., Kezic, S., Robinson, D. A., Fallon, P. G., Foster, T. J., Dufrêne, Y. F., Irvine, A. D. & Geoghegan, J. A., Jun 2017, In : Infection and Immunity. 85, 6, p. 1-12 12 p., e00994-16.

Research output: Contribution to journalArticle

Open Access
File
Atopic Dermatitis
Staphylococcus aureus
Skin
Ligands
Bacterial Adhesion
1 Citation (Scopus)
113 Downloads (Pure)

Keratin 6b variant p.Gly499Ser reported in delayed-onset pachyonychia congenita is a non-pathogenic polymorphism

Smith, F. J. D. & McLean, W. H. I., 3 Dec 2017, In : Journal of Dermatology. 44, 12, p. e312 1 p.

Research output: Contribution to journalLetter

Open Access
File
11 Citations (Scopus)
102 Downloads (Pure)

Large Intragenic Deletion in DSTYK Underlies Autosomal-Recessive Complicated Spastic Paraparesis, SPG23

Lee, J. Y. W., Hsu, C-K., Michael, M., Nanda, A., Liu, L., McMillan, J. R., Pourreyron, C., Takeichi, T., Tolar, J., Reid, E., Hayday, T., Blumen, S. C., Abu-Mouch, S., Straussberg, R., Basel-Vanagaite, L., Barhum, Y., Zouabi, Y., Al-Ajmi, H., Huang, H-Y., Lin, T-C. & 6 others, Akiyama, M., Lee, J. Y. Y., McLean, W. H. I., Simpson, M. A., Parsons, M. & McGrath, J. A., 2 Feb 2017, In : American Journal of Human Genetics. 100, 2, p. 364-370 7 p.

Research output: Contribution to journalArticle

Open Access
File
Spastic Paraparesis
Protein-Serine-Threonine Kinases
Protein-Tyrosine Kinases
Pedigree
Keratinocytes
7 Citations (Scopus)
75 Downloads (Pure)

Mutations in POGLUT1 in Galli-Galli/Dowling Degos-disease

Wilson, N. J., Cole, C., Kroboth, K., Hunter, W. N., Mann, J. A., Irwin McLean, W. H., Kernland Lang, K., Beltraminelli, H., Sabroe, R. A., Tiffin, N., Sobey, G. J., Borradori, L., Simpson, E. & Smith, F. J. D., Jan 2017, In : British Journal of Dermatology. 176, 1, p. 270-274 5 p.

Research output: Contribution to journalLetter

Open Access
File
Glucosyltransferases
Genetic Databases
Mutation
Proteins
Keratin-5
99 Citations (Scopus)
107 Downloads (Pure)

Skin microbiome prior to development of atopic dermatitis: early colonization with commensal staphylococci at 2 months is associated with a lower risk of atopic dermatitis at 1 year

Kennedy, E. A., Connolly, J., O.'B. Hourihane, J., Fallon, P. G., McLean, W. H. I., Murray, D., Jo, J-H., Segre, J. A., Kong, H. H. & Irvine, A. D., Jan 2017, In : Journal of Allergy and Clinical Immunology. 139, 1, p. 1-7 7 p., 166-172.

Research output: Contribution to journalArticle

Open Access
File
Microbiota
Atopic Dermatitis
Staphylococcus
Skin
Staphylococcus aureus
2016
22 Citations (Scopus)

Association between domestic water hardness, chlorine, and atopic dermatitis risk in early life: A population-based cross-sectional study

Perkin, M. R., Craven, J., Logan, K., Strachan, D., Marrs, T., Radulovic, S., Campbell, L. E., MacCallum, S. F., McLean, W. H. I., Lack, G. & Flohr, C., Aug 2016, In : Journal of Allergy and Clinical Immunology. 138, 2, p. 509-516 8 p.

Research output: Contribution to journalArticle

Chlorine
Hardness
Atopic Dermatitis
Cross-Sectional Studies
Water
7 Citations (Scopus)

Compound heterozygotes for filaggrin gene mutations do not always show severe atopic dermatitis

Sekiya, A., Kono, M., Tsujiuchi, H., Kobayashi, T., Nomura, T., Kitakawa, M., Suzuki, N., Yamanaka, K., Sueki, H., McLean, W. H. I., Shimizu, H. & Akiyama, M., 20 Dec 2016, In : Journal of the European Academy of Dermatology and Venereology. 31, 1, p. 158-162 5 p.

Research output: Contribution to journalArticle

Open Access
Ichthyosis Vulgaris
Atopic Dermatitis
Heterozygote
Mutation
Genes
44 Citations (Scopus)
109 Downloads (Pure)

CRISPR/Cas9 DNA cleavage at SNP-derived PAM enables both in vitro and in vivo KRT12 mutation-specific targeting

Courtney, D. G., Moore, J. E., Atkinson, S. D., Maurizi, E., Allen, E. H. A., Leslie Pedrioli, D. M. L., Mclean, W. H. I., Nesbit, M. A. & Moore, C. B. T., 2016, In : Gene Therapy. 23, 1, p. 108-112

Research output: Contribution to journalArticle

Open Access
File
Clustered Regularly Interspaced Short Palindromic Repeats
Guide RNA
DNA Cleavage
Single Nucleotide Polymorphism
Mutation
25 Citations (Scopus)
154 Downloads (Pure)

Filaggrin failure - from ichthyosis vulgaris to atopic eczema and beyond

McLean, W., 26 Sep 2016, In : British Journal of Dermatology. 175, 52, p. 4-7 4 p.

Research output: Contribution to journalReview article

Open Access
File
Ichthyosis Vulgaris
Atopic Dermatitis
Cornea
Polyproteins
Mutation
6 Citations (Scopus)
86 Downloads (Pure)

Filaggrin genotype does not determine the skin's threshold to UV-induced erythema

Forbes, D., Johnston, L., Gardner, J., MacCallum, S. F., Campbell, L. E., Dinkova-Kostova, A. T., McLean, W. H. I., Ibbotson, S. H., Dawe, R. S. & Brown, S. J., Apr 2016, In : Journal of Allergy and Clinical Immunology. 137, 4, p. 1280-1282.e3 6 p.

Research output: Contribution to journalLetter

Open Access
File
11 Citations (Scopus)
110 Downloads (Pure)

Filaggrin-null mutations are associated with increased maturation markers on Langerhans cells

Leitch, C. S., Natafji, E., Yu, C., Abdul-Ghaffar, S., Madarasingha, N., Venables, Z. C., Chu, R., Fitch, P. M., Muinonen-Martin, A. J., Campbell, L. E., McLean, W. H. I., Schwarze, J., Howie, S. E. M. & Weller, R. B., Aug 2016, In : Journal of Allergy and Clinical Immunology. 138, 2, p. 482-490.e7 16 p.

Research output: Contribution to journalArticle

Open Access
File
Langerhans Cells
Urocanic Acid
Mutation
NSC 153174
Dendritic Cells
3 Citations (Scopus)
111 Downloads (Pure)

Keratin 12 missense mutation induces the unfolded protein response and apoptosis in meesmann epithelial corneal dystrophy

Allen, E. H. A., Courtney, D. G., Atkinson, S. D., Moore, J. E., Mairs, L., Poulsen, E. T., Schiroli, D., Maurizi, E., Cole, C., Hickerson, R. P., James, J., Murgatroyd, H., Smith, F. J. D., MacEwen, C., Enghild, J. J., Nesbit, M. A., Leslie Pedrioli, D. M., McLean, W. H. I. & Moore, C. B. T., 15 Mar 2016, In : Human Molecular Genetics. 25, 6, p. 1176-1191 16 p., ddw001.

Research output: Contribution to journalArticle

Open Access
File
Juvenile Epithelial of Meesmann Corneal Dystrophy
Keratin-12
Unfolded Protein Response
Missense Mutation
Apoptosis
85 Citations (Scopus)

Skin barrier impairment at birth predicts food allergy at 2 years of age

Kelleher, M. M., Dunn-Galvin, A., Gray, C., Murray, D. M., Kiely, M., Kenny, L., McLean, W. H. I., Irvine, A. D. & Hourihane, J. OB., Apr 2016, In : Journal of Allergy and Clinical Immunology. 137, 4, p. 1111-1116.e1-8 14 p.

Research output: Contribution to journalArticle

Food Hypersensitivity
Parturition
Skin
Food
Water
3 Citations (Scopus)

Too much, too little or just enough: a Goldilocks effect for IL-13 and skin barrier regulation?

Strid, J., McLean, W. H. I. & Irvine, A. D., Mar 2016, In : Journal of Investigative Dermatology. 136, 3, p. 561-564 4 p.

Research output: Contribution to journalComment/debate

Interleukin-13
Interleukin-4
Skin
Keratinocytes
Homeostasis