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2020
12 Downloads (Pure)

A conserved ATG2-GABARAP family interaction is critical for phagophore formation

Bozic, M., van den Bekerom, L., Milne, B. A., Goodman, N., Roberston, L., Prescott, A., Macartney, T., Dawe, N. & McEwan, D., 3 Feb 2020, In : EMBO Reports. p. 1-17 17 p., e48412.

Research output: Contribution to journalArticle

Open Access
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Autophagy
Elongation
Seals
Recycling
Proteins
2019
2 Citations (Scopus)
111 Downloads (Pure)

A comparative map of macroautophagy and mitophagy in the vertebrate eye

McWilliams, T. G., Prescott, A., Villarejo-Zori, B., Ball, G., Boya, P. & Ganley, I., 1 Jul 2019, In : Autophagy. 15, 7, p. 1296-1308 13 p.

Research output: Contribution to journalArticle

Open Access
File
Mitochondrial Degradation
Autophagy
Vertebrates
Retina
Homeostasis
1 Citation (Scopus)

EMSY expression affects multiple components of the skin barrier with relevance to atopic dermatitis

Elias, M. S., Wright, S. C., Remenyi, J., Abbott, J. C., Bray, S. E., Cole, C., Edwards, S., Gierlinski, M., Glok, M., McGrath, J. A., Nicholson, W. V., Paternoster, L., Prescott, A. R., Have, S. T., Whitfield, P. D., Lamond, A. I. & Brown, S. J., Aug 2019, In : Journal of Allergy and Clinical Immunology. 144, 2, p. 470-481 12 p.

Research output: Contribution to journalArticle

Open Access
Atopic Dermatitis
Skin
Genome-Wide Association Study
Keratinocytes
Skin Diseases
2 Citations (Scopus)
61 Downloads (Pure)

FAM83D directs protein kinase CK1α to the mitotic spindle for proper spindle positioning

Fulcher, L. J., He, Z., Mei, L., Macartney, T. J., Wood, N. T., Prescott, A. R., Whigham, A., Varghese, J., Gourlay, R., Ball, G., Clarke, R., Campbell, D., Maxwell, C. A. & Sapkota, G. P., 24 Jul 2019, In : EMBO Reports. p. 1-19 19 p., e47495.

Research output: Contribution to journalArticle

Open Access
File
Casein Kinase I
Spindle Apparatus
Phosphotransferases
Cells
Mitosis
26 Downloads (Pure)
Open Access
File
Organoids
Proteomics
Skin
Keratinocytes
Caspase 14
33 Downloads (Pure)

Phosphoproteomics reveals that the hVPS34 regulated SGK3 kinase specifically phosphorylates endosomal proteins including Syntaxin-7, Syntaxin-12, RFIP4 and WDR44

Malik, N., Nirujogi, R. S., Peltier, J., Macartney, T., Wightman, M., Prescott, A., Gourlay, R., Trost, M., Alessi, D. & Karapetsas, A., 30 Oct 2019, In : Biochemical Journal. 476, 20, p. 3081-3107 27 p.

Research output: Contribution to journalArticle

Open Access
File
Qa-SNARE Proteins
Phosphorylation
Phosphotransferases
SNARE Proteins
Substrates
39 Downloads (Pure)
Open Access
File
Organoids
Crosstalk
Keratinocytes
Proteomics
Skin
4 Citations (Scopus)
129 Downloads (Pure)

Rapid and reversible knockdown of endogenously tagged endosomal proteins via an optimized HaloPROTAC degrader

Tovell, H., Testa, A., Maniaci, C., Zhou, H., Prescott, A., Macartney, T., Ciulli, A. & Alessi, D., 17 May 2019, In : ACS Chemical Biology. 14, 5, p. 882-892 11 p.

Research output: Contribution to journalArticle

Open Access
File
Degradation
Clustered Regularly Interspaced Short Palindromic Repeats
Proteins
Ubiquitination
Phosphorylation
2 Citations (Scopus)
148 Downloads (Pure)

Triggering MSR1 promotes JNK-mediated inflammation in IL-4 activated macrophages

Guo, M., Härtlova, A., Gierlinski, M., Prescott, A., Castellvi, J., Hernandez Losa, J., Petersen, S. K., Wenzel, U. A., Dill, B. D., Emmerich, C. H., Ramon Y Cajal, S., Russell, D. G. & Trost, M., 3 Jun 2019, In : EMBO Journal. 38, 11, p. 1-15 15 p., e100299.

Research output: Contribution to journalArticle

Open Access
File
Scavenger Receptors
Macrophages
Interleukin-4
Inflammation
Chemical activation
2018
98 Citations (Scopus)
150 Downloads (Pure)

Basal Mitophagy Occurs Independently of PINK1 in Mouse Tissues of High Metabolic Demand

McWilliams, T. G., Prescott, A. R., Montava-Garriga, L., Ball, G., Singh, F., Barini, E., Muqit, M. M. K., Brooks, S. P. & Ganley, I. G., 6 Feb 2018, In : Cell Metabolism. 27, 2, p. 439-449.e5 17 p.

Research output: Contribution to journalArticle

Open Access
File
Mitochondrial Degradation
Parkinson Disease
Dopaminergic Neurons
Microglia
Islets of Langerhans
6 Citations (Scopus)
93 Downloads (Pure)

Lysosomal protease deficiency or substrate overload induces an oxidative-stress mediated STAT3-dependent pathway of lysosomal homeostasis

Martinez-Fabregas, J., Prescott, A., van Kasteren, S., Leslie Pedrioli, D., McLean, W., Moles, A., Reinheckel, T., Poli, V. & Watts, C., 17 Dec 2018, In : Nature Communications. 9, 1, p. 1-16 16 p., 5343.

Research output: Contribution to journalArticle

Open Access
File
homeostasis
protease
Oxidative stress
Endopeptidases
Oxidative Stress
8 Citations (Scopus)
211 Downloads (Pure)

Mechanism of activation of SGK3 by growth factors-via the Class 1 and Class 3 PI3Ks

Malik, N., Macartney, T., Hornberger, A., Anderson, K., Tovell, H., Prescott, A. R. & Alessi, D. R., 2 Jan 2018, In : Biochemical Journal. 475, 1, p. 117-135 19 p.

Research output: Contribution to journalArticle

Open Access
File
Phosphatidylinositol 3-Kinases
Intercellular Signaling Peptides and Proteins
Chemical activation
Phosphatidylinositols
Phosphotransferases
11 Citations (Scopus)
126 Downloads (Pure)

PAWS1controls cytoskeletal dynamics and cell migration through association with the SH3 adaptor CD2AP

Cummins, T. D., Wu, K. Z. L., Bozatzi, P., Dingwell, K. S., Macartney, T. J., Wood, N. T., Varghese, J., Gourlay, R., Campbell, D. G., Prescott, A., Griffis, E., Smith, J. C. & Sapkota, G. P., 10 Jan 2018, In : Journal of Cell Science. 131, 1, p. 1-12 12 p., jcs202390.

Research output: Contribution to journalArticle

Open Access
File
Cell Movement
Actins
Clustered Regularly Interspaced Short Palindromic Repeats
Focal Adhesions
Osteosarcoma
12 Citations (Scopus)
98 Downloads (Pure)

Phosphorylation of Parkin at Serine65 is essential for its activation in vivo

McWilliams, T. G., Barini, E., Pohjolan-Pirhonen, R., Brooks, S. P., Singh, F., Burel, S., Balk, K., Kumar, A., Montava Garriga, L., Prescott, A., Hassoun, S. M., Mouton-Liger, F., Ball, G., Hills, R., Knebel, A., Ulusoy, A., Di Monte, D. A., Tamjar, J., Antico, O., Fears, K. & 11 others, Smith, L., Brambilla, R., Palin, E., Valori, M., Eerola-Rautio, J., Tienari, P., Corti, O., Dunnett, S. B., Ganley, I., Suomalainen, A. & Muqit, M., 7 Nov 2018, In : Open Biology. 8, 11, p. 1-18 18 p., 181108.

Research output: Contribution to journalArticle

Open Access
File
Phosphorylation
serine
Serine
phosphorylation
Chemical activation
2017
16 Citations (Scopus)
379 Downloads (Pure)

Bifunctionality of a biofilm matrix protein controlled by redox state

Arnaouteli, S., Ferreira, A. S., Schor, M., Morris, R. J., Bromley, K. M., Jo, J., Cortez, K. L., Sukhodub, T., Prescott, A. R., Dietrich, L. E. P., MacPhee, C. E. & Stanley-Wall, N. R., 25 Jul 2017, In : Proceedings of the National Academy of Sciences. 114, 30, p. E6184-E6191 8 p.

Research output: Contribution to journalArticle

Open Access
File
Biofilms
Oxidation-Reduction
Dimerization
Proteins
Gram-Positive Bacteria
4 Citations (Scopus)
147 Downloads (Pure)
Open Access
File
Regulator Genes
Protein Isoforms
Genes
Specifications
Pluripotent Stem Cells
2 Citations (Scopus)
141 Downloads (Pure)

Rab-GTPase binding effector protein 2 (RABEP2) is a primed substrate for Glycogen Synthase kinase-3 (GSK3)

Logie, L., Van Aalten, L., Knebel, A., Force, T., Hastie, C. J., MacLauchlan, H., Campbell, D. G., Gourlay, R., Prescott, A., Davidson, J., Fuller, W. & Sutherland, C., 15 Dec 2017, In : Scientific Reports. 7, p. 1-14 14 p., 17682.

Research output: Contribution to journalArticle

Open Access
File
rab GTP-Binding Proteins
Glycogen Synthase Kinase 3
Carrier Proteins
Phosphorylation
rab5 GTP-Binding Proteins
2016
5 Citations (Scopus)
108 Downloads (Pure)

Deep intronic sequence variants in COL2A1 affect the alternative splicing efficiency of Exon 2, and may confer a risk for rhegmatogenous retinal detachment

Spickett, C., Hysi, P., Hammond, C. J., Prescott, A., Fincham, G. S., Poulson, A. V., McNinch, A. M., Richards, A. J. & Snead, M. P., 21 Aug 2016, In : Human Mutation. 37, 10, p. 1085-1096 12 p.

Research output: Contribution to journalArticle

Open Access
File
Alternative Splicing
Retinal Detachment
Exons
Vitreous Detachment
Alleles
97 Citations (Scopus)
232 Downloads (Pure)

mito-QC illuminates mitophagy and mitochondrial architecture in vivo

McWilliams, T., Prescott, A., Allen, G., Tamjar, J., Munson, M., Thomson, C., Muqit, M. & Ganley, I., 25 Jul 2016, In : Journal of Cell Biology. 214, 3, p. 333-345 13 p.

Research output: Contribution to journalArticle

Open Access
File
Mitochondrial Degradation
Quality Control
Translational Medical Research
Confocal Microscopy
Transgenic Mice
5 Citations (Scopus)
107 Downloads (Pure)

The E3 ubiquitin ligase ZNRF2 is a substrate of mTORC1 and regulates its activation by amino acids

Hoxhaj, G., Caddye, E., Najafov, A., Houde, V. P., Johnson, C., Dissanayake, K., Toth, R., Campbell, D. G., Prescott, A. R. & MacKintosh, C., 22 Apr 2016, In : eLife. 5, p. 1-18 18 p., e12278.

Research output: Contribution to journalArticle

Open Access
File
Aminoacylation
Ubiquitin-Protein Ligases
Vacuolar Proton-Translocating ATPases
Chemical activation
Amino Acids