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2019
11 Downloads (Pure)

Early-life stress influences acute and sensitized responses of adult mice to cocaine by interacting with GABAA α2 receptor expression

Dixon, C. I., Walker, S. E., Swinny, J., Belelli, D., Lambert, J. J., King, S. L. & Stephens, D. N., Apr 2019, In : Behavioural Pharmacology. 30, 2-3, p. 272-281 10 p.

Research output: Contribution to journalArticle

Open Access
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GABA-A Receptors
Cocaine
Psychological Stress
Genotype
Cocaine-Related Disorders
27 Downloads (Pure)

Realising the therapeutic potential of neuroactive steroid modulators of the GABAA receptor

Belelli, D., Hogenkamp, D., Gee, K. W. & Lambert, J. J., 23 Dec 2019, In : Neurobiology of Stress. 12, p. 1-11 11 p., 100207.

Research output: Contribution to journalArticle

Open Access
File
GABA-A Receptors
Modulators
Neurotransmitter Agents
Steroids
Hypnotics and Sedatives
2018
3 Citations (Scopus)
107 Downloads (Pure)

An isotope dilution based-targeted and non-targeted carbonyl neurosteroid/steroid profiling

Sharp, S., Mitchell, S., Vallée, M., Kuzmanova, E., Cooper, M., Belelli, D., Lambert, J. & Huang, J., 17 Apr 2018, In : Analytical Chemistry. 90, 8, p. 5247-5255 9 p.

Research output: Contribution to journalArticle

Open Access
File
Isotopes
Dilution
Neurotransmitter Agents
Steroids
Brain
2 Citations (Scopus)
120 Downloads (Pure)

Early-life adversity selectively impairs α2-GABAA receptor expression in the mouse nucleus accumbens and influences the behavioral effects of cocaine

Mitchell, S. J., Maguire, E. P., Cunningham, L., Gunn, B. G., Linke, M., Zechner, U., Dixon, C. I., King, S. L., Stephens, D. N., Swinny, J. D., Belelli, D. & Lambert, J. J., Oct 2018, In : Neuropharmacology. 141, p. 98-112 15 p.

Research output: Contribution to journalArticle

Open Access
File
Nucleus Accumbens
GABA-A Receptors
Cocaine
Haplotypes
Cocaine-Related Disorders
5 Citations (Scopus)
119 Downloads (Pure)

Endogenous neurosteroids influence synaptic GABAA receptors during post-natal development

Belelli, D., Brown, A. R., Mitchell, S. J., Gunn, B. G., Herd, M. B., Phillips, G. D., Seifi, M., Swinny, J. D. & Lambert, J. J., 18 Feb 2018, In : Journal of Neuroendocrinology. 30, 2, p. 11-15 5 p., e12537.

Research output: Contribution to journalReview article

Open Access
File
Neurotransmitter Receptor
GABA-A Receptors
Neurotransmitter Agents
Synaptic Transmission
gamma-Aminobutyric Acid
10 Citations (Scopus)
106 Downloads (Pure)

Metformin reverses early cortical network dysfunction and behavior changes in Huntington's disease

Arnoux, I., Willam, M., Griesche, N., Krummeich, J., Watari, H., Offermann, N., Weber, S., Narayan Dey, P., Chen, C., Monteiro, O., Buettner, S., Meyer, K., Bano, D., Radyushkin, K., Langston, R., Lambert, J. J., Wanker, E., Methner, A., Krauss, S., Schweiger, S. & 1 others, Stroh, A., 4 Sep 2018, In : eLife. 7, p. 1-32 32 p., e38744.

Research output: Contribution to journalArticle

Open Access
File
Metformin
Huntington Disease
Animal Behavior
Aberrations
Visual Cortex
144 Downloads (Pure)

Pharmacological disruption of the MID1/α4 interaction reduces mutant Huntingtin levels in primary neuronal cultures

Monteiro, O., Chen, C., Bingham, R., Argyrou, A., Buxton, R., Jönsson, C. P., Jones, E., Bridges, A., Gatfield, K., Krauß, S., Lambert, J., Langston, R., Schweiger, S. & Uings, I., 23 Apr 2018, In : Neuroscience Letters. 673, p. 44-50 7 p.

Research output: Contribution to journalArticle

Open Access
File
Huntington Disease
Pharmacology
Peptides
Human Immunodeficiency Virus Proteins
S 6
2017
10 Citations (Scopus)
118 Downloads (Pure)

Behavioural pharmacology of the α5-GABAA receptor antagonist S44819: Enhancement and remediation of cognitive performance in preclinical models

Gacsályi, I., Móricz, K., Gigler, G., Wellmann, J., Nagy, K., Ling, I., Barkóczy, J., Haller, J., Lambert, J. J., Szénási, G., Spedding, M. & Antoni, F. A., Oct 2017, In : Neuropharmacology. 125, p. 30-38 9 p.

Research output: Contribution to journalArticle

Open Access
File
GABA-A Receptor Antagonists
Pharmacology
Anti-Anxiety Agents
Antidepressive Agents
Fear
23 Citations (Scopus)
133 Downloads (Pure)

GABAA receptor subtype involvement in addictive behaviour

Stephens, D. N., King, S. L., Lambert, J. J., Belelli, D. & Duka, T., Jan 2017, In : Genes, Brain and Behavior. 16, 1, p. 149-184 36 p.

Research output: Contribution to journalReview article

Open Access
File
Addictive Behavior
GABA-A Receptors
Protein Isoforms
Neurotransmitter Receptor
Brain
5 Citations (Scopus)
126 Downloads (Pure)
Open Access
File
Ventral Tegmental Area
mu Opioid Receptor
Morphine
Inhibitory Postsynaptic Potentials
Neurons
16 Citations (Scopus)
107 Downloads (Pure)

Nestorone® as a Novel Progestin for Nonoral Contraception: Structure-Activity Relationships and Brain Metabolism Studies

Kumar, N., Fagart, J., Liere, P., Mitchell, S. J., Knibb, A. R., Petit-Topin, I., Rame, M., El-Etr, M., Schumacher, M., Lambert, J. J., Rafestin-Oblin, M-E. & Sitruk-Ware, R., 1 Jan 2017, In : Endocrinology. 158, 1, p. 170-182 12 p.

Research output: Contribution to journalArticle

Open Access
File
Progestins
Structure-Activity Relationship
Contraception
Brain
GABA-A Receptors
8 Citations (Scopus)
75 Downloads (Pure)

Role of GABAA receptor subtypes in the behavioural effects of intravenous general anaesthetics

Weir, C. J., Mitchell, S. J. & Lambert, J. J., Dec 2017, In : British Journal of Anaesthesia. 119, Suppl. 1, p. i167-i175 9 p.

Research output: Contribution to journalArticle

Open Access
File
Intravenous Anesthetics
General Anesthetics
GABA-A Receptors
Anesthetics
Central Nervous System
14 Citations (Scopus)
100 Downloads (Pure)

Selective inhibition of extra-synaptic α5-GABAA receptors by S44819, a new therapeutic agent

Etherington, L-A., Mihalik, B., Pálvölgyi, A., Ling, I., Pallagi, K., Kertész, S., Varga, P., Gunn, B. G., Brown, A. R., Livesey, M. R., Monteiro, O., Belelli, D., Barkóczy, J., Spedding, M., Gacsályi, I., Antoni, F. A. & Lambert, J. J., Oct 2017, In : Neuropharmacology. 125, p. 353-364 12 p.

Research output: Contribution to journalArticle

Open Access
File
GABA-A Receptors
Benzodiazepines
gamma-Aminobutyric Acid
Therapeutics
Central Nervous System
2016
7 Citations (Scopus)
103 Downloads (Pure)

During postnatal development endogenous neurosteroids influence GABA-ergic neurotransmission of mouse cortical neurons

Brown, A. R., Mitchell, S., Peden, D. R., Herd, M. B., Seifi, M., Swinny, J. D., Belelli, D. & Lambert, J., Apr 2016, In : Neuropharmacology. 103, p. 163-173 11 p.

Research output: Contribution to journalArticle

Open Access
File
Synaptic Transmission
gamma-Aminobutyric Acid
Neurotransmitter Agents
Neurons
Pyramidal Cells