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2020
28 Downloads (Pure)

Setting our sights on infectious diseases

De Rycker, M., Horn, D., Aldridge, B., Amewu, R. K., Barry, C. E., Buckner, F. S., Cook, S., Ferguson, M. A. J., Gobeau, N., Herrmann, J., Herrling, P., Hope, W., Keiser, J., Lafuente-Monasterio, M. J., Leeson, P. D., Leroy, D., Manjunatha, U. H., McCarthy, J., Miles, T. J., Mizrahi, V. & 17 others, Moshynets, O., Niles, J., Overington, J. P., Pottage, J., Rao, S. P. S., Read, K. D., Ribeiro, I., Silver, L. L., Southern, J., Spangenberg, T., Sundar, S., Taylor, C., Van Voorhis, W. C., White, N. J., Wyllie, S., Wyatt, P. G. & Gilbert, I. H., 10 Jan 2020, In : ACS Infectious Diseases. 6, p. 3-13 11 p.

Research output: Contribution to journalArticle

Open Access
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Drug Discovery
Communicable Diseases
Infectious Disease Medicine
Pharmacokinetics
Learning
2019
89 Downloads (Pure)

Organizational innovation for developing new medicines that target aging and age-related conditions

Ford, G. A., Lord, J. M., Ferguson, M. A. J., Bountra, C. & Le Couteur, D. G., 6 Mar 2019, In : The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. p. 1-4 4 p., glz062.

Research output: Contribution to journalEditorial

Open Access
File
2 Citations (Scopus)
133 Downloads (Pure)
Open Access
File
Leishmania donovani
Pharmacology
Parasites
Enzymes
Pharmaceutical Preparations
7 Citations (Scopus)
97 Downloads (Pure)

Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition

Wyllie, S., Brand, S., Thomas, M., De Rycker, M., Chung, C-W., Peña, I., Bingham, R., Bueren-Calabuig, J., Cantizani, J., Cebrian, D., Craggs, P. D., Ferguson, L., Goswami, P., Hobrath, J., Howe, J., Jeacock, L., Ko, E. J., Korczynska, J., MacLean, L., Manthri, S. & 29 others, Santos Martinez, M., Mata-Cantero, L., Moniz, S., Nuhs, A., Osuna-Cabello, M., Pinto, E., Riley, J., Robinson, S., Rowland, P., Simeons, F., Shishikura, Y., Spinks, D., Stojanovski, L., Thomas, J., Thompson, S., Viayna Gaza, E., Wall, R., Zuccotto, F., Horn, D., Ferguson, M., Fairlamb, A., Fiandor, J. M., Martín, J., Gray, D., Miles, T. J., Gilbert, I., Read, K., Marco, M. & Wyatt, P., 7 May 2019, In : Proceedings of the National Academy of Sciences. 116, 19, p. 9318-9323 6 p., 201820175.

Research output: Contribution to journalArticle

Open Access
File
Leishmania infantum
Visceral Leishmaniasis
Proteasome Endopeptidase Complex
Leishmania donovani
Parasites
1 Citation (Scopus)
38 Downloads (Pure)
Open Access
File
Trypanosoma brucei brucei
Proteome
Proteomics
Proteins
African Trypanosomiasis
1 Citation (Scopus)
85 Downloads (Pure)

Reprogramming of Trypanosoma cruzi metabolism triggered by parasite interaction with the host cell extracellular matrix

Mattos, E. C., Canuto, G., Varón, N. C. M., Magalhães, R. D. M., Crozier, T. W. M., Lamont, D. J., Tavares, M. F. M., Colli, W., Ferguson, M. A. J. & Alves, M. J. M., 6 Feb 2019, In : PLoS Neglected Tropical Diseases. 13, 2, p. 1-27 27 p., e0007103.

Research output: Contribution to journalArticle

Open Access
File
Host-Parasite Interactions
Trypanosoma cruzi
Extracellular Matrix
Phosphorylation
Parasites
51 Downloads (Pure)

Trypanosoma cruzi phosphomannomutase and guanosine diphosphate-mannose pyrophosphorylase ligandability assessment

Zmuda, F., Shepherd, S. M., Ferguson, M. A. J., Gray, D. W., Torrie, L. S. & De Rycker, M., Oct 2019, In : Antimicrobial Agents and Chemotherapy. 63, 10, p. 1-11 11 p., e01082-19.

Research output: Contribution to journalArticle

Open Access
File
Guanosine Diphosphate Mannose
Trypanosoma cruzi
Chagas Disease
Enzymes
Glycoconjugates
2018
8 Citations (Scopus)
191 Downloads (Pure)

African trypanosomes evade immune clearance by O-glycosylation of the VSG surface coat

Pinger, J., Nešić, D., Ali, L., Aresta-Branco, F., Lilic, M., Chowdhury, S., Kim, H. S., Verdi, J., Raper, J., Ferguson, M. A. J., Papavasiliou, F. N. & Stebbins, C. E., Aug 2018, In : Nature Microbiology. 3, 8, p. 932-938 7 p.

Research output: Contribution to journalArticle

Open Access
File
Trypanosomiasis
Membrane Glycoproteins
Glycosylation
Antigenic Variation
Immunity
18 Citations (Scopus)
324 Downloads (Pure)

Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis

Wyllie, S., Thomas, M., Patterson, S., Crouch, S., De Rycker, M., Lowe, R., Gresham, S., Urbaniak, M. D., Otto, T. D., Stojanovski, L., Simeons, F. R. C., Manthri, S., MacLean, L. M., Zuccotto, F., Homeyer, N., Pflaumer, H., Boesche, M., Sastry, L., Connolly, P., Albrecht, S. & 12 others, Berriman, M., Drewes, G., Gray, D. W., Ghidelli-Disse, S., Dixon, S., Fiandor, J. M., Wyatt, P. G., Ferguson, M. A. J., Fairlamb, A. H., Miles, T. J., Read, K. D. & Gilbert, I. H., 9 Aug 2018, In : Nature. 560, 7717, p. 192-197 6 p.

Research output: Contribution to journalArticle

Open Access
File
Visceral Leishmaniasis
Cyclin-Dependent Kinases
Pharmaceutical Preparations
Toxicology
Parasites
2 Citations (Scopus)
80 Downloads (Pure)

Gluconeogenesis using glycerol as a substrate in bloodstream-form Trypanosoma brucei

Kovarova, J., Nagar, R., Correia Faria, J., Ferguson, M., Barrett, M. P. & Horn, D., 27 Dec 2018, In : PLoS Pathogens. 14, 12, p. 1-22 22 p., e1007475.

Research output: Contribution to journalArticle

Open Access
File
Trypanosoma brucei brucei
Gluconeogenesis
Glycerol
Trypanosomiasis
Monosaccharide Transport Proteins
14 Citations (Scopus)
95 Downloads (Pure)

N-glycan microheterogeneity regulates interactions of plasma proteins

Wu, D., Struwe, W. B., Harvey, D. J., Ferguson, M. A. J. & Robinson, C. V., 28 Aug 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 35, p. 8763-8768 6 p., 201807439.

Research output: Contribution to journalArticle

Open Access
File
Polysaccharides
Blood Proteins
Glycoproteins
Haptoglobins
Proteins
6 Citations (Scopus)
104 Downloads (Pure)

Proteomic analysis of the cell cycle of procylic form Trypanosoma brucei

Crozier, T. W. M., Tinti, M., Wheeler, R. J., Ly, T., Ferguson, M. A. J. & Lamond, A. I., 1 Jun 2018, In : Molecular & Cellular Proteomics. 17, 6, p. 1184-1195 12 p.

Research output: Contribution to journalArticle

Open Access
File
Trypanosoma brucei brucei
Proteomics
Trypanosomiasis
Cell Cycle
Cells
2 Citations (Scopus)
90 Downloads (Pure)

The mRNA cap methyltransferase gene TbCMT1 is not essential in vitro but is a virulence factor in vivo for bloodstream form Trypanosoma brucei

Kelner, A., Tinti, M., Guther, M., Foth, B. J., Chappell, L., Berriman, M., Cowling, V. & Ferguson, M., 24 Jul 2018, In : PLoS ONE. 13, 7, p. 1-14 14 p., e0201263.

Research output: Contribution to journalArticle

Open Access
File
bloodstream forms
Trypanosoma brucei
Null Lymphocytes
Trypanosoma brucei brucei
methyltransferases
2017
114 Citations (Scopus)
235 Downloads (Pure)
Open Access
File
Drug Discovery
Public Health
Neglected Diseases
Disease Eradication
African Trypanosomiasis
7 Citations (Scopus)
100 Downloads (Pure)

Fluorescent mannosides serve as acceptor substrates for glycosyltransferase and sugar-1-phosphate transferase activities in Euglena gracilis membranes

Ivanova, I. M., Nepogodiev, S. A., Saalbach, G., O'Neill, E. C., Urbaniak, M. D., Ferguson, M. A. J., Gurcha, S. S., Besra, G. S. & Field, R. A., 13 Jan 2017, In : Carbohydrate Research. 438, p. 26-38 13 p.

Research output: Contribution to journalArticle

Open Access
File
Mannosides
Euglena gracilis
Sugar Phosphates
Glycosyltransferases
Transferases
2 Citations (Scopus)
98 Downloads (Pure)

Genetic Metabolic Complementation establishes a requirement for GDP-fucose in Leishmania

Guo, H., Novozhilova, N. M., Bandini, G., Turco, S. J., Ferguson, M. A. J. & Beverley, S. M., 23 Jun 2017, In : Journal of Biological Chemistry. 292, 25, p. 10696-10708 13 p.

Research output: Contribution to journalArticle

Open Access
File
Guanosine Diphosphate Fucose
Leishmania
Leishmania major
Salvaging
Fucose
5 Citations (Scopus)
138 Downloads (Pure)

Prediction of protein complexes in Trypanosoma brucei by protein correlation profiling mass spectrometry and machine learning

Crozier, T. W. M., Tinti, M., Larance, M., Lamond, A. I. & Ferguson, M. A. J., 1 Dec 2017, In : Molecular & Cellular Proteomics. 16, 12, p. 2254-2267 14 p.

Research output: Contribution to journalArticle

Open Access
File
Trypanosoma brucei brucei
Mass spectrometry
Learning systems
Mass Spectrometry
Trypanosomiasis
4 Citations (Scopus)
155 Downloads (Pure)
Open Access
File
Glycosylation
Trypanosoma brucei brucei
Polysaccharides
Glycoside Hydrolases
Dolichol
2016
3 Citations (Scopus)
130 Downloads (Pure)

A gene of the β3-glycosyltransferase family encodes N-acetylglucosaminyltransferase II function in Trypanosoma brucei

Damerow, M., Graalfs, F., Guther, M. L. S., Mehlert, A., Izquierdo, L. & Ferguson, M. A. J., 24 Jun 2016, In : Journal of Biological Chemistry. 291, 26, p. 13834-13845 12 p.

Research output: Contribution to journalArticle

Open Access
File
Glycosyltransferases
Trypanosoma brucei brucei
Polysaccharides
Genes
Pathogens
3 Citations (Scopus)
273 Downloads (Pure)

Evaluation of antigens for development of a serological test for Human African Trypanosomiasis

Biéler, S., Waltenberger, H., Barrett, M. P., McCulloch, R., Mottram, J. C., Carrington, M., Schwaeble, W., McKerrow, J., Phillips, M. A., Michels, P. A., Büscher, P., Sanchez, J-C., Bishop, R., Robinson, D. R., Bangs, J., Ferguson, M., Nerima, B., Albertini, A., Michel, G., Radwandska, M. & 1 others, Ndung'u, J. M., 9 Dec 2016, In : PLoS ONE. 11, 12, p. 1-23 23 p., e0168074.

Research output: Contribution to journalArticle

Open Access
File
African trypanosomiasis
African Trypanosomiasis
Serologic Tests
immunologic techniques
antigens
25 Citations (Scopus)
99 Downloads (Pure)

Global membrane protein interactome analysis using in vivo crosslinking and MS-based protein correlation profiling

Larance, M., Kirkwood, K. J., Tinti, M., Brenes Murillo, A., Ferguson, M. & Lamond, A., 1 Jul 2016, In : Molecular & Cellular Proteomics. 15, 7, p. 2476-2490 15 p.

Research output: Contribution to journalArticle

Open Access
File
Membrane Proteins
Proteins
Formaldehyde
High Pressure Liquid Chromatography
Proteome
9 Citations (Scopus)
137 Downloads (Pure)

Proteomic identification of immunodiagnostic antigens for Trypanosoma vivax infections in cattle and generation of a proof-of-concept lateral flow test diagnostic device

Fleming, J. R., Sastry, L., Wall, S. J., Sullivan, L. & Ferguson, M. A. J., 8 Sep 2016, In : PLoS Neglected Tropical Diseases. 10, 9, 11 p., e0004977.

Research output: Contribution to journalArticle

Open Access
File
Trypanosoma vivax
Routine Diagnostic Tests
Proteomics
Antigens
Equipment and Supplies