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  • James Chalmers
2019

A 2 × 2 factorial, randomised, open-label trial to determine the clinical and cost-effectiveness of hypertonic saline (HTS 6%) and carbocisteine for airway clearance versus usual care over 52 weeks in adults with bronchiectasis: a protocol for the CLEAR clinical trial

Bradley, J. M., Anand, R., O'Neill, B., Ferguson, K., Clarke, M., Carroll, M., Chalmers, J., De Soyza, A., Duckers, J., Hill, A. T., Loebinger, M. R., Copeland, F., Gardner, E., Campbell, C., Agus, A., McGuire, A., Boyle, R., McKinney, F., Dickson, N., McAuley, D. F. & 1 others, Elborn, S., 19 Dec 2019, In : Trials. 20, 1, p. 1-10 10 p., 747.

Research output: Contribution to journalArticle

Open Access
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32 Downloads (Pure)

Airway Bacterial Load and Inhaled Antibiotic Response in Bronchiectasis

Sibila, O., Laserna, E., Shoemark, A., Keir, H. R., Finch, S., Rodrigo-Troyano, A., Perea, L., Lonergan, M., Goeminne, P. C. & Chalmers, J. D., 1 Jul 2019, In : American Journal of Respiratory and Critical Care Medicine. 200, 1, p. 33-41 9 p.

Research output: Contribution to journalArticle

Open Access
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10 Citations (Scopus)
3 Downloads (Pure)

Antimicrobial peptides, disease severity and exacerbations in bronchiectasis

Sibila, O., Perea, L., Cantó, E., Shoemark, A., Cassidy, D., Smith, A. H., Suarez-cuartin, G., Rodrigo-troyano, A., Keir, H. R., Oriano, M., Ong, S., Vidal, S., Blasi, F., Aliberti, S. & Chalmers, J. D., Sep 2019, In : Thorax. 74, 9, p. 835-842 8 p.

Research output: Contribution to journalArticle

Open Access
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2 Citations (Scopus)
171 Downloads (Pure)

A point of care neutrophil elastase activity assay identifies bronchiectasis severity, airway infection and risk of exacerbation

Shoemark, A., Cant, E., Carreto, L., Smith, A., Oriano, M., Keir, H. R., Perea, L., Canto, E., Terranova, L., Vidal, S., Moffitt, K., Aliberti, S., Sibila, O. & Chalmers, J. D., 1 Jun 2019, In : European Respiratory Journal. 53, 6, 1900303.

Research output: Contribution to journalArticle

Open Access
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2 Citations (Scopus)
4 Downloads (Pure)

A systematic review of pharmacotherapeutic clinical trial end-points for bronchiectasis in adults

Crichton, M. L., Aliberti, S. & Chalmers, J. D., 31 Mar 2019, In : European Respiratory Review. 28, 151, p. 1-14 14 p., 180108.

Research output: Contribution to journalReview article

Open Access
File
3 Citations (Scopus)
126 Downloads (Pure)

British Thoracic Society Guideline for bronchiectasis in adults

Hill, A. T., Sullivan, A. L., Chalmers, J. D., De Soyza, A., Elborn, J. S., Floto, R. A., Grillo, L., Gruffydd-Jones, K., Harvey, A., Haworth, C. S., Hiscocks, E., Hurst, J. R., Johnson, C., Kelleher, W. P., Bedi, P., Payne, K., Saleh, H., Screaton, N. J., Smith, M., Tunney, M. & 3 others, Whitters, D., Wilson, R. & Loebinger, M. R., Jan 2019, In : Thorax. 74, Suppl 1, p. 1-69 69 p., 74.

Research output: Contribution to journalArticle

Open Access
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37 Citations (Scopus)
86 Downloads (Pure)

Bronchiectasis in India: results from the European Multicentre Bronchiectasis Audit and Research Collaboration (EMBARC) and Respiratory Research Network of India Registry

Dhar, R., Singh, S., Talwar, D., Mohan, M., Tripathi, S. K., Swarnakar, R., Trivedi, S., Rajagopala, S., D'Souza, G., Padmanabhan, A., Baburao, A., Mahesh, P. A., Ghewade, B., Nair, G., Jindal, A., Jayadevappa, G. D. H., Sawhney, H., Sarmah, K. R., Saha, K., Anantharaj, S. & 44 others, Khanna, A., Gami, S., Shah, A., Shah, A., Dutt, N., Garg, H., Vyas, S., Venugopal, K., Prasad, R., Aleemuddin, N. M., Karmakar, S., Singh, V., Jindal, S. K., Sharma, S., Prajapat, D., Chandrashekaria, S., McDonnell, M. J., Mishra, A., Rutherford, R., Ramanathan, R. P., Goeminne, P. C., Vasudev, P., Dimakou, K., Crichton, M. L., Jayaraj, B. S., Kungwani, R., Das, A., Sawhney, M., Polverino, E., Torres, A., Gulecha, N. S., Shteinberg, M., De Soyza, A., Mangala, A., Shah, P., Chauhan, N. K., Jajodia, N., Singhal, A., Batra, S., Hasan, A., Limaye, S., Salvi, S., Aliberti, S. & Chalmers, J. D., 1 Sep 2019, In : The Lancet Global Health. 7, 9, p. e1269-e1279 11 p.

Research output: Contribution to journalArticle

Open Access
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6 Citations (Scopus)
65 Downloads (Pure)

Bronchiectasis insanity: Doing the same thing over and over again and expecting different results?

Metersky, M. & Chalmers, J., 15 Mar 2019, In : F1000Research. 8, p. 1-7 7 p., 293.

Research output: Contribution to journalReview article

Open Access
File
1 Citation (Scopus)
96 Downloads (Pure)

Challenges in severe community-acquired pneumonia: a point-of-view review

Torres, A., Chalmers, J. D., Dela Cruz, C. S., Dominedò, C., Kollef, M., Martin-Loeches, I., Niederman, M. & Wunderink, R. G., Feb 2019, In : Intensive Care Medicine. 45, 2, p. 159-171 13 p.

Research output: Contribution to journalReview article

7 Citations (Scopus)

Control of Confounding and Reporting of Results in Causal Inference Studies: Guidance for Authors from Editors of Respiratory, Sleep, and Critical Care Journals

Lederer, D. J., Bell, S. C., Branson, R. D., Chalmers, J. D., Marshall, R., Maslove, D. M., Ost, D. E., Punjabi, N. M., Schatz, M., Smyth, A. R., Stewart, P. W., Suissa, S., Adjei, A. A., Akdis, C. A., Azoulay, É., Bakker, J., Ballas, Z. K., Bardin, P. G., Barreiro, E., Bellomo, R. & 28 others, Bernstein, J. A., Brusasco, V., Buchman, T. G., Chokroverty, S., Collop, N. A., Crapo, J. D., Fitzgerald, D. A., Hale, L., Hart, N., Herth, F. J., Iwashyna, T. J., Jenkins, G., Kolb, M., Marks, G. B., Mazzone, P., Moorman, J. R., Murphy, T. M., Noah, T. L., Reynolds, P., Riemann, D., Russell, R. E., Sheikh, A., Sotgiu, G., Swenson, E. R., Szczesniak, R., Szymusiak, R., Teboul, J-L. & Vincent, J-L., Jan 2019, In : Annals of the American Thoracic Society. 16, 1, p. 22-28 7 p.

Research output: Contribution to journalArticle

Open Access
File
92 Citations (Scopus)
334 Downloads (Pure)

Distinct 'Immuno-Allertypes' of Disease and High Frequencies of Sensitisation in Non-Cystic-Fibrosis Bronchiectasis

Mac Aogáin, M., Tiew, P. Y., Lim, A. Y. H., Low, T. B., Tan, G. L., Hassan, T., Ong, T. H., Pang, S. L., Lee, Z. Y., Gwee, X. W., Martinus, C., Sio, Y. Y., Matta, S. A., Ong, T. C., Tiong, Y. S., Wong, K. N., Narayanan, S., Bijin Au, V., Marlier, D., Keir, H. R. & 8 others, Tee, A., Abisheganaden, J. A., Koh, M. S., Wang, D. Y., Connolly, J. E., Chew, F. T., Chalmers, J. D. & Chotirmall, S. H., 1 Apr 2019, In : American Journal of Respiratory and Critical Care Medicine. 199, 7, p. 842-853 12 p.

Research output: Contribution to journalArticle

Open Access
File
15 Citations (Scopus)
167 Downloads (Pure)

Evaluation of active neutrophil elastase in sputum of bronchiectasis and cystic fibrosis patients: A comparison among different techniques

Oriano, M., Terranova, L., Sotgiu, G., Saderi, L., Bellofiore, A., Retucci, M., Marotta, C., Gramegna, A., Miglietta, D., Carnini, C., Marchisio, P., Chalmers, J. D., Aliberti, S. & Blasi, F., Dec 2019, In : Pulmonary Pharmacology & Therapeutics. 59, p. 1-6 6 p., 101856.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Healthcare-associated pneumonia: is there any reason to continue to utilize this label in 2019?

Ewig, S., Kolditz, M., Pletz, M. W. & Chalmers, J., Oct 2019, In : Clinical Microbiology and Infection. 25, 10, p. 1173-1179 7 p.

Research output: Contribution to journalReview article

3 Citations (Scopus)

Improving anti-fungal stewardship and the management of chronic pulmonary aspergillosis through a complex lung infection MDT

Browne, A., Wilkie, M., Waqar, A., Shaw, A., Hill, K., Rae, N., Chalmers, J., Fardon, T. & Connell, D., 12 Nov 2019.

Research output: Contribution to conferenceAbstract

Open Access

Inhaled liposomal ciprofloxacin in patients with non-cystic fibrosis bronchiectasis and chronic lung infection with Pseudomonas aeruginosa (ORBIT-3 and ORBIT-4): two phase 3, randomised controlled trials

Haworth, C. S., Bilton, D., Chalmers, J. D., Davis, A. M., Froehlich, J., Gonda, I., Thompson, B., Wanner, A. & O'Donnell, A. E., Mar 2019, In : The Lancet Respiratory Medicine. 7, 3, p. 213-226 14 p.

Research output: Contribution to journalArticle

Open Access
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26 Citations (Scopus)
244 Downloads (Pure)

Intermittent prophylactic antibiotics for bronchiectasis

Spencer, S., Donovan, T., Chalmers, J. D., Mathioudakis, A. G., Mcdonnell, M. J., Tsang, A. & Pilkington, G., 31 Jan 2019, In : Cochrane Database of Systematic Reviews. 2019, 1, 15 p., CD013254.

Research output: Contribution to journalArticle

Long-term macrolide antibiotics for the treatment of bronchiectasis in adults: an individual participant data meta-analysis

Chalmers, J. D., Boersma, W., Lonergan, M., Jayaram, L., Crichton, M. L., Karalus, N., Taylor, S. L., Martin, M. L., Burr, L. D., Wong, C. & Altenburg, J., Oct 2019, In : The Lancet Respiratory Medicine. 7, 10, p. 845-854 10 p.

Research output: Contribution to journalArticle

Open Access
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7 Citations (Scopus)
69 Downloads (Pure)

Microbiological changes observed over 48 weeks of treatment with inhaled liposomal ciprofloxacin in individuals with non-cystic fibrosis bronchiectasis and chronic Pseudomonas aeruginosa lung infection

VanDevanter, D. R., Gonda, I., Dahms, J., Cipolla, D., Davis, A. M., Chalmers, J. D. & Froehlich, J., Dec 2019, In : Clinical Microbiology and Infection. 25, 12, p. 1532-1538 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Personalised anti-inflammatory therapy for bronchiectasis and cystic fibrosis: selecting patients for controlled trials of neutrophil elastase inhibition

Keir, H. R., Fong, C. J., Crichton, M. L., Barth, P., Chevalier, E., Brady, G., Kennedy, G., Zimmermann, J., Bruijnzeel, P. L. B., Dicker, A. J. & Chalmers, J. D., 1 Feb 2019, In : ERJ Open Research. 5, 1, p. 1-9 9 p., 00252-2018.

Research output: Contribution to journalArticle

Open Access
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103 Downloads (Pure)

Plasma desmosine, an elastin degradation product, predicts outcomes in at risk populations

Iskandar, Z., Mordi, I., Huang, J. T. J., Newby, D., Chalmers, J., Bown, M., Lang, C. & Choy, A. M., 12 Mar 2019, In : Journal of the American College of Cardiology. 73, 9, Supplement 1, p. 1805 1 p.

Research output: Contribution to journalArticle

Pregnancy Zone Protein is Associated with Airway Infection, Neutrophil Extracellular Trap Formation and Disease Severity in Bronchiectasis

Finch, S., Shoemark, A., Dicker, A. J., Keir, H. R., Smith, A., Ong, S., Tan, B., Choi, J., Fardon, T. C., Cassidy, D., Huang, J. T. J. & Chalmers, J. D., 15 Oct 2019, In : American Journal of Respiratory and Critical Care Medicine. 200, 8, p. 992-1001 10 p.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
128 Downloads (Pure)

Pulmonary Rehabilitation after exacerbation of bronchiectasis: a pilot randomized controlled trial

Chalmers, J. D., Crichton, M. L., Brady, G., Finch, S., Lonergan, M. & Fardon, T., 6 May 2019, In : BMC Pulmonary Medicine. 19, p. 1-9 9 p., 85.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
102 Downloads (Pure)

Recomendaciones de las guías de bronquiectasias llevadas a la práctica clínica

Translated title of the contribution: Bronchiectasis Guidelines-Recommendations Into PracticeRedondo, M. & Chalmers, J. D., Jun 2019, In : Archivos de Bronconeumologia. 55, 6, p. 286-288 3 p.

Research output: Contribution to journalEditorial

Recomendaciones de las guías de bronquiectasias llevadas a la práctica clínica

Translated title of the contribution: Bronchiectasis Guidelines-Recommendations Into PracticeRedondo, M. & Chalmers, J. D., 1 Jun 2019, In : Archivos de Bronconeumologia. 55, 6, p. 286-288 3 p.

Research output: Contribution to journalEditorial

1 Citation (Scopus)

Recommendations for travelling with bronchiectasis: a joint ELF/EMBARC/ERN-Lung collaboration

Shteinberg, M., Crossley, B., Lavie, T., Nadler, S., Boyd, J., Ringshausen, F. C., Aksamit, T., Chalmers, J. D. & Goeminne, P., Oct 2019, In : ERJ Open Research. 5, 4, p. 1-22 22 p., 00113-2019.

Research output: Contribution to journalArticle

Open Access
File
56 Downloads (Pure)

Reply: More on causal inference studies

Lederer, D. J., Bell, S. C., Smyth, A. R. & Chalmers, J. D., 1 May 2019, In : Annals of the American Thoracic Society. 16, 5, p. 646 1 p.

Research output: Contribution to journalLetter

Open Access
File
83 Downloads (Pure)

Respiratory physiotherapy in the bronchiectasis guidelines: is there a loud voice we are yet to hear?

Spinou, A. & Chalmers, J. D., 28 Sep 2019, In : The European respiratory journal. 54, 3, p. 1-6 6 p., 1901610.

Research output: Contribution to journalEditorial

Response

Chalmers, J. D., Jun 2019, In : Chest. 155, 6, p. 1302-1303 2 p.

Research output: Contribution to journalLetter

Rheumatoid arthritis-associated bronchiectasis - Authors' reply

Flume, P. A., Chalmers, J. D. & Olivier, K. N., 18 May 2019, In : Lancet. 393, 10185, p. 2036 1 p.

Research output: Contribution to journalLetter

2 Citations (Scopus)

Same meat, different gravy: ignore the new names of mycobacteria

Tortoli, E., Brown-Elliott, B. A., Chalmers, J. D., Cirillo, D. M., Daley, C. L., Emler, S., Floto, R. A., Garcia, M. J., Hoefsloot, W., Koh, W-J., Lange, C., Loebinger, M., Maurer, F. P., Morimoto, K., Niemann, S., Richter, E., Turenne, C. Y., Vasireddy, R., Vasireddy, S., Wagner, D. & 3 others, Wallace, R. J., Wengenack, N. & van Ingen, J., 11 Jul 2019, In : The European respiratory journal. 54, 1, p. 1-3 3 p., 1900795.

Research output: Contribution to journalEditorial

Single-inhaler triple therapy in patients with chronic obstructive pulmonary disease: a systematic review

Langham, S., Lewis, J., Pooley, N., Embleton, N., Langham, J., Han, M. K. & Chalmers, J. D., 4 Nov 2019, In : Respiratory Research. 20, p. 1-13 13 p., 242.

Research output: Contribution to journalReview article

Open Access
File
69 Downloads (Pure)

The economic burden of bronchiectasis - known and unknown: a systematic review

Goeminne, P. C., Hernandez, F., Diel, R., Filonenko, A., Hughes, R., Juelich, F., Solomon, G. M., Upton, A., Wichmann, K., Xu, W. & Chalmers, J. D., 28 Feb 2019, In : BMC Pulmonary Medicine. 19, 1, p. 1-11 11 p., 54.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
116 Downloads (Pure)
Open Access
File
6 Citations (Scopus)
24 Downloads (Pure)

The evolution of the European Respiratory Journal: volume 2

Chalmers, J. D. & Kolb, M., 2019, In : European Respiratory Journal. 53, 1, p. 1-4 4 p., 1802459.

Research output: Contribution to journalEditorial

The microbiome in bronchiectasis

Richardson, H., Dicker, A. J., Barclay, H. & Chalmers, J. D., 30 Sep 2019, In : European Respiratory Review. 28, 153, p. 1-10 10 p., 190048.

Research output: Contribution to journalArticle

Open Access
File
75 Downloads (Pure)

The Tayside Complex Lung Infection MDT: a year’s experience and perspective

Browne, A., Waqar, A., Shaw, A., Hill, K., Rae, N., Chalmers, J., Fardon, T. & Connell, D., 20 Jun 2019.

Research output: Contribution to conferenceAbstract

Treatment to prevent exacerbations in bronchiectasis: macrolides as first line?

Laska, I. F. & Chalmers, J. D., 18 Jul 2019, In : The European respiratory journal. 54, 1, p. 1-5 5 p., 1901213.

Research output: Contribution to journalEditorial

1 Citation (Scopus)

Validation of the COPD Assessment Test (CAT) as an outcome measure in bronchiectasis

Finch, S., Laska, I. F., Abo-Leyah, H., Fardon, T. C. & Chalmers, J. D., 12 Nov 2019, In : Chest. 9 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2017

10 years since TORCH: shining a new light on the risks of inhaled corticosteroids in COPD

Chalmers, J. D. & Keir, H. R., 1 Sep 2017, In : European Respiratory Journal. 50, 3, 5 p., 1701582.

Research output: Contribution to journalEditorial

3 Citations (Scopus)

Additional important research priorities for bronchiectasis in China

Aliberti, S., Dhar, R., Aksamit, T. R., Morgan, L. & Chalmers, J. D., 1 Jan 2017, In : European Respiratory Journal. 49, 1, 1602317.

Research output: Contribution to journalLetter

Open Access
File
149 Downloads (Pure)

A new free-cost e-service supporting clinicians to manage their difficult-to-treat tuberculosis cases: The European Respiratory Society-World Health Organization tuberculosis Consilium

D'Ambrosio, L., Tadolini, M., Centis, R., Chalmers, J. D. & Migliori, G. B., 27 Jul 2017, In : Indian Journal of Medical Research. 145, 3, p. 261-263 3 p.

Research output: Contribution to journalEditorial

Open Access
File
19 Downloads (Pure)

Anti-Pseudomonas aeruginosa IgG antibodies and chronic airway infection in bronchiectasis

Suarez-Cuartin, G., Smith, A., Abo-Leyah, H., Rodrigo-Troyano, A., Perea, L., Vidal, S., Plaza, V., Fardon, T. C., Sibila, O. & Chalmers, J. D., Jul 2017, In : Respiratory Medicine. 128, p. 1-6 6 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

A randomised control trial of atorvastatin in bronchiectasis patients infected with Pseudomonas aeruginosa- a proof of concept study

Bedi, P., Chalmers, J. D., Graham, C., Clarke, A., Donaldson, S., Doherty, C. J., Govan, J. R. W., Davidson, D. J., Rossi, A. G. & Hill, A. T., Aug 2017, In : Chest. 152, 2, p. 368-378 11 p.

Research output: Contribution to journalArticle

Open Access
File
19 Citations (Scopus)
136 Downloads (Pure)

Bronchiectasis: Phenotyping a Complex Disease

Chalmers, J. D., 17 Mar 2017, In : COPD. 14, Suppl.1, p. S12-S18 7 p.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
144 Downloads (Pure)

Bronchiectasis and COPD Overlap: A Case of Mistaken Identity?

Chalmers, J. D., Jun 2017, In : Chest. 151, 6, p. 1204-1206 3 p.

Research output: Contribution to journalEditorial

11 Citations (Scopus)

Bronchiectasis Management: The State of the Union

Chalmers, J. D. & Restrepo, M. I., Dec 2017, In : Chest. 152, 6, p. 1097-1099 3 p.

Research output: Contribution to journalEditorial

2 Citations (Scopus)

Bronchiectasis Rheumatoid Overlap Syndrome Is an Independent Risk Factor for Mortality in Patients With Bronchiectasis: A Multicenter Cohort Study

De Soyza, A., McDonnell, M. J., Goeminne, P. C., Aliberti, S., Lonni, S., Davison, J., Dupont, L. J., Fardon, T. C., Rutherford, R. M., Hill, A. T. & Chalmers, J. D., Jun 2017, In : Chest. 151, 6, p. 1247-1254 8 p.

Research output: Contribution to journalArticle

Open Access
File
31 Citations (Scopus)
169 Downloads (Pure)

Community-acquired pneumonia in the United Kingdom: a call to action

Chalmers, J., Campling, J., Ellsbury, G., Hawkey, P. M., Madhava, H. & Slack, M., 5 Oct 2017, In : Pneumonia . 9, 6 p., 15.

Research output: Contribution to journalComment/debate

Open Access
File
165 Downloads (Pure)

Continuous versus intermittent antibiotics for non-cystic fibrosis bronchiectasis

Donovan, T., Felix, L. M., Chalmers, J. D., Milan, S. J., Mathioudakis, A. G. & Spencer, S., 26 Jul 2017, In : Cochrane Database of Systematic Reviews. 2017, 7, p. 1-13 13 p., CD012733.

Research output: Contribution to journalArticle

Open Access
File
92 Downloads (Pure)