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  • James Chalmers

Efficacy and safety of TOBI Podhaler® in Pseudomonas aeruginosa-infected bronchiectasis patients: iBEST study

Loebinger, M. R., Polverino, E., Chalmers, J. D., Tiddens, H. A. W. M., Goossens, H., Ringhausen, F. C., Tunney, M., Hill, A. T., Pathan, R., Angyalosi, G., Blasi, F., Elborn, S. J. & Haworth, C. S., 27 Aug 2020, In : European Respiratory Journal.

Research output: Contribution to journalArticle

Efficacy and safety of tobramycin inhalation powder in bronchiectasis patients with P. aeruginosa infection: Design of a dose-finding study (iBEST-1)

Loebinger, M. R., Polverino, E., Blasi, F., Elborn, S. J., Chalmers, J. D., Goossens, H., Tiddens, H. A., Tunney, M., Zhou, W., Angyalosi, G., Hill, A. T. & Haworth, C. S., Oct 2019, In : Pulmonary Pharmacology & Therapeutics. 58, 29 p., 101834.

Research output: Contribution to journalArticle

Empirical coverage of methicillin-resistant Staphylococcus aureus in community-acquired pneumonia: those who do not remember the past are doomed to repeat it

Chalmers, J. D., Reyes, L. F., Aliberti, S. & Restrepo, M. I., 15 Oct 2016, In : Clinical Infectious Diseases. 63, 8, p. 1145-1146 1 p.

Research output: Contribution to journalLetter

8 Citations (Scopus)
16 Downloads (Pure)

Endothelial adhesion molecules and multiple organ failure in patients with severe sepsis

Amalakuhan, B., Habib, S. A., Mangat, M., Reyes, L. F., Rodriguez, A. H., Hinojosa, C. A., Soni, N. J., Gilley, R. P., Bustamante, C. A., Anzueto, A., Levine, S. M., Peters, J. I., Aliberti, S., Sibila, O., Chalmers, J. D., Torres, A., Waterer, G. W., Martin-Loeches, I., Bordon, J., Blanquer, J. & 15 others, Sanz, F., Marcos, P. J., Rello, J., Ramirez, J., Solé-Violán, J., Luna, C. M., Feldman, C., Witzenrath, M., Wunderink, R. G., Stolz, D., Wiemken, T. L., Shindo, Y., Dela Cruz, C. S., Orihuela, C. J. & Restrepo, M. I., Dec 2016, In : Cytokine. 88, p. 267-273 7 p.

Research output: Contribution to journalArticle

Open Access
File
12 Citations (Scopus)
128 Downloads (Pure)
Open Access
File
1 Citation (Scopus)
8 Downloads (Pure)

European Respiratory Society guidelines for the management of adult bronchiectasis

Polverino, E., Goeminne, P. C., McDonnell, M. J., Aliberti, S., Marshall, S. E., Loebinger, M. R., Murris-Espin, M., Cantón, R., Torres, A., Dimakou, K., De Soyza, A., Hill, A. T., Haworth, C. S., Vendrell, M., Ringshausen, F. C., Subotic, D., Wilson, R., Vilaró, J., Stallberg, B., Welte, T. & 9 others, Rohde, G., Blasi, F., Elborn, J. S., Almagro, M., Timothy, A., Ruddy, T., Tonia, T., Rigau, D. & Chalmers, J. D., Sep 2017, In : European Respiratory Journal. 50, 3, p. 1-23 23 p., 1700629.

Research output: Contribution to journalArticle

Open Access
File
263 Citations (Scopus)
241 Downloads (Pure)

Evaluation of active neutrophil elastase in sputum of bronchiectasis and cystic fibrosis patients: A comparison among different techniques

Oriano, M., Terranova, L., Sotgiu, G., Saderi, L., Bellofiore, A., Retucci, M., Marotta, C., Gramegna, A., Miglietta, D., Carnini, C., Marchisio, P., Chalmers, J. D., Aliberti, S. & Blasi, F., Dec 2019, In : Pulmonary Pharmacology & Therapeutics. 59, 6 p., 101856.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Evaluation of serum inflammatory biomarkers as predictors of treatment outcome in pulmonary tuberculosis

Singanayagam, A., Manalan, K., Connell, D. W., Chalmers, J. D., Sridhar, S., Ritchie, A. I., Lalvani, A., Wickremasinghe, M. & Kon, O. M., 1 Dec 2016, In : International Journal of Tuberculosis and Lung Disease. 20, 12, p. 1653-1660 8 p.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
149 Downloads (Pure)

Evaluation of severity score-guided approaches to macrolide use in community-acquired pneumonia

Singanayagam, A., Aliberti, S., Cillóniz, C., Torres, A., Blasi, F. & Chalmers, J. D., Sep 2017, In : European Respiratory Journal. 50, 3, 1602306.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
189 Downloads (Pure)

Global impact of bronchiectasis and cystic fibrosis

Redondo, M., Keyt, H., Dhar, R. & Chalmers, J. D., 1 Sep 2016, In : Breathe. 12, 3, p. 222-235 14 p.

Research output: Contribution to journalReview article

Open Access
File
18 Citations (Scopus)
188 Downloads (Pure)

Happy Birthday Bronchiectasis: 200 Years of Targeting Mucus

Chalmers, J. D. & Sibila, O., 15 Mar 2020, In : American Journal of Respiratory and Critical Care Medicine. 201, 6, p. 639-640 2 p.

Research output: Contribution to journalEditorial

Open Access
File
24 Downloads (Pure)

Healthcare-associated pneumonia: is there any reason to continue to utilize this label in 2019?

Ewig, S., Kolditz, M., Pletz, M. W. & Chalmers, J., Oct 2019, In : Clinical Microbiology and Infection. 25, 10, p. 1173-1179 7 p.

Research output: Contribution to journalReview article

3 Citations (Scopus)

High endocan levels are associated with the need for mechanical ventilation among patients with severe sepsis

Mangat, M., Amalakuhan, B., Habib, S. A., Reyes, L. F., Hinojosa, C. A., Rodriguez, A. H., Soni, N. J., Anzueto, A., Levine, S. M., Peters, J. I., Aliberti, S., Sibila, O., Rello, J., Witzenrath, M., Waterer, G. W., Martin-Loeches, I., Blanquer, J., Sanz, F., Marcos, P. J., Solé-Violán, J. & 6 others, Chalmers, J. D., Feldman, C., Wunderink, R. G., Cruz, C. S. D., Orihuela, C. J. & Restrepo, M. I., 1 Jul 2017, In : European Respiratory Journal. 50, 1, p. 1-4 4 p., 1700013.

Research output: Contribution to journalLetter

3 Citations (Scopus)

Improving anti-fungal stewardship and the management of chronic pulmonary aspergillosis through a complex lung infection MDT

Browne, A., Wilkie, M., Waqar, A., Shaw, A., Hill, K., Rae, N., Chalmers, J., Fardon, T. & Connell, D., 12 Nov 2019.

Research output: Contribution to conferenceAbstract

Open Access

Increased Chitotriosidase Is Associated With Aspergillus and Frequent Exacerbations in South-East Asian Patients With Bronchiectasis

Poh, T. Y., Tiew, P. Y., Hou Lim, A. Y., Thng, K. X., Binte Mohamed Ali, N. A., Narayana, J. K., Aogáin, M. M., Tien, Z., Chew, W. M., Wai Chan, A. K., Keir, H. R., Dicker, A. J., Hassan, T. M., Xu, H., Tee, A. K. H., Ong, T. H., Koh, M. S., Abisheganaden, J. A., Chalmers, J. D. & Chotirmall, S. H., Aug 2020, In : Chest. 158, 2, p. 512-522 11 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Inhaled liposomal ciprofloxacin in patients with non-cystic fibrosis bronchiectasis and chronic lung infection with Pseudomonas aeruginosa (ORBIT-3 and ORBIT-4): two phase 3, randomised controlled trials

Haworth, C. S., Bilton, D., Chalmers, J. D., Davis, A. M., Froehlich, J., Gonda, I., Thompson, B., Wanner, A. & O'Donnell, A. E., Mar 2019, In : The Lancet Respiratory Medicine. 7, 3, p. 213-226 14 p.

Research output: Contribution to journalArticle

Open Access
File
32 Citations (Scopus)
298 Downloads (Pure)

Intermittent prophylactic antibiotics for bronchiectasis

Spencer, S., Donovan, T., Chalmers, J. D., Mathioudakis, A. G., Mcdonnell, M. J., Tsang, A. & Pilkington, G., 31 Jan 2019, In : Cochrane Database of Systematic Reviews. 2019, 1, 15 p., CD013254.

Research output: Contribution to journalArticle

International perspective on the new 2019 ATS/IDSA CAP guideline - a critical appraisal by a global expert panel

Pletz, M. W., Blasi, F., Chalmers, J. D., Dela Cruz, C. S., Feldman, C., Luna, C. M., Ramirez, J. A., Shindo, Y., Stolz, D., Torres, A., Webb, B., Welte, T., Wunderink, R. & Aliberti, S., 25 Aug 2020, In : Chest.

Research output: Contribution to journalReview article

Is bronchiectasis really a disease?

Shteinberg, M., Flume, P. A. & Chalmers, J. D., 31 Mar 2020, In : European Respiratory Review. 29, 155, p. 1-10 10 p., 190051.

Research output: Contribution to journalArticle

Open Access
File
48 Downloads (Pure)

Long-term macrolide antibiotics for the treatment of bronchiectasis in adults: an individual participant data meta-analysis

Chalmers, J. D., Boersma, W., Lonergan, M., Jayaram, L., Crichton, M. L., Karalus, N., Taylor, S. L., Martin, M. L., Burr, L. D., Wong, C. & Altenburg, J., Oct 2019, In : The Lancet Respiratory Medicine. 7, 10, p. 845-854 10 p.

Research output: Contribution to journalArticle

Open Access
File
9 Citations (Scopus)
124 Downloads (Pure)

Macrolide antibiotics for non-cystic fibrosis bronchiectasis

Kelly, C., Evans, D. J., Chalmers, J. D., Crossingham, I., Spencer, S., Relph, N., Felix, L. M. & Milan, S. J., 21 Oct 2016, In : Cochrane Database of Systematic Reviews. 10, p. 1-11 13 p., CD012406.

Research output: Contribution to journalReview article

Open Access
File
6 Citations (Scopus)
155 Downloads (Pure)

Macrolide resistance in Pseudomonas aeruginosa: implications for practice

Chalmers, J. D., May 2017, In : European Respiratory Journal. 49, 5, p. 1-3 3 p., 1700689.

Research output: Contribution to journalEditorial

4 Citations (Scopus)

Management of chronic airway diseases: What can we learn from real-life data?

Chalmers, J. D., 17 Mar 2017, In : COPD. 14, Suppl. 1, p. S1-S2 2 p.

Research output: Contribution to journalArticle

Open Access
File
202 Downloads (Pure)

"Management of Community-Acquired Pneumonia in Immunocompromised Adults: A Consensus Statement Regarding Initial Strategies"

Ramirez, J. A., Musher, D. M., Evans, S. E., Dela Cruz, C., Crothers, K. A., Hage, C. A., Aliberti, S., Anzueto, A., Arancibia, F., Arnold, F., Azoulay, E., Blasi, F., Bordon, J., Burdette, S., Cao, B., Cavallazzi, R., Chalmers, J., Charles, P., Chastre, J., Claessens, Y-E. & 26 others, Dean, N., Duval, X., Fartoukh, M., Feldman, C., File, T., Froes, F., Furmanek, S., Gnoni, M., Lopardo, G., Luna, C., Maruyama, T., Menendez, R., Metersky, M., Mildvan, D., Mortensen, E., Niederman, M. S., Pletz, M., Rello, J., Restrepo, M. I., Shindo, Y., Torres, A., Waterer, G., Webb, B., Welte, T., Witzenrath, M. & Wunderink, R., 16 Jun 2020, In : Chest.

Research output: Contribution to journalReview article

Managing and preventing exacerbation of bronchiectasis

Abo-Leyah, H. & Chalmers, J. D., Apr 2020, In : Current Opinion in Infectious Diseases. 33, 2, p. 189-196 8 p.

Research output: Contribution to journalArticle

Microbial dysbiosis after lung transplantation

Chalmers, J. D., 15 Nov 2016, In : American Journal of Respiratory and Critical Care Medicine. 194, 10, p. 1184-1186 3 p.

Research output: Contribution to journalEditorial

3 Citations (Scopus)

Microbial Dysbiosis in Bronchiectasis and Cystic Fibrosis

Dicker, A. J. & Chalmers, J. D., Sep 2017, In : Archivos de Bronconeumologia. 53, 9, p. 471-472 2 p.

Research output: Contribution to journalEditorial

Open Access
File
1 Citation (Scopus)
219 Downloads (Pure)

Microbiological changes observed over 48 weeks of treatment with inhaled liposomal ciprofloxacin in individuals with non-cystic fibrosis bronchiectasis and chronic Pseudomonas aeruginosa lung infection

VanDevanter, D. R., Gonda, I., Dahms, J., Cipolla, D., Davis, A. M., Chalmers, J. D. & Froehlich, J., Dec 2019, In : Clinical Microbiology and Infection. 25, 12, p. 1532-1538 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Multidimensional severity assessment in bronchiectasis: An analysis of 7 European cohorts.

McDonnell, M. J., Alberti, S., Goeminne, P. C., Dimakou, K., Davidson, J., Ward, C., LAffey, JG., Finch, S., Pesci, A., Dupont, LJ., Fardon, T. C., Skrbic, D., Obradovic, D., Cowman, S., Loebinger, M. R., Rutherford, RM., De Soyza, A. & Chalmers, J. D., Dec 2016, In : Thorax. 71, 12, p. 1110-1118 9 p.

Research output: Contribution to journalArticle

Open Access
File
75 Citations (Scopus)
155 Downloads (Pure)

Neutrophil elastase activity is associated with exacerbations and lung function decline in Bronchiectasis

Chalmers, J. D., Moffitt, K. L., Suarez-Cuartin, G., Sibila, O., Finch, S., Furrie, E., Dicker, A., Wrobel, K., Elborn, J. S., Walker, B., Martin, S. L., Marshall, S. E., Huang, J. T-J. & Fardon, T. C., 15 May 2017, In : American Journal of Respiratory and Critical Care Medicine. 195, 10, p. 1384-1393 10 p.

Research output: Contribution to journalArticle

Open Access
File
86 Citations (Scopus)
150 Downloads (Pure)

New therapies for the prevention and treatment of exacerbations of bronchiectasis

Abo-Leyah, H. & Chalmers, J. D., May 2017, In : Current Opinion in Pulmonary Medicine. 23, 3, p. 218-224 7 p.

Research output: Contribution to journalReview article

Open Access
File
6 Citations (Scopus)
187 Downloads (Pure)

Non-cystic fibrosis bronchiectasis

Finch, S., Dicker, A. & Chalmers, J., 1 Sep 2017, Acute Exacerbations of Pulmonary Diseases. Burgel, P-R., Contoli, M. & López-Campos, J. L. (eds.). European Respiratory Society, p. 38-57 20 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Oral versus inhaled antibiotics for non-cystic fibrosis bronchiectasis

Spencer, S., Felix, L. M., Milan, S. J., Normansell, R., Goeminne, P. C. & Chalmers, J. D., 27 Mar 2017, In : Cochrane Database of Systematic Reviews. 3, 11 p., CD012579.

Research output: Contribution to journalReview article

4 Citations (Scopus)

Oral versus intravenous clarithromycin in moderate to severe community-acquired pneumonia: an observational study

Rae, N., Singanayagam, A., Schembri, S. & Chalmers, J. D., 5 Feb 2017, In : Pneumonia . 9, p. 1-5 5 p., 2.

Research output: Contribution to journalArticle

Open Access
File
163 Downloads (Pure)

Patient participation in ERS guidelines and research projects: the EMBARC experience

EMBARC/ELF patient advisory group, Chalmers, J. D., Timothy, A., Polverino, E., Almagro, M., Ruddy, T., Powell, P. & Boyd, J., 1 Sep 2017, In : Breathe. 13, 3, p. 194-207 14 p.

Research output: Contribution to journalReview article

Open Access
File
7 Citations (Scopus)
207 Downloads (Pure)

Personalised anti-inflammatory therapy for bronchiectasis and cystic fibrosis: selecting patients for controlled trials of neutrophil elastase inhibition

Keir, H. R., Fong, C. J., Crichton, M. L., Barth, P., Chevalier, E., Brady, G., Kennedy, G., Zimmermann, J., Bruijnzeel, P. L. B., Dicker, A. J. & Chalmers, J. D., 1 Feb 2019, In : ERJ Open Research. 5, 1, p. 1-9 9 p., 00252-2018.

Research output: Contribution to journalArticle

Open Access
File
118 Downloads (Pure)

Phase 2 Trial of the DPP-1 Inhibitor Brensocatib in Bronchiectasis

Chalmers, J. D., Haworth, C. S., Metersky, M. L., Loebinger, M. R., Blasi, F., Sibila, O., O'Donnell, A. E., Sullivan, E. J., Mange, K. C., Fernandez, C., Zou, J. & Daley, C. L., 7 Sep 2020, In : New England Journal of Medicine. 11 p.

Research output: Contribution to journalArticle

Plasma desmosine, an elastin degradation product, predicts outcomes in at risk populations

Iskandar, Z., Mordi, I., Huang, J. T. J., Newby, D., Chalmers, J., Bown, M., Lang, C. & Choy, A. M., 12 Mar 2019, In : Journal of the American College of Cardiology. 73, 9, Supplement 1, p. 1805 1 p.

Research output: Contribution to journalArticle

Pregnancy Zone Protein is Associated with Airway Infection, Neutrophil Extracellular Trap Formation and Disease Severity in Bronchiectasis

Finch, S., Shoemark, A., Dicker, A. J., Keir, H. R., Smith, A., Ong, S., Tan, B., Choi, J., Fardon, T. C., Cassidy, D., Huang, J. T. J. & Chalmers, J. D., 15 Oct 2019, In : American Journal of Respiratory and Critical Care Medicine. 200, 8, p. 992-1001 10 p.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
137 Downloads (Pure)
5 Citations (Scopus)

Pseudomonas aeruginosa resistance patterns and clinical outcomes in hospitalized exacerbations of COPD

Rodrigo-Troyano, A., Suarez-Cuartin, G., Peiró, M., Barril, S., Castillo, D., Sanchez-Reus, F., Plaza, V., Restrepo, M. I., Chalmers, J. D. & Sibila, O., Oct 2016, In : Respirology . 21, 7, p. 1235-1242 8 p.

Research output: Contribution to journalArticle

Open Access
File
21 Citations (Scopus)
175 Downloads (Pure)

Pulmonary exacerbation in adults with bronchiectasis: a consensus definition for clinical research

Hill, A. T., Haworth, C. S., Aliberti, S., Barker, A., Blasi, F., Boersma, W., Chalmers, J. D., De Soyza, A., Dimakou, K., Elborn, J. S., Feldman, C., Flume, P., Goeminne, P. C., Loebinger, M. R., Menendez, R., Morgan, L., Murris-Espin, M., Polverino, E., Quittner, A., Ringshausen, F. C. & 9 others, Tino, G., Torres, A., Vendrell, M., Welte, T., Wilson, R., Wong, C., O'Donnell, A., Aksamit, T. & for the EMBARC/BRR definitions working group, 1 Jun 2017, In : European Respiratory Journal. 49, 6, 8 p., 1700051.

Research output: Contribution to journalArticle

Open Access
85 Citations (Scopus)

Pulmonary Rehabilitation after exacerbation of bronchiectasis: a pilot randomized controlled trial

Chalmers, J. D., Crichton, M. L., Brady, G., Finch, S., Lonergan, M. & Fardon, T., 6 May 2019, In : BMC Pulmonary Medicine. 19, p. 1-9 9 p., 85.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
118 Downloads (Pure)

Quality standards for the management of bronchiectasis in Italy: a national audit

SIP Bronchiectasis Audit Working Group, Aliberti, S., Hill, A. T., Mantero, M., Battaglia, S., Centanni, S., Lo Cicero, S., Lacedonia, D., Saetta, M., Chalmers, J. D. & Blasi, F., 30 Jun 2016, In : European Respiratory Journal. 48, 1, p. 244-248 5 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Raising awareness of bronchiectasis in primary care: overview of diagnosis and management strategies in adults

Chalmers, J. D. & Sethi, S., 13 Mar 2017, In : NPJ Primary Care Respiratory Medicine. 27, p. 1-9 9 p., 18.

Research output: Contribution to journalReview article

Open Access
File
16 Citations (Scopus)
166 Downloads (Pure)

Recomendaciones de las guías de bronquiectasias llevadas a la práctica clínica

Translated title of the contribution: Bronchiectasis Guidelines-Recommendations Into PracticeRedondo, M. & Chalmers, J. D., 1 Jun 2019, In : Archivos de Bronconeumologia. 55, 6, p. 286-288 3 p.

Research output: Contribution to journalEditorial

1 Citation (Scopus)

Recommendations for travelling with bronchiectasis: a joint ELF/EMBARC/ERN-Lung collaboration

Shteinberg, M., Crossley, B., Lavie, T., Nadler, S., Boyd, J., Ringshausen, F. C., Aksamit, T., Chalmers, J. D. & Goeminne, P., Oct 2019, In : ERJ Open Research. 5, 4, p. 1-22 22 p., 00113-2019.

Research output: Contribution to journalArticle

Open Access
File
67 Downloads (Pure)

Relationship between Symptoms, Exacerbations, and Treatment Response in Bronchiectasis

Gao, Y-H., Abo Leyah, H., Finch, S., Lonergan, M., Aliberti, S., De Soyza, A., Fardon, T. C., Tino, G. & Chalmers, J. D., 15 Jun 2020, In : American Journal of Respiratory and Critical Care Medicine. 201, 12, p. 1499-1507 9 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Reply: Measuring airway Mucin 2 in patients with severe Chronic Obstructive Pulmonary Disease with bacterial colonization

Sibila, O., Mateus, E. F., Restrepo, M. I., Chalmers, J. D. & Vidal, S., 1 Nov 2016, In : Annals of the American Thoracic Society. 13, 11, p. 2104-2105 2 p.

Research output: Contribution to journalLetter

1 Citation (Scopus)