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• 2020

  Association between hydrochlorothiazide exposure and different incident skin, lip and oral cavity cancers: a series of population-based nested case-control studies

  Morales, D., Pacurariu, A., Slattery, J. & Kurz, X., 26 Jun 2020, In: British Journal of Clinical Pharmacology. 86, 7, p. 1336-1345 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Hydrochlorothiazide
  • Lip Neoplasms
  • Mouth Neoplasms
  • Lip
  • Mouth
  5 Citations (Scopus)

  45 Downloads (Pure)

• Comment on "Hydrochlorothiazide use and the risk of skin cancer in patients with hypertensive disorder: a nationwide retrospective cohort study from Korea"

  Pottegård, A. & Morales, D., 1 Jul 2020, In: Korean Journal of Internal Medicine. 35, 4, p. 1014-1015 2 p.

  Research output: Contribution to journal › Letter › peer-review

  Open Access

  File
  33 Downloads (Pure)

• Deep phenotyping of 34,128 adult patients hospitalised with COVID-19 in an international network study

  Burn, E., You, S. C., Sena, A. G., Kostka, K., Abedtash, H., Abrahão, M. T. F., Alberga, A., Alghoul, H., Alser, O., Alshammari, T. M., Aragon, M., Areia, C., Banda, J. M., Cho, J., Culhane, A. C., Davydov, A., DeFalco, F. J., Duarte-Salles, T., DuVall, S., Falconer, T. & 49 others, Fernandez-Bertolin, S., Gao, W., Golozar, A., Hardin, J., Hripcsak, G., Huser, V., Jeon, H., Jing, Y., Jung, C. Y., Kaas-Hansen, B. S., Kaduk, D., Kent, S., Kim, Y., Kolovos, S., Lane, J. C. E., Lee, H., Lynch, K. E., Makadia, R., Matheny, M. E., Mehta, P. P., Morales, D. R., Natarajan, K., Nyberg, F., Ostropolets, A., Park, R. W., Park, J., Posada, J. D., Prats-Uribe, A., Rao, G., Reich, C., Rho, Y., Rijnbeek, P., Schilling, L. M., Schuemie, M., Shah, N. H., Shoaibi, A., Song, S., Spotnitz, M., Suchard, M. A., Swerdel, J. N., Vizcaya, D., Volpe, S., Wen, H., Williams, A. E., Yimer, B. B., Zhang, L., Zhuk, O., Prieto-Alhambra, D. & Ryan, P., 6 Dec 2020, In: Nature Communications. 11, 11 p., 5009.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Coronavirus
  • influenza
  • South Korea
  • Human Influenza
  • Spain
  64 Downloads (Pure)

• Does additional monitoring status increase the reporting of ADRs? An interrupted time series analysis of EudraVigilance data

  Segec, A., Slattery, J., Morales, D. R., Januskiene, J., Kurz, X. & Arlett, P., 16 Nov 2020, In: Pharmacoepidemiology and Drug Safety. 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Interrupted Time Series Analysis
  • Denosumab
  • Drug-Related Side Effects and Adverse Reactions
  • N-(3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl)-3-(2-((((1,1-dimethylethyl)amino)carbonyl)amino)-3,3-dimethyl-1-oxobutyl)-6,6-dimethyl-3-azabicyclo(3.1.0)hexan-2-carboxamide
  • CI 22
  17 Downloads (Pure)

• Exclusion rates in randomized controlled trials of treatments for physical conditions: a systematic review

  He, J., Morales, D. R. & Guthrie, B., 26 Feb 2020, In: Trials. 21, 11 p., 228.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Systematic Reviews
  • Randomized Controlled Trials
  • Population
  • Multimorbidity
  • Morbidity
  3 Citations (Scopus)

  47 Downloads (Pure)

• Impact of EMA regulatory label changes on systemic diclofenac initiation, discontinuation, and switching to other pain medicines in Scotland, England, Denmark, and The Netherlands

  Morales, D. R., Morant, S. V., MacDonald, T. M., Mackenzie, I. S., Doney, A. S. F., Mitchell, L., Bennie, M., Robertson, C., Hallas, J., Pottegard, A., Ernst, M. T., Wei, L., Nicholson, L., Morris, C., Herings, R. M. C., Overbeek, J. A., Smits, E. & Flynn, R. W. V., Mar 2020, In: Pharmacoepidemiology and Drug Safety. 29, 3, p. 296-305 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Diclofenac
  • Scotland
  • Denmark
  • England
  • Netherlands
  1 Citation (Scopus)

  56 Downloads (Pure)

• Impact of EU regulatory label changes for diclofenac in people with cardiovascular disease in four countries: interrupted time series regression analysis

  Morales, D. R., Morant, S. V., MacDonald, T. M., Hallas, J., Ernst, M. T., Pottegard, A., Herings, R. M. C., Smits, E., Overbeek, J. A., Mackenzie, I. S., Doney, A. S. F., Mitchell, L., Bennie, M., Robertson, C., Wei, L., Nicholson, L., Morris, C. & Flynn, R. W. V., 15 Jul 2020, In: British Journal of Clinical Pharmacology. 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Interrupted Time Series Analysis
  • Diclofenac
  • Scotland
  • Cardiovascular Diseases
  • England
  1 Citation (Scopus)

  17 Downloads (Pure)

• Impact of medicines regulatory risk communications in the UK on prescribing and clinical outcomes: systematic review, time series analysis and meta-analysis

  Weatherburn, C. J., Guthrie, B., Dreischulte, T. & Morales, D. R., Apr 2020, In: British Journal of Clinical Pharmacology. 86, 4, p. 698-710 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Meta-Analysis
  • Systematic Reviews
  • Confidence Intervals
  • Product Recalls and Withdrawals
  • Health
  9 Citations (Scopus)

  26 Downloads (Pure)

• Proposals for Engaging Patients and Healthcare Professionals in Risk Minimisation from an Analysis of Stakeholder Input to the EU Valproate Assessment Using the Novel Analysing Stakeholder Safety Engagement Tool (ASSET)

  Bahri, P., Morales, D. R., Inoubli, A., Dogné, J-M. & Straus, S. M. J. M., 30 Oct 2020, In: Drug Safety. 17 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Stakeholder Participation
  • European Union
  • Valproic Acid
  • Delivery of Health Care
  • Safety
  15 Downloads (Pure)

• Quinine exposure and the risk of acute kidney injury: a population based observational study of older people

  Duncan, A. D. S., Hapca, S., De Souza, N., Morales, D. & Bell, S., 28 May 2020, In: Age and Ageing. 49, 6, p. 1042-1047 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Quinine
  • Acute Kidney Injury
  • Observational Studies
  • Population
  • Prescriptions
  1 Citation (Scopus)

  14 Downloads (Pure)

• Renin-angiotensin system blockers and susceptibility to COVID-19: an international, open science, cohort analysis

  Morales, D. R., Conover, M. M., You, S. C., Pratt, N., Kostka, K., Duarte-Salles, T., Fernández-Bertolín, S., Aragón, M., DuVall, S. L., Lynch, K., Falconer, T., van Bochove, K., Sung, C., Matheny, M. E., Lambert, C. G., Nyberg, F., Alshammari, T. M., Williams, A. E., Park, R. W., Weaver, J. & 13 others, Sena, A. G., Schuemie, M. J., Rijnbeek, P. R., Williams, R. D., Lane, J. C. E., Prats-Uribe, A., Zhang, L., Areia, C., Krumholz, H. M., Prieto-Alhambra, D., Ryan, P. B., Hripcsak, G. & Suchard, M. A., 17 Dec 2020, In: The Lancet. Digital health. 17 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Open Science
  • Cohort Analysis
  • Inhibitor
  • Susceptibility
  • Renin-Angiotensin System

• Risk of depression, suicide and psychosis with hydroxychloroquine treatment for rheumatoid arthritis: a multinational network cohort study

  Lane, J. C. E., Weaver, J., Kostka, K., Duarte-Salles, T., Abrahao, M. T. F., Alghoul, H., Alser, O., Alshammari, T. M., Areia, C., Biedermann, P., Banda, J. M., Burn, E., Casajust, P., Fister, K., Hardin, J., Hester, L., Hripcsak, G., Kaas-Hansen, B. S., Khosla, S., Kolovos, S. & 28 others, Lynch, K. E., Makadia, R., Mehta, P. P., Morales, D. R., Morgan-Stewart, H., Mosseveld, M., Newby, D., Nyberg, F., Ostropolets, A., Woong Park, R., Prats-Uribe, A., Rao, G. A., Reich, C., Rijnbeek, P., Sena, A. G., Shoaibi, A., Spotnitz, M., Vignesh, S., Suchard, M. A., Vizcaya, D., Wen, H., de Wilde, M., Xie, J., You, S. C., Zhang, L., Lovestone, S., Ryan, P. & Prieto-Alhambra, D., 25 Dec 2020, In: Rheumatology. 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Hydroxychloroquine
  • Suicidal Ideation
  • Psychotic Disorders
  • Suicide
  • Rheumatoid Arthritis

• Risk of hydroxychloroquine alone and in combination with azithromycin in the treatment of rheumatoid arthritis: a multinational, retrospective study

  Lane, J. C. E., Weaver, J., Kostka, K., Duarte-Salles, T., Abrahao, M. T. F., Alghoul, H., Alser, O., Alshammari, T. M., Biedermann, P., Banda, J. M., Burn, E., Casajust, P., Conover, M. M., Culhane, A. C., Davydov, A., DuVall, S. L., Dymshyts, D., Fernandez-Bertolin, S., Fišter, K., Hardin, J. & 42 others, Hester, L., Hripcsak, G., Kaas-Hansen, B. S., Kent, S., Khosla, S., Kolovos, S., Lambert, C. G., van der Lei, J., Lynch, K. E., Makadia, R., Margulis, A. V., Matheny, M. E., Mehta, P., Morales, D. R., Morgan-Stewart, H., Mosseveld, M., Newby, D., Nyberg, F., Ostropolets, A., Park, R. W., Prats-Uribe, A., Rao, G. A., Reich, C., Reps, J., Rijnbeek, P., Sathappan, S. M. K., Schuemie, M., Seager, S., Sena, A. G., Shoaibi, A., Spotnitz, M., Suchard, M. A., Torre, C. O., Vizcaya, D., Wen, H., de Wilde, M., Xie, J., You, S. C., Zhang, L., Zhuk, O., Ryan, P. & Prieto-Alhambra, D., 21 Aug 2020, In: The Lancet Rheumatology. 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Hydroxychloroquine
  • Azithromycin
  • Rheumatoid Arthritis
  • Retrospective Studies
  • Sulfasalazine
  13 Citations (Scopus)

  5 Downloads (Pure)
• 2019

  Addendum to: Relative and Absolute Risk of Tendon Rupture with Fluoroquinolone and Concomitant Fluoroquinolone/Corticosteroid Therapy: Population-Based Nested Case-Control Study

  Morales, D. R., Flynn, R. & Kurz, X., Jun 2019, In: Clinical Drug Investigation. 39, 6, p. 591-594 4 p.

  Research output: Contribution to journal › Letter › peer-review
  3 Citations (Scopus)

• A European multicentre drug utilisation study of the impact of regulatory measures on prescribing of codeine for pain in children

  Hedenmalm, K., Blake, K., Donegan, K., Macia, M. A., Gil, M., Williams, J., Montero, D., Candore, G., Morales, D., Kurz, X. & Arlett, P., Aug 2019, In: Pharmacoepidemiology and Drug Safety. 28, 8, p. 1086-1096 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Drug Utilization
  • Codeine
  • Germany
  • Adenoidectomy
  • Spain
  6 Citations (Scopus)

  109 Downloads (Pure)

• Association Between Peripheral Neuropathy and Exposure to Oral Fluoroquinolone or Amoxicillin-Clavulanate Therapy

  Morales, D., Pacurariu, A., Slattery, J., Pinheiro, L., McGettigan, P. & Kurz, X., 1 Jul 2019, In: JAMA Neurology. 76, 7, p. 827-833 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Clavulanic Acid
  • Fluoroquinolones
  • Amoxicillin
  • Peripheral Nervous System Diseases
  • Anti-Bacterial Agents
  15 Citations (Scopus)

• Correction to: Relative and Absolute Risk of Tendon Rupture with Fluoroquinolone and Concomitant Fluoroquinolone/Corticosteroid Therapy: Population-Based Nested Case-Control Study

  Morales, D. R., Slattery, J., Pacurariu, A., Pinheiro, L., McGettigan, P. & Kurz, X., Feb 2019, In: Clinical Drug Investigation. 39, 2, p. 215 1 p.

  Research output: Contribution to journal › Article

  Open Access

  File

  • Fluoroquinolones
  • Tendons
  • Rupture
  • Case-Control Studies
  • Adrenal Cortex Hormones
  1 Citation (Scopus)

  132 Downloads (Pure)

• Effect of withdrawal of fusafungine from the market on prescribing of antibiotics and other alternative treatments in Germany: a pharmacovigilance impact study

  Hedenmalm, K., Kurz, X. & Morales, D., Jul 2019, In: European Journal of Clinical Pharmacology. 75, 7, p. 979-984 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • fusafungin
  • Product Recalls and Withdrawals
  • Pharmacovigilance
  • Germany
  • Anti-Bacterial Agents
  4 Citations (Scopus)

  138 Downloads (Pure)

• Effects of fluoxetine on functional outcomes after acute stroke (FOCUS): a pragmatic, double-blind, randomised, controlled trial

  Dennis, M., Mead, G., Forbes, J., Graham, C., Hackett, M., Hankey, G. J., House, A., Lewis, S., Lundström, E., Sandercock, P., Innes, K., Williams, C., Drever, J., Mcgrath, A., Deary, A., Fraser, R., Anderson, R., Walker, P., Perry, D., Mcgill, C. & 31 others, Buchanan, D., Chun, Y., Dinsmore, L., Maschauer, E., Barugh, A., Mikhail, S., Blair, G., Hoeritzauer, I., Scott, M., Fraser, G., Burgess, D., Morales, D., Sullivan, F., Ross, F., Burgess, L., Young, R., Bokhari, M., Bruce, D., Potter, A., Evans, R., Smith, A., Johnston, S., Ross, S., Stirling, M., Simpson, J., Wright, A., Raza, S. A., Bell, A., Kumar, P., Thompson, A. & Khan, M. F., 19 Jan 2019, In: The Lancet. 393, 10168, p. 265-274 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Fluoxetine
  • Stroke
  • Randomized Controlled Trials
  • Placebos
  • Bone Fractures
  85 Citations (Scopus)

  150 Downloads (Pure)

• Facial palsy: when and why to refer for specialist care

  Butler, D. P., Morales, D. R., Johnson, K. & Nduka, C., Nov 2019, In: British Journal of General Practice. 69, 688, p. 579-580 2 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Facial Paralysis
  • Secondary Care
  • Primary Health Care
  • Facial Muscles
  • Facial Expression
  2 Citations (Scopus)

  13 Downloads (Pure)

• How to validate a diagnosis recorded in electronic health records

  Nissen, F., Quint, J. K., Morales, D. R. & Douglas, I. J., 1 Mar 2019, In: Breathe. 15, 1, p. 64-68 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Electronic Health Records
  • Databases
  3 Citations (Scopus)

  130 Downloads (Pure)

• Opioid use, postoperative complications, and implant survival after unicompartmental versus total knee replacement: a population-based network study

  Burn, E., Weaver, J., Morales, D., Prats-Uribe, A., Delmestri, A., Strauss, V. Y., He, Y., Robinson, D. E., Pinedo-Villanueva, R., Kolovos, S., Duarte-Salles, T., Sproviero, W., Yu, D., Van Speybroeck, M., Williams, R., John, L. H., Hughes, N., Sena, A. G., Costello, R., Birlie, B. & 6 others, Culliford, D., O'Leary, C., Morgan, H., Burkard, T., Prieto-Alhambra, D. & Ryan, P., Dec 2019, In: The Lancet Rheumatology. 1, 4, p. e229-e236 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Knee Replacement Arthroplasties
  • Opioid Analgesics
  • Postoperative Complications
  • Survival
  • Population
  5 Citations (Scopus)

  65 Downloads (Pure)

• Prescribing patterns of tramadol in adults in IMS® primary care databases in France and Germany between 1 January 2006 and 30 June 2016

  Hedenmalm, K., Slattery, J., Skibicka-stepien, I., Kurz, X. & Morales, D., May 2019, In: European Journal of Clinical Pharmacology. 75, 5, p. 707-716 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Tramadol
  • France
  • Germany
  • Primary Health Care
  • Databases
  3 Citations (Scopus)

  137 Downloads (Pure)

• Relative and Absolute Risk of Tendon Rupture with Fluoroquinolone and Concomitant Fluoroquinolone/Corticosteroid Therapy: Population-Based Nested Case-Control Study

  Morales, D. R., Slattery, J., Pacurariu, A., Pinheiro, L., McGettigan, P. & Kurz, X., Feb 2019, In: Clinical Drug Investigation. 39, 2, p. 205-213 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Fluoroquinolones
  • Tendons
  • Rupture
  • Case-Control Studies
  • Adrenal Cortex Hormones
  16 Citations (Scopus)

  67 Downloads (Pure)
• 2017

  Application of real-time global media monitoring and ‘derived questions’ for enhancing communication by regulatory bodies: the case of human papillomavirus vaccines

  Bahri, P., Fogd, J., Morales, D. & Kurz, X., 2 May 2017, In: BMC Medicine. 15, p. 1-13 13 p., 91.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Postural Orthostatic Tachycardia Syndrome
  • Papillomavirus Vaccines
  • Complex Regional Pain Syndromes
  • European Union
  • Vaccines
  13 Citations (Scopus)

  196 Downloads (Pure)

• Comorbidities in adults with asthma: population-based cross-sectional analysis of 1.4 million adults in Scotland

  Weatherburn, C. J., Guthrie, B., Mercer, S. W. & Morales, D. R., 28 Sep 2017, In: Clinical and Experimental Allergy. 47, 10, p. 1246-1252 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Scotland
  • Comorbidity
  • Asthma
  • Cross-Sectional Studies
  • Population
  27 Citations (Scopus)

  152 Downloads (Pure)

• Measuring the impact of medicines regulatory interventions - systematic review and methodological considerations

  Goedecke, T., Morales, D., Pacurariu, A. & Kurz, X., 20 Dec 2017, In: British Journal of Clinical Pharmacology. 84, p. 419-433 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Systematic Reviews
  • Communication
  • Drug Labeling
  • Public Health
  • Interrupted Time Series Analysis
  33 Citations (Scopus)

  154 Downloads (Pure)

• Off-label prescribing of antidepressants

  Morales, D. R. & Guthrie, B., 21 Feb 2017, In: BMJ. 356, 2 p., j849.

  Research output: Contribution to journal › Editorial

  Open Access

  File
  2 Citations (Scopus)

  217 Downloads (Pure)

• Respiratory effect of beta-blockers in people with asthma and cardiovascular disease: population-based nested case control study

  Morales, D. R., Lipworth, B. J., Donnan, P. T., Jackson, C. & Guthrie, B., 27 Jan 2017, In: BMC Medicine. 15, 9 p., 18.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Case-Control Studies
  • Asthma
  • Cardiovascular Diseases
  • Population
  • Incidence
  31 Citations (Scopus)

  317 Downloads (Pure)

• Validation of asthma recording in the Clinical Practice Research Datalink (CPRD)

  Nissen, F., Morales, D. R., Mullerova, H., Smeeth, L., Douglas, I. J. & Quint, J. K., 1 Aug 2017, In: BMJ Open. 7, 8, p. 1-9 9 p., e017474.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Asthma
  • Advisory Committees
  • Prescriptions
  • Primary Health Care
  • Peer Review
  32 Citations (Scopus)

  172 Downloads (Pure)
• 2016

  Accounting for multimorbidity in pay for performance: a modelling study using UK Quality and Outcomes Framework data

  Ruscitto, A., Mercer, S. W., Morales, D. & Guthrie, B., 5 Jul 2016, In: British Journal of General Practice. 66, 649, p. e561-e567 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Incentive Reimbursement
  • Multimorbidity
  • Human Influenza
  • Immunization
  • Blood Pressure
  2 Citations (Scopus)

• Respiratory effect of beta-blocker eye drops in asthma: population-based study and meta-analysis of clinical trials

  Morales, D. R., Dreischulte, T., Lipworth, B. J., Donnan, P. T., Jackson, C. & Guthrie, B., 8 Aug 2016, In: British Journal of Clinical Pharmacology. 82, 3, p. 814-822 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Ophthalmic Solutions
  • Asthma
  • Meta-Analysis
  • Clinical Trials
  • Ocular Hypertension
  24 Citations (Scopus)

  189 Downloads (Pure)