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Article

Application of Healthcare ‘Big Data’ in CNS Drug Research: The Example of the Neurological and mental health Global Epidemiology Network (NeuroGEN)

Ilomäki, J., Bell, J. S., Chan, A. Y. L., Tolppanen, A. M., Luo, H., Wei, L., Lai, E. C. C., Shin, J. Y., De Paoli, G., Pajouheshnia, R., Ho, F. K., Reynolds, L., Lau, K. K., Crystal, S., Lau, W. C. Y., Man, K. K. C., Brauer, R., Chan, E. W., Shen, C. Y., Kim, J. H. & 10 others, Lum, T. Y. S., Hartikainen, S., Koponen, M., Rooke, E., Bazelier, M., Klungel, O., Setoguchi, S., Pell, J. P., Cook, S. & Wong, I. C. K., 22 Jun 2020, In : CNS Drugs. 17 p.

Research output: Contribution to journalArticle

Application of hepatic cytochrome b5/P450 reductase null (HBRN) mice to study the role of cytochrome b5 in the cytochrome P450-mediated bioactivation of the anticancer drug ellipticine

Reed, L., Indra, R., Mrizova, I., Moserova, M., Schmeiser, H. H., Wolf, C. R., Henderson, C. J., Stiborova, M., Phillips, D. H. & Arlt, V. M., 1 Mar 2019, In : Toxicology and Applied Pharmacology. 366, p. 64-74 11 p.

Research output: Contribution to journalArticle

Open Access
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1 Citation (Scopus)
130 Downloads (Pure)

Application of higher-order spectra for the characterization of Coronary artery disease using electrocardiogram signals

Rajendra Acharya, U., Sudarshan, V. K., Koh, J. E. W., Martis, R. J., Tan, J. H., Oh, S. L., Muhammad, A., Hagiwara, Y., Mookiah, M. R. K., Chua, K. P., Chua, C. K. & Tan, R. S., Jan 2017, In : Biomedical Signal Processing and Control. 31, p. 31-43

Research output: Contribution to journalArticle

50 Citations (Scopus)

Application of High-Sensitivity Troponin in Suspected Myocardial Infarction

Neumann, J. T., Twerenbold, R., Ojeda, F., Sörensen, N. A., Chapman, A. R., Shah, A. S. V., Anand, A., Boeddinghaus, J., Nestelberger, T., Badertscher, P., Mokhtari, A., Pickering, J. W., Troughton, R. W., Greenslade, J., Parsonage, W., Mueller-Hennessen, M., Gori, T., Jernberg, T., Morris, N., Liebetrau, C. & 34 others, Hamm, C., Katus, H. A., Münzel, T., Landmesser, U., Salomaa, V., Iacoviello, L., Ferrario, M. M., Giampaoli, S., Kee, F., Thorand, B., Peters, A., Borchini, R., Jørgensen, T., Söderberg, S., Sans, S., Tunstall-Pedoe, H., Kuulasmaa, K., Renné, T., Lackner, K. J., Worster, A., Body, R., Ekelund, U., Kavsak, P. A., Keller, T., Lindahl, B., Wild, P., Giannitsis, E., Than, M., Cullen, L. A., Mills, N. L., Mueller, C., Zeller, T., Westermann, D. & Blankenberg, S., 27 Jun 2019, In : New England Journal of Medicine. 380, 26, p. 2529-2540 12 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)
Open Access
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5 Citations (Scopus)
132 Downloads (Pure)

Application of non-HDL cholesterol for population-based cardiovascular risk stratification: results from the Multinational Cardiovascular Risk Consortium

Brunner, F. J., Waldeyer, C., Ojeda, F., Salomaa, V., Kee, F., Sans, S., Thorand, B., Giampaoli, S., Brambilla, P., Tunstall-Pedoe, H., Moitry, M., Iacoviello, L., Veronesi, G., Grassi, G., Mathiesen, E. B., Söderberg, S., Linneberg, A., Brenner, H., Amouyel, P., Ferrières, J. & 20 others, Tamosiunas, A., Nikitin, Y. P., Drygas, W., Melander, O., Jöckel, K-H., Leistner, D. M., Shaw, J. E., Panagiotakos, D. B., Simons, L. A., Kavousi, M., Vasan, R. S., Dullaart, R. P. F., Wannamethee, S. G., Risérus, U., Shea, S., de Lemos, J. A., Omland, T., Kuulasmaa, K., Landmesser, U. & Blankenberg, S., 14 Dec 2019, In : Lancet. 394, 10215, p. 2173-2183 11 p.

Research output: Contribution to journalArticle

Open Access
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21 Citations (Scopus)
52 Downloads (Pure)

Application of pharmacogenomics and bioinformatics to exemplify the utility of human ex vivo organoculture models in the field of precision medicine

Cowan, K., MacLuskie, G., Finch, M., Palmer, C. N. A., Hair, J., Bylesjo, M., Lynagh, S., Brankin, P., McNeil, M., Low, C., Mallinson, D., Gourlay, E. M., Child, H., Cheyne, L. & Bunton, D. C., 20 Dec 2019, In : PLoS ONE. 14, 12, p. 1-15 15 p., e0226564.

Research output: Contribution to journalArticle

Open Access
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67 Downloads (Pure)
Open Access
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11 Citations (Scopus)
184 Downloads (Pure)

Application of Three-dimensional IGN-2 Equations to Wave Diffraction Problems

Zhao, B., Zhang, T., Duan, W., Ertekin, R. C. & Hayatdavoodi, M., 16 Dec 2019, In : Journal of Ocean Engineering and Marine Energy. 13 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Application of wavelet techniques for cancer diagnosis using ultrasound images: A Review

Sudarshan, V. K., Mookiah, M. R. K., Rajendra Acharya, U., Chandran, V., Molinari, F., Fujita, H. & Ng, K., Feb 2016, In : Computers in Biology and Medicine. 69, p. 97-111 15 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)

Applications of emerging transmission electron microscopy technology in PCD research and diagnosis

Shoemark, A., Sep 2017, In : Ultrastructural Pathology. 41, 6, p. 408-414 7 p.

Research output: Contribution to journalArticle

Open Access
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2 Citations (Scopus)
239 Downloads (Pure)
Open Access
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2 Citations (Scopus)
62 Downloads (Pure)

Approaches to communication assessment with children and adults with profound intellectual and multiple disabilities

Chadwick, D., Buell, S. & Goldbart, J., 1 Mar 2019, In : Journal of Applied Research in Intellectual Disabilities. 32, 2, p. 336-358 23 p.

Research output: Contribution to journalArticle

Open Access
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1 Citation (Scopus)
147 Downloads (Pure)

Approach to the treatment of faecal incontinence and external full thickness rectal prolapse

Ziyaie, D., Aug 2017, In : Surgery (Oxford). 35, 8, p. 462-466 5 p.

Research output: Contribution to journalArticle

A primary care web-based intervention modelling experiment replicated behaviour changes seen in earlier paper-based experiment

Treweek, S., Francis, J. J., Bonetti, D., Barnett, K., Eccles, M. P., Hudson, J., Jones, C., Pitts, N. B., Ricketts, I. W., Sullivan, F., Weal, M. & MacLennan, G., Dec 2016, In : Journal of Clinical Epidemiology. 80, p. 116-122 7 p.

Research output: Contribution to journalArticle

Open Access
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4 Citations (Scopus)
138 Downloads (Pure)
Open Access
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288 Downloads (Pure)

A prospective comparison of ER, PR, Ki67 and gene expression in paired sequential core biopsies of primary, untreated breast cancer

Hadad, S. M., Jordan, L. B., Roy, P. G., Purdie, C. A., Iwamoto, T., Pusztai, L., Moulder-Thompson, S. L. & Thompson, A. M., 22 Sep 2016, In : BMC Cancer. 16, p. 1-11 11 p., 745.

Research output: Contribution to journalArticle

Open Access
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6 Citations (Scopus)
164 Downloads (Pure)

A prospective multicentre observational study of Permacol collagen paste for anorectal fistula: Preliminary results

Giordano, P., Sileri, P., Buntzen, S., Stuto, A., Nunoo-Mensah, J., Lenisa, L., Singh, B., Thorlacius-Ussing, O., Griffiths, B. & Ziyaie, D., Mar 2016, In : Colorectal Disease. 18, 3, p. 286-294 9 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

A prospective observational study of the utility of early diagnostic laparoscopy for right lower abdominal pain: a safe and effective diagnostic and therapeutic tool

Guthrie, G. J. K., Johnston, T., Ewing, A., Mullen, R., Suttie, S. A. & Patil, P. V., 1 May 2019, In : Scottish Medical Journal. 64, 2, p. 49-55 7 p.

Research output: Contribution to journalArticle

A prospective observational study protocol to investigate long-term adverse effects of methylphenidate in children and adolescents with ADHD: The Attention Deficit Hyperactivity Disorder Drugs Use Chronic Effects (ADDUCE) study

Inglis, S., Carucci, S., Garas, P., Häge, A., Banaschewski, T., Buitelaar, J. K., Dittmann, R. W., Falissard, B., Hollis, C., Kovshoff, H., Liddle, E., McCarthy, S., Nagy, P., Neubert, A., Rosenthal, E., Sonuga-Barke, E., Wong, I., Zuddas, A., Coghill, D. C. & ADDUCE Consortium, 26 Apr 2016, In : BMJ Open. 6, 4, p. 1-12 12 p., e010433.

Research output: Contribution to journalArticle

Open Access
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14 Citations (Scopus)
159 Downloads (Pure)

A prospective questionnaire-based study on staff awareness of intimate partner violence (IPV) in orthopaedic trauma patients

Downie, S., Madden, K., Bhandari, M. & Jariwala, A., Aug 2019, In : Surgeon: Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland. 17, 4, p. 207-214 8 p.

Research output: Contribution to journalArticle

A protein phosphatase network controls the temporal and spatial dynamics of differentiation commitment in human epidermis

Mishra, A., Oulès, B., Pisco, A. O., Ly, T., Liakath-Ali, K., Walko, G., Viswanathan, P., Tihy, M., Nijjhar, J., Dunn, S-J., Lamond, A. I. & Watt, F. M., 18 Oct 2017, In : eLife. 6, p. 1-20 20 p., e27356.

Research output: Contribution to journalArticle

Open Access
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12 Citations (Scopus)
232 Downloads (Pure)

A Proteomic Approach to Analyze the Aspirin-mediated Lysine Acetylome

Tatham, M. H., Cole, C., Scullion, P., Wilkie, R., Westwood, N. J., Stark, L. A. & Hay, R. T., 1 Feb 2017, In : Molecular & Cellular Proteomics. 16, 2, p. 310-326 17 p.

Research output: Contribution to journalArticle

Open Access
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21 Citations (Scopus)
189 Downloads (Pure)

A proteomic signature for CNS adaptations to the valence of environmental stimulation

Shaw, A., Arnold, L. D., Privitera, L., Whitfield, P. D., Doherty, M. K. & Morè, L., 6 Apr 2020, In : Behavioural Brain Research. 383, 112515.

Research output: Contribution to journalArticle

A protocol for co-creating research project lay summaries with stakeholders: Guideline development for Canada's AGE-WELL Network

Wada, M., Sixsmith, J., Harwood, G., Cosco, T. D., Fang, M. L. & Sixsmith, A., 8 May 2020, In : Research Involvement and Engagement. 6, p. 1-8 8 p., 22.

Research output: Contribution to journalArticle

Open Access
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17 Downloads (Pure)
Open Access
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1 Citation (Scopus)
85 Downloads (Pure)
Open Access
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3 Citations (Scopus)
74 Downloads (Pure)

Aquaglyceroporin-null trypanosomes display glycerol transport defects and respiratory-inhibitor sensitivity

Jeacock, L., Baker, N., Wiedemar, N., Mäser, P. & Horn, D., 30 Mar 2017, In : PLoS Pathogens. 13, 3, p. 1-16 16 p., e1006307.

Research output: Contribution to journalArticle

Open Access
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17 Citations (Scopus)
146 Downloads (Pure)

A qualitative exploration of memory cuing by personal items in the home

Zijlema, A., van den Hoven, E. & Eggen, B., Aug 2019, In : Memory Studies. 12, 4, p. 377-397 21 p.

Research output: Contribution to journalArticle

Open Access
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1 Citation (Scopus)
102 Downloads (Pure)

A Quantitative Study of In Vivo Protoporphyrin IX Fluorescence Build Up During Occlusive Treatment Phases

Campbell, C. L., Brown, C. T. A., Wood, K., Salvio, A. G., Inada, N. M., Bagnato, V. S. & Moseley, H., Jun 2017, In : Photodiagnosis and photodynamic therapy. 18, p. 204-207

Research output: Contribution to journalArticle

Open Access
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2 Citations (Scopus)
158 Downloads (Pure)

A quasi-cyclic RNA nano-scale molecular object constructed using kink turns

Huang, L. & Lilley, D. M. J., 7 Sep 2016, In : Nanoscale. 8, 33, p. 15189-15195 7 p.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
176 Downloads (Pure)

A quasi-experimental evaluation of dried blood spot testing through community pharmacies in the Tayside region of Scotland

Radley, A., Melville, K., Tait, J., Stephens, B., Evans, J. M. M. & Dillon, J. F., 1 Jul 2017, In : Frontline Gastroenterology. 8, 3, p. 221-228 8 p.

Research output: Contribution to journalArticle

Open Access
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15 Citations (Scopus)
187 Downloads (Pure)

Arabidopsis FORGETTER1 mediates stress-induced chromatin memory through nucleosome remodeling

Brzezinka, K., Altmann, S., Czesnick, H., Nicolas, P., Gorka, M., Benke, E., Kabelitz, T., Jähne, F., Graf, A., Kappel, C. & Bäurle, I., 28 Sep 2016, In : eLife. 5, September, p. 1-23 23 p., e17061.

Research output: Contribution to journalArticle

Open Access
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32 Citations (Scopus)
209 Downloads (Pure)

A randomised, double-blind, parallel-group trial to assess mercaptopurine versus placebo to prevent or delay recurrence of Crohn's disease following surgical resection (TOPPIC)

Satsangi, J., Kennedy, N. A., Mowat, C., Arnott, I., Keerie, C., Lewis, S., Ennis, H. & on behalf of the TOPPIC Collaborators Group, Sep 2017, In : Efficacy and Mechanism Evaluation. 4, 4, p. 1-59 86 p.

Research output: Contribution to journalArticle

Open Access
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195 Downloads (Pure)

A randomised, factorial trial to reduce arterial stiffness independently of blood pressure: Proof of concept? The 'VaSera' trial testing dietary nitrate and spironolactone

Mills, C. E., Govoni, V., Faconti, L., Casagrande, M-L., Morant, S. V., Crickmore, H., Iqbal, F., Maskell, P., Masani, A., Nanino, E., Webb, A. J. & Cruickshank, J. K., 17 Apr 2020, In : British Journal of Clinical Pharmacology. 86, 5, p. 891-902 12 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
Open Access
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1 Citation (Scopus)
60 Downloads (Pure)

A randomised controlled trial assessing the severity and duration of depressive symptoms associated with a clinically significant response to sertraline versus placebo, in people presenting to primary care with depression (PANDA trial): study protocol for a randomised controlled trial

Salaminios, G., Duffy, L., Ades, A., Araya, R., Button, K. S., Churchill, R., Croudace, T., Derrick, C., Dixon, P., Dowrick, C., Gilbody, S., Hollingworth, W., Jones, V., Kendrick, T., Kessler, D., Kounali, D., Lanham, P., Malpass, A., Peters, T. J., Riozzie, D. & 6 others, Robinson, J., Sharp, D., Thomas, L., Welton, N. J., Wiles, N. & Lewis, G., 24 Oct 2017, In : Trials. 18, p. 1-14 14 p., 496.

Research output: Contribution to journalArticle

Open Access
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5 Citations (Scopus)
160 Downloads (Pure)
Open Access
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18 Downloads (Pure)

A randomised control trial of atorvastatin in bronchiectasis patients infected with Pseudomonas aeruginosa- a proof of concept study

Bedi, P., Chalmers, J. D., Graham, C., Clarke, A., Donaldson, S., Doherty, C. J., Govan, J. R. W., Davidson, D. J., Rossi, A. G. & Hill, A. T., Aug 2017, In : Chest. 152, 2, p. 368-378 11 p.

Research output: Contribution to journalArticle

Open Access
File
19 Citations (Scopus)
153 Downloads (Pure)

A randomised cross-over trial comparing the McGrath® Series 5 videolaryngoscope with the Macintosh laryngoscope in patients with cervical spine immobilisation

Foulds, L. T., McGuire, B. E. & Shippey, B. J., Apr 2016, In : Anaesthesia. 71, 4, p. 437-442 6 p., 13384.

Research output: Contribution to journalArticle

12 Citations (Scopus)

A randomised phase III study of 72 hour infusional versus bolus bleomycin in BEP (bleomycin, etoposide and cisplatin) chemotherapy to treat IGCCCG good prognosis metastatic germ cell tumours (TE-3)

Shamash, J., Sarker, S. J., Huddart, R., Harland, S., Joffe, J. K., Mazhar, D., Birtle, A., White, J., Chowdhury, K., Wilson, P., Marshall, M. R. & Vinnicombe, S., Jun 2017, In : Annals of Oncology. 28, 6, p. 1333-1338 6 p.

Research output: Contribution to journalArticle

Open Access
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6 Citations (Scopus)
169 Downloads (Pure)

A randomised placebo-controlled trial of oral and topical antibiotics for children with clinically infected eczema in the community: the ChildRen with Eczema, Antibiotic Management (CREAM) study

Francis, N. A., Ridd, M. J., Thomas-Jones, E., Shepherd, V., Butler, C. C., Hood, K., Huang, C., Addison, K., Longo, M., Marwick, C., Wootton, M., Howe, R., Roberts, A., Haq, M. I-U., Madhok, V. & Sullivan, F., Mar 2016, In : Health Technology Assessment. 20, 19, p. 1-84 84 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

A randomized, open-label study of the efficacy and safety of AZD4547 monotherapy versus paclitaxel for the treatment of advanced gastric adenocarcinoma with FGFR2 polysomy or gene amplification

Van Cutsem, É., Bang, Y-J., Mansoor, W., Petty, R. D., Chao, Y., Cunningham, D., Ferry, D. R., Smith, N. R., Frewer, P., Rarnayake, J., Stockman, P. K., Kilgour, E. & Landers, D., 1 Jun 2017, In : Annals of Oncology. 28, 6, p. 1316-1324 8 p.

Research output: Contribution to journalArticle

Open Access
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44 Citations (Scopus)
158 Downloads (Pure)

A randomized clinical trial of the effectiveness of 0.018-inch and 0.022-inch slot orthodontic bracket systems: part 2 - quality of treatment

Yassir, Y. A., El-Angbawi, A. M., McIntyre, G. T., Revie, G. & Bearn, D. R., Apr 2019, In : European Journal of Orthodontics. 41, 2, p. 143-153 11 p., cyj038.

Research output: Contribution to journalArticle

Open Access
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7 Citations (Scopus)
110 Downloads (Pure)

A randomized clinical trial of the effectiveness of 0.018-inch and 0.022-inch slot orthodontic bracket systems: part 1 - duration of treatment

Yassir, Y. A., El-Angbawi, A. M., McIntyre, G. T., Revie, G. F. & Bearn, D. R., Apr 2019, In : European Journal of Orthodontics. 41, 2, p. 133-142 10 p., cjy037.

Research output: Contribution to journalArticle

Open Access
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4 Citations (Scopus)
123 Downloads (Pure)

A randomized clinical trial of the effectiveness of 0.018-inch and 0.022-inch slot orthodontic bracket systems: part 3 - biological side-effects of treatment

El-Angbawi, A. M., Yassir, Y. A., McIntyre, G. T., Revie, G. F. & Bearn, D. R., Apr 2019, In : European Journal of Orthodontics. 41, 2, p. 154-164 11 p., cjy039.

Research output: Contribution to journalArticle

Open Access
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3 Citations (Scopus)
136 Downloads (Pure)

A randomized controlled trial of allopurinol in patients with peripheral arterial disease

Robertson, A. J. & Struthers, A. D., Feb 2016, In : Canadian Journal of Cardiology. 32, 2, p. 190-196 7 p.

Research output: Contribution to journalArticle

Open Access
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8 Citations (Scopus)
149 Downloads (Pure)

A Randomized Controlled Trial of Metformin on Left Ventricular Hypertrophy in Patients with Coronary Artery Disease without Diabetes: The MET-REMODEL Trial

Mohan, M., Al-Talabany, S., McKinnie, A., Mordi, I., Singh, J., Gandy, S., Baig, F., Hussain, M. S. ., Bhalraam, U., Khan, F., Choy, A., Matthew, S., Houston, G., Struthers, A., George, J. & Lang, C. C., 1 Nov 2019, In : European Heart Journal. 40, 41, p. 3409-3417 9 p.

Research output: Contribution to journalArticle

Open Access
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19 Citations (Scopus)
99 Downloads (Pure)

A Randomized Trial Directly Comparing Ventral Capsule and Anteromedial Subthalamic Nucleus Stimulation in Obsessive-Compulsive Disorder: Clinical and Imaging Evidence for Dissociable Effects

Tyagi, H., Apergis-Schoute, A. M., Akram, H., Foltynie, T., Limousin, P., Drummond, L. M., Fineberg, N. A., Matthews, K., Jahanshahi, M., Robbins, T. W., Sahakian, B. J., Zrinzo, L., Hariz, M. & Joyce, E. M., 1 May 2019, In : Biological Psychiatry. 85, 9, p. 726-734 9 p.

Research output: Contribution to journalArticle

Open Access
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23 Citations (Scopus)
114 Downloads (Pure)

A rapid review to identify physical activity accrued while playing golf

Luscombe, J., Murray, A. D., Jenkins, E. & Archibald, D., 28 Nov 2017, In : BMJ Open. 7, 11, 9 p., 018993.

Research output: Contribution to journalArticle

Open Access
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6 Citations (Scopus)
2 Downloads (Pure)