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  • 2020
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  • James Chalmers
2020

ACCORD: A Multicentre, Seamless, Phase 2 Adaptive Randomisation Platform Study to Assess the Efficacy and Safety of Multiple Candidate Agents for the Treatment of COVID-19 in Hospitalised Patients: A structured summary of a study protocol for a randomised controlled trial

Wilkinson, T., Dixon, R., Page, C., Carroll, M., Griffiths, G., Ho, L-P., De Soyza, A., Felton, T., Lewis, K. E., Phekoo, K., Chalmers, J. D., Gordon, A., McGarvey, L., Doherty, J., Read, R. C., Shankar-Hari, M., Martinez-Alier, N., O'Kelly, M., Duncan, G., Walles, R. & 3 others, Sykes, J., Summers, C. & Singh, D., 31 Jul 2020, In : Trials. 21, 1, 3 p., 691.

Research output: Contribution to journalArticle

Open Access
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31 Downloads (Pure)

A cuckoo covid coincidence?

Chalmers, J. D. & Lonergan, M., 9 Sep 2020, In : European Respiratory Journal. 4 p.

Research output: Contribution to journalArticle

Open Access
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13 Downloads (Pure)

A membrane-depolarizing toxin substrate of the Staphylococcus aureus type VII secretion system mediates intraspecies competition

Ulhuq, F. R., Gomes, M. C., Duggan, G. M., Guo, M., Mendonca, C., Buchanan, G., Chalmers, J. D., Cao, Z., Kneuper, H., Murdoch, S., Thomson, S., Strahl, H., Trost, M., Mostowy, S. & Palmer, T., 25 Aug 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 34, p. 20836-20847 12 p.

Research output: Contribution to journalArticle

Open Access
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10 Downloads (Pure)

Blood eosinophils as a biomarker of future COPD exacerbation risk: pooled data from 11 clinical trials

Singh, D., Wedzicha, J. A., Siddiqui, S., de la Hoz, A., Xue, W., Magnussen, H., Miravitlles, M., Chalmers, J. D. & Calverley, P. M. A., 17 Sep 2020, In : Respiratory Research. 21, 10 p., 240.

Research output: Contribution to journalArticle

Open Access
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Blood neutrophil counts are associated with exacerbation frequency and mortality in COPD

Lonergan, M., Dicker, A. J., Crichton, M. L., Keir, H. R., Van Dyke, M. K., Mullerova, H., Miller, B. E., Tal-Singer, R. & Chalmers, J. D., 1 Jul 2020, In : Respiratory Research. 21, p. 1-10 10 p., 166.

Research output: Contribution to journalArticle

Open Access
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13 Downloads (Pure)

Changes in respiratory symptoms during 48 weeks treatment with ARD-3150 (inhaled liposomal ciprofloxacin) in bronchiectasis: results from the ORBIT-3 and -4 studies

Chalmers, J. D., Cipolla, D., Thompson, B., Davis, A. M., O'Donnell, A., Tino, G., Gonda, I., Haworth, C. & Froehlich, J., 18 Jun 2020, In : European Respiratory Journal. 55, 6

Research output: Contribution to journalArticle

Counting the cost of bronchiectasis

Gao, Y-H. & Chalmers, J. D., 30 Jun 2020, In : Respirology . 2 p.

Research output: Contribution to journalEditorial

Cystic fibrosis lung disease and bronchiectasis

Chalmers, J. D., Jan 2020, In : The Lancet Respiratory Medicine. 8, 1, p. 12-14 3 p.

Research output: Contribution to journalComment/debate

Open Access
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44 Downloads (Pure)

Development and initial validation of the bronchiectasis exacerbation and symptom tool (BEST)

Artaraz, A., Crichton, M. L., Finch, S., Abo-Leyah, H., Goeminne, P., Aliberti, S., Fardon, T. & Chalmers, J. D., 13 Jan 2020, In : Respiratory Research. 21, 1, p. 1-9 1 p., 18.

Research output: Contribution to journalArticle

Open Access
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46 Downloads (Pure)

Development and Reporting of Prediction Models: Guidance for Authors From Editors of Respiratory, Sleep, and Critical Care Journals

Leisman, D. E., Harhay, M. O., Lederer, D. J., Abramson, M., Adjei, A. A., Bakker, J., Ballas, Z. K., Barreiro, E., Bell, S. C., Bellomo, R., Bernstein, J. A., Branson, R. D., Brusasco, V., Chalmers, J. D., Chokroverty, S., Citerio, G., Collop, N. A., Cooke, C. R., Crapo, J. D., Donaldson, G. & 19 others, Fitzgerald, D. A., Grainger, E., Hale, L., Herth, F. J., Kochanek, P. M., Marks, G., Moorman, J. R., Ost, D. E., Schatz, M., Sheikh, A., Smyth, A. R., Stewart, I., Stewart, P. W., Swenson, E. R., Szymusiak, R., Teboul, J-L., Vincent, J-L., Wedzicha, J. A. & Maslove, D. M., May 2020, In : Critical Care Medicine. 48, 5, p. 623-633 11 p.

Research output: Contribution to journalArticle

Open Access
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7 Citations (Scopus)
167 Downloads (Pure)

Development of Drugs for Nontuberculous Mycobacterial Disease: Clinicians' Interpretation of a US FDA Workshop

Flume, P. A., Griffith, D. E., Chalmers, J. D., Daley, C. L., Olivier, K., O'Donnell, A., Aksamit, T., Kasperbauer, S., Leitman, A. & Winthrop, K. L., 24 Aug 2020, In : Chest.

Research output: Contribution to journalReview article

Drive-through testing for SARS-CoV-2 in symptomatic health and social care workers and household members: an observational cohort study

Parcell, B., Brechin, K., Allstaff, S., Park, M., Third, W., Bean, S., Hind, C., Farmer, R. & Chalmers, J. D., 27 Aug 2020, In : Thorax. 3 p.

Research output: Contribution to journalArticle

Open Access
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43 Downloads (Pure)

Efficacy and safety of TOBI Podhaler® in Pseudomonas aeruginosa-infected bronchiectasis patients: iBEST study

Loebinger, M. R., Polverino, E., Chalmers, J. D., Tiddens, H. A. W. M., Goossens, H., Ringhausen, F. C., Tunney, M., Hill, A. T., Pathan, R., Angyalosi, G., Blasi, F., Elborn, S. J. & Haworth, C. S., 27 Aug 2020, In : European Respiratory Journal.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
8 Downloads (Pure)

Happy Birthday Bronchiectasis: 200 Years of Targeting Mucus

Chalmers, J. D. & Sibila, O., 15 Mar 2020, In : American Journal of Respiratory and Critical Care Medicine. 201, 6, p. 639-640 2 p.

Research output: Contribution to journalEditorial

Open Access
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24 Downloads (Pure)

Increased Chitotriosidase Is Associated With Aspergillus and Frequent Exacerbations in South-East Asian Patients With Bronchiectasis

Poh, T. Y., Tiew, P. Y., Hou Lim, A. Y., Thng, K. X., Binte Mohamed Ali, N. A., Narayana, J. K., Aogáin, M. M., Tien, Z., Chew, W. M., Wai Chan, A. K., Keir, H. R., Dicker, A. J., Hassan, T. M., Xu, H., Tee, A. K. H., Ong, T. H., Koh, M. S., Abisheganaden, J. A., Chalmers, J. D. & Chotirmall, S. H., Aug 2020, In : Chest. 158, 2, p. 512-522 11 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

International perspective on the new 2019 ATS/IDSA CAP guideline - a critical appraisal by a global expert panel

Pletz, M. W., Blasi, F., Chalmers, J. D., Dela Cruz, C. S., Feldman, C., Luna, C. M., Ramirez, J. A., Shindo, Y., Stolz, D., Torres, A., Webb, B., Welte, T., Wunderink, R. & Aliberti, S., 25 Aug 2020, In : Chest.

Research output: Contribution to journalReview article

Is bronchiectasis really a disease?

Shteinberg, M., Flume, P. A. & Chalmers, J. D., 31 Mar 2020, In : European Respiratory Review. 29, 155, p. 1-10 10 p., 190051.

Research output: Contribution to journalArticle

Open Access
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48 Downloads (Pure)

"Management of Community-Acquired Pneumonia in Immunocompromised Adults: A Consensus Statement Regarding Initial Strategies"

Ramirez, J. A., Musher, D. M., Evans, S. E., Dela Cruz, C., Crothers, K. A., Hage, C. A., Aliberti, S., Anzueto, A., Arancibia, F., Arnold, F., Azoulay, E., Blasi, F., Bordon, J., Burdette, S., Cao, B., Cavallazzi, R., Chalmers, J., Charles, P., Chastre, J., Claessens, Y-E. & 26 others, Dean, N., Duval, X., Fartoukh, M., Feldman, C., File, T., Froes, F., Furmanek, S., Gnoni, M., Lopardo, G., Luna, C., Maruyama, T., Menendez, R., Metersky, M., Mildvan, D., Mortensen, E., Niederman, M. S., Pletz, M., Rello, J., Restrepo, M. I., Shindo, Y., Torres, A., Waterer, G., Webb, B., Welte, T., Witzenrath, M. & Wunderink, R., 16 Jun 2020, In : Chest.

Research output: Contribution to journalReview article

Managing and preventing exacerbation of bronchiectasis

Abo-Leyah, H. & Chalmers, J. D., Apr 2020, In : Current Opinion in Infectious Diseases. 33, 2, p. 189-196 8 p.

Research output: Contribution to journalArticle

Phase 2 Trial of the DPP-1 Inhibitor Brensocatib in Bronchiectasis

Chalmers, J. D., Haworth, C. S., Metersky, M. L., Loebinger, M. R., Blasi, F., Sibila, O., O'Donnell, A. E., Sullivan, E. J., Mange, K. C., Fernandez, C., Zou, J. & Daley, C. L., 7 Sep 2020, In : New England Journal of Medicine. 11 p.

Research output: Contribution to journalArticle

Relationship between Symptoms, Exacerbations, and Treatment Response in Bronchiectasis

Gao, Y-H., Abo Leyah, H., Finch, S., Lonergan, M., Aliberti, S., De Soyza, A., Fardon, T. C., Tino, G. & Chalmers, J. D., 15 Jun 2020, In : American Journal of Respiratory and Critical Care Medicine. 201, 12, p. 1499-1507 9 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Rewiring the Immune Response in COVID-19

Chalmers, J. D. & Chotirmall, S. H., 5 Aug 2020, In : American Journal of Respiratory and Critical Care Medicine. 7 p.

Research output: Contribution to journalArticle

Sputum Neutrophil Elastase associates with microbiota and P. aeruginosa in bronchiectasis

Oriano, M., Gramegna, A., Terranova, L., Sotgiu, G., Sulaiman, I., Ruggiero, L., Saderi, L., Wu, B., Chalmers, J. D., Segal, L. N., Marchisio, P., Blasi, F. & Aliberti, S., 4 Jun 2020, In : European Respiratory Journal.

Research output: Contribution to journalArticle

Sputum neutrophil elastase in bronchiectasis: a Southern European cohort study

Gramegna, A., Aliberti, S., Sibila, O., Di Francesco, C., Sotgiu, G., Perea, L., Terranova, L., Oriano, M., Pilocane, T., Saderi, L., Chalmers, J. D., Marchisio, P. & Blasi, F., 25 Jun 2020, In : European Respiratory Journal. 56, 1

Research output: Contribution to journalArticle

The evolution of the European Respiratory Journal: ready for the new decade!

Chalmers, J. D., Reeves, E. L., Bullen, N. J. & Kolb, M., Jan 2020, In : European Respiratory Journal. 55, 1, p. 1-4 4 p., 1902503.

Research output: Contribution to journalEditorial

The microbiome in bronchiectasis: Cutting a lung story short

Smith, A. H. & Chalmers, J. D., 1 Jan 2020, In : Respirology . 25, 1, p. 43-44 2 p.

Research output: Contribution to journalEditorial

The Sputum Microbiome, Airway Inflammation and Mortality in Chronic Obstructive Pulmonary Disease

Dicker, A. J., Huang, J. T. J., Lonergan, M., Keir, H. R., Fong, C. J., Tan, B., Cassidy, A. J., Finch, S., Mullerova, H., Miller, B. E., Tal-Singer, R. & Chalmers, J. D., 28 Apr 2020, In : Journal of Allergy and Clinical Immunology. 10 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Utility of routine screening for alpha-1 antitrypsin deficiency in patients with bronchiectasis

Carreto, L., Morrison, M., Donovan, J., Finch, S., Tan, G. L., Fardon, T., Wilson, R., Furrie, E., Loebinger, M. & Chalmers, J. D., 26 Jun 2020, In : Thorax. 75, 7, p. 592-593 2 p.

Research output: Contribution to journalArticle

Open Access
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17 Downloads (Pure)

Variability in airway inflammation, symptoms, lung function and reliever use in asthma: anti-inflammatory reliever hypothesis and STIFLE study design

Harrison, T., Pavord, I. D., Chalmers, J. D., Whelan, G., Fagerås, M., Rutgersson, A., Belton, L., Siddiqui, S. & Gustafson, P., 8 Jun 2020, In : ERJ Open Research. 6, 2, p. 1-10 10 p., 00333.

Research output: Contribution to journalArticle

Open Access
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11 Downloads (Pure)

Withdrawal of inhaled corticosteroids in COPD: A European Respiratory Society Guideline

Chalmers, J. D., Laska, I. F., Franssen, F. M. E., Janssens, W., Pavord, I., Rigau, D., McDonnell, M. J., Roche, N., Sin, D. D., Stolz, D., Suissa, S., Wedzicha, J. & Miravitlles, M., 1 Jun 2020, In : European Respiratory Journal. 55, 6, 12 p., 2000351.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2019

A 2 × 2 factorial, randomised, open-label trial to determine the clinical and cost-effectiveness of hypertonic saline (HTS 6%) and carbocisteine for airway clearance versus usual care over 52 weeks in adults with bronchiectasis: a protocol for the CLEAR clinical trial

Bradley, J. M., Anand, R., O'Neill, B., Ferguson, K., Clarke, M., Carroll, M., Chalmers, J., De Soyza, A., Duckers, J., Hill, A. T., Loebinger, M. R., Copeland, F., Gardner, E., Campbell, C., Agus, A., McGuire, A., Boyle, R., McKinney, F., Dickson, N., McAuley, D. F. & 1 others, Elborn, S., 19 Dec 2019, In : Trials. 20, 1, p. 1-10 10 p., 747.

Research output: Contribution to journalArticle

Open Access
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40 Downloads (Pure)

Airway Bacterial Load and Inhaled Antibiotic Response in Bronchiectasis

Sibila, O., Laserna, E., Shoemark, A., Keir, H. R., Finch, S., Rodrigo-Troyano, A., Perea, L., Lonergan, M., Goeminne, P. C. & Chalmers, J. D., 1 Jul 2019, In : American Journal of Respiratory and Critical Care Medicine. 200, 1, p. 33-41 9 p.

Research output: Contribution to journalArticle

Open Access
File
12 Citations (Scopus)
19 Downloads (Pure)

Antimicrobial peptides, disease severity and exacerbations in bronchiectasis

Sibila, O., Perea, L., Cantó, E., Shoemark, A., Cassidy, D., Smith, A. H., Suarez-cuartin, G., Rodrigo-troyano, A., Keir, H. R., Oriano, M., Ong, S., Vidal, S., Blasi, F., Aliberti, S. & Chalmers, J. D., Sep 2019, In : Thorax. 74, 9, p. 835-842 8 p.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
187 Downloads (Pure)

A point of care neutrophil elastase activity assay identifies bronchiectasis severity, airway infection and risk of exacerbation

Shoemark, A., Cant, E., Carreto, L., Smith, A., Oriano, M., Keir, H. R., Perea, L., Canto, E., Terranova, L., Vidal, S., Moffitt, K., Aliberti, S., Sibila, O. & Chalmers, J. D., 1 Jun 2019, In : European Respiratory Journal. 53, 6, 1900303.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
17 Downloads (Pure)

A systematic review of pharmacotherapeutic clinical trial end-points for bronchiectasis in adults

Crichton, M. L., Aliberti, S. & Chalmers, J. D., 31 Mar 2019, In : European Respiratory Review. 28, 151, p. 1-14 14 p., 180108.

Research output: Contribution to journalReview article

Open Access
File
3 Citations (Scopus)
140 Downloads (Pure)

British Thoracic Society Guideline for bronchiectasis in adults

Hill, A. T., Sullivan, A. L., Chalmers, J. D., De Soyza, A., Elborn, J. S., Floto, R. A., Grillo, L., Gruffydd-Jones, K., Harvey, A., Haworth, C. S., Hiscocks, E., Hurst, J. R., Johnson, C., Kelleher, W. P., Bedi, P., Payne, K., Saleh, H., Screaton, N. J., Smith, M., Tunney, M. & 3 others, Whitters, D., Wilson, R. & Loebinger, M. R., Jan 2019, In : Thorax. 74, Suppl 1, p. 1-69 69 p., 74.

Research output: Contribution to journalArticle

Open Access
File
44 Citations (Scopus)
111 Downloads (Pure)

Bronchiectasis Guidelines-Recommendations Into Practice

Redondo, M. & Chalmers, J. D., Jun 2019, In : Archivos de Bronconeumologia. 55, 6, p. 286-288 3 p.

Research output: Contribution to journalEditorial

Bronchiectasis in India: results from the European Multicentre Bronchiectasis Audit and Research Collaboration (EMBARC) and Respiratory Research Network of India Registry

Dhar, R., Singh, S., Talwar, D., Mohan, M., Tripathi, S. K., Swarnakar, R., Trivedi, S., Rajagopala, S., D'Souza, G., Padmanabhan, A., Baburao, A., Mahesh, P. A., Ghewade, B., Nair, G., Jindal, A., Jayadevappa, G. D. H., Sawhney, H., Sarmah, K. R., Saha, K., Anantharaj, S. & 44 others, Khanna, A., Gami, S., Shah, A., Shah, A., Dutt, N., Garg, H., Vyas, S., Venugopal, K., Prasad, R., Aleemuddin, N. M., Karmakar, S., Singh, V., Jindal, S. K., Sharma, S., Prajapat, D., Chandrashekaria, S., McDonnell, M. J., Mishra, A., Rutherford, R., Ramanathan, R. P., Goeminne, P. C., Vasudev, P., Dimakou, K., Crichton, M. L., Jayaraj, B. S., Kungwani, R., Das, A., Sawhney, M., Polverino, E., Torres, A., Gulecha, N. S., Shteinberg, M., De Soyza, A., Mangala, A., Shah, P., Chauhan, N. K., Jajodia, N., Singhal, A., Batra, S., Hasan, A., Limaye, S., Salvi, S., Aliberti, S. & Chalmers, J. D., 1 Sep 2019, In : The Lancet Global Health. 7, 9, p. e1269-e1279 11 p.

Research output: Contribution to journalArticle

Open Access
File
16 Citations (Scopus)
78 Downloads (Pure)

Bronchiectasis insanity: Doing the same thing over and over again and expecting different results?

Metersky, M. & Chalmers, J., 15 Mar 2019, In : F1000Research. 8, p. 1-7 7 p., 293.

Research output: Contribution to journalReview article

Open Access
File
1 Citation (Scopus)
109 Downloads (Pure)

Challenges in severe community-acquired pneumonia: a point-of-view review

Torres, A., Chalmers, J. D., Dela Cruz, C. S., Dominedò, C., Kollef, M., Martin-Loeches, I., Niederman, M. & Wunderink, R. G., Feb 2019, In : Intensive Care Medicine. 45, 2, p. 159-171 13 p.

Research output: Contribution to journalReview article

11 Citations (Scopus)

Control of Confounding and Reporting of Results in Causal Inference Studies: Guidance for Authors from Editors of Respiratory, Sleep, and Critical Care Journals

Lederer, D. J., Bell, S. C., Branson, R. D., Chalmers, J. D., Marshall, R., Maslove, D. M., Ost, D. E., Punjabi, N. M., Schatz, M., Smyth, A. R., Stewart, P. W., Suissa, S., Adjei, A. A., Akdis, C. A., Azoulay, É., Bakker, J., Ballas, Z. K., Bardin, P. G., Barreiro, E., Bellomo, R. & 28 others, Bernstein, J. A., Brusasco, V., Buchman, T. G., Chokroverty, S., Collop, N. A., Crapo, J. D., Fitzgerald, D. A., Hale, L., Hart, N., Herth, F. J., Iwashyna, T. J., Jenkins, G., Kolb, M., Marks, G. B., Mazzone, P., Moorman, J. R., Murphy, T. M., Noah, T. L., Reynolds, P., Riemann, D., Russell, R. E., Sheikh, A., Sotgiu, G., Swenson, E. R., Szczesniak, R., Szymusiak, R., Teboul, J-L. & Vincent, J-L., Jan 2019, In : Annals of the American Thoracic Society. 16, 1, p. 22-28 7 p.

Research output: Contribution to journalArticle

Open Access
File
110 Citations (Scopus)
358 Downloads (Pure)

Distinct 'Immuno-Allertypes' of Disease and High Frequencies of Sensitisation in Non-Cystic-Fibrosis Bronchiectasis

Mac Aogáin, M., Tiew, P. Y., Lim, A. Y. H., Low, T. B., Tan, G. L., Hassan, T., Ong, T. H., Pang, S. L., Lee, Z. Y., Gwee, X. W., Martinus, C., Sio, Y. Y., Matta, S. A., Ong, T. C., Tiong, Y. S., Wong, K. N., Narayanan, S., Bijin Au, V., Marlier, D., Keir, H. R. & 8 others, Tee, A., Abisheganaden, J. A., Koh, M. S., Wang, D. Y., Connolly, J. E., Chew, F. T., Chalmers, J. D. & Chotirmall, S. H., 1 Apr 2019, In : American Journal of Respiratory and Critical Care Medicine. 199, 7, p. 842-853 12 p.

Research output: Contribution to journalArticle

Open Access
File
18 Citations (Scopus)
186 Downloads (Pure)

Efficacy and safety of tobramycin inhalation powder in bronchiectasis patients with P. aeruginosa infection: Design of a dose-finding study (iBEST-1)

Loebinger, M. R., Polverino, E., Blasi, F., Elborn, S. J., Chalmers, J. D., Goossens, H., Tiddens, H. A., Tunney, M., Zhou, W., Angyalosi, G., Hill, A. T. & Haworth, C. S., Oct 2019, In : Pulmonary Pharmacology & Therapeutics. 58, 29 p., 101834.

Research output: Contribution to journalArticle

Evaluation of active neutrophil elastase in sputum of bronchiectasis and cystic fibrosis patients: A comparison among different techniques

Oriano, M., Terranova, L., Sotgiu, G., Saderi, L., Bellofiore, A., Retucci, M., Marotta, C., Gramegna, A., Miglietta, D., Carnini, C., Marchisio, P., Chalmers, J. D., Aliberti, S. & Blasi, F., Dec 2019, In : Pulmonary Pharmacology & Therapeutics. 59, 6 p., 101856.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Healthcare-associated pneumonia: is there any reason to continue to utilize this label in 2019?

Ewig, S., Kolditz, M., Pletz, M. W. & Chalmers, J., Oct 2019, In : Clinical Microbiology and Infection. 25, 10, p. 1173-1179 7 p.

Research output: Contribution to journalReview article

3 Citations (Scopus)