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• An Extensively Humanized Mouse Model to Predict Pathways of Drug Disposition and Drug/Drug Interactions, and to Facilitate Design of Clinical Trials

  Henderson, C. J., Kapelyukh, Y., Scheer, N., Rode, A., McLaren, A., MacLeod, K., Lin, D., Wright, J., Stanley, L. A. & Wolf, C. R., Jun 2019, In: Drug Metabolism and Disposition. 47, 6, p. 601-615 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Drug Interactions
  • Clinical Trials
  • Pharmaceutical Preparations
  • Pharmacokinetics
  • Cytochrome P-450 CYP2C9
  5 Citations (Scopus)

  102 Downloads (Pure)

• Application of hepatic cytochrome b5/P450 reductase null (HBRN) mice to study the role of cytochrome b5 in the cytochrome P450-mediated bioactivation of the anticancer drug ellipticine

  Reed, L., Indra, R., Mrizova, I., Moserova, M., Schmeiser, H. H., Wolf, C. R., Henderson, C. J., Stiborova, M., Phillips, D. H. & Arlt, V. M., 1 Mar 2019, In: Toxicology and Applied Pharmacology. 366, p. 64-74 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cytochrome P-450 Enzyme System
  • ellipticine
  • Cytochromes b5
  • NADPH-Ferrihemoprotein Reductase
  • Oxidoreductases
  1 Citation (Scopus)

  138 Downloads (Pure)

• Application of Mice Humanised for Cytochrome P450 CYP2D6 to the Study of Tamoxifen Metabolism and Drug-Drug Interaction with Antidepressants

  MacLeod, A. K., McLaughlin, L. A., Henderson, C. J. & Wolf, C. R., Jan 2017, In: Drug Metabolism and Disposition. 45, 1, p. 17-22 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • 4-hydroxy-N-desmethyltamoxifen
  • Cytochrome P-450 CYP2D6
  • N-desmethyltamoxifen
  • Tamoxifen
  • Drug Interactions
  6 Citations (Scopus)

  151 Downloads (Pure)

• Application of the in vivo oxidative stress reporter Hmox1 as mechanistic biomarker of arsenic toxicity

  Inesta-Vaquera, F., Navasumrit, P., Henderson, C. J., Frangova, T. G., Honda, T., Dinkova-Kostova, A. T., Ruchirawat, M. & Wolf, C. R., 9 Nov 2020, In: Environmental Pollution. 12 p., 116053.

  Research output: Contribution to journal › Article › peer-review

  • Oxidative stress
  • Arsenic
  • Biomarkers
  • Toxicity
  • Oxidative Stress

• Aryl hydrocarbon receptor is required for optimal B-cell proliferation

  Villa, M., Gialitakis, M., Tolaini, M., Ahlfors, H., Henderson, C. J., Wolf, C. R., Brink, R. & Stockinger, B., 4 Jan 2017, In: EMBO Journal. 36, 1, p. 116-128 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cell proliferation
  • Aryl Hydrocarbon Receptors
  • B-Lymphocytes
  • Cell Proliferation
  • Cells
  29 Citations (Scopus)

  220 Downloads (Pure)

• Constitutive androstane receptor 1 is constitutively bound to chromatin and ‘primed’ for transactivation in hepatocytes

  McMahon, M., Ding, S., Acosta-Jimenez, L., Terranova, R., Gerard, M-A., Vitobello, A., Moggs, J. G., Henderson, C. J. & Wolf, C. R., 1 Jan 2019, In: Molecular Pharmacology. 95, 1, p. 97-105 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • constitutive androstane receptor
  • Transcriptional Activation
  • Chromatin
  • Hepatocytes
  • Xenobiotics
  3 Citations (Scopus)

  144 Downloads (Pure)

• Corrigendum to "Aldo-keto reductases are biomarkers of NRF2 activity and are co-ordinately overexpressed in non-small cell lung cancer"

  MacLeod, A. K., Acosta-Jimenez, L., Coates, P. J., McMahon, M., Carey, F. A., Honda, T., Hayes, J. D., Henderson, C. J. & Wolf, C. R., 22 Aug 2017, In: British Journal of Cancer. 117, 1 p., e1.

  Research output: Contribution to journal › Article
  1 Citation (Scopus)

• Cytochrome b₅ impacts on cytochrome P450-mediated metabolism of benzo[a]pyrene and its DNA adduct formation: studies in hepatic cytochrome b₅ /P450 reductase null (HBRN) mice

  Reed, L., Mrizova, I., Barta, F., Indra, R., Moserova, M., Kopka, K., Schmeiser, H. H., Wolf, C. R., Henderson, C. J., Stiborova, M., Phillips, D. H. & Arlt, V. M., Apr 2018, In: Archives of Toxicology. 92, 4, p. 1625-1638 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cytochrome P-450 Enzyme System
  • benzo(a)pyrene-DNA adduct
  • Cytochromes b5
  • NADPH-Ferrihemoprotein Reductase
  • Metabolism
  17 Citations (Scopus)

  163 Downloads (Pure)

• Defining the Contribution of CYP1A1 and CYP1A2 to Drug Metabolism Using Humanized CYP1A1/1A2 and Cyp1a1/Cyp1a2 Knockout Mice

  Kapelyukh, Y., Henderson, C. J., Scheer, N., Rode, A. & Wolf, R., 1 Aug 2019, In: Drug Metabolism and Disposition. 47, 8, p. 907-918 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cytochrome P-450 CYP1A2
  • Cytochrome P-450 CYP1A1
  • Knockout Mice
  • Polychlorinated Dibenzodioxins
  • Pharmaceutical Preparations
  2 Citations (Scopus)

  25 Downloads (Pure)

• Discovery of common and rare genetic risk variants for colorectal cancer

  Huyghe, J. R., Bien, S. A., Harrison, T. A., Kang, H. M., Chen, S., Schmit, S. L., Conti, D. V., Qu, C., Jeon, J., Edlund, C. K., Greenside, P., Wainberg, M., Schumacher, F. R., Smith, J. D., Levine, D. M., Nelson, S. C., Sinnott-Armstrong, N. A., Albanes, D., Alonso, M. H., Anderson, K. & 179 others, Arnau-Collell, C., Arndt, V., Bamia, C., Banbury, B. L., Baron, J. A., Berndt, S. I., Bézieau, S., Bishop, D. T., Boehm, J., Boeing, H., Brenner, H., Brezina, S., Buch, S., Buchanan, D. D., Burnett-Hartman, A., Butterbach, K., Caan, B. J., Campbell, P. T., Carlson, C. S., Castellví-Bel, S., Chan, A. T., Chang-Claude, J., Chanock, S. J., Chirlaque, M-D., Cho, S. H., Connolly, C. M., Cross, A. J., Cuk, K., Curtis, K. R., de la Chapelle, A., Doheny, K. F., Duggan, D., Easton, D. F., Elias, S. G., Elliott, F., English, D. R., Feskens, E. J. M., Figueiredo, J. C., Fischer, R., FitzGerald, L. M., Forman, D., Gala, M., Gallinger, S., Gauderman, W. J., Giles, G. G., Gillanders, E., Gong, J., Goodman, P. J., Grady, W. M., Grove, J. S., Gsur, A., Gunter, M. J., Haile, R. W., Hampe, J., Hampel, H., Harlid, S., Hayes, R. B., Hofer, P., Hoffmeister, M., Hopper, J. L., Hsu, W-L., Huang, W-Y., Hudson, T. J., Hunter, D. J., Ibañez-Sanz, G., Idos, G. E., Ingersoll, R., Jackson, R. D., Jacobs, E. J., Jenkins, M. A., Joshi, A. D., Joshu, C. E., Keku, T. O., Key, T. J., Kim, H. R., Kobayashi, E., Kolonel, L. N., Kooperberg, C., Kühn, T., Küry, S., Kweon, S-S., Larsson, S. C., Laurie, C. A., Le Marchand, L., Leal, S. M., Lee, S. C., Lejbkowicz, F., Lemire, M., Li, C. I., Li, L., Lieb, W., Lin, Y., Lindblom, A., Lindor, N. M., Ling, H., Louie, T. L., Männistö, S., Markowitz, S. D., Martín, V., Masala, G., McNeil, C. E., Melas, M., Milne, R. L., Moreno, L., Murphy, N., Myte, R., Naccarati, A., Newcomb, P. A., Offit, K., Ogino, S., Onland-Moret, N. C., Pardini, B., Parfrey, P. S., Pearlman, R., Perduca, V., Pharoah, P. D. P., Pinchev, M., Platz, E. A., Prentice, R. L., Pugh, E., Raskin, L., Rennert, G., Rennert, H. S., Riboli, E., Rodríguez-Barranco, M., Romm, J., Sakoda, L. C., Schafmayer, C., Schoen, R. E., Seminara, D., Shah, M., Shelford, T., Shin, M-H., Shulman, K., Sieri, S., Slattery, M. L., Southey, M. C., Stadler, Z. K., Stegmaier, C., Su, Y-R., Tangen, C. M., Thibodeau, S. N., Thomas, D. C., Thomas, S. S., Toland, A. E., Trichopoulou, A., Ulrich, C. M., Van Den Berg, D. J., van Duijnhoven, F. J. B., Van Guelpen, B., van Kranen, H., Vijai, J., Visvanathan, K., Vodicka, P., Vodickova, L., Vymetalkova, V., Weigl, K., Weinstein, S. J., White, E., Win, A. K., Wolf, C. R., Wolk, A., Woods, M. O., Wu, A. H., Zaidi, S. H., Zanke, B. W., Zhang, Q., Zheng, W., Scacheri, P. C., Potter, J. D., Bassik, M. C., Kundaje, A., Casey, G., Moreno, V., Abecasis, G. R., Nickerson, D. A., Gruber, S. B., Hsu, L. & Peters, U., 1 Jan 2019, In: Nature Genetics. 51, 1, p. 76-87 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Colorectal Neoplasms
  • Whole Genome Sequencing
  • Long Noncoding RNA
  • Genome-Wide Association Study
  • Drug Development
  73 Citations (Scopus)

  280 Downloads (Pure)

• Drug-induced chromatin accessibility changes associate with sensitivity to liver tumor promotion

  Vitobello, A., Perner, J., Beil, J., Zhu, J., Del Río-Espínola, A., Morawiec, L., Westphal, M., Dubost, V., Altorfer, M., Naumann, U., Mueller, A., Kapur, K., Borowsky, M., Henderson, C., Wolf, C. R., Schwarz, M., Moggs, J. & Terranova, R., Oct 2019, In: Life Science Alliance. 2, 5, 18 p., e201900461.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • liver neoplasms
  • Liver
  • phenobarbital
  • Phenobarbital
  • tumor
  125 Downloads (Pure)

• Feedback control of AHR signalling regulates intestinal immunity

  Schiering, C., Wincent, E., Metidji, A., Iseppon, A., Li, Y., Potocnik, A. J., Omenetti, S., Henderson, C. J., Wolf, C. R., Nebert, D. W. & Stockinger, B., 9 Feb 2017, In: Nature. 542, 7640, p. 242-245 4 p.

  Research output: Contribution to journal › Letter › peer-review

  Open Access

  File

  • Aryl Hydrocarbon Receptors
  • Immunity
  • Ligands
  • Cytochromes
  • Epithelial Cells
  148 Citations (Scopus)

  218 Downloads (Pure)

• Genetically Humanized Animal Models

  Samuelsson, K., Scheer, N., Wilson, I., Wolf, C. & Henderson, C. J., 13 Jun 2017, Comprehensive Medicinal Chemistry III. Chackalamannil, S., Rotella, D. P. & Ward, S. E. (eds.). Elsevier, p. 130-149 20 p. (Reference Module in Chemistry, Molecular Sciences and Chemical Engineering).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Animal Models
  • Drug-Related Side Effects and Adverse Reactions
  • Drug Discovery
  • Drug Development
  • Hepatocytes

• Identification of novel pathways of osimertinib disposition and potential implications for the outcome of lung cancer therapy

  MacLeod, A. K., Lin, D., Huang, J. T-J., McLaughlin, L. A., Henderson, C. J. & Wolf, C. R., May 2018, In: Clinical Cancer Research. 24, 9, p. 2138-2147 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • osimertinib
  • Lung Neoplasms
  • Cytochrome P-450 CYP3A
  • Therapeutics
  • Enzyme Induction
  8 Citations (Scopus)

  165 Downloads (Pure)

• Interaction between polymorphisms in aspirin metabolic pathways, regular aspirin use and colorectal cancer risk: A case-control study in unselected white European populations

  Sheth, H., Northwood, E., Ulrich, C. M., Scherer, D., Elliott, F., Barrett, J. H., Forman, D., Wolf, C. R., Smith, G., Jackson, M. S., Santibanez-Koref, M., Haile, R., Casey, G., Jenkins, M., Win, A. K., Hopper, J. L., Marchand, L. L., Lindor, N. M., Thibodeau, S. N., Potter, J. D. & 2 others, Burn, J. & Bishop, D. T., 9 Feb 2018, In: PLoS ONE. 13, 2, p. 1-17 17 p., e0192223.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Metabolic Networks and Pathways
  • case-control studies
  • Polymorphism
  • colorectal neoplasms
  • aspirin
  3 Citations (Scopus)

  206 Downloads (Pure)

• Measuring in vivo responses to endogenous and exogenous oxidative stress using a novel haem oxygenase 1 reporter mouse

  McMahon, M., Ding, S., Acosta-Jimenez, L. P., Frangova, T. G., Henderson, C. J. & Wolf, C. R., 1 Jan 2018, In: Journal of Physiology. 596, 1, p. 105-127 23 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Heme Oxygenase (Decyclizing)
  • Galactosidases
  • Oxidative Stress
  • Firefly Luciferases
  • Toxicology
  6 Citations (Scopus)

  126 Downloads (Pure)

• Novel Pathways Of Ponatinib Disposition Catalysed By CYP1A1 Involving Generation Of Potentially Toxic Metabolites

  Lin, D., Kostov, R., Huang, J., Henderson, C. J. & Wolf, C., Oct 2017, In: Journal of Pharmacology and Experimental Therapeutics. 363, 1, p. 12-19 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • ponatinib
  • Cytochrome P-450 CYP1A1
  • Poisons
  • Glutathione Transferase
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive
  15 Citations (Scopus)

  136 Downloads (Pure)

• Progress in identifying epigenetic mechanisms of xenobiotic-induced non-genotoxic carcinogenesis

  Terranova, R., Vitobello, A., Del Rio Espinola, A., Wolf, C. R., Schwarz, M., Thomson, J. M., Meehan, R. & Moggs, J. G., Apr 2017, In: Current Opinion in Toxicology. 3, p. 62-70 9 p.

  Research output: Contribution to journal › Review article › peer-review

  • Xenobiotics
  • Epigenomics
  • Carcinogenesis
  • Tissue
  • Animals
  8 Citations (Scopus)

• Xenobiotic CAR activators induce Dlk1-Dio3 locus non-coding RNA expression in mouse liver

  Pouché, L., Vitobello, A., Römer, M., Glogovac, M., MacLeod, A. K., Ellinger-Ziegelbauer, H., Westphal, M., Dubost, V., Stiehl, D. P., Dumotier, B., Fekete, A., Moulin, P., Zell, A., Schwarz, M., Moreno, R., Huang, J. T. J., Elcombe, C. R., Henderson, C. J., Wolf, C. R., Moggs, J. G. & 1 others, Terranova, R., Aug 2017, In: Toxicological Sciences. 158, 2, p. 367-378 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • constitutive androstane receptor
  • Liver
  • Untranslated RNA
  • Xenobiotics
  • Biomarkers
  4 Citations (Scopus)

  182 Downloads (Pure)