Find Research Outputs

Search results

• 2020

  Application of the in vivo oxidative stress reporter Hmox1 as mechanistic biomarker of arsenic toxicity

  Inesta-Vaquera, F., Navasumrit, P., Henderson, C. J., Frangova, T. G., Honda, T., Dinkova-Kostova, A. T., Ruchirawat, M. & Wolf, C. R., 9 Nov 2020, In: Environmental Pollution. 12 p., 116053.

  Research output: Contribution to journal › Article › peer-review

  • Oxidative stress
  • Arsenic
  • Biomarkers
  • Toxicity
  • Oxidative Stress
• 2018

  Cytochrome b₅ impacts on cytochrome P450-mediated metabolism of benzo[a]pyrene and its DNA adduct formation: studies in hepatic cytochrome b₅ /P450 reductase null (HBRN) mice

  Reed, L., Mrizova, I., Barta, F., Indra, R., Moserova, M., Kopka, K., Schmeiser, H. H., Wolf, C. R., Henderson, C. J., Stiborova, M., Phillips, D. H. & Arlt, V. M., Apr 2018, In: Archives of Toxicology. 92, 4, p. 1625-1638 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cytochrome P-450 Enzyme System
  • benzo(a)pyrene-DNA adduct
  • Cytochromes b5
  • NADPH-Ferrihemoprotein Reductase
  • Metabolism
  17 Citations (Scopus)

  163 Downloads (Pure)

• Identification of novel pathways of osimertinib disposition and potential implications for the outcome of lung cancer therapy

  MacLeod, A. K., Lin, D., Huang, J. T-J., McLaughlin, L. A., Henderson, C. J. & Wolf, C. R., May 2018, In: Clinical Cancer Research. 24, 9, p. 2138-2147 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • osimertinib
  • Lung Neoplasms
  • Cytochrome P-450 CYP3A
  • Therapeutics
  • Enzyme Induction
  8 Citations (Scopus)

  165 Downloads (Pure)

• Interaction between polymorphisms in aspirin metabolic pathways, regular aspirin use and colorectal cancer risk: A case-control study in unselected white European populations

  Sheth, H., Northwood, E., Ulrich, C. M., Scherer, D., Elliott, F., Barrett, J. H., Forman, D., Wolf, C. R., Smith, G., Jackson, M. S., Santibanez-Koref, M., Haile, R., Casey, G., Jenkins, M., Win, A. K., Hopper, J. L., Marchand, L. L., Lindor, N. M., Thibodeau, S. N., Potter, J. D. & 2 others, Burn, J. & Bishop, D. T., 9 Feb 2018, In: PLoS ONE. 13, 2, p. 1-17 17 p., e0192223.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Metabolic Networks and Pathways
  • case-control studies
  • Polymorphism
  • colorectal neoplasms
  • aspirin
  3 Citations (Scopus)

  206 Downloads (Pure)

• Measuring in vivo responses to endogenous and exogenous oxidative stress using a novel haem oxygenase 1 reporter mouse

  McMahon, M., Ding, S., Acosta-Jimenez, L. P., Frangova, T. G., Henderson, C. J. & Wolf, C. R., 1 Jan 2018, In: Journal of Physiology. 596, 1, p. 105-127 23 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Heme Oxygenase (Decyclizing)
  • Galactosidases
  • Oxidative Stress
  • Firefly Luciferases
  • Toxicology
  6 Citations (Scopus)

  126 Downloads (Pure)
• 2017

  Application of Mice Humanised for Cytochrome P450 CYP2D6 to the Study of Tamoxifen Metabolism and Drug-Drug Interaction with Antidepressants

  MacLeod, A. K., McLaughlin, L. A., Henderson, C. J. & Wolf, C. R., Jan 2017, In: Drug Metabolism and Disposition. 45, 1, p. 17-22 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • 4-hydroxy-N-desmethyltamoxifen
  • Cytochrome P-450 CYP2D6
  • N-desmethyltamoxifen
  • Tamoxifen
  • Drug Interactions
  6 Citations (Scopus)

  151 Downloads (Pure)

• Aryl hydrocarbon receptor is required for optimal B-cell proliferation

  Villa, M., Gialitakis, M., Tolaini, M., Ahlfors, H., Henderson, C. J., Wolf, C. R., Brink, R. & Stockinger, B., 4 Jan 2017, In: EMBO Journal. 36, 1, p. 116-128 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cell proliferation
  • Aryl Hydrocarbon Receptors
  • B-Lymphocytes
  • Cell Proliferation
  • Cells
  29 Citations (Scopus)

  220 Downloads (Pure)

• Corrigendum to "Aldo-keto reductases are biomarkers of NRF2 activity and are co-ordinately overexpressed in non-small cell lung cancer"

  MacLeod, A. K., Acosta-Jimenez, L., Coates, P. J., McMahon, M., Carey, F. A., Honda, T., Hayes, J. D., Henderson, C. J. & Wolf, C. R., 22 Aug 2017, In: British Journal of Cancer. 117, 1 p., e1.

  Research output: Contribution to journal › Article
  1 Citation (Scopus)

• Feedback control of AHR signalling regulates intestinal immunity

  Schiering, C., Wincent, E., Metidji, A., Iseppon, A., Li, Y., Potocnik, A. J., Omenetti, S., Henderson, C. J., Wolf, C. R., Nebert, D. W. & Stockinger, B., 9 Feb 2017, In: Nature. 542, 7640, p. 242-245 4 p.

  Research output: Contribution to journal › Letter › peer-review

  Open Access

  File

  • Aryl Hydrocarbon Receptors
  • Immunity
  • Ligands
  • Cytochromes
  • Epithelial Cells
  148 Citations (Scopus)

  218 Downloads (Pure)

• Genetically Humanized Animal Models

  Samuelsson, K., Scheer, N., Wilson, I., Wolf, C. & Henderson, C. J., 13 Jun 2017, Comprehensive Medicinal Chemistry III. Chackalamannil, S., Rotella, D. P. & Ward, S. E. (eds.). Elsevier, p. 130-149 20 p. (Reference Module in Chemistry, Molecular Sciences and Chemical Engineering).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Animal Models
  • Drug-Related Side Effects and Adverse Reactions
  • Drug Discovery
  • Drug Development
  • Hepatocytes

• Novel Pathways Of Ponatinib Disposition Catalysed By CYP1A1 Involving Generation Of Potentially Toxic Metabolites

  Lin, D., Kostov, R., Huang, J., Henderson, C. J. & Wolf, C., Oct 2017, In: Journal of Pharmacology and Experimental Therapeutics. 363, 1, p. 12-19 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • ponatinib
  • Cytochrome P-450 CYP1A1
  • Poisons
  • Glutathione Transferase
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive
  15 Citations (Scopus)

  136 Downloads (Pure)

• Progress in identifying epigenetic mechanisms of xenobiotic-induced non-genotoxic carcinogenesis

  Terranova, R., Vitobello, A., Del Rio Espinola, A., Wolf, C. R., Schwarz, M., Thomson, J. M., Meehan, R. & Moggs, J. G., Apr 2017, In: Current Opinion in Toxicology. 3, p. 62-70 9 p.

  Research output: Contribution to journal › Review article › peer-review

  • Xenobiotics
  • Epigenomics
  • Carcinogenesis
  • Tissue
  • Animals
  8 Citations (Scopus)

• Xenobiotic CAR activators induce Dlk1-Dio3 locus non-coding RNA expression in mouse liver

  Pouché, L., Vitobello, A., Römer, M., Glogovac, M., MacLeod, A. K., Ellinger-Ziegelbauer, H., Westphal, M., Dubost, V., Stiehl, D. P., Dumotier, B., Fekete, A., Moulin, P., Zell, A., Schwarz, M., Moreno, R., Huang, J. T. J., Elcombe, C. R., Henderson, C. J., Wolf, C. R., Moggs, J. G. & 1 others, Terranova, R., Aug 2017, In: Toxicological Sciences. 158, 2, p. 367-378 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • constitutive androstane receptor
  • Liver
  • Untranslated RNA
  • Xenobiotics
  • Biomarkers
  4 Citations (Scopus)

  182 Downloads (Pure)